Welcome to “Analytically Speaking,” the new podcast from LCGC and Spectroscopy.

Here in Episode #1, podcast host Jerry Workman talks to Prof. Barry Lavine of the Department of Chemistry at Oklahoma State University. Prof. Lavine and his research group have been working on new approaches and algorithms for identification and classification of samples measured using infrared (IR) imaging microscopy in forensic analysis. He discusses aspects of sampling, spectra collection, image generation, and data analysis for infrared imaging and sample identification. Data analytics topics include alternate least squares (ALS) reconstruction of the IR spectra of the individual layers from automotive paint samples using machine learning techniques, spectral database searching, and special experimental design methods.

References and Further Reading:
Barry Lavine faculty page: https://chemistry.okstate.edu/bios/356-faculty-member-bio-lavine

F. Kwofie, N.U.D Perera, K.S. Dahal, G.P. Affadu-Danful, K. Nishikida, and B.K. Lavine, Transmission Infrared Microscopy and Machine Learning Applied to the Forensic Examination of Original Automotive Paint. Applied Spectroscopy 76(1), 118–131 (2022). https://doi.org/10.1177/00037028211057574

B.K. Lavine, A. Fasasi, N. Mirjankar, K. Nishikida, and J. Campbell, Simulation of attenuated total reflection infrared absorbance spectra: applications to automotive clear coat forensic analysis. Applied Spectroscopy 68(5), 608–615 (2014). https://doi.org/10.1366/13-07266

A. Fasasi, N. Mirjankar, R.I. Stoian, C. White, M. Allen, M.P. Sandercock, and B.K. Lavine, Pattern recognition-assisted infrared library searching of automotive clear coats. Applied Spectroscopy 69(1), 84–94 (2015). https://doi.org/10.1177/0003702816666287

B.K. Lavine, K. Nuguru, N. Mirjankar, and J. Workman, Pattern recognition assisted infrared library searching. Applied Spectroscopy 66(8), 917–925 (2012). https://doi.org/10.1366/11-06576
 
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Ep. 1: Transmission Infrared Imaging Microscopy (with Data Analytics)

In this episode, podcast host Dr. Dwight Stoll talks with Dr. Katelynn Perrault, an Associate Professor of Forensic Science and Chemistry at Chaminade university in Honolulu, about her pathway to separation science, her research on the composition of odors from decomposing remains, and her thoughts about what the separation science community can do to get more women involved in the field. Drs. Stoll and Perrault talk about multi-dimensional gas chromatography (GCxGC)— which is Perrault’s primary research tool—ranging from where the technique stands today, to where progress will likely occur in the near future, and why the technique is so well suited to the analysis of decomposition odors.


Useful Links

•	Kate Perrault’s website : https://chaminade.edu/nsm/nsm-faculty/katelynn-perrault/

•	Conference website for the 14th Multi-Dimensional Chromatography Workshop, which will be held in Liege, Belgium, at the end of January, 2023 http://www.multidimensionalchromatography.com/ 

•	Kate’s post on women in separation science in the LCGC blog: https://www.chromatographyonline.com/view/the-lcgc-blog-she-separates-the-female-voices-of-separation-science


Recent Literature Discussed: 
•	K. Raninen, R. Nenonen, E. Reijonen, K. Poutanen, H. Mykkänen, O. Raatikainen, Comprehensive Two-Dimensional Gas Chromatography-Mass Spectrometry Analysis of Exhaled Breath Compounds After Whole Grain Diets. Molecules 26(9), 2667 (2021). https://doi.org/10.3390/molecules26092667.

•	M. Markowska, A. Krajewski, D. Maciejewska, H. Jelen, M. Kaczmarek, E. Stachowska, Qualitative Analysis of Surgical Smoke Produced During Burn Operations. Burns 46(6), 1356-1364 (2020). https://doi.org/10.1016/j.burns.2020.02.014.

