The Wu Wei Tea Temple in Fairfax, California, celebrated their 7th anniversary. I wanted to offer something special and so spent a good few weeks sifting through over 30 years of my music collection. I took a peak in my old Ableton Live sets, which i used in the early days of Ecstatic Dance in Oakland and found some stonking tracks that I had forgotten about. This is a live recording of what went down. Feel free to download, for listening later. Enjoy!

Wu Wei Tea Temple 2022 Live Set

In our previous interview with Dr. Kapahi, we discussed his work examining how advanced glycation end products (also known as AGEs) drive the aging process. Since we last spoke, Pankaj has been hard at work trying to identify compounds that can rein in the deleterious impact of AGEs, primarily by lowering levels of methylglyoxal. Methylglyoxal is formed as a side product of the breakdown of sugars, and is involved with the formation of AGEs, so it is a logical molecular target here. In his screening process of over 800 compounds, he managed to find five compounds which, when combined, had synergistic protective effects against methylglyoxal toxicity.
This powerful combo now makes up the product GLYLO, and preliminary testing of GLYLO in rodent models revealed, sure enough, that the combo reduced glycolytic byproducts, improved insulin sensitivity, extended lifespan by 30-40% when administered late in life, and reduced caloric intake, and promoted weight loss. Importantly, this effect was shown to be independent of peripheral hormones like leptin and ghrelin. In fact, injecting ghrelin into mice treated with GLYLO did not result in increased energy intake - suggesting that GLYLO was changing how the hypothalamus responded to ghrelin. In other words, reducing methylglyoxal, through GLYLO, appeared to be lowering their body fat set point.

humanOS Radio

#090 - The Effects of Glylo on Weight Loss, Blood Sugar, and Longevity - Professor Pankaj Kapahi

Taurine is often associated with energy drinks and pre-workout supplements, although ironically, it is not a stimulant and may have the opposite effect. While taurine is not considered an essential nutrient for adults, as our bodies can produce it from other amino acids, recent evidence suggests that it offers numerous health benefits. These include improved blood sugar regulation, reduced oxidative stress, and lower blood pressure.

One intriguing aspect of taurine is its potential to vary in production between individuals. Furthermore, studies indicate that taurine levels may decline with age. This brings us to the focus of this week's episode of humanOS Radio.

We are delighted to have Vijay Yadav, an Assistant Professor at Columbia University's Department of Genetics and Development, as our guest. He is the senior author of a fascinating new study published in Science, which explores the connection between taurine and the aging process.

Yadav and his team conducted measurements of blood taurine concentrations in mice, monkeys, and humans at different ages. Their findings revealed a consistent decline in taurine levels associated with aging across all species. In fact, the reduction was significant, with elderly humans exhibiting an 80% decrease in taurine compared to younger individuals.

The crucial question posed by the authors is whether these changes are mere correlations or if they play a causal role in the aging process. In other words, do declining taurine levels contribute to physiological aging and age-related diseases, or are they simply associated with them?

If taurine reductions do indeed cause aging, restoring taurine levels to that of youth could potentially extend both lifespan and healthspan. This means not only living longer but also living better.

To begin unraveling this question, Vijay and his colleagues conducted a series of experiments. To discover their findings and delve deeper into the relationship between taurine and aging, we invite you to listen to the interview on humanOS Radio.

092 - humanOS Radio - Vijay Yadav - Taurine On Health And Lifespan (2023.06.20)

What an epic night! I eventually came on at 2.30am and krushed it for all those that could wait...

Solstice Grove Live Set - 2023

Volume 1 - Disco

In his first set in over 40,000 years, DJ Zombie Amadeus creaked up to the decks as midnight approached on Halloween night as Saint Vaughan Palace in Zilker Park became a spectral soundscape with haunting screams and beats. The night kicked off with funky house beats, reminiscent of spirits dancing mischievously. The atmosphere thickened with haunting house rhythms, resonating with the palace's ancient stones. The hypnotic pulse of tech house then took over, drawing attendees into a deep trance, as if the palace's own spirits had joined the dance. The dreamy melodies of indie house transported the crowd through a haunted forest of nostalgic tales. Finally, the powerful crescendo of progressive house promised a new dawn after a night of ghostly escapades. As the sun hinted its arrival, the unforgettable set concluded, leaving an indelible mark on every doomed soul who dared to groove the night away.

