Cold Spring Harbor Laboratory's first fully-produced podcast series!  Base Pairs ​tells​ stories that ​convey​ the power of genetic information — past and present.

This pilot episode exemplifies the series, offering one story about the quirky history ​behind the field of genetics​, and another about how a ​scientist recently discovered a new​ disorder.

1 - From Phages to Faces

A sneak listen of Base Pairs Episode 2: How a little something called "hybrid vigor" changed America's corn —and genetics!— forever.

Tune in on July 15 for the full episode. Find us on iTunes, Stitcher, and Google Play.

EP2 Sneak Peek

The ongoing GMO labeling debate wasn't the first agricultural controversy. In the early 1900s, it was a new and so-called "wicked" breeding technique that had everyone on edge.

In this episode of Base Pairs, we dive into the surprisingly contentious history and genetics of America's corn.

2 - Corn Controversy

A sneak listen of Base Pairs Episode 3: How a frozen murder victim, ancient bones, and a LOT of math exposed new secrets of the human genome.

Tune in on August 15 for the full episode. Find us on iTunes, Stitcher, and Google Play.

EP3 Sneak Peek

From the scale of a single ancient murder victim to interactions between large groups of humans and Neanderthals who lived 100,000 years ago, genetic information holds many secrets about human history.

In this episode, "Ötzi the Iceman" and Dr Adam Siepel help us expose new secrets of the human genome.

3 - Non-modern Family

Nearly ten billion people will walk the Earth by 2050, and for some of the poorest and fastest growing countries, that could mean a bleak and hungry future.

Dr Josef Schmidhuber of the FAO and CSHL Professor David Jackson explain what has gone wrong, and how genetics can help.

4 - The People Problem

Professor Adrian Krainer was offered the opportunity to run his own lab when he was just 27 years old as part of a brand new “Fellows” program—which allowed him, in his words, to “sink or swim.” These kinds of programs are rare, as investing in young, relatively inexperienced people is risky. Krainer’s story makes us question what we’re risking by not investing in more young, dedicated, passionate scientists.

5 - Sink or Swim

Fighting cancer is so difficult in part because the healthy cells we want to support often end up casualties in the crossfire of toxic treatments. This episode is about how we might overcome this obstacle even in some of the most difficult cases: patients with pancreatic cancer. Of all major cancers, pancreatic has the lowest survival rate, because patients are usually too sick to be helped by conventional therapies by the time they’re diagnosed. But recent research on antioxidant levels in the cells of pancreatic cancer patients is homing in on a new, safer avenue for treatment—and it’s not what you’d think based on the reputation antioxidants have gained in popular culture.

6 - When Antioxidants are Pro-cancer

One in six people suffers from a mental disorder, and yet, compared to cancer and infectious disease, neuropsychiatric treatment options have barely improved since the 1950s. But why is that? In this episode of Base Pairs, we explore some of the problems neuropsychiatric drug discovery faces… and how a single, simple method may help.



*Cover image by Vacon Sartirani

7 – The Brain Atlas

We are Base Pairs, the podcast about "the power of genetic information." But why did we choose this name? In this bonus episode, we explain the molecules and the metaphor.

Pictured: Tin model of Adenine as first constructed by James Watson and Francis Crick whilst working at the Cavendish Laboratory, Cambridge in 1953. (Science Museum London / Science and Society Picture Library)

0 – Molecules and a Mission

Could “genome” be a misnomer? The name implies that our genetic information is mainly genes, yet when the Human Genome Project was completed in 2003, it revealed that genes comprise a tiny minority. About 98 percent of the genome is something else — a kind of genomic dark matter.

We chat with an astrophysicist-turned-genome-biologist, Assistant Professor Molly Hammell, about how she ended up studying a type of genomic dark matter called transposons.

8 – Dark Matter of the Genome (part 1)

One scientist’s junk is apparently everyone’s treasure! They just haven’t realized it yet. . .  In this episode of Base Pairs, we question the mythos that is “junk DNA” and explore how and why scientists are becoming enthralled by the mysterious non-coding portions of the genome.