•	F. Schleich, D. Zanella, P. Stefanuto, K. Bessonov, A. Smolinska, J. Dallinga, M. Henket, V. Paulus, F. Guissard, S. Graff, C. Moermans, E. Wouters, K. Van Steen, F. van Schooten, J. Focant, R. Louis, Exhaled Volatile Organic Compounds Are Able to Discriminate between Neutrophilic and Eosinophilic Asthma. American Journal of Respiratory and Critical Care Medicine 200(4) 444-453 (2018). https://doi.org/10.1164/rccm.201811-2210OC.


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Email us at LCGCedit@mmhgroup.com.

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Ep 2: We Really Feel the Need to Know What’s in Stuff

Welcome to “Analytically Speaking,” the new podcast from LCGC and Spectroscopy.

Here in Episode 3, podcast host Jerry Workman talks to talks to Prof. Karl Booksh of the Department of Chemistry and Biochemistry at the University of Delaware, Newark, who is an expert in Raman and Raman imaging, LIBS, fluorescence, portable chemical sensors, miniaturization of analytical devices, and data driven science incorporating many chemometrics and data analytics techniques. He discusses a National Science Foundation workshop he is organizing with Prof. Barry Lavine entitled, “Data-Driven Measurements and Instruments for Chemistry.” 

We spoke to Prof. Karl Booksh about his organizing an NSF workshop to explore research on the development of portable chemical sensors for environmental, biomedical, and industrial process monitoring. Karl’s own research is predicated on the belief that it is better to build small chemical sensors capable of reliable measurements in the field or in the process than to collect samples for future laboratory analysis.
References and Further Reading:
Karl Booksh faculty page: https://www.chem.udel.edu/people/full-list-searchable/kbooksh

K.S. Booksh and B.R. Kowalski, Theory of analytical chemistry. Analytical Chemistry 66(15), 782A–791A (1994). https://doi.org/10.1021/ac00087a001

D.M. Wilson, S. Hoyt, J. Janata, K. Booksh, and L. Obando, Chemical sensors for portable, handheld field instruments. IEEE sensors journal 1(4), 256–274 (2001). https://doi.org/10.1109/7361.983465

D.M Wilson, S. Garrod, S. Hoyt, S. McKennoch, K.S. and Booksh, Array optimization and preprocessing techniques for chemical sensing microsystems. Sensors Update 10(1), 77–106 (2002). https://doi.org/10.1002/1616-8984(200201)10:1<77::AID-SEUP77>3.0.CO;2-F

J.P. Smith, E.C. Holahan, F.C. Smith, V. Marrero, and K.S. Booksh, A novel multivariate curve resolution-alternating least squares (MCR-ALS) methodology for application in hyperspectral Raman imaging analysis. Analyst 144(18), 5425–5438 (2019). https://doi.org/10.1039/C9AN00787C

C.P. Celani, C.A. Lancaster, J.A. Jordan, E.O. Espinoza, and K.S. Booksh, Assessing utility of handheld laser induced breakdown spectroscopy as a means of Dalbergia speciation. Analyst 144(17), 5117–5126 (2019). https://doi.org/10.1039/C9AN00984A

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To advertise on the show, contact Ed Fantuzzi at efantuzzi@MJHlifesciences.com

Ep. 3: The Future of Chemometrics—Data-Driven Measurements and Instruments for Chemistry

In this episode, podcast host Dr. Dwight Stoll talks with Dr. Deirdre Cabooter, a professor working in the Department of Pharmaceutical and Pharmacological Sciences at KU Leuven in Leuven, Belgium, about her pathway to separation science, her research on fundamental aspects of band broadening in liquid chromatography and emerging work on the use of machine learning in method development, and her work as organizer of the HTC conference and Editor of the Journal of Chromatography A. Drs. Stoll and Cabooter talk about the importance of continuing to dig deeper and understand more about dispersion processes nearly 70 years after the famous van Deemter equation was first published, as well as the increasing importance of multi-dimensional separations in a variety of research areas.

Ep. 4: The Future of Method Development for Liquid Chromatography

Here in Episode 5, podcast host Jerry Workman speaks with Dr. Paul Gemperline who is Dean of the Graduate School and faculty member in the Department of Chemistry at East Carolina University in Greenville, North Carolina. We have invited Paul to our Analytically Speaking podcast to discuss his research on development of new computer algorithms and software tools for analysis of multivariate spectroscopic data.

