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Depuis le 1er avril 2017, Hoshino est un membre de l'Orchestre National de la Radiophonie du Japon (ONRJ). Il est notamment l'interprète de la chanson en trois voix du titre de son deuxieme album, Angels. Il est également l'interprète de la partie instrumental de ce titre. 1549432396

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Fallout 4's Old World Radio Boston mod is one of the most popular audio mods in the game, with over 300,000 downloads to date. However, the creator's method for adding an extra radio station to the game that continues to play music in real time - even when a player changes the channel - is surely an odd one. As uncovered by Twitter user Chris Boyd, modder Brandoman has utilized invisible cats in order to make the mod work.
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As a starting point of the study, we unravelled the transcriptional changes that occur at the NMJ upon a rapidly reversible injury to the MAT. To do so, we choose to profile the transcriptome of NMJs in the mouse soleus: indeed, slow-twitch muscles (like the soleus) display a higher degree of plasticity and remodelling capability than fast-twitch muscles (e.g. the EDL) in response to denervation, and are less vulnerable to aging and neurodegenerative conditions [15,16,17]. We determined the transcriptional profiling of soleus NMJs during the time-course of nerve terminal degeneration and regeneration induced by the pore-forming toxin α-Latrotoxin (α-LTx). This neurotoxin specifically targets the MAT causing an acute, calcium-dependent degeneration that is fully reversible, with complete recovery within a few days in mice [18,19,20]. The process of MAT degeneration/regeneration by α-LTx is highly reproducible and can be temporally assessed by imaging the progressive disappearance/reappearance of pre-synaptic markers, and through quantitative electrophysiological analyses of neurotransmission [20, 21]. Upon damage, neurons produce hydrogen peroxide (H2O2), which acts as a major activator of Schwann cells (SCs) both in vivo and in vitro; this manifests as profound morphological changes that allow the clearing of nerve debris by phagocytosis, and the engagement of the pro-regenerative ERK pathway through phosphorylation [20, 22,23,24]. Therefore, to identify genes most critical to regeneration of the NMJ, we intersected the differentially expressed genes (DEGs) caused by α-LTx with our previously published data set of genes activated by H2O2 in SCs [23].
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