DJ Zombie Amadeus - Live at St. Vaughan Palace, Ford St, ATX - Halloween 2023

A DJ mix from the top of the trees where the bees sting your knees.  Moody and deep, the way she likes it.  With tracks from Nic Fanciulli, Daniel Rateuke, Giacca & Flores, and more...

LIVE FROM THE TREEHOUSE

In this exclusive 3-hour set played by Dajopa, live on New Year's Eve in a private location in Las Vegas. This intimate setting was perfect for groove enthusiasts looking to welcome the new year in style. Relive every beat as we welcome in 2024 with a magical vibe.

2024 - Dajopa - NYE in Las Vegas

On this episode of humanOS Radio, Dan welcomes Pankaj Kapahi to the show. Pankaj is a professor at the Buck Institute, an independent biomedical research institute that is devoted solely to research on aging. 

He and his team have begun to investigate the role of advanced glycation end products (also known as AGEs) in the aging process. Advanced glycation end products are compounds that are formed when proteins or lipids become glycated, as a result of being exposed to sugars. 

This has been carefully studied and exploited by the food industry for decades, because of its appealing effects on sensory qualities of food. However, it was only recognized comparatively recently that AGEs may impair our health and function over time. 

Aptly enough, the formation and accumulation of AGEs is a hallmark of age. AGEs wreak havoc by binding with cell surface receptors and cross-linking with body proteins, altering their structure and function. This produces a range of deleterious effects throughout the body. 

So, how can we reduce our exposure to advanced glycation end products in the food that we eat? And how can we control the formation of AGEs inside the body? To learn more, check out the interview below!

#065 - The Role of AGEs in Aging and Disease - Professor Pankaj Kapahi

In this episode of humanOS Radio, Dan speaks with Pamela Maher. Dr. Maher has a Ph.D. in biochemistry from the University of British Columbia. She was formerly an associate professor at The Scripps Research Institute in La Jolla. In 2004, she moved to her current position as a research scientist at the Salk Institute for Biological Studies.

Her research has centered on understanding responses of nerve cells to oxidative stress, and how chemical compounds can modulate these responses to enhance nerve cell function and survival. Her current work is focused on using natural products such as flavonoids to maintain nerve cell function in the presence of toxic insults. Flavonoids are a diverse class of secondary metabolites found in almost all fruits and vegetables. One of the great advantages of these phytochemicals is that they are tiny molecules - small enough to cross the blood-brain barrier. This has been convincingly demonstrated in studies of rodents. For instance, when rats are fed blueberries for ten weeks, and then dissected, anthocyanins from the fruit can actually be found distributed inside the brain!

Maher and her colleagues have been focusing their attention particularly on a few of these flavonoids as potential neuroprotective agents. One of these is fisetin, a flavonoid that is most highly concentrated in strawberries. We have discussed it previously on the show as a possible senolytic agent. Maher and her group have been developing more potent and more bioavailable versions of the flavonoid that might protect nerve cells and even promote learning and memory. Good stuff! 

The other phytochemical we’ll be discussing on the show is sterubin. Sterubin is a flavonoid found in Yerba santa, a plant that native tribes in California have long prized for its medicinal properties. When Dr. Maher screened for plant extracts that could act on toxicity pathways relevant to age-associated degenerative disease, sterubin emerged as one with broad protective effects in cell assays.

To learn more about the power of flavonoids and the future of anti-aging research, please check out the interview!

#069 - Flavonoids and Brain Health - Dr. Pam Maher

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Hello everyone! Merry Christmas and Happy Holidays to all of you! This year has been a rollercoaster for all of us on this planet. For me personally it meant a lot of heavy weight on my shoulders whenever the pandemic hit us and many different kind of emotions during all the stages throughout the year. So many people have lost loved ones, lost their jobs, homes and (decent) food. All I can do is try to be there for my friends, my family and my fans. I bet many of you want to do so much more but all we can do has a limit. But all the little things help so please keep on being there for your loved ones, that stranger on the street and the human being with the same red blood but different skin colour. We are all in this together, now and always. And please look and feel the sun when you have a hard moment. The sun is very powerful and energetic, let it warm you when you feel (mentally or physically) cold. I hope this podcast brings you some sunshine as well! And for 2021: all the best and let us dance together again. Let our vibrations come together and create that united feel. Much love, Alex

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#069 - Flavonoids and Brain Health - Dr. Pam Maher

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