2022/01/15 空總 C-LAB

沛瑩備料，甘水熬湯。人類基因序用大音量噪音熬煮，正弦波大戰核苷酸，湯湯水水渾沌濃稠。

Prepared by Pei, stewed by Gam Zuei. Human genome simmered with a high volume of noise. Sine wave at war with Amino Acid. Soup, water, mixed, chaos.

對話作品：《相即共生練習簿：族譜Ｘ》

In Conversation with: ‘Studies of Interbeing - Pedigree X’

《甘水湯》--甘水

http://www.trasportimarittimi.net/trans-aeolian_transmission.html

Neo-Shamanism Post-Insdustrial

KUMSKAR  - Xinjiang, Taklamakan & Karakoram - Trans-Aeolian Transmission

Mysterious Grassland - Dialogue With Nature

飛天之舞 - Sitar

第９曼荼羅、９万打達成記念楽曲

第9曼荼羅 (The 9 th MANDALA)

What you hear is the sonified expression of the 3D structure of the protein with PDB ID 1akg (ALPHA-CONOTOXIN PNIB FROM CONUS PENNACEUS, see: http://dx.doi.org/10.2210/pdb1AKG/pdb), translated into an orchestral setting (koto [a Japanese string instrument], cello, double bass, viola, flute, and fluegelhorn). The koto is used to express the primary, secondary and tertiary structure of the protein.  

The piece reflects a classical period model of the hierarchical mapping to describe the 3D folded structure of a protein in musical space. The musical mapping begins from the primary amino acid sequence (GCCSLPPCALSNPDYCX) and encodes multiple hierarchical structural levels, and adds musical experimentation. 

We use the concept proposed by Yu, Buehler et al. (ACS Nano) to map amino acid sequences to music, and augment the mapping by adding more data. The 3D folded structure of a protein is coded by inserting strummed chords and interwoven melodies that code for the geometric arrangement of amino acids, the protein's tertiary structure. Rhythm and note volume code for secondary structure.

[1] The protein used for this example is 6cjc (CRYSTAL STRUCTURE OF A FC FRAGMENT LALA MUTANT (L234A, L235A) OF HUMAN IGG1 (CRYSTAL FORM 3))

[2] https://doi.org/10.1021/acsnano.9b02180

Koto Ensemble of Protein 1akg (Venom of Predatory Marine Snails)

MAMER & IZ
From the album Kolengke, 2012.

At first Mamur released a solo CD on Peter Gabriel's record label REALWORLD. Tired about this “fantastic world-music business”, Mamur & Iz turned in devolopping their own wiew of a ethno-folk-post-insdustrial China. With a gorgeous evident success.
Website http://site.douban.com/iz/
MS http://www.myspace.com/izkazak


MAMER & IZ - Kargashay

This piece is a sonification of the spike protein of the pathogen of COVID-19, 2019-nCoV (protein data bank identifier 6VSB [1]). What you hear is a multi-layered sonification approach featuring both the vibrational spectrum of the entire protein (expressed in sound and rhythmic elements), as well as the sequence and folding of amino acids that compose the virus spike structure [2]. 

References
[1] Wrapp et al., "Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation," Science, 2020, DOI: 10.1126/science.abb2507
[2] Buehler et al., "A Self-Consistent Sonification Method to Translate Amino Acid Sequences into Musical Compositions and Application in Protein Design Using Artificial Intelligence," ACS Nano, 2019, DOI: https://pubs.acs.org/doi/10.1021/acsnano.9b02180

Sonification of a virus spike protein

Sonification of the Coronavirus Spike Protein (Amino Acid Scale)

While we cannot see small nanoscopic objects like proteins or other molecules that make up virtually all living matter including our cells, tissues, as well as pathogens such as viruses, our computational algorithm allows us to make its material manifestation audible.  This piece is a musical representation of the amino acid sequence and structure of the spike protein of the pathogen of COVID-19, 2019-nCoV (protein data bank identifier 6VSB [1]). 

MUSICAL DECEIT

A virus’ genome hijacks the host cell’s protein manufacturing machinery, and forces it to replicate the viral genome and produce viral proteins to make new viruses from it.  This musical art teaches us something about the fine line between beauty of life and death as an opposite pole.  As you listen to the protein you will find that the intricate design results in incredibly interesting and actually pleasing, relaxing sounds. This doesn’t really convey the deadly impacts this particularly protein is having on the world. This aspect of the music shows the deceiving nature of the virus, how it hijacks our body to replicate, and hurt us along the way. So, the music is a metaphor for this nature of the virus to deceive the host and exploit it for its own multiplication. 

HOW IT IS DONE: 

What you hear is a multi-layered algorithmic composition featuring both the vibrational spectrum of the entire protein (expressed in sound and rhythmic elements), the sequence and folding of amino acids that compose the virus spike structure, as well as interwoven melodies - forming counterpoint music - reflecting the complex hierarchical intersecting geometry of the protein [2].

Scientific references:

[1] Wrapp et al., "Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation," Science, 2020, DOI: 10.1126/science.abb2507

[2] Buehler et al., "A Self-Consistent Sonification Method to Translate Amino Acid Sequences into Musical Compositions and Application in Protein Design Using Artificial Intelligence," ACS Nano, 2019, DOI: pubs.acs.org/doi/10.1021/acsnano.9b02180

Viral counterpoint of the coronavirus spike protein (2019-nCoV)

Viral Counterpoint of the Coronavirus Spike Protein (2019-nCoV)

What you hear is a comparison between two coronavirus protein spikes, here focusing on their overall frequency spectrum using the method we published in EML in 2019. The left image, heard first, is from HKU1 (a human betacoronavirus that causes mild yet prevalent respiratory disease). The right image is from COVID-19, and heard second. You can see and hear that the novel coronavirus spike protein has a much lower frequency spectrum, reflecting slower motions. 

Listen to this piece for a fuller musical assessment of the entire spike protein in the virus: https://soundcloud.com/user-275864738/viral-counterpoint-of-the-coronavirus-spike-protein-2019-ncov

《甘水湯》--甘水

ca3rine

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