In this World Shared Practice Forum Podcast, Dr. Mark Hall discusses immunology and inflammation in pediatric sepsis treatment, using immune phenotyping to personalize treatment for pediatric sepsis.

LEARNING OBJECTIVES
Upon listening to this presentation, learners will be able to:
- Recall the history of understanding the inflammatory response in critically ill children
- Identify the distinction between the pro-inflammatory response and the immune paralysis phenomenon
- Describe the study of immune phenotyping to personalize treatment for pediatric sepsis

AUTHORS
Mark W. Hall, MD, FAAP, FCCM 
Chief, Division of Critical Care Medicine 
Nationwide Children's Hospital
Professor in the Department of Pediatrics
Division of Critical Care Medicine
Nationwide Children's Hospital and The Ohio State University College of Medicine

Jeffrey Burns, MD, MPH
Chief and Shapiro Chair, Division of Critical Care Medicine; Executive Chair, International Health Services
Senior Associate in Critical Care Medicine; Department of Anesthesiology, Critical Care and Pain Medicine
Boston Children's Hospital
Professor of Anesthesia
Harvard Medical School

DATES
Initial publication: November 27, 2023.

ARTICLES REFERENCED
15:48: Cornell TT, Sun L, Hall MW, et al. Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2012;143(5):1160-1166.e1. doi:10.1016/j.jtcvs.2011.09.011
 
16:10 Collaborative Pediatric Critical Care Research Network, https://www.cpccrn.org/
 
17:04 VanBuren JM, Hall M, Zuppa AF, et al. The Design of Nested Adaptive Clinical Trials of Multiple Organ Dysfunction Syndrome Children in a Single Study [published online ahead of print, 2023 Jul 27]. Pediatr Crit Care Med. 2023;10.1097/PCC.0000000000003332. doi:10.1097/PCC.0000000000003332

Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

CITATION
Hall MW, O’Hara JE, Burns JP. Immunoparalysis and the Future of Personalized Immunotherapy for Critically Ill Children. 11/2023. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/immunoparalysis-and-the-future-of-personalized-immunotherapy-for-critically-ill-children.

Immunoparalysis and the Future of Personalized Immunotherapy for Critically Ill Children by M. Hall

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In this Complex Care Journal Club podcast episode, Dr. Julie Hauer and Ms. Jennifer Siedman discuss the development of an anticipatory guidance tool for children with severe neurologic impairment called NeuroJourney, an initiative of the Courageous Parents Network. They describe its grounding in palliative care principles and literature, opportunities to support collaborative relationships between clinicians and families, and next steps from this work.

SPEAKERS
Julie Hauer, MD
Pediatrician, Division of General Pediatrics
Boston Children's Hospital
Medical Director
Seven Hills Pediatrics Center

Jennifer Siedman, MEd
Director of Community Engagement﻿
Courageous Parents Network

HOST
Emily Goodwin, MD
Clinical Associate Professor of Pediatrics, University of Missouri Kansas City School of Medicine
Pediatrician, General Academic Pediatrics Beacon Program, Children’s Mercy Kansas City

DATES
Initial publication: February 5, 2024.

JOURNAL ARTICLE
Hauer J, Siedman J, Trager C, Thienprayoon R. NeuroJourney. Courageous Parents Network. Accessed Jan 25th, 2024. https://neurojourney.courageousparentsnetwork.org/

OTHER REFERENCES
Thienprayoon, R; Lord, BT; Siedman, J; Hauer, J. Creating a “Journey Map” for Children with Severe Neurologic Impairment: A Collaboration Between Private and Academic Pediatric Palliative Care, Nonprofit Organizations, and Parents. Journal of Pain and Symptom Management. 2023; 65:e270-e271.

Orkin J, Beaune L, Moore C, Weiser N, Arje D, Rapoport A, Netten K, Adams S, Cohen E, Amin R. Toward an Understanding of Advance Care Planning in Children With Medical Complexity. Pediatrics. 2020 Mar;145(3):e20192241. doi: 10.1542/peds.2019-2241.

