Ready to stay with uu - 𝚒𝚗𝚜𝚌𝚕𝚒𝚏𝚎 .𝚌𝚘𝚖

The podcast for evidence based medicine - where research, guidance and practice are debated and demystified

Talk Evidence

As Contas N Dou Conta A + A - (Mal Pela Raiz remix)

Dj ARG August2022 Vinyl Mixtape

In this week's episode, Joe Ross, professor of medicine at Yale, and The BMJ's US research editor, and Juan Franco, researcher at Heinrich-Heine-Universität and editor in chief of BMJ EBM are in the hot-seat.

They will discuss new research on the effectiveness of antidepressants - based on all the individual patient data submitted to the FDA between 1979 and now. 

We'll take a look at a study of industry sponsorship of cost effectiveness analysis, and seeing similar patters of publication bias to RCTs.

And finally we'll be talking about new research on the ongoing, and emergent pandemics - covid and monkeypox.

Reading listResponse to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration: individual participant data analysis
https://www.bmj.com/content/378/bmj-2021-067606)
 
Using individual participant data to improve network meta-analysis projects
https://ebm.bmj.com/content/early/2022/08/10/bmjebm-2022-111931 
 
Industry sponsorship bias in cost effectiveness analysis: registry based analysis
https://www.bmj.com/content/377/bmj-2021-069573
 
Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak https://www.bmj.com/content/378/bmj-2022-072410
 
Effectiveness of a fourth dose of covid-19 mRNA vaccine against the omicron variant among long term care residents in Ontario, Canada:
https://www.bmj.com/content/378/bmj-2022-071502

Talk Evidence - a new way of understanding antidepressant effectiveness

Jori Samarin is introducing the first release on DarkCrow Sinful Edition with a bombshell track: 'Place Of Harm'. This track delivers the power you want to unleash on your subwoofers and dance floors

The Place of Harm

Jori Samarin - Place Of Harm

The Casimir Effect airs every fourth Wednesday of the month. Tune in for two hours of decadent techno & acid delights for episode 053.

More about your host:
Madison-based Sari Postol is very quickly earning a reputation for delivering hard-hitting, no-nonsense DJ sets across a variety of genres. Techno (acid, industrial, dark), hardcore, neurofunk, techstep, and hardcore jungle are just a few of the tools in the arsenal Sari deploys to devastating effect. Since her first set in 2016, Sari has become a familiar name on local lineups and in cities across the Midwest due to her hard work and dedication to honing her skills on the decks, on both digital and vinyl platforms.
While maintaining an active tour schedule, Sari has featured on several prominent podcasts and radio shows, leading to the launch of her own show entitled, ‘The Casimir Effect’, for London-based Fnoob Techno Radio in August 2018, and in January 2021, Postol took on the role of Monday Programme Manager for Fnoob.
In 2022, Sari debuted her Drum & Bass moniker, Amen Alice at Vinyl & Bass. This junglist utilizes an eloquent combination of acid-infused rollers & hard hitting amen-breaks x venetian snares to leave a lasting impression on dancefloors wherever she goes.

Connect:
link.tree/saripostol

TL:
TERAGON - 05
Mod21 - Offset (Original Mix)
Vaktsinaa - Lyghtaryk (Original Mix) [Substantiv]
ANTGT - We emptied the ocean
Ars Dementis - Lethargic Alpha Drones (Original Mix) [Abnormal Frequency Music]
Albert Zhirnov - Shooter
Kander - Imminent (Original Mix)
Violent - Anxiety
Subtraum - T647 II
Arnaud Le Texier - Grey Freq
D.A.V.E. The Drummer - Pump Department
Darzack & Electric Rescue - Digitalis
Ø [Phase] - Intensity Fluctuations (Setaoc Mass Remix)
Frode - Lowlands
Nonoftheabove - Hell On Earth
Antonio De Angelis - ssss
Volyk Artem - Deviant Behavior
Phase Fatale - Forward Chrome
Nailbiter - The Grass Is Greener (Original Mix) [Nodding Heads]
Temudo - The Beholder (Original Mix)
Drvg Cvltvre - Radiation Sickness (Original Mix) [Obscuur Records]
VII Circle - Doom (Original Mix)
Electrorites - M##########R (Original Mix) [Substantiv]
Rebekah, X-Tension - Don't Tell Mama (Original Mix)
Lester Fitzpatrick - Blaster (Original Mix) [Mastoid Kollektive]
MarAxe - Slammer (Hector Da Rosa Remix)
C-System - Dying For Growth (Original Mix) [Substantiv]
AMBASSADOR21 - Retoxicated Rage - Industrial Strength
SUB IMPERIUM - PROPHECY
Tim Williams - Son Of Perdition
Datawave - Scanshift
Phara - Great Attractor (Setaoc Mass Remix)
HAEDES - Nightmares
Nailbiter - The Duel (Original Mix) [Nodding Heads]
Not Even Noticed - Rein Da (Original Mix) [Everyone On Acid]
GUS & JORG - Mechanical Tension (Sekulahr Remix) [Vast Perception]
David Oblivion - No Warning (Tik Tok Taylor & Daesu Remix) [New Glam]
Samantha Togni - Burns Hot Like The Sun (Original Mix) [Substantiv]
RAMKKA - Punished Beings (Original Mix) [Exordio Records]
Temprano - Nasty Crap
Drvg Cvltvre - Brass Knuckles (Duellist Remix) [Obscuur Records]

