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Discover the top, most popular movies available now! Across theaters, streaming, and on-demand, these are the movies Rotten Tomatoes users are checking out at this very moment, including 
The Hunger Games: The Ballad of Songbirds and Snakes
, Wish (see Disney animated movies ranked) and 
Napoleon 
from director Ridley Scottt.


Common terms for the field, in general, include "the big screen", "the silver screen", "the movies", and "cinema"; the last of these is commonly used, as an overarching term, in scholarly texts and critical essays. In the early years, the word "sheet" was sometimes used instead of "screen".


Émile Reynaud already mentioned the possibility of projecting the images of the Praxinoscope in his 1877 patent application. He presented a praxinoscope projection device at the Société française de photographie on 4 June 1880, but did not market his 
praxinoscope a projection
 before 1882. He then further developed the device into the Théâtre Optique which could project longer sequences with separate backgrounds, patented in 1888. He created several movies for the machine by painting images on hundreds of gelatin plates that were mounted into cardboard frames and attached to a cloth band. From 28 October 1892 to March 1900 Reynaud gave over 12,800 shows to a total of over 500,000 visitors at the Musée Grévin in Paris.


In the 1920s, the development of electronic sound recording technologies made it practical to incorporate a soundtrack of speech, music and sound effects synchronized with the action on the screen.[
citation needed
] The resulting sound films were initially distinguished from the usual silent "moving pictures" or "movies" by calling them "talking pictures" or "talkies."[
citation needed
] The revolution they wrought was swift. By 1930, silent film was practically extinct in the US and already being referred to as "the old medium."[
citation needed
]


The evolution of sound in cinema began with the idea of combining moving images with existing phonograph sound technology. Early sound-film systems, such as Thomas Edison's Kinetoscope and the Vitaphone used by Warner Bros., laid the groundwork for synchronized sound in film. The Vitaphone system, produced alongside Bell Telephone Company and Western Electric, faced initial resistance due to expensive equipping costs, but sound in cinema gained acceptance with movies like 
Don Juan
 (1926) and 
The Jazz Singer
 (1927).[8]


American film studios, while Europe standardized on Tobis-Klangfilm and Tri-Ergon systems. This new technology allowed for greater fluidity in film, giving rise to more complex and epic movies like King Kong (1933).[9]





The terminology used for describing motion pictures varies considerably between British and American English. In British usage, the name of the medium is "film". The word "movie" is understood but seldom used.[34][35] Additionally, "the pictures" (plural) is used semi-frequently to refer to the place where movies are exhibited, while in American English this may be called "the movies", but it is becoming outdated. In other countries, the place where movies are exhibited may be called a cinema or movie theatre. By contrast, in the United States, "movie" is the predominant form. Although the words "film" and "movie" are sometimes used interchangeably, "film" is more often used when considering artistic, theoretical, or technical aspects. The term "movies" more often refers to entertainment or commercial aspects, as where to go for fun evening on a date. For example, a book titled "How to Understand a Film" would probably be about the aesthetics or theory of film, while a book entitled "Let's Go to the Movies" would probably be about the history of entertaining movies and blockbusters.


Further terminology is used to distinguish various forms and media used in

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Therapeutic strategies targeting phantom limb pain (PLP) provide inadequate pain relief; therefore, a robust and clinically relevant animal model is necessary. Animal models of PLP are based on a deafferentation injury followed by autotomy behavior. Clinical studies have shown that the presence of pre-amputation pain increases the risk of developing PLP. In the current study, we used Sprague-Dawley male rats with formalin injections or constriction nerve injury at different sites or time points prior to axotomy to mimic clinical scenarios of pre-amputation inflammatory and neuropathic pain. Animals were scored daily for PLP autotomy behaviors, and several pain-related biomarkers were evaluated to discover possible underlying pathological changes. Majority displayed some degree of autotomy behavior following axotomy. Injury prior to axotomy led to more severe PLP behavior compared to animals without preceding injury. Autotomy behaviors were more directed toward the pretreatment insult origin, suggestive of pain memory. Increased levels of IL-1β in cerebrospinal fluid and enhanced microglial responses and the expression of NaV1.7 were observed in animals displaying more severe PLP outcomes. Decreased expression of GAD65/67 was consistent with greater PLP behavior. This study provides a preclinical basis for future understanding and treatment development in the management of PLP.


