@will-kaiser-351227020: you're welcome, and I agree with you. Thanks for listening!

Weight OS

The Wu Wei Tea Temple in Fairfax, California, celebrated their 7th anniversary. I wanted to offer something special and so spent a good few weeks sifting through over 30 years of my music collection. I took a peak in my old Ableton Live sets, which i used in the early days of Ecstatic Dance in Oakland and found some stonking tracks that I had forgotten about. This is a live recording of what went down. Feel free to download, for listening later. Enjoy!

Wu Wei Tea Temple 2022 Live Set

In our previous interview with Dr. Kapahi, we discussed his work examining how advanced glycation end products (also known as AGEs) drive the aging process. Since we last spoke, Pankaj has been hard at work trying to identify compounds that can rein in the deleterious impact of AGEs, primarily by lowering levels of methylglyoxal. Methylglyoxal is formed as a side product of the breakdown of sugars, and is involved with the formation of AGEs, so it is a logical molecular target here. In his screening process of over 800 compounds, he managed to find five compounds which, when combined, had synergistic protective effects against methylglyoxal toxicity.
This powerful combo now makes up the product GLYLO, and preliminary testing of GLYLO in rodent models revealed, sure enough, that the combo reduced glycolytic byproducts, improved insulin sensitivity, extended lifespan by 30-40% when administered late in life, and reduced caloric intake, and promoted weight loss. Importantly, this effect was shown to be independent of peripheral hormones like leptin and ghrelin. In fact, injecting ghrelin into mice treated with GLYLO did not result in increased energy intake - suggesting that GLYLO was changing how the hypothalamus responded to ghrelin. In other words, reducing methylglyoxal, through GLYLO, appeared to be lowering their body fat set point.

humanOS Radio

#090 - The Effects of Glylo on Weight Loss, Blood Sugar, and Longevity - Professor Pankaj Kapahi

Taurine is often associated with energy drinks and pre-workout supplements, although ironically, it is not a stimulant and may have the opposite effect. While taurine is not considered an essential nutrient for adults, as our bodies can produce it from other amino acids, recent evidence suggests that it offers numerous health benefits. These include improved blood sugar regulation, reduced oxidative stress, and lower blood pressure.

One intriguing aspect of taurine is its potential to vary in production between individuals. Furthermore, studies indicate that taurine levels may decline with age. This brings us to the focus of this week's episode of humanOS Radio.

We are delighted to have Vijay Yadav, an Assistant Professor at Columbia University's Department of Genetics and Development, as our guest. He is the senior author of a fascinating new study published in Science, which explores the connection between taurine and the aging process.

Yadav and his team conducted measurements of blood taurine concentrations in mice, monkeys, and humans at different ages. Their findings revealed a consistent decline in taurine levels associated with aging across all species. In fact, the reduction was significant, with elderly humans exhibiting an 80% decrease in taurine compared to younger individuals.

The crucial question posed by the authors is whether these changes are mere correlations or if they play a causal role in the aging process. In other words, do declining taurine levels contribute to physiological aging and age-related diseases, or are they simply associated with them?

If taurine reductions do indeed cause aging, restoring taurine levels to that of youth could potentially extend both lifespan and healthspan. This means not only living longer but also living better.

To begin unraveling this question, Vijay and his colleagues conducted a series of experiments. To discover their findings and delve deeper into the relationship between taurine and aging, we invite you to listen to the interview on humanOS Radio.

092 - humanOS Radio - Vijay Yadav - Taurine On Health And Lifespan (2023.06.20)

What an epic night! I eventually came on at 2.30am and krushed it for all those that could wait...

Solstice Grove Live Set - 2023

Volume 1 - Disco

A DJ mix from the top of the trees where the bees sting your knees.  Moody and deep, the way she likes it.  With tracks from Nic Fanciulli, Daniel Rateuke, Giacca & Flores, and more...

LIVE FROM THE TREEHOUSE

The Fantastic Now

Why are we fatter than our ancestors? In this interview, the second with Dr. Stephan Guyenet, we discuss his new book entitled, 'The Hungry Brain - Outsmarting the Instincts That Make Us Overeat.'

In this episode, Stephan and Dan discuss genetics, stress, food palatability and reinforcement, and other important factors to shed light onto the mechanics behind weight regulation.

