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Objective: 
 The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) has anticolorectal cancer activity in vitro and in preclinical models. The present study tested whether a novel, enteric-coated formulation of EPA, as the free fatty acid (EPA-FFA), has chemopreventative efficacy in patients with familial adenomatous polyposis (FAP), in a randomised, double-blind, placebo-controlled trial.


Methods: 
 Patients undergoing endoscopic surveillance of their retained rectum postcolectomy were randomised to EPA-FFA (SLA Pharma) 2 g daily or placebo for 6 months. The number and size of polyps in an area of mucosa defined by a tattoo were determined before and after intervention. Global rectal polyp burden was scored (-1, 0, +1) by examination of video endoscopy records. Mucosal fatty acid content was measured by gas chromatography-mass spectrometry.


Results: 
 55 patients with FAP were evaluated by an intention-to-treat analysis (EPA-FFA 28, placebo 27). Treatment with EPA-FFA for 6 months was associated with a mean 22.4% (95% CI 5.1% to 39.6%) reduction in polyp number (p=0.012) and a 29.8% (3.6% to 56.1%) decrease in the sum of polyp diameters (p=0.027). Global polyp burden worsened over 6 months in the placebo group (-0.34) unlike the EPA-FFA group (+0.09, difference 0.42 (0.10-0.75), p=0.011). EPA-FFA treatment led to a mean 2.6-fold increase in mucosal EPA levels (p=0.018 compared with placebo). EPA-FFA was well tolerated with an incidence of adverse events similar to placebo.


In chemistry, 
acid value
 (
AV
, 
acid number
, 
neutralization number
 or 
acidity
) is a number used to quantify the acidity of a given chemical substance. It is the quantity of base (usually potassium hydroxide (KOH)), expressed as milligrams of KOH required to neutralize the acidic constituents in 1 gram of a sample.[1][2][3][4]


A liquid fat sample combined with neutralized 95% ethanol is titrated with standardized sodium hydroxide of 0.1 eq/L normality to a phenolphthalein endpoint. The volume and normality of the sodium hydroxide are used, along with the weight of the sample, to calculate the free fatty acid value.[3]


For determining the acid value of mineral oils and biodiesel, there are standard methods such as ASTM D 974 and DIN 51558, and especially for biodiesel the European Standard EN 14104 and ASTM D664 are both widely used worldwide.[2] Acid value of biodiesel should be lower than 0.50 mg KOH/g in both EN 14214 and ASTM D6751 standard fuels. This is because the FFAs produced can corrode automotive parts, hence these limits protect vehicle engines and fuel tanks.[5]


When oils and fats become rancid, triglycerides are converted into fatty acids and glycerol, causing an increase in acid value.[8] A similar situation is observed during aging of biodiesel through analogous oxidation and when subjected to prolonged high temperatures (ester thermolysis) or through exposure to acids or bases (acid/base ester hydrolysis).[5]





Total acidity, fatty acid profiles, and free fatty acids (FFAs) can be determined for oils such as sunflower and soybean oils obtained by green processes involving supercritical carbon dioxide (scCO2) and pressurized liquid extraction (PLE). The identification and separation of the primary fatty acids responsible for acidity can ensure higher quality of fat and oil products.[12]


In 2020, Dallas Group of America (DGA)[13] and American Oil Chemists' Society (AOCS) devised a standard method (5a-40) for testing free fatty acid in cooking oils.[14][15] The DGA FFAs hand-held test kit was produced from the AOCS test method, but without the burets, flasks, and laboratory hardware. Its portable nature is convenient for both small and large frying operations. Testing next to the fryer or in the comfort of a labo

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I've decided to give up on this particular campaign, and maybe the whole DLC. Perhaps there are people out there who really had a blast with this, but I am so addled. It feels like there is fun to be had here but it's hidden inside a Rubik cube which I can't figure out. Like I've never played basketball in my life and someone told me to have fun with a basket. The developers clearly put a lot of work into this but what on earth it is they were going for is beyond all my powers of cognition, unless the idea was to make a game that looks like Total War game and doesn't play like it in the slightest. Thoughts?