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AMPK, a serine/threonine kinase straddling a cellular metabolic regulatory role with a concurrent influence on tau-driven AD pathology, has been reported to be activated in the hypothalamus of mice as a consequence of atypical antipsychotic exposure [57]. AMPK plays a central role in cellular energy homeostasis, and is activated by metabolic stress (hypoxia, ischemia, poor nutrient availability) [58]. The activation of AMPK is associated with increased food intake; the use of antipsychotic medications (including haloperidol but more dramatically the atypicals) [59] has been associated with weight gain and metabolic syndrome, including an atherogenic lipid profile and emergent diabetes mellitus [60]. AMPK activity has been implicated as a potential medication-induced mediator of the syndrome. In support of this, the atypical antipsychotics, including clozapine, olanzapine, and quetiapine, but not haloperidol, have been shown to induce AMPK phosphorylation in mice (activating the enzyme), whereas polymorphisms in AMPK subunit genes have been implicated in human antipsychotic-induced weight gain [57], [61]. Only one previous study has investigated the influence of antipsychotics on AMPK in the brains of a mouse model of AD. Consistent with expected outcomes, in an amyloid mouse model of AD, clozapine exposure was shown to increase AMPK phosphorylation activating the enzyme [62]. N

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Background: 
 Skin involvement is of major prognostic value in systemic sclerosis (SSc) and often the primary outcome in clinical trials. Nevertheless, an objective, validated biomarker of skin fibrosis is lacking. Optical coherence tomography (OCT) is an imaging technology providing high-contrast images with 4 μm resolution, comparable with microscopy ('virtual biopsy'). The present study evaluated OCT to detect and quantify skin fibrosis in SSc.


Methods: 
 We performed 458 OCT scans of hands and forearms on 21 SSc patients and 22 healthy controls. We compared the findings with histology from three skin biopsies and by correlation with clinical assessment of the skin. We calculated the optical density (OD) of the OCT images employing Matlab software and performed statistical analysis of the results, including intraobserver/interobserver reliability, employing SPSS software.


Results: 
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Conclusions: 
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The
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Virtual skin cancer spot checks are our most flexible option to get advice on concerning moles. You can submit a skin cancer spot check at any time or place you have an internet connection. This service is designed to analyze 1-2 specific moles. It does not replace a full body skin check.


A Virtual Skin Cancer Spot Check is a way to receive medical advice on concerning moles without needing to go in-person to a clinic. 
This service is designed to analyze 1-2 specific moles
. 
They are not meant to replace a full body skin check
.


You should seek an expert opinion when you believe you have a mole that might be cancerous. Detecting skin cancers early is critical, especially for melanomas (the most deadly form of skin cancer). The earlier a melanoma is caught and treated, the better chance of survival.


Confession: I've had three dermatologist appointments in the past two months, which is a record even for my skin-obsessed self. When New York was first put under stay-at-home orders, my previously smooth skin erupted in a bout of what I can only assume was stress-induced acne. I took the video call with my dermatologist from my fire escape and held back tears. A few weeks and an increased dosage of spironolactone later, I met with my dermatologist for a virtual follow-up visit while seated on my bedroom floor, and she cheered when she saw my finally breakout-free skin.


