UKCTOCS (UK Collaborative Trial of Ovarian Cancer Screening) is one of the largest screening trials in ovarian cancer. More than 200,000 women from England, Wales and Northern Ireland took part in it, and it ran for almost two decades. Designing and running such a large and lengthy trial came with its own challenges. In this episode, Professor Usha Menon discusses the key challenges that UKCTOCS faced in its design, conduct an analysis, and how the team addressed them.

Further information is available on the UKCTOCS website at https://ukctocs.mrcctu.ucl.ac.uk/
Listen to the episode about the UKCTOCS trial results at https://bit.ly/48pK94J
For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk
For more information and to access the transcript: https://bit.ly/45XRyWT
As a listener, your opinion is very valuable to us. Please help us to improve the podcast in the future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g

Lessons from UKCTOCS, a large-scale trial in ovarian cancer screening

About the Lecture:

A tapestry of cosmic events stretching over the past 13.8 billion years have shaped our existence in a vast universe. This lecture will explore how the computer simulations to study the cosmos have developed in tandem with more down-to-earth pursuits like weather forecasting. We will see how the resulting computer codes have unlocked our understanding of the universe, from galaxies and black holes to the essence of matter. And the lecture will conclude with a look at the multiverse and the contentious idea put forward by some philosophers and scientists that we may already