A poco menos de un año de que finalice la administración de Andrés Manuel López Obrador, son varios los retos en materia de salud que enfrenta el Gobierno, a los que ahora se suma la situación sanitaria en Guerrero tras el paso de Otis. Marcela Madrazo, profesora en el Posgrado de Derecho Sanitario de la Facultad de Derecho de la UNAM, nos habla al respecto.

En otros temas:

En medio de reclamos y acusaciones, Diputados aprueban en lo general y particular el Presupuesto 2024. Dejan fuera la ayuda a Guerrero / El New York Times revela que la Fiscalía de la Ciudad de México solicitó registros telefónicos y de geolocalización de políticos de oposición durante la gestión de Claudia Sheinbaum.

10 Noviembre, 2023 - Ideología o ciencia en Salud

© New Level Music, LLC on behalf of Limelight Music Productions - All Rights Reserved
Produced by Andy Jones of Limelight Music Productions 
A Brand Managed by New Level Music
This is a Semi Original PLUS Mix
All Content Used In This Mix Is from New Level’s own Licensed Song Catalog, Level 77 Music, and Andy Jones Personal Catalog

Pure All Stars Prophecy 2023-2024

Anita

Deep Progressive Spook 120 E 2 24 Premaster

MDS OST: Till Death do us Part

BUFFALO, NY- November 15, 2023 – A new #researchpaper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 21, entitled, “Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model.”

Neurodegenerative disorders, such as Alzheimer’s disease (AD), have the gradual onset of neurobiological changes preceding clinical diagnosis by decades. In their new study, researchers Qing Cao, Manasa Kumar, Allea Frazier, Jamal B. Williams, Shengkai Zhao, and Zhen Yan from the State University of New York at Buffalo’s Jacobs School of Medicine and Biomedical Sciences aimed to elucidate how brain dysfunction proceeds in neurodegenerative disorders.

“[...] we performed longitudinal characterization of behavioral, morphological, and transcriptomic changes in a tauopathy mouse model, P301S transgenic mice.” 

P301S mice exhibited cognitive deficits as early as 3 months old, and deficits in social preference and social cognition at 5–6 months. They had a significant decrease of arborization in basal dendrites of hippocampal pyramidal neurons from 3 months and apical dendrites of PFC pyramidal neurons at 9 months. Transcriptomic analysis of genome-wide changes revealed the enrichment of synaptic gene upregulation at 3 months of age, while most of these synaptic genes were downregulated in PFC and hippocampus of P301S mice at 9 months. These time-dependent changes in gene expression may lead to progressive alterations of neuronal structure and function, resulting in the manifestation of behavioral symptoms in tauopathies.

“In conclusion, our longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model is to elucidate potential mechanisms that drive the progression of AD and related neurodegenerative disorders. Manipulation of key molecular players coupled with electrophysiological measurements of neuronal functions in future studies will help identify early intervention strategies for these diseases.”

DOI - https://doi.org/10.18632/aging.205057

Corresponding author - Zhen Yan - zhenyan@buffalo.edu

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Keywords - aging, Alzheimer’s disease, tau, cognitive behaviors, transcriptomic, neuronal morphology

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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Facebook - https://www.facebook.com/AgingUS/
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YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
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Aging (Aging-US)

Behavioral, Morphological and Transcriptomic Changes in a Tauopathy Mouse Model

A rare coad:E 2 deck set from 120 to 148 bpm with some spooky-ish friday the 13 vibes
 
Where is Kittin?	-	Marc Houle & Miss Kittin
Mindtrap (Original Mix)	-	Robert Junior
Igloo (Hertz Remix)	-	Enrico Sangiuliano
Addition (Kamil Van Derson Remix)	-	Marco Ginelli
Uncuttable	-	Cadans
No Connection (Broken Mix)	-	Cadans
First Words	-	Cassegrain
Dear Marko	-	Hertz
Flirtaholic	-	Ortin Cam
Reckless	-	Fadi Mohem
Trust (V.2)	-	Sleeparchive
Cyborg	-	Stef Mendesidis
Tempest (Original)	-	Altinbas
Rejection	-	59909 Alliance
Cynical Moves	-	Altinbas, Cirkle
Lea-The Fatal Call (Original Mix)	-	Alarico
Groove Street	-	JXXXO, joaquin poletti
Radau	-	BAUGRUPPE90, Tim Rausch, Paul Hauck
Lexicon	-	Rosati
Thought Dealer (Original Mix)	-	AADJA

Live sets

coad: E @ Velvet Studios Wildcard Wednesdays (Oct 13, 2023)

" What Do The Lonely Do At Christmas" is definitely one of Christmas favorites and classic with the beautiful harmonies and falsetto we had to do our own rendition to it. Enjoy

What Do The Lonely Do At Christmas

The remix I finally posted, despite the fact that I can't do anything about the echo on the vocals, which is hard to remove. If the vocals were without effects, it would be better.

Parkol vs Pet Shop Boys - Minimal (Parkol Backlogged Mix)

Texto da Colaboradora: Dione Dias de Moraes

Conversando com Você - 10/11/2023 - Crenças, Mitos e Conceitos

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Somos el podcast de noticias al alcance de tu mano: #Broojula con Ana Paula Ordorica.  Infórmate en menos de 30 minutos en tu plataforma favorita.

10 Noviembre, 2023 - Ideología o ciencia en Salud

Broojula con Ana Paula Ordorica

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