From the later part of the siege of Rome onwards, reinforcements had arrived in Italy;[15] during the siege of Ariminum, another 5,000 reinforcements landed in Italy, close to the siege where they were needed, clearly by design.[13] The last group of reinforcements was 7,000 strong and led by Narses.[13] After these arrived, the Byzantines had around 20,000 troops in Italy in total.[13] John claimed that about half of the troops were loyal to Narses instead of Belisarius.[13]
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I am using CCSv8 for CC1310 development and facing JVM heap low detected issue. My ccstudio.ini have Xmx128m and Xmx768m values configured. Can anyone help me to avoid ccs continuously notifying the JVM heap space??


as the title says it seems like ccs doesn't start...
At first i had installed (and successfully used) ccs v6.1. That was until today, when i double clicked the desktop icon to open it, it firstly showed the usual logo of ti's code composer and then nothing happened...
After many trials and restarts of my computer i decided to uninstall it and re-install it...In vain, i am afraid, as nothing changed and it didn't work out...
Desperate as i was, i even uninstalled everything and made a clean install of 
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The exact same thing occurs again..
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what is kind of crazy is that if i run eclipse it works just fine!
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Information is carried between brain regions through neurotransmitter release from axonal presynaptic terminals. Understanding the functional roles of defined neuronal projection pathways requires temporally precise manipulation of their activity. However, existing inhibitory optogenetic tools have low efficacy and off-target effects when applied to presynaptic terminals, while chemogenetic tools are difficult to control in space and time. Here, we show that a targeting-enhanced mosquito homolog of the vertebrate encephalopsin (eOPN3) can effectively suppress synaptic transmission through the Gi/o signaling pathway. Brief illumination of presynaptic terminals expressing eOPN3 triggers a lasting suppression of synaptic output that recovers spontaneously within minutes in vitro and in vivo. In freely moving mice, eOPN3-mediated suppression of dopaminergic nigrostriatal afferents induces a reversible ipsiversive rotational bias. We conclude that eOPN3 can be used to selectively suppress neurotransmitter release at presynaptic terminals with high spatiotemporal precision, opening new avenues for functional interrogation of long-range neuronal circuits in vivo.


Yes. I could do a test on an executable with Release vs. RelWithDebInfo. That would definitely give me the answer about the size of the code, but would be very difficult to conclude that it has NO impact on performance if my test case showed similar performance. How would I know if I exercised aspects of the language that might be impacted by the change? That is, empirical testing could produce a false negative.


Releasing with debug info is mandatory for real-life development. When shit happens your primary tool would be a crash dump analysis that would be rather pointless without debug information. Note that this does not imply shipping debug info with product.


If you build as Release, surely you won't have Debug Info in the binary. I could see a lot of cases on Windows that people build "Release", but add flags to have debug info. So, i think the default real-life case for most Windows Users, even without knowing that, is Release With Debug Info.


We must not forget about ASSERTS, at least for C/C++. Building with DEBUG, all Asserts are enabled, so they are not removed from the code during preprocessing. Release and RelwithDebugInfo remove the Asserts, so you won't have them. Some projects nowadays prefer to keep Asserts while developing (so that tests can catch "software" errors during development), and then finally remove in Production Code. Some other projects, for whom Fault-Tolerance is a must, may want to keep Asserts even in production code, so that software cannot execute with wrong Assertions about the software itself.


It should be basically the same but it is not. You need to look at the different Compiler flags set in your CMake defaut conf for Release or ReleaseDbgInfo. For example for msvc Release is Ob2 and DbgInfo Ob1. Meaning with DbgInfo inlining will be less aggressive as not all functions are considered.That way you can pretty much get the exact line of crash in your source code file from the mem dump, thats nice, but that could mean also missed inlining opportunities so less perf.


Is there a way to build Qt in "Release with Debug info" mode ? My application crashes only in "release" mode (works fine in Debug mode) and seems the issue comes from Qt (may be a bug in Qt).So I want to see the debug info of Qt.


This way you can at least check if the crash happens in your code.Building Qt with this mode is not supported, see this bug.You can only do it manually by changing vcproj-files or Makefiles like in the answer of Macke.


There are two ways to release a print job with Universal Print: direct print and secure release. With direct print, the print job is immediately released at the printer after the use

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The 
police
 are a constituted body of persons empowered by a state, with the aim to enforce the law, to ensure the safety, health, and possessions of citizens, and to prevent crime and civil disorder.[1][2] Their lawful powers include arrest and the use of force legitimized by the state via the monopoly on violence. The term is most commonly associated with the police forces of a sovereign state that are authorized to exercise the police power of that state within a defined legal or territorial area of responsibility. Police forces are often defined as being separate from the military and other organizations involved in the defense of the state against foreign aggressors; however, gendarmerie are military units charged with civil policing.[3] Police forces are usually public sector services, funded through taxes.