The Casimir Effect

The Casimir Effect 053 | Sari Postol

Track 1 - A1 on the vinyl - on Nihil Fist: Resistance is Fertile, originally released in 2005 with the catalogue number Praxis 42.

Original label info: Militant speedcore noize possibly even more extreme than his vinyl debut “Think & Destroy” (Praxis 38). Here a strong element of metal is woven into the rapid fire beats, and the political aspect is more overt. 5 incomparable assaults on the senses!

Praxis discography page with more infos and all relevant links:
praxis-records.net/nihil-fist-resistance-is-fertile/

Resistance is Fertil

Buy on Bandcamp

Nihil Fist: Resistance is Fertile - Track 1 [Praxis 42, 2005]

Mysterio (original mix) 130 bpm

It's almost time for the Christmas edition of the BMJ to hit your doormats, and in this festive edition of Talk Evidence we're going to be talking Christmas research.

Joining Helen and Juan, we have Tim Feeney, BMJ research editor and researcher into Surgical outcomes at Boston University.

In this episode we'll be hearing about the health of footballers, and if a career in the sport predisposes Swedish players to substance use disorders. We'll hear about the performance of BMJ’s editors, when it comes to assessing the impact of a paper. We'll find out if AI algorithms can pass UK radiology exams, misinformation and a belief that everything causes cancer, and finally, some tips from BMJ’s statisticians to set the world right

Talking evidence at Christmas

Night TIme

New release, a bit harder techno.

hope you all enjoy it!

Everyone Singing

In this week's episode, we're focusing on covid and the ongoing crisis in the NHS.

Helen Macdonald, Juan Franco and Joseph Ross cast their evidence seeking eyes over research into outcomes as well as the workload of doctors.

Firstly, Joe tells us about a new big data study into longer term outcomes after mild covid-19, how those ongoing symptoms relate to long covid, and how often they resolve themselves.

Juan looks back to his homeland to see what Argentina which was very early to offer children vaccinations against covid-19. He tells us how a new study design can help understand how effective different combinations of vaccines were.

Joe has a Danish registry paper, which links people's employment status after a MI, explains how that gives us an insight into morbidity following that event.

Helen looks at a new analysis which outlines the concept of "time needed to treat" - a measure of how much time it would take a clinician to actually carry out a guideline - and you'd be surprised how much GP time would be swallowed by a "brief" intervention to reduce inactivity in their patients.

Finally, the data on excess mortality in the UK has been up for debate recently - our health minister calling into question the Office of National Statistic's data. We hear from Nazrul Islam, Associate professor of medical statistics, advisor to the ONS and BMJ research editor, who has some bad news for him.

Reading list:
Long covid outcomes at one year after mild SARS-CoV-2 infection
https://www.bmj.com/content/380/bmj-2022-072529

Effectiveness of mRNA-1273, BNT162b2, and BBIBP-CorV vaccines against infection and mortality in children in Argentina, during predominance of delta and omicron covid-19 variants
https://www.bmj.com/content/379/bmj-2022-073070


Guidelines should consider clinicians’ time needed to treat
https://www.bmj.com/content/380/bmj-2022-072953

Expanding the measurement of overdiagnosis in the context of disease precursors and risk factors
https://ebm.bmj.com/content/early/2023/01/10/bmjebm-2022-112117

Excess deaths associated with covid-19 pandemic in 2020
https://www.bmj.com/content/373/bmj.n1137.abstract

Talk Evidence - excess deaths, the ONS, and the healthcare crisis

In this episode of Talk Evidence, Helen Macdonald is joined by Juan Franco and Joe Ross, to bring you the newest evidence in The BMJ.