9 – Dark Matter of the Genome (part 2)

Set aside your notions of how biologists are born, or what the word “gene” means as you listen to our first chat episode. We talk with Assistant Professor Molly Hammell, a genome biologist who started out as an astrophysicist. She tells us what it’s like to peer deep into space using a high-tech telescope. We also speak with Professor Tom Gingeras about whether it’s time to redefine the gene.

9.5 – Redefining Biologists, Redefining Genes

Much of the hype around the genome editing tool known as CRISPR focuses on its potential to cure genetic diseases. But our bodies need more than a healthy genome to survive and thrive—they also need food, and that’s where we may see CRISPR’s earliest effects on our lives. In this episode, we talk with plant scientist and Associate Professor Zach Lippman about the threats that climate change poses to agriculture, and how CRISPR could help overcome them.

10 – CRISPR vs Climate Change

Plant scientist Zachary Lippman tells stories from the field of bizarre tomatoes, intensely hot peppers, and giant pumpkins in this latest "chat" episode of Base Pairs.

Hear more from Zack in episode 10 – CRISPR vs Climate Change.

10.5 – Tomato Baby and its Family

A "behind the screens" look at how biology is addressing its "most wonderful problem" – too much data. Associate Professor Gurinder S. "Mickey" Atwal joins us to explain the essential enigma that is quantitative biology.

11 – Biology, Behind the Screens

A few favorite moments from our talk with theoretical physicist and quantitative biologist, Associate Professor Gurinder "Mickey" Atwal, that touch on topics ranging from his stint in medical school to the job market in the age of big data to Schrödinger's cat.

11.5 - What Silicon Valley and Biology Research Share

CSHL's Dr Adrian Krainer explains how an exhausting method to isolate specific proteins helped him discover a key for treating deadly spinal muscular atrophy.

An excerpt from Base Pairs episode 5 – Sink or Swim

The Cold Room: an excerpt from the Base Pairs podcast

In the early 1900s, American science took a wrong turn toward eugenics. In this episode, we talk with experts in both science and history about what we can learn from this dark period in today’s age of unprecedented control over the genome.

12 - Good Genes, Bad Science

Who will use CRISPR to alter their child's DNA? Who gets to decide which traits are desirable? Following up on our last episode, "Good Genes, Bad Science," we hear from David Micklos, executive director at CSHL’s DNA Learning Center, and Miriam Rich, CSHL Archives Sydney Brenner Research Scholar and doctoral student at Harvard, on these big questions.

12.5 - Big Decisions

No, we're not talking about high society or your biology class! In this episode, we share three distinct stories about classification in the life sciences and how genetic information is changing how we define important categories.

13 – A Lesson in Class

We look at the "reproducibility crisis" in science, and dive into a case in which cancer researchers discovered something completely unexpected while experimenting with a supposed drug target.

14 - The Cancer Answer That Wasn't

Base Pairs was just named among the 2018 Webby Award’s “five best podcasts in the world” for the subjects of science and education. Now, WE NEED YOUR HELP to take home the People's Voice award🏆

Place your vote at: http://bit.ly/cshlwebby

From the hosts: An exciting update!

It’s important to know that a drug works, but knowing how it works can be just as crucial. CSHL Fellow Jason Sheltzer discovered that the hypothesis explaining the action of a new cancer drug was incorrect, indicating that its beneficial effects had to be due to other factors. Hear more from him following up on his discussion in episode 14, “The cancer answer that wasn’t.” Also, in a new pop culture segment, we talk about movie “mad scientists” and how they contribute to misconceptions about the way real science is done.

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Disclaimer: This product is a not-for-profit learning resource. All film clips included are solely for the purposes of critique and education. They are solely the property of (in order of mention) Universal Pictures (as Universal Pictures Corp.), Universal Pictures, Amblin Entertainment, U-Drive Productions, and Universal Pictures (presents).

