In this special late-breakthrough episode of the ISTH Pulse Podcast, recorded live at #ISTH2025, host Dr. Geoffrey Barnes sits down with Dr. Robert Sidonio, Jr. to discuss groundbreaking results from a Phase 3 clinical trial of rurioctocog alfa pegol in previously untreated patients (PUPs) with severe hemophilia A. Dr. Sidonio breaks down the study design, clinical outcomes, and what sets rurioctocog alfa pegol apart from other FVIII therapies. The conversation explores the potential impact on early treatment strategies, quality of life, and the future of prophylactic care in hemophilia management. Tune in for first-hand insights from one of the leading investigators in the field—and learn how these findings could help shape clinical practice for patients and families around the world.



Late-Breakthrough Spotlight: Phase 3 Trial Results for Rurioctocog Alfa Pegol in PUPs with Hemophilia A

Nearly four decades ago, Dr. Sara Israels and Dr. Margaret Rand met at an ISTH Congress. Today, the two colleagues and friends sit down to share about their research, careers and how the ISTH helped them cultivate a lifelong friendship.

40 years later: Sara Israels and Margaret Rand on collaboration, science and friendship

Antiphospholipid syndrome (APS) is a complex autoimmune clotting disorder and its treatment remains one of the most debated topics in hematology. In this episode, host Geoffrey Barnes sits down with Deepa Jayakody Arachchillage, founder of the APS Clinic at Hammersmith Hospital and Chair of the ISTH SSC Subcommittee on Antiphospholipid Syndrome. Together, they explore the evolving landscape of APS management, including whether direct oral anticoagulants (DOACs) have a role to play, the challenges of balancing clotting and bleeding risks, and how clinicians can apply the latest guidance to patient care. 

The Complexities of Anticoagulation and Antiphospholipid Syndrome

In this episode, the ISTH announces that Julia Sandrin Gauer is joining the Pulse podcast as a host! Julia brings a wealth of expertise in thrombosis and hemostasis research, along with a passion for science communication that will spark fresh, engaging conversations with leading experts worldwide. Tune in to to learn more about Julia and get ready for a new era of the Pulse Podcast—where science, innovation, and voices from around the world come together.

Meet the New Voice of The ISTH Pulse Podcast: Dr. Julia Sandrin Gauer

In this special episode of the ISTH Pulse Podcast, we teamed up with the World Thrombosis Day campaign to spotlight the powerful voice of patients in shaping awareness, research and change. Our guest is Carol West, blood clot survivor, advocate and the 2024 World Thrombosis Day Patient Ambassador of the Year. Carol shares her personal journey through her clot story, advocacy efforts and her mission to ensure the patient perspective is heard. From navigating diagnosis to driving global awareness, Carol’s story is one of resilience, advocacy and hope. 

Please visit worldthrombosisday.org to get involved.

Amplifying the patient voice: A World Thrombosis Day discussion with Carol West

In this episode, Tamrat Assefa Tadesse, Ph.D., shares insights on advancing anticoagulation management in Ethiopia and beyond. Drawing from his experience as an ISTH Reach-the-World Fellow in Canada and Co-Chair of the ISTH SSC Subcommittee on Control of Anticoagulation, he discusses the challenges and opportunities in expanding access to care, building research capacity, and strengthening global collaboration in thrombosis and hemostasis.


Tamrat Assefa Tadesse discusses anticoagulation management in Ethiopia

Hospital-associated venous thromboembolism (VTE) remains a leading cause of preventable death for hospitalized patients. In this episode, experts Lai Heng Lee (Singapore) and Beverley Hunt (United Kingdom) share an important update on the state of hospital-associated VTE prevention worldwide, as well as discuss gaps in care and opportunities for improvement. Learn more about hospital-associated VTE at www.worldthrombosisday.org.

The state of VTE prophylaxis in 2025: A special episode for World Thrombosis Day

While anticoagulation remains the cornerstone of DVT and PE management, advances in catheter-based therapies are offering new hope for patients who need more than medication alone. Host Geoffrey Barnes, M.D. sits down with Vic Tapson, M.D., professor of medicine at Cedars-Sinai Medical Center and Vice President of Medical Affairs at Inari Medical and Andrew Niekamp, M.D. an interventional radiologist specializing in minimally invasive endovascular treatments and Senior Director of Medical Affairs at Stryker, to discuss when and how these innovative interventions are changing standards of care. Whether you're a clinician managing VTE patients or a researcher interested in the latest advances in thrombosis care, this episode offers practical perspectives on an evolving area of treatment. This episode is supported by Inari Medical, now part of Stryker. 

The role of mechanical thrombectomy in transforming VTE care

In this episode, we explore groundbreaking new research from Stanford University that could revolutionize the way thrombectomy procedures are performed. Renee Zhao, Ph.D., discusses an innovative “milli-spinner” device, designed to improve precision and success rates in clot removal. Hear how Zhao and her team are using soft robotics to make new breakthroughs that could transform patient outcomes. Read more about this new research here: https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202508180 and watch these videos to learn more about the milli-spinner procedure: 
Overview video: www.youtube.com/watch?v=8--vxLNgu4Y
Mag milli-spinner swims in blood vessel: www.youtube.com/watch?v=M0V7k2_b3eA
Mag milli-spinner "eats" a clot: www.youtube.com/watch?v=00HUJu_O7SM


New technology from Stanford University could revolutionize blood clot treatment

In this episode, we explore the evolving role of artificial intelligence in thrombosis and hemostasis with Nikola Vladic. Drawing from his personal experience with hematological malignancy and his passion for clinical research, Nikola discusses his recent study comparing the performance of AI language models, including ChatGPT, LaMDA Mistral, and DeepSeek, to thrombosis experts in clinical decision-making and patient education. The conversation dives into how these models performed and what this means for the future of medical practice. Listeners will also hear insights on the ethical implications, collaborative nature of AI-driven research and the next steps in advancing responsible innovation within thrombosis care. Read the entire study published in JTH: www.jthjournal.org/article/S1538-7836(25)00592-6/fulltext

Can artificial intelligence think like a thrombosis specialist?

Join guests Dr. May Anne Cheong and Dr. Thita Joy Chiasakul to learn how digital platforms are transforming the way scientific research is communicated and elevated across the global thrombosis and hemostasis community. As Social Media Editors of the Journal of Thrombosis and Haemostasis (JTH), they unpack the strategies that help researchers cut through the noise with clear, impactful messaging that resonates worldwide. The conversation also explores emerging best practices for using AI responsibly in publishing to strengthen the visibility and integrity of scientific work. Learn more about JTH at jthjournal.org.

Amplifying science: Social media, publishing and the power of connection

ISTH is the leading international professional society on thrombosis and hemostasis. Listen to our podcast for the latest educational resources in our field.

Late-Breakthrough Spotlight: Phase 3 Trial Results for Rurioctocog Alfa Pegol in PUPs with Hemophilia A

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