TRANSCRIPT
https://op-docebo-images.s3.amazonaws.com/Transcripts/Shared+Journeys_+Evidence-Based+Anticipatory+Guidance_020524.pdf

Clinicians across healthcare professions, advocates, researchers, and patients/families are all encouraged to engage and provide feedback! You can recommend an article for discussion using this form: https://forms.gle/Bdxb86Sw5qq1uFhW6

Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

CITATION
Hauer J, Siedman J, Goodwin EJ. Shared Journeys: Evidence-Based Anticipatory Guidance for Children with Severe Neurologic Impairment. 2/2024. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/shared-journeys-evidence-based-anticipatory-guidance-for-children-with-severe-neurologic-impairment

Shared Journeys: Evidence-Based Anticipatory Guidance for Children with Severe Neurologic Impairment

In this World Shared Practice Forum Podcast, authors of the newly released publication, International Consensus Criteria for Pediatric Sepsis and Septic Shock, review their research and findings for treating and caring for children with sepsis and septic shock. They discuss how using the novel Phoenix Sepsis Score guided the development of this new globally applicable research model.

LEARNING OBJECTIVES
Upon listening to this presentation, learners will be able to:
- Describe the goals and development of the new Phoenix Sepsis Score
- Discuss how clinicians can apply the score in clinical practice and for research endeavors
- Explain the challenges and limitations of using the Phoenix Sepsis score in lower-resource settings

AUTHORS
Luregn Schlapbach, MD, PhD, Prof, FCICM
Head, Department of Intensive Care and Neonatology
University Children’s Hospital in Zurich, Switzerland

Scott Watson, MD, MPH
Professor of Pediatrics
University of Washington School of Medicine
Associate Division Chief
Division of Pediatric Critical Care Medicine
Seattle Children’s Hospital

Claudio Flauzino de Oliveira, MD, PhD
Researcher
Latin American Sepsis Institute

Halden Scott, MD, MSCS
Director of Research
Section of Pediatric Emergency Medicine
University of Colorado School of Medicine
Children’s Hospital Colorado

Tellen Bennett, MD, MS
Professor of Biomedical Informatics and Pediatrics
Vice Chair of Clinical Informatics
Department of Biomedical Informatics
University of Colorado School of Medicine
Attending Physician
Pediatric Intensive Care Unit
Children’s Hospital Colorado

Traci Wolbrink, MD, MPH
Senior Associate in Critical Care Medicine; Department of Anesthesiology, Critical Care and Pain Medicine
Boston Children's Hospital
Associate Professor of Anesthesia
Harvard Medical School

DATES
Initial publication date: March 26, 2024.

ARTICLES REFERENCED
Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock
https://jamanetwork.com/journals/jama/fullarticle/2814296

Global Study of Disease
https://pubmed.ncbi.nlm.nih.gov/31954465/
        
Sepsis-3
https://jamanetwork.com/journals/jama/fullarticle/2492881

Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

CITATION
Schlapbach LJ, Bennett TD, de Oliveira CF, Scott HF, Watson RS, O’Hara JE, Wolbrink TA. New Phoenix Pediatric Sepsis Criteria. 03/2024. OPENPediatrics. Online Podcast. https://soundcloud.com/openpediatrics/new-phoenix-pediatric-sepsis-criteria.

New Phoenix Pediatric Sepsis Criteria by L. Schlapbach et al | OPENPediatrics

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Meet pediatrician Dr. Jay Gordon, as we discuss the importance of people doing their own research when it comes to making informed decisions about the controversial and much-debated subject of vaccines. Dr, Gordon always encourages education as a first course of action regarding medical decisions in determining what is right for your family. This show was recorded in 2007.

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Meet Barbara Loe Fisher, Co-Founder and President of the National Vaccine Information Center (NVIC), a grassroots non-profit charity founded with parents of vaccine-injured children in 1982 to prevent vaccine injuries and deaths through public education. She co-authored the seminal book DPT: A Shot in the Dark (Harcourt Brace Jovanovich 1985; Warner 1986; Avery/Putnam 1991) and has also authored several other books on the subject of vaccine safety. This show was recorded in 2007.

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