14.5 – Medicine and Mad Scientists

(Without music : CC BY-NC-SA 4.0)

We look at the "reproducibility crisis" in science, and dive into a case in which cancer researchers discovered something completely unexpected while experimenting with a supposed drug target.

14 - The Cancer Answer That Wasn't (no music)

You may have heard of it; "immunotherapy" has started to appear in headlines over the last few years. In this episode, however, we reveal that the practice of cancer immunotherapy is actually far older than even our understanding of the immune system! We also talk to a CSHL researcher who is showing that the immune system doesn’t even need to be engineered to kill cancer. It just needs to be unleashed.

15 – The Immune System, Unleashed

Immunotherapy has been receiving much more attention over the past few years, but the history of this promising type of cancer therapy is a long one. Adding to the story of William Coley’s early immunotherapy from Base Pairs 15, “The Immune System, Unleashed!” we hear about how his daughter used a barn full of case notes to start the Cancer Research Institute. Then, Professor Doug Fearon talks about on why the immune system is able to identify certain types of cancer cells more easily than others. Finally, in our pop culture segment, we talk about how invaders in the body are often met with the might of the white blood cell, no matter what (or who) they are!
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Disclaimer: This product is a not-for-profit learning resource. All film clips included are solely for the purposes of critique and education. They are solely the property of South Carolina ETV, Nelvana, Public Broadcasting Service (PBS),  Warner Bros., and Conundrum Entertainment.

15.5 – Cellular Hide and Seek

As concentrations of greenhouse gasses continue to rise, scientists are working hard to develop ways to ween the world off our need for fossil fuels. Biofuels are one promising solution, and they're commonly made from food crops like corn, or even byproducts like husks. Now CSHL Professor Rob Martienssen is trying to pull fuel from something surprisingly unique: pond scum.

16 – Big Plans for a Tiny Plant

Biofuels are the wave of the future, and a small plant called duckweed could be a significant part of that. Hear more from Professor Rob Martienssen about how genetic modification and advances in genome mapping technology factor in to the future of fuel. On our pop culture segment, we dive into some cinematic biofuels of the future, both hopeful and dystopian.
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Disclaimer: This product is a not-for-profit learning resource. All film clips included are solely for the purposes of critique and education. They are solely the property of Warner Bros. production, Warner Bros. Pictures, and in association with Village Roadshow Pictures and Groucho Film Partnership. Music and sounds from White Noise Factory.

16.5 – Fuels of the Future

Mail-order genetic testing —more accurately known as genotyping— is a growing trend. But what exactly is this data that's send back? And what can people (even law enforcement) DO with that data?
We explore the tricky situation posed by private genetic information in an "open data" world.

17 – Genomes, Justice, and the Journey Here

SPECIAL EPISODE! [We strongly recommend listening to Base Pairs episode 17 to contextualize this extended discussion.]

Some of the most sought after gifts this holiday season are at-home DNA tests. These tests let anyone send a sample of his or her DNA to get analyzed for various results: the geographic location of ancestors;  predisposition to illness; and other data points a person’s genetic code can reveal about themselves. But there is more to personal genotyping than simply learning about ourselves.

Host Brian Stallard sat down with Dr. Yaniv Erlich, a Watson School of Biological Sciences alumnus who is currently the Chief Scientific officer at MyHeritage DNA, to get his unique academic and commercial perspective on the use of personal genetic information. Listen as Erlich discusses privacy concerns, using genetics for justice, and his list of pros and cons for finding out about your genetic code.

17.5 – Special interview with Yaniv Erlich

Cold Spring Harbor Laboratory's Base Pairs podcast ​tells​ stories that ​convey​ the power of genetic information – past and present.

Named among the 2018 Webby Awards’ “five best podcasts in the world” for the subjects of science and education.
Presented the Platinum Award for podcasting by PR News.

Popular tracks by Base Pairs – a Cold Spring Harbor Lab podcast