And last week, I met with Orit Markowitz, the director of pigmented lesions and skin cancer at Mount Sinai Hospital in New York City, via Zoom for my first-ever 
skin check
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According to the Skin Cancer Foundation, an all-over skin self-examination should happen once per month, with an additional once per year check with a dermatologist. With stay-at-home orders keeping p

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Assuming that suitable audio hardware is available, multi-channel audio recording is also possible. SF9 could, therefore, be used in live recording contexts where a multi-mic configuration is in use. This might include a traditional studio recording session with a full band laying down a backing track, a surround sound microphone configuration (perhaps of an orchestral performance) or where multiple microphones are used to make voice recordings in conference or meeting contexts. The example four-track and six-track test recordings I made during the review period suggest that this aspect of SF9 is both robust and straightforward in operation.


Effects can be applied to single channels, stereo pairs or, if the plug-in supports it, multiple channels. As far as I could see, only the Wave Hammer plug-in is currently supplied in a format compatible with surround. This provides both compression and volume maximisation for a six-channel audio file, and therefore could be useful for some basic mastering of a surround sound project. The plug-ins within the Izotope mastering suite (described more fully below) are designed for use with mono or stereo files only, although it is, of course, possible to apply them to individual channels or pairs of channels within a multi-channel audio file.


Each new audio file opens in its own data window, with extensive tools available to view and analyze the sound, including custom colors, channel meters, statistics, and a spectrum analysis window. It now also supports viewing and editing the metadata associated with audio files.


You can do basic cut and paste / drag and drop editing directly in the window, and more with the toolbars, and then turn to the menus to apply further processing: Insert synthesized sounds, Process clip formats (e.g., depth, EQ, normalize, resample), clean with Tools (noise reduction, click and crackle, restoration), and apply Effects (delay, reverb, pitch). The Plug-In Manager tool also organizes other non-Sony plug-ins under the FX Favorites menu.





Sound Forge Pro is for audio editing and mastering, including sound design, audio restoration, processing and effects, and even Red Book CD creation. Sound Forge Pro version 10 is a strong upgrade, with a more customizable interface, enhanced editing tools, and more included processing and effects plug-ins for higher quality audio editing.


Special mention must be made of the tutorial system included with Sound Forge Pro 15. In addition to the manual, upon loading up the software for the first time you are greeted with an interactive tutorial system which provides a very visual walkthrough of all the components, menus and windows and will have you oriented in no time. It may sound trivial, but coming from another audio editor / DAW environment, it can often be frustrating figuring out how to accomplish often simple functions and this mitigated that issue elegantly.


Sound Forge 15 contains an impressive array of industry leading tools for audio professionals of all types over the years. It is a 'Swiss Army Knife' of an audio app that every engineer, podcaster, sound designer and mastering engineer would do well to have in their arsenal. Most impressive is how easy it is to mold it to one's needs, excelling at specific tasks, achieving results, and doing so quickly and effectively without confusion or distraction. Spend a bit of time tailoring Sound Forge to your personal workflow and it will fit you like a glove.



About the author

 Nate Raubenheimer is a member of the KVR team and an accomplished producer, audio engineer and self-proclaimed gear junkie with a career spanning over twenty years. Producing under his Protoculture alias (amongst others) his production and remix credits include the likes of Armin van Buuren, Paul Oakenfold, Bryan Adams, Ferry Corsten

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Resident Evil

 is a 2002 action horror film written and directed by Paul W. S. Anderson. The film stars Milla Jovovich, Michelle Rodriguez, Eric Mabius, James Purefoy, Martin Crewes, and Colin Salmon. It is the first installment in the 
Resident Evil
 film series, which is loosely based on the video game series of the same name. Borrowing elements from the video games 
Resident Evil
 and 
Resident Evil 2
, the film follows amnesiac heroine Alice and a band of Umbrella Corporation commandos as they attempt to contain the outbreak of the T-virus at a secret underground facility.


German studio Constantin Film bought the rights to adapt the series in live-action in January 1997. Several writers and filmmakers, such as Alan B. McElroy, George A. Romero and Jamie Blanks, were initially hired to direct and write the film, but their scripts were rejected. In 2000, Anderson was announced as writer and director. Developed as a prequel set in the same continuity as the video game series, the film was initially titled 
Resident Evil: Ground Zero
, but was retitled after the September 11 attacks. Cast was announced in early 2001 and principal photography commenced in March 2001 in Berlin.