#016 - Why Are We Fatter Than Our Ancestors? - Stephan Guyenet, PhD

In this episode of humanOS Radio, Dan talks to Dr. Laura Fonken who is a post-doctoral fellow in Steven Maier’s lab in the Department of Psychology and Neuroscience at the University of Colorado.

Her research investigates how disruptions to circadian rhythms may affect physiological functions, and ultimately could make individuals more vulnerable to disease.

This affects all of us, to varying degrees, and perhaps in ways that we don't even realize. Listen hear as we discuss her fascinating work.

#022 - Does Dim Light at Night Make You Fat? - Laura Fonkin, PhD

So much of the discussion on nutrition is about the food itself. What's discussed far less regularly is the impact of food timing, fasting periods, and meal skipping on the same outcomes we're interested in when we talk about saturated fat, carbs, fiber, etc. It turns out, there is a whole lot to discuss here that matters for human health.

In this episode, Dan speaks with two topic experts - both with several peer-reviewed scientific publications related to the subjects discussed in the episode - and both of whom are collaborators on humanOS.me. Enjoy the conversation.

#026 - The Health Impact of Breakfast Skipping and Food Timing - Greg Potter & Jeff Rothschild

We are in control of our decisions, right? Well, at least we all feel that way but the social science of behavioral economics demonstrates that we are really products of our environmental triggers and cultures. Still, we can act willfully but it's typical that environment will win out, for many behaviors, over time. One interesting line of work that has come from this field looks to understand how to create better products that leverage true modifiers of behavior for better outcomes. Today, I have Duke University Professor Dan Ariely on to discuss the field and the science related to a new product he's involved in called the Shapa body weight scale and he thinks it can help you have better control over your weight than the scale in your bathroom.

#028 - Can a Scale That Leverages Behavioral Psychology Help You Lose Weight? - Professor Dan Ariely

Does a ketogenic diet cure diabetes? A new study set out to explore the efficacy of this diet in a diabetic population and it's been getting a lot of attention. The results, in fact, are impressive but claims are being made about what the study showed that are not entirely true. In this episode, I've brought on the multi-time guest, Stephan Guyenet, PhD - author of the book the Hungry Brain, and co-author of the Ideal Weight Program on humanOS.me - to help sort out the findings from the hype.

#031 - The Ketogenic Diet and Diabetes - a New Study by Virta Health - Dr. Stephan Guyenet

You probably already know that ambient light regulates circadian rhythms by interacting with light-sensitive neurons in the eye. What hasn’t been clear is whether visible light has physiological effects on other tissues in the body outside of the retina...until now.

In this episode of humanOS Radio, Dan talks to Peter Light. Dr. Light is a pharmacologist and a leader in the field of cellular electrical activity. He is chief investigator at the Light Lab at the University of Alberta, and director of the U of A's Alberta Diabetes Institute.

He and his research team discovered - largely by accident - that chronic exposure to blue light causes human fat cells to shrink, store less lipid, and alter their function in other ways that are likely relevant to metabolic health. This suggests that subcutaneous fat might be a sort of peripheral biological clock, and raises all sorts of intriguing questions. Could repeated exposure to blue light serve as a protective mechanism against insulin resistance, chronic systemic inflammation, or even obesity? Listen to the interview below to learn more!

#032 - Fat Tissue Has Receptors for Sunlight and They Affect Fat Metabolism - Professor Peter Light

On this episode of humanOS Radio, Dan welcomes Pankaj Kapahi to the show. Pankaj is a professor at the Buck Institute, an independent biomedical research institute that is devoted solely to research on aging. 

He and his team have begun to investigate the role of advanced glycation end products (also known as AGEs) in the aging process. Advanced glycation end products are compounds that are formed when proteins or lipids become glycated, as a result of being exposed to sugars. 

This has been carefully studied and exploited by the food industry for decades, because of its appealing effects on sensory qualities of food. However, it was only recognized comparatively recently that AGEs may impair our health and function over time. 

Aptly enough, the formation and accumulation of AGEs is a hallmark of age. AGEs wreak havoc by binding with cell surface receptors and cross-linking with body proteins, altering their structure and function. This produces a range of deleterious effects throughout the body. 

So, how can we reduce our exposure to advanced glycation end products in the food that we eat? And how can we control the formation of AGEs inside the body? To learn more, check out the interview below!

#065 - The Role of AGEs in Aging and Disease - Professor Pankaj Kapahi

Master Your Health
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#016 - Why Are We Fatter Than Our Ancestors? - Stephan Guyenet, PhD

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