Ep. 5: New Software Tools for Analysis of Spectroscopic Data

In this episode, podcast host Dr. Dwight Stoll talks with Dr. Mary Ellen McNally, a Global Research and Development Fellow at FMC Corporation, in Newark, Delaware. They discuss the origins of her interest in separation science and her short stay in an anti-doping laboratory on her way to a long and distinguished career in industry. Dr. McNally shares her perspectives on the challenges associated with counterfeit products in the agrochemical industry, as well as on the sustainability of separations methods and how we can improve the “green-ness” of these techniques going forward. Finally, Dr. McNally shares some advice for young scientists, whether they are still in school or early in their careers.

Ep. 8: Analytical science is critical to staying ahead of chemical counterfeiters

Welcome to “Analytically Speaking,” the podcast from LCGC and Spectroscopy.

Here in Episode 9, podcast host Jerry Workman speaks to Prof. Rasmus Bro, who is a full professor at the University of Copenhagen and one of the foremost active living data analytics and chemometrics experts. 

We spoke to Prof. Bro about the world of data analysis used for spectroscopy and other analytical methods. Over the years he has worked on many aspects of chemometrics, developing numerous algorithms and methods such as fuzzy logic, deep learning, analysis of variance, and tensor modeling. He has received multiple awards in chemometrics and in the analytical sciences, and is the second-most-cited scientist within the field of chemometrics with nearly 37,000 citations and an h-index of 78 (Google Scholar). Most of the algorithms and data sets he has worked on have been made publicly available on the internet. We have invited Prof. Bro to our Analytically Speaking podcast to discuss his research on the development and automation of several chemometrics methods for use with any spectroscopic technique.

Ep. 9: Automating Advanced Chemometric Methods for Data Processing

Welcome to “Analytically Speaking,” the podcast from LCGC and Spectroscopy. 

Here in Episode 15, podcast host Dr. Jerry Workman talks to Dr. Ellen Miseo and Dr. Zac Schultz about the benefits of participating in the Coblentz Society.

Ellen has been involved in vibrational spectroscopy and instrument development her entire career and is trained as a physical chemist. She has worked for instrument companies as well as run laboratory operations. She is past president of both the Coblentz Society and Society for Applied Spectroscopy. She currently heads Miseo Consulting. 

Zachary Schultz is Professor of Chemistry and Biochemistry at The Ohio State University and is the current President of the Coblentz Society. He is widely published on the subject of vibrational spectroscopy and also has an interest in undergraduate science education, and professional development, advancement, and mentoring.

Ep. 15: Building Professional Spectroscopy Skills and Valuable Networks with the Coblentz Society

In this episode, podcast host Dr. Dwight Stoll talks with Dr. Emanuella Gionfriddo, associate professor in the Department of Chemistry at the University of Toledo, Ohio. Dr. Gionfriddo is an expert in bioanalysis and analyte extraction technologies, and works on both the development of new technologies, and the application of those technologies to contemporary analytical challenges. In their conversation, they discuss the origins of Dr. Gionfriddo’s interest in science, and several recent papers, including topics including extraction of neurotoxins from water, markers of hydraulic fracturing activity in wastewater, and development of thin-film extraction for improved performance of DNA amplification assays. Finally, Dr. Gionfriddo shares several pieces of advice for young and aspiring scientists.

Ep. 14: The more diverse is your toolbox, the more analytical problems you can solve

In this episode, podcast host Dr. Dwight Stoll talks with Dr. David Bell, Research Fellow at Restek Corporation in Bellefonte, PA. Dr. Bell is an expert in the chemistry of stationary phases used for chromatography, and has contributed to all aspects of the lifecycle of commercial columns for chromatography, including research, development, and applications. In their conversation, they discuss Dr. Bell’s in separation science, opportunities that have come through his work as the Editor of “Column Watch” for LCGC Magazine, and the increasing influence of green chemistry principles on research in separations community. Finally, they discuss the important ingredients for successful collaborations between industry and academic researchers, and Dr. Bell shares a few bits of advice for young scientists.

