Are you curious about the technology that largely contributes to our present & future? Look no further! The Explain Podcast TEASER is out&about!

In this short preview, we offer a sneak peek into the world of the next generation sequencing. We highlight its potential to transform the way we live, work, and play. It’s the perfect opportunity to get a taste of what’s to come!

But that’s not all – stay tuned because the full-length first episode is just around the corner! From genomics to transcriptomics, we’ll release episodes where we unravel what stands behind cutting-edge sequencing technologies and explain them in simple, digestible terms.

Whether you’re a tech enthusiast or simply eager to understand the NGS technology, our podcast is a great match for you. Join us as we dive into the NGS science, making it accessible and relatable for all.
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The Explain Podcast is recorded at the Medienlabor at the University of Düsseldorf. Our podcast is an outreach activity within the national genomics facility “West German Genome Center” under the umbrella of the Next Generation Sequencing Competence Network.

Teaser

Episode 001: From DNA to Sanger sequencing

Iuliia is confused about RNA and Daniel doesn’t know the size of a DNA nucleotide

Topics:

DNA, RNA, Protein, PCR, Gel Electrophoresis, Sanger Sequencing

- The Royal Institution on the DNA Discovery: https://www.youtube.com/watch?v=_w2453iom9s
- The discovery of DNA on science history: https://sciencehistory.org/education/scientific-biographies/james-watson-francis-crick-maurice-wilkins-and-rosalind-franklin/
- The New York Times on Franklins’ part: https://www.nytimes.com/2023/04/25/science/rosalind-franklin-dna.html
- Wikipedias article on Proteins with history: https://en.wikipedia.org/wiki/Protein
- Jrank on RNA: https://science.jrank.org/pages/5871/Ribonucleic-Acid-RNA-discovery-RNA.html
- Microbe Notes showing the central dogma of molecular biology: https://microbenotes.com/central-dogma-replication-transcription-translation/
- ThoughtCo on RNA and DNA: https://www.thoughtco.com/dna-versus-rna-608191
- khanacademy explainers on PCR and Gel electrophoresis: https://www.khanacademy.org/science/ap-biology/gene-expression-and-regulation/biotechnology/a/polymerase-chain-reaction-pcr
- Amoeba Sisters on PCR: https://www.youtube.com/watch?v=a5jmdh9AnS4
- Promega explaining Sanger sequencing: https://www.youtube.com/watch?v=dVRB4CaLizc
- Microbe online’s writeup on Sanger sequencing: https://microbeonline.com/dna-sequencing-sanger-sequencing-method/
- LibreTextsBiology on Proteins and Enzymes: https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Book%3A_General_Biology_(Boundless)/03%3A_Biological_Macromolecules/3.07%3A_Proteins_-_Types_and_Functions_of_Proteins
- excedr on Taq Polymerase and PCR: https://www.excedr.com/resources/taq-polymerase-what-is-it-and-what-does-it-do/


Since 2018, West German Genome Center (https://wggc.de/) operates as the next generation sequencing facility and supports research in genomics & transcriptomics by providing expertise and sequencing services. WGGC is a part of the Next Generation Sequencing Competence Network (NGS-CN: https://ngs-kn.de/) - network of NGS core facilities in Germany.
Listen to our podcast and we're happy to receive your feedback&questions via Email ( podcast[dot]explain[at]gmail[dot]com ).

The Explain Podcast is recorded at the Medienlabor at Heinrich-Heine University of Düsseldorf (https://medienlab.phil.hhu.de/).

Our podcast is an outreach activity within the national genomics facility "West German Genome Center" funded by the DFG (https://www.dfg.de/) (No. 407493903).

P.S.: One DNA nucleotide is 0.34 nanometers in „length“ - DR

Episode 1: Basics: from DNA to Sanger sequencing

Episode 002: Pyrosequencing

Daniel and Iuliia are confused about fireflies

- Scientific american on how fireflies create light: https://www.scientificamerican.com/article/how-and-why-do-fireflies/
- A small breakdown of a typical Pyrosequencing workflow: https://www.news-medical.net/life-sciences/What-is-Pyrosequencing.aspx
- Biology-pages on Pyrosequencing: https://www.biology-pages.info/P/Pyrosequencing.html
- Biotechfront on Pyrosequencing: https://www.biotechfront.com/2021/04/pyrosequencing-principle-and-steps.html
- Shomu's Biology on Pyrosequencing: https://www.youtube.com/watch?v=he6kJStE2zs
- Quick Biochemistry Basics explaining the method: https://www.youtube.com/watch?v=wY8to-_zAEo
- Bionity on Pyrosequencing: https://www.bionity.com/en/encyclopedia/454_Life_Sciences.html

Chapters:

1:00 Intro
3:00 Fireflies
4:00 Energy
6:00 Luciferase Reaction
11:00 TTTTTTTTTTTTTTT...T?
14:00 microwell Plates
18:00 Pyrosequencing
25:00 Storage & Price
30:00 Teaser
31:00 Pyro?
34:00 Outro




Since 2018, West German Genome Center (https://wggc.de/) operates as the next generation sequencing facility and supports research in genomics & transcriptomics by providing expertise and sequencing services. WGGC is a part of the Next Generation Sequencing Competence Network (NGS-CN: https://ngs-kn.de/) - network of NGS core facilities in Germany.
Listen to our podcast and we're happy to receive your feedback&questions via Email ( podcast[dot]explain[at]gmail[dot]com ).

The Explain Podcast is recorded at the Medienlabor at Heinrich-Heine University of Düsseldorf (https://medienlab.phil.hhu.de/).

Our podcast is an outreach activity within the national genomics facility "West German Genome Center" funded by the DFG (https://www.dfg.de/) (No. 407493903).

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