First, chronic pain. As prescribers move away from opioids, Juan finds an overview of systematic reviews asking whether anti-depressants might help. 

Joe finds new research on the link between six healthy lifestyle markers and cognitive decline. 

Helen looks at a trial to reduce prescribing among older people with suspected urinary tract infection or UTI.

Juan has a nuanced take on the updated evidence on masks to reduce the spread of respiratory viruses. 

Finally, an international group of researchers traced the health claims made about infant formula milk back to the evidence or lack of it 

Reading list:
Efficacy, safety, and tolerability of antidepressants for pain in adults
https://www.bmj.com/content/380/bmj-2022-072415

Association between healthy lifestyle and memory decline in older adults
https://www.bmj.com/content/380/bmj-2022-072691

Effect of a multifaceted antibiotic stewardship intervention to improve antibiotic prescribing for suspected urinary tract infections in frail older adults 
https://www.bmj.com/content/380/bmj-2022-072319

Physical interventions to interrupt or reduce the spread of respiratory viruses
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD006207.pub6/full

Health and nutrition claims for infant formula
https://www.bmj.com/content/380/bmj-2022-071075

Talk Evidence - masks, chronic pain, and baby milk formulae claims

Hybrid orchestral midtempo composition with synths, strings and percussion

Spirits of the sea

In this month’s Talk Evidence, Helen Macdonald, Juan Franco and Joseph Ross are back to talk us through some of the latest research, 

They’ll talk about pay-for-perfomance schemes, and whether the data they routinely collect is measuring outcomes or  tickboxes. They’ll also talk about a new analysis published on bmj.com which suggests ways in which that data could be better.


We’re also by Huseyin Naci, associate professor of health policy at the London School of Economics and Political Science, who will tell us about proposed changes to drug regulation in the UK - and we discuss research which has linked speedier regulatory approval to more adverse advents in post marketing studies.

Finally, we talk about point of care apps. The availability of medical information in the clinic has changed practice, but how good is that information? We hear about research which has evaluated those point of care apps (including BMJ’s Best Practice app) and rates them against different criteria.


Reading list

Estimated impact from the withdrawal of primary care financial incentives on selected indicators of quality of care in Scotland 
https://www.bmj.com/content/380/bmj-2022-072098
How can we improve the quality of data collected in general practice?
https://www.bmj.com/content/380/bmj-2022-071950#


UK to give “near automatic sign off” for treatments approved by “trusted” regulators
https://www.bmj.com/content/380/bmj.p633


Smartphone apps for point-of-care information summaries
https://ebm.bmj.com/content/early/2023/03/14/bmjebm-2022-112146

Talk Evidence - automatic approval, evidence apps, and pay for performance data

Helen Macdonald, Juan Franco, and Joe Ross are back with our monthly update on the world of evidence based medicine.

This episode delves into new methodologies which can use observational data to emulate trial data.  We discuss a new systematic review and meta-analysis of RCTs for surgical treatment of sciatica.  There is elaboration and explanation of the CONSORT Harms 2022 statement - and we'll be asking if it goes far enough. Finally, the old chestnut of surrogate endpoints in cancer treatment trials - are benefits communicated to patients accurately?

Reading list;
Nirmatrelvir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records - https://www.bmj.com/content/381/bmj-2022-073312

Surgical versus non-surgical treatment for sciatica
https://www.bmj.com/content/381/bmj-2022-070730


CONSORT Harms 2022 statement, explanation, and elaboration
https://www.bmj.com/content/381/bmj-2022-073725

Funders crack down on unpublished clinical trials—but is it enough?
https://www.bmj.com/content/381/bmj.p840

Communication of anticancer drug benefits and related uncertainties to patients and clinicians
https://www.bmj.com/content/380/bmj-2022-073711

Talk Evidence - a new way of understanding antidepressant effectiveness

BMJ talk medicine

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