Law enforcement is only part of policing activity.[4] Policing has included an array of activities in different situations, but the predominant ones are concerned with the preservation of order.[5] In some societies, in the late 18th and early 19th centuries, these developed within the context of maintaining the class system and the protection of private property.[6] Police forces have become ubiquitous in modern societies. Nevertheless, their role can be controversial, as they may be involved to varying degrees in corruption, brutality, and the enforcement of authoritarian rule.


A police force may also be referred to as a police department, police service, constabulary, gendarmerie, crime prevention, protective services, law enforcement agency, civil guard, or civic guard. Members may be referred to as police officers, troopers, sheriffs, constables, rangers, peace officers or civic/civil guards. Ireland differs from other English-speaking countries by using the Irish language terms 
Garda
 (singular) and 
Gardaí
 (plural), for both the national police force and its members. The word 
police
 is the most universal and similar terms can be seen in many non-English speaking countries.[7]


Numerous slang terms exist for the police. Many slang terms for police officers are decades or centuries old with lost etymologies. One of the oldest, 
cop
, has largely lost its slang connotations and become a common colloquial term used both by the public and police officers to refer to their profession.[8]


Law enforcement in ancient China was carried out by "prefects" for thousands of years since it developed in both the Chu and Jin kingdoms of the Spring and Autumn period. In Jin, dozens of prefects were spread across the state, each having limited authority and employment period. They were appointed by local magistrates, who reported to higher authorities such as governors, who in turn were appointed by the emperor, and they oversaw the civil administration of their "prefecture", or jurisdiction. Under each prefect were "subprefects" who helped collectively with law enforcement in the area. Some prefects were responsible for handling investigations, much like modern police detectives. Prefects could also be women.[13] Local citizens could report minor judicial offenses against them such as robberies at a local prefectural office. The concept of the "prefecture system" spread to other cultures such as Korea and Japan.


In Babylonia, law enforcement tasks were initially entrusted to individuals with military backgrounds or imperial magnates during the Old Babylonian period, but eventually, law enforcement was delegated to officers known as paqūdus
, who were present in both cities and rural settlements. A paqūdu
 was responsible for investigating petty crimes and carrying out arrests.[14][15]


In ancient Egypt evidence of law enforcement exists as far back as the Old Kingdom period. There are records of an office known as "Judge Commandant of the Police"

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If you're doing well and you've found value in these tools, 
I'm asking for your financial support
. I'll keep creating content, building HeroMuster, and trying to make the world a better place for roleplayers. No hard feelings if you can't help.



Reminder:
 The tool will 
not
 warn you if you select a Feat where the character does not meet the prerequisite attributes or feats. This change is an effort to not expose those feats to you in the first place.


Some time ago i made a Web app based on a Webmap, but when i open the Web app now the legend is not vissible anymore, all the legend items look the same (grey cirkel) but when i look at the web map the legend is ok and all the legend items are different.


So in reviewing this item, I came across a similar Esri Support Services case. It had to do with an option not being set when sharing the web layer out to either ArcGIS Online or ArcGIS Enterprise. When you share the layer out from say ArcGIS Pro, there is a setting on the Share as a Web layer GP tool ->Configuration tab and Configure Parameters tab called "Use symbol types compatible with all clients" When the web layer overwrites the old web layer with this parameter checked, the issue disappeared in Web AppBuilder and other apps.







Axie Legend was taken down for some time today, the amount of traffic was too high, and that's not a bad thing (Thank you all for that), but the hosting provider blocked the tool for that reason. I already negotiated a price with them. So the tool is back up and for good now!


Open the Analysis menu > Legends and select the desired option. Only legends that are relevant to the view can be selected. That is, if nothing is on the Size shelf, the size legend cannot be turned on.


Tooltips are details that appear whenyou rest the pointer over one or more marks in the view. Tooltipsalso offer convenient tools to quickly filter or remove a selection, select marks that have the same valueor view underlying data.


The All Fields option on the Insert menu adds all field namesand values that are used in the view. Inserting the All Fields parameterupdates the tooltip as you change the view. Youcan also use the All Fields option to exclude fields.


For example,including command buttons will add Keep Only, Exclude, and ViewData buttons to the tooltip. These command buttonsare available both in Tableau Desktop and when the view is publishedto the web or viewed on a mobile device.Unchecking Include command buttonswill also hide the aggregation summary if multiple marks are selected.