Resident Evil
 was theatrically released in Germany on March 12, 2002, by Constantin Film Verleih, and in the United Kingdom on July 12, 2002, by Pathé Distribution. The film received generally negative reviews from critics and grossed $103 million worldwide against a production budget of $33 million. It was followed by five sequels establishing their own alternate continuity: 
Apocalypse
 (2004), 
Extinction
 (2007), 
Afterlife
 (2010), 
Retribution
 (2012), and 
The Final Chapter
 (2016).


German production company Constantin Film bought the live-action film rights for 
Resident Evil
 in January 1997, and hired screenwriter Alan B. McElroy to write the script.[5][6] At the time, McElroy was also writing the film adaptation for another video game, 
Doom
, which ultimately wasn't used.[7] The May 1998 issue of 
PlayStation Magazine
 published an article about McElroy's 
Resident Evil
 script. Described as action- and horror-packed and very violent, the script was similar to the original game. Some changes were made; for example, there was no mention of the Umbrella Corporation or STARS. Instead, the plot followed a special forces team sent by the government to rescue scientists from the mansion laboratory after the SWAT team sent in earlier was killed, during which they realize the mission was a trap and that they are specimens in a medical experiment. The script included all major characters and monsters from the game. McElroy's script was rejected.[8][9][10]


In 1998, George A. Romero directed a television commercial for the video game 
Resident Evil 2
. The original game's director, Shinji Mikami, was a fan of Romero and had been influenced by his films. The commercial was only shown in Japan, but impressed Sony enough for them to ask him to write and direct 
Resident Evil
. Romero stated that he had his secretary play the entire game through and record the gameplay so he could study it as a resource. Romero's screenplay was based on the first 
Resident Evil
 game and included characters from the video games. Chris Redfield and Jill Valentine were the lead characters, involved in a romantic relationship. Barry Burton, Rebecca Chambers, Ada Wong, and Albert Wesker were to also appear. The ending to the film would have been similar to the 
best
 ending to the first 
Resident Evil
 game.[11] Romero also hired artist Bernie Wrightson to design some concept artwork of creatures for the film, and Wrightson did several designs of Tyrant, based on its look in the original game and its description in Romero's script.[12] In a 2002 interview in 
Fangoria</

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Wine Folly: The Essential Guide to Wine will help you make sense of it all in a unique infographic wine book. Designed by the creators of the Wine Folly website, which has won Wine Blogger of the Year from the International Wine & Spirits Competition, this book combines sleek, modern information design with data visualization and gives readers pragmatic answers to all their wine questions, including:


Paso Robles (Pass-oh Row-buhlz), meaning Pass of the Oak Trees, has over 60 different grape varieties and almost as many microclimates! This means that we find amazingly powerful-yet-refreshing red and white wines despite its hot climate.


So, what's special about Walla Walla Valley wines? For lovers of bold red wines this is the spot in Washington state to hunt for Cabernet Sauvignon, Syrah and Merlot. Of course, Walla Walla Valley has more wines to offer for those who make the journey.


Wines taste dry, saline, and flinty on the palate with high acidity and a long tingly finish. With age, wines soften and deliver richer yellow apple and peach flavors with petrol or diesel-like aromas.


That being said, the wine is made in Sicily, so you'd be remiss not to try it with herbed and breaded stuffed sardines, arancine di riso ripiene di formaggio (cheese-stuffed rice balls), and eggplant cutlets.


I recently bought the new 
Wine Folly: Magnum Edition
, a book about wine with a big focus on concise information. A lot of infographics help to simplify the matter. In fact it over-simplifies many topics. I was surprised to see sherry (a family of different styles) included in a chapter that lists grape varieties. Port and Madeira are also treated this way. That is problematic as sherry is essentially a denomination of origin rather than one specific wine. It uses different grapes and production methods to create a very wide array of styles and aromas.