Ep. 16: If you’re not having fun while learning, it’s time to study something else

In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Kevin Schug, Shimadzu Distinguished Professor of Analytical Chemistry at the University of Texas, Arlington. Dr. Schug is an expert in separations and mass spectrometry, and leads a research program with diverse interests ranging from clinical analysis to environmental analysis. In their conversation, they discuss several of Dr. Schug’s recent research articles focused on the thermodynamics of headspace analysis using ionic liquids as cosolvents, analysis of intact proteins using triple quadrupole mass spectrometry, and the coupling of supercritical fluid extraction with supercritical fluid chromatography. They also discuss several of Kevin’s topic interests, including mentoring the next generation of separation scientists, and the importance of rigorous analytical chemistry in the courtroom. Finally, Dr. Schug shares a few bits of advice, in addition to a plea for academic institutions to reconsider the way they support major research instrumentation.

Ep. 18: Teaching it forward in separation science

Here in Episode 21, podcast host Dr. Jerry Workman speaks with Dr. Art Springsteen about the history and challenges associated with reflection and color standards used around the world for optical spectroscopy.

Ep 21: Using Reference Standards for Spectroscopic Measurements

In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Heather Bean, Associate Professor of Biomedicine and Biotechnology at Arizona State University. Dr. Bean is an expert in volatilomics and leads a research program focused on the use of omics approaches to better understand a variety of physiological conditions ranging from disease and illness, such as cystic fibrosis and Valley fever, to fatigue. In their conversation, they discuss several of Dr. Bean’s recent research articles focused on the use of two-dimensional gas chromatography coupled with mass spectrometry to profile hundreds of volatile compounds present in biological samples that are relevant to these conditions. In addition to aspects of the actual separations that produce these data, they also discuss some of the current challenges in this type of work, including “missingness” in the datasets, and the importance of retention databases to omics work.

Listeners are also referred to the upcoming Multidimensional Chromatography Workshop, which will be held at California State University, Los Angeles, from January 10-12. For more information, see the conference website - http://www.multidimensionalchromatography.com/.

Ep. 20: Using multi-dimensional gas chromatography to help people breathe easier

Welcome to “Analytically Speaking,” the podcast from LCGC International and Spectroscopy. 

Here in Episode #23, podcast host Dr. Jerry Workman speaks with Dr. Art Springsteen and Dr. David Wyble about the challenges of creating color standards and making color measurements using optical spectroscopy.

Ep 23: Color My World: The Complexities of Color Measurements

In this episode, podcast host Dr. Dwight Stoll talks with Dr. Katelynn Perrault Uptmor, Dr. Pierre-Hugues Stefanuto, and Dr. Petr Vozka about the multidimensional chromatography workshop, better known as the MDCW for short. Kate, PH, Petr, and Dwight are co-organizers of the MDCW workshop, which was held most recently at California State University, Los Angeles. In their conversation they discuss how the MDCW is different from, and similar to, conventional scientific conferences. They reflect on the most recent (15th) meeting, including highlights from both the technical and social programs, and in the impact on the local student community at Cal State LA. Then, they switch gears and look forward to the 16th MDCW, which will be held February 3-5 at the University of Liege, in Liege, Belgium.

Ep. 22: Around the world with The Multidimensional Chromatography Workshop

Here in Episode 25, podcast host Dr. Jerry Workman speaks with Dr. Brian C. Smith about the challenges of training scientists to interpret infrared spectra and how to leverage that expertise into building a specialized instrument for analysis of Cannabis.

Ep 25: How to Interpret Infrared Spectra and How to Develop a Specialized Infrared Analyzer

In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Andre de Villiers, Professor of Chemistry at Stellenbosch University in South Africa. Dr. de Villiers is an expert in multi-dimensional chromatography and leads a research program mainly focused on the use of two-dimensional liquid chromatography coupled with mass spectrometric detection for the deep characterization of natural products such as tea, wine, wood, and cocoa. Some of his recent work has explored the potential for ion mobility separations to increase the utility of mass spectrometric detection coupled with two-dimensional liquid chromatography separations.

In the conversation, we talk about the development of Andre’s interest in separation science as a result of a chance meeting with Pat Sandra, and the increasingly apparent “perception problem” facing the field of analytical chemistry. Finally, Dr. de Villiers shares his views on some of the most pressing challenges he sees in the work he is doing right now, including the need for better methods to separate complex mixtures of tannins in natural products, and the need for better data analysis tools in multi-dimensional separations in general.

Ep 24: For the Love of Separation Science

Here in Episode #27, podcast host Dr. Jerry Workman speaks with Dr. Richard Crocombe of Crocombe Spectroscopic Consulting, about the world of ever shrinking spectrometers. We explore the technologies and applications for such portable and wearable systems and the future of spectroscopy in our everyday lives.

Ep 27: Exploring the World of Spectroscopy for Portable and Wearable Systems: Technology and Apps

Here in Episode #29, podcast host Dr. Jerry Workman speaks with Dr. Thomas Mayerhöfer  from the Leibniz Institute of Photonic Technology in Jena, Germany, about quantitative spectroscopy and wave optics in infrared spectroscopy, including the theory, simulation, and modeling aspects.

Ep 29: Quantitative Spectroscopy and Wave Optics in Infrared Spectroscopy

In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias discuss highlights and observations from the recently completed HPLC2024 that was held in Denver, Colorado in July. The “HPLC Meeting”, as the conference is affectionately known by regular attendees, is widely regarded as the premier venue to discuss the latest advances in liquid chromatography research and applications, and is well attended by influencers in the community from both academic and industrial research laboratories. This year’s meeting was no exception, with fantastic talks and posters presented by scientists from around the world.

In the conversation, we discuss some of the major themes and trends we observed at the meeting, including the proliferation of research around therapeutic oligonucleotides, and the increasing emphasis on the “green-ness” of analytical science in general, and liquid phase separations in particular. We also highlight the recipients of several awards presented at the meeting, and the value of attending the meeting, especially for students and other young scientists. Upcoming instances of the HPLC Meeting will be held in Dalian, China (2024), Bruges, Belgium (2025), and Indianapolis in the U.S. (2026).

Ep 26: HPLC2024 Conference Recap

In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Molly Atkinson, Assistant Professor of Chemistry at the University of North Texas in Denton, TX, and her graduate student David Hamilton. Atkinson and Hamilton are experts in Chemistry Education Research (CER), and they recently published a paper discussing results of a survey of bachelors-level chemists working in industry that asked them “What does industry want new chemists to know?”. The paper, published earlier this year in the Journal of Chemical Education, generated quite a lot of buzz on analytical chemistry social media.

In the conversation we talk about highlights from the article, and touch on potential future work that could fill in knowledge gaps identified by the first survey. The survey revealed some trends that will be familiar to readers of LCGC Magazine. For example, the surveyed chemists indicated that liquid and gas chromatography are two of the top five most important instrumental techniques that new chemists entering industry should know how to use. On the other hand, the survey also revealed some surprising results - for example, nuclear magnetic resonance (NMR) spectroscopy was not in the top-five instrumental techniques, despite that NMR occupies a prominent position in most undergraduate chemistry curricula in the United States. Finally, the guests and co-hosts discuss a bit about how Chemistry Education Research “works”, for listeners who are less familiar with this discipline than other more traditional research areas.

Ep. 28: What does industry want new chemists to know?

Here in Episode #31, podcast host Dr. Jerry Workman speaks with Dr. Barry M. Wise, Founder and President of Eigenvector Research, Inc. about the meaning of the terms chemometrics, artificial intelligence (AI), machine learning (ML), and  neural networks (NNs) within the context of analytical chemistry and process analysis.

Ep 31: Clarifying the Meaning of Chemometrics in the World of Artificial Intelligence (AI)

In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Farooq Wahab, Research Engineering Scientist at the University of Texas at Arlington. Wahab has interests and expertise in chiral separations, improving the green-ness of chromatographic separations, new detectors for chromatography such as microwave rotational spectroscopy, and new techniques for signal processing in chromatography, among other areas. He and several coauthors recently published a paper in Analytical Chemistry discussing their experiences using generative artificial intelligence (i.e. chatGPT) as a research assistant when working on tasks in measurement science ranging from extraction of rotational microwave spectra from free induction decay signals, to baseline removal from chromatographic data.

In the conversation we talk about the origins of this study, strengths and weaknesses of chatGPT as a research assistant in the analytical chemistry space, and the role of generative AI in chemistry teaching and learning. We also touch on tips and tricks also published by Wahab and coworkers for dealing with equations and symbol-heavy text when using generative AI tools. One very interesting application of these tricks is in the translation of relatively old (decades) papers that were published before English became the standard language for much of science publication.

Ep. 30: The Potential of Generative A.I. as a Research Assistant for Measurement Science

Here in Episode #33, podcast host Dr. Jerry Workman speaks with Dr. Brian G. Rohrback, President of Infometrix, Inc. in Bothell, WA, USA—who has been active in chemometrics research and creating software for complex calibrations and multivariate data analysis since 1983. Infometrix was founded by researchers Bruce Kowalski and Gerry Erickson in 1978.  We have invited Brian to our Analytically Speaking podcast to discuss his research and experience in automating the process of building multivariate calibrations.

Ep 33: Automating Chemometrics for an Expert Calibration System

In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Benjamin Garcia. Dr. Garcia is the Raymond H. Wittcoff Distinguished Professor and Head of the Department of Biochemistry and Molecular Biophysics in the School of Medicine at Washington University in St. Louis. His research interests primarily focus on the development of mass spectrometry-based proteomic approaches for the analysis of post-translational modifications of proteins (PTMs) and modified proteomes. His group specializes in high-throughput and quantitative analysis of many classes of modified proteins, especially epigenetic histone PTMs. He is a prolific author and scientific leader, with an h-index approaching 120. He has received a LOT of awards to date, but we sat down with him at the Eastern Analytical Symposium where he was recognized for his recent EAS Award for Outstanding Achievement in Mass Spectrometry.

In the conversation we talk about the origins of Dr. Garcia’s interests in analytical science, mass spectrometry, and biomedical research, and he shares his thoughts about the current state and near future for technologies used for biomolecule separations including peptides, proteins, and oligonucleotides. We also discuss Dr. Garcia’s highly impactful efforts to promote participation in the analytical sciences by people from all backgrounds, and he shares some thoughts about the “to-do list” for his upcoming term as chair of the ACS Division of Analytical Chemistry.

Ep. 32: Don’t skip seminar…you might miss a life-changing event

Perrault Uptmor of William & Mary, and Dr. Emanuela Gionfriddo of SUNY at Buffalo. Kate and Emanuela are both returning guests of the pod (see episodes 2 and 14), and joined us on-site at the Boston Convention Center to reflect on what we saw and heard at Pittcon 2025. 

In a wide-ranging conversation, we touch on a variety of aspects of the Pittcon experience, including networking opportunities, award sessions recognizing both early-career scientists and achievements over lifetimes, and of course trends in various areas as observed from the numerous technical sessions and talks.

Several notable award sessions honoring great work in separation science included:
●	ACS Division of Analytical Chemistry Young Investigator in Separation Science - awarded to Prof. Xiao Su of the University of Illinois at Urbana-Champaign
●	Pittcon Analytical Chemistry Award - awarded to Prof. Dan Armstrong of the University of Texas at Arlington
●	LCGC Emerging Leader Award - awarded to Prof. Katelynn Perrault Uptmor of William & Mary
●	LCGC Lifetime Achievement Award - awarded to Christopher Pohl of CAP Chromatography and Consulting
●	Chromatography Forum of the Delaware Valley Dal Nogare Award - awarded to Terry Berger

Some of the trends discussed during the episode include developments in the use of machine learning and artificial intelligence tools in our field, multi-dimensional separations, green chemistry, and more!


Ep. 34: A Banner Year for Separation Science at Pittcon 2025

Here in Episode #35, podcast host Dr. Jerry Workman speaks with Dr. Ellen V. Miseo, who has been active in vibrational spectroscopy and instrument development her entire career and is formally trained as a physical chemist. She has worked for instrument companies as well as run laboratory operations. She is past president of both the Coblentz Society and Society for Applied Spectroscopy and currently heads Miseo Consulting.

We have invited Ellen to our Analytically Speaking podcast to discuss the current activities of SAS and Coblentz to foster further education in the essential aspects of spectroscopy for current and future practitioners.  


Ep 35: On the Subject of Continuing Education for Spectroscopists.

In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Alix Rodowa, Research Chemist within the Organic Chemical Metrology Group at the National Institute of Standards & Technology (NIST) in Gaithersburg, Maryland. At NIST, she is the Environmental Sector Task Lead for the Organic Analysis Working Group for the Consultative Committee for Amount of Substance: Metrology in Chemistry and Biology (or CCQM).

After discussing some of the events that sparked Dr. Rodowa’s interest in science, and analytical chemistry in particular, we discuss her path to a career as a NIST scientist, including cold-emailing potential research advisors, and an experience as a National Research Council (NRC) postdoctoral fellow. We then discuss her work on polyfluoroalkyl substances (PFAS), including the development of the PFAS Interference List - affectionately known as the “PIL” - and the development of a Standard Reference Material (SRM) for that research area. We also touch on emerging uses of machine learning in workflows for analytical target and suspect screening. Finally, Alix provides some insight into a day in the life of a NIST scientist, why she enjoys working in a government laboratory, and how aspiring scientists can explore this environment as a potential career option.


Ep. 36: A Day in the Life of a NIST Scientist

Here in Episode #37, podcast host Dr. Jerry Workman speaks with Dr. Austin Daniels, application scientist for Yokogawa Fluid Imaging Technologies. This Episode will focus on flow imaging microscopy (FIM), a new technology for subvisible particle characterization in biologics.

We have invited Austin to our Analytically Speaking podcast to discuss the current trends and state of using FIM to ensure the quality and safety of biologics. This requires precise monitoring of subvisible particles, which can impact drug efficacy and patient health. Traditional analysis methods, such as light obscuration (LO) and membrane microscopy (MM), provide limited data on particle types and morphology, making it difficult to pinpoint contamination sources.



Ep 37: On the Subject of Flow Imaging Microscopy in Collaboration with the American Association of Pharmaceutical Scientists

Here in Episode #39, podcast host Dr. Jerry Workman speaks with Dr. Macarena Garcia Marin, who is an astrophysicist and instrument scientist for the European Space Agency based at the Space Telescope and Science Institute in Baltimore, MD USA. She will be discussing the highlights of the role of the James Webb Space Telescope, also known as JWST, and its abilities and discoveries using the science of spectroscopy in space, since performing spectroscopic research since its launch in 2021.

We have invited Macarena to our Analytically Speaking podcast to discuss the current discoveries using JWST and what the future hopes are for a deeper understanding of the amazing universe that surrounds our home, planet Earth.  



Ep 39: Space and Spectroscopy: Two Very Important Things” or “The Universe and Spectroscopy”

Analytically Speaking, the podcast from LCGC and Spectroscopy magazines, addresses important issues in separation science and analytical spectroscopy. Topics include new analytical techniques, methods, and approaches; the latest trends; advances in instrument and software technology; practical solutions for specific applications; recent papers in the scientific literature and their applicability; challenges and solutions for data analysis and interpretation; analytical chemistry theory and fundamentals (from advanced research to tutorials and troubleshooting); and more. Our regular hosts are Dwight Stoll, PhD, a professor of chemistry at Gustavus Adolphus College in St. Peter, Minnesota, and Jerry Workman, PhD, a spectroscopist, noted author, and currently the Senior Technical Editor of Spectroscopy and LCGC. Dwight covers separation science and Jerry addresses spectroscopy related topics.

Analytically Speaking

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