A tool set Legend is created from the Tool Chest and will automatically include any markup on associated pages that is in the tool set. When it is generated, it will automatically include any markups that have already been placed from the tool set if there are any. Unlike an ad-hoc Legend, a tool set Legend can be added to a drawing before any markups have been placed.


Any markups placed on the associated pages from the selected tool set will be automatically added to the Legend. Additionally, any markups added to the tool set after the Legend has been placed will be automatically added to the Legend, if appropriate (that is, if the markup is also on an associated page).


The Be Internet Legends programme is designed to teach your child the skills they need to stay safe and have a positive time online. Your involvement at home can really help reinforce these key messages to help your child become more confident when exploring the online world.


Legends help your audience recognize and understand data that is displayed on a map. Interactive Legend is a map-based Instant App that allows you to explore feature layers in the map by
 interacting with the legend
.


For example, the Global Power Generation ref

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I just want to know is there any limitation size (maximum size) of infraworks model? Now im working in a large and detail city model and my file size more than 50 GB. I have powerful system and make sure all the setting so my infraworks model not slow based on this


Now, Its so take a long time to edit even simple edit in my model. Is there any chance to reduce file size of our model? I know infraworks its kind of database, one file related to another file.. But I still wondering to ask, if it can be done..


I'm new in using infraworks 360 free version. Accidentally I've cut out the map I imported via model builder at the beginning of my work. Is there any possibility to get it back? Or can I "copy" the attributes I've changed (roads, bridges, etc.) somehow into a new model containing the area I need for my project? I hope I could clarify my question, if not don't hesitate to ask. Thanks for your help in advance.
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This book includes all five volumes in the award-winning epic fantasy saga, The Story of Evil. During an annual jousting tournament, a mysterious villain attacks the capital with his army. Because of this disastrous event, Stephen Brightflame, an aspiring knight, embarks on a quest to save the kingdom from further destruction. He joins up with a convicted felon, an arrogant warrior, and a Halfling woman, but learns their tragic pasts are just as dark and disturbing as his own. This 430,000 word adventure features everything that makes the fantasy genre great: knights, castles, war, prophecies, magic, monsters, and dragons! After ten years in the making, experience the complete Story of Evil!


Splotches of deep crimson soaked into the golden sand as those who bled slipped into timelessness. Everything was timeless here in the 
 Caverns; and it was what the Caverns sheltered that the fallen dragons of Azeroth had died to defend.


Wrathion, Earth-Warder, Aspect of the black dragonflight, turned sand to glass with the magma he breathed. His loyal flight, a dancing wave of gleaming ebony scales, followed him, weaving between the swirling pillars of sand to fight back against the tide of infinite darkness.


Presently, all eyes were on the wedding party. With his keen dragon eyes, Wrathion could see the lingering magic of the dome that once encased Suramar; its faint curve and the fel-ravaged area that it had stalwartly held at bay were testimony to all the Nightborne had endured.


As he waited for a much-desired glass of arcwine, he sidled up alongside Taelia Fordragon of Kul Tiras. She was speaking with the former blue dragon Aspect, Kalecgos, who was in his visage of a half-elf with a hand on his chest as if in a pledge. Wrathion noted he looked a bit sad.


The black dragon averted his gaze, thinking their behavior spoke volumes about the changes the past five years had brought, and it dawned on him: His loyal spies who kept him up to date had informed him there had long been tension between the two. Wrathion supposed a thousand years of war could do that to a couple. But it appeared the Light-infused paladin and the Void-touched elf had rekindled what had been a legendary romance.


The Aspects had surrendered titan-granted powers to finally and utterly destroy Deathwing. They were still dragons, of course, but Aspects now in name alone. The blues, Wrathion knew, had drifted to disconnected places all over the world.


Wrathion did not expect to see any of his own flight there, of course. There were plenty of red and bronze dragons, and many greens as well, but he was saddened to spot so few blue dragons in comparison. Kalec was right about them being scattered.





Now that he knew what the hurt in his chest represented, it dissipated, transforming into something close to exultation. And as the Dragon Queen turned to continue in sharing the jubilant revelation with all those gathered below, Wrathion, the Black Prince, the dragon without a flight, realized his recurring nightmare also had the power to transform.


The Tannoy switched off with an echoing click. Bondglanced at his watch. At least another ten minutes beforeTransamerica would be called. He signalled to a waitressand ordered another double bourbon on the rocks. Whenthe wide, chunky glass came, he swirled the liquor roundfor the ice to blunt it down and swallowed half of it. Hestubbed out the butt of his cigarette and sat, his chinresting on his left hand, and gazed moodily across thetwinkling tarmac to where the last half of the sun was slippinggloriously into the Gulf.


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Sales of the An-124 to various commercial operators proceeded throughout the 1990s and into the mid 2000s; many of these were former military aircraft that were refurbished by Antonov prior to delivery, or unfinished fuselages that had been preserved, rather than producing new-build aircraft.[15] During the early 2000s, the cargo operator Volga-Dnepr opted to upgrade its An-124 freighter fleet, these works included engine modifications to conform with chapter four noise regulations, various structural improvements that increased service life, and numerous avionics and systems changes to facilitate four person operations, reducing the crew needed from six or seven.[16]
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Deus ex machina

 (/ˌdeɪəs ɛks ˈmækɪnə, ˈmɑːk-/ DAY-əs ex-MA(H)K-in-ə
,[1] .mw-parser-output .IPA-label-smallfont-size:85%.mw-parser-output .references .IPA-label-small,.mw-parser-output .infobox .IPA-label-small,.mw-parser-output .navbox .IPA-label-smallfont-size:100%Latin: [ˈdɛ.ʊs ɛks ˈmaːkʰɪnaː]; plural: 
dei ex machina
; English "god from the machine")[2][3] is a plot device whereby a seemingly unsolvable problem in a story is suddenly or abruptly resolved by an unexpected and unlikely occurrence.[4][5] Its function is generally to resolve an otherwise irresolvable plot situation, to surprise the audience, to bring the tale to a happy ending or act as a comedic device.[6]


Aeschylus used the device in his 
Eumenides
 but it became an established stage machine with Euripides. More than half of Euripides' extant tragedies employ a 
deus ex machina
 in their resolution and some critics claim that Euripides invented it, not Aeschylus.[9] A frequently cited example is Euripides' 
Medea
 in which the 
deus ex machina
 is a dragon-drawn chariot sent by the sun god Helios, used to convey his granddaughter Medea away from her husband Jason to the safety of Athens. In 
Alcestis
 the heroine agrees to give up her own life to spare the life of her husband Admetus. At the end, Heracles appears and seizes Alcestis from Death, restoring her to life and to Admetus.


Aristotle (in the Poetics 15 1454b1) was the first to use a Greek term equivalent to the Latin phrase 
deus ex machina
 to describe the technique as a device to resolve the plot of tragedies.[8] It is said by one person to be undesirable in writing and often implies a lack of creativity on the part of the author. The reasons for this are that it damages the story's internal logic and is often so unlikely that it challenges the reader's suspension of disbelief.[13]


In medicine, the phrase is often used for supposedly "magical remedies" which are not likely to work in practice. For instance, in the 2020 COVID-19 outbreak, when double lung transplantation for terminal COVID-19 patients was suggested, it was immediately denounced as a 
deus ex machina.
[22] In 2006, when electronic fetal heart monitoring was being touted as a preventive measure for cerebral palsy, 
The New England Journal of Medicine
, denounced it as 
deus ex machina
.[23]


The 
deus ex machina
 device is often criticized as inartistic, too convenient, and overly simplistic. However, champions of the device say that it opens up ideological and artistic possibilities.[24][25]





Antiphanes was one of the device's earliest critics. He believed that the use of the 
deus ex machina
 was a sign that the playwright was unable to properly manage the complications of his plot.[26]


Toward the end of the 19th century, Friedrich Nietzsche criticized Euripides for making tragedy an optimistic genre by use of the device, and was highly skeptical of the "Greek cheerfulness", prompting what he viewed as the plays' "blissful delight in life".[30] The 
deus ex machina
 as Nietzsche saw it was symptomatic of Socratic culture, which valued knowledge over Dionysiac music and ultimately caused the death of tragedy:[31]


But the new non-Dionysiac spirit is most clearly apparent in the 
endings
 of the new dramas. At the end of the old tragedies there was a sense of metaphysical conciliation without which it is impossible to imagine our taking delight in tragedy; perhaps the conciliatory tones from another world echo most purely in 
Oedipus at Colonus
. Now, once tragedy had lost the genius of music, tragedy in the strictest sense was dead: for where was that metaphysical consolation now to be found? Hence an earthly resolution for tragic dissonance was sought; the hero, having been adequately tormented by fate, won his wel

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