Treating the sherry family as one wine will inevitably lead to generalization: characteristics can never apply to all individual styles. Writing about Palomino and PX as separate grapes would have been better, after all they are not exclusive to the sherry region.


Wine Folly gives a score of four out of five stripes for acidity, which is misleading as 
sherry has a low acidity level compared to other (white) wines
. Especially Fino and Manzanilla have some of the lowest level of (volatile) acidity of all wines. The nature of Palomino grapes and the fact that they are picked late results in an average total acidity of 3.7 g/l and virtually no malic acid. In fact the pH in Palomino grape juice is troubling and often has to be corrected to avoid bacterial contamination.



SherryNotes
 is aiming to be an authorative and comprehensive sherry wine resource online. It includes sherry reviews, bodega profiles and background articles. Discover the versatile 'Vinos de Jerez', the traditional wines of Andalusia - Spain: Manzanilla, Fino, Palo Cortado, Amontillado, Oloroso, Moscatel and Pedro Ximénez.

rnI am a Certified Sherry Educator and also run a whisky blog over at www.whiskynotes.be


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The wines are meant to age no matter their quality level. Some much longer than others. For people looking to build a cellar over a long time period, you'll want to look for "Grand Cru Classé" somewhere on the label, expect to pay a bit more for that quality level though!



Château Mouton Rothschild
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It was during this time that Marshall realized that the holding in Plessy was inherently flawed, for "separate" could never be "equal." Marshall had always felt that the only way for African-Americans, or anyone for that matter, to succeed was to receive an education. Yet, the discrepancy in the caliber of education for whites and blacks was made all too apparent to him when, one day while traveling with Houston, Marshall witnessed a black child biting into an orange. He had received such a poor education that he neither knew what it was nor how to properly eat it. From this point on, Marshall and Houston were dedicated to a strategy which aimed at ending segregation.


After Brown, Marshall argued many more court cases in support of civil rights. His zeal for ensuring the rights of all citizens regardless of race caught the attention of President John F. Kennedy, who appointed him to the U.S. Court of Appeals. In 1965, Lyndon Johnson appointed him to the post of Solicitor General (this person argues cases on behalf of the U.S. government before the Supreme Court; it is the third highest office in the Justice Department). Finally, in 1967, President Johnson appointed him to the U.S. Supreme Court. Until his retirement from the Court in 1991, Marshall continued to strive to protect the rights of all citizens. Thurgood Marshall died in 1993, leaving behind a legacy that earned him the nickname "Mr. Civil Rights." Before his funeral, his flag-draped casket was laid in state in the Great Hall of the Supreme Court. He was only the second justice to be given this honor.


Justice Thurgood Marshall was one of the country's greatest jurists and civil rights advocates, but he was also a gifted storyteller who liked to leaven even a serious tale with a sprinkling of humor.


The Civil Service aims to ensure that all employees have the tools and skills needed to provide public services more effectively. Once in post, you'll be able to access Civil Service Learning, an online portal that provides access to e-learning, online resources and classroom courses. The portal aims to develop skills that are common to all civil servants.





The government has launched a new Government Curriculum to help civil servants plan their training and improve how they do their job. There are five strands with courses covering areas such as initial induction, working in government, line management training and specialist courses.


You need to be working at the higher executive officer grade (or equivalent) or below to be eligible, and can apply at the same time as external applicants. The selection process for civil servants is the same as for external candidates, but you may not need a degree to be eligible to apply for some schemes. Check with individual schemes for degree exemptions for civil servants.


Moving between roles and advancement to more senior levels is dependent on opportunities arising, but there is usually plenty of scope for civil servants to move within departments and there are clear progression structures in place. Salaries may be restricted by set-pay scales, depending on Civil Service grade level.


The Senior Civil Service (SCS) is the most senior grade in the Civil Service and makes up only 1.5% of civil servants. It comprises the senior management team who are responsible for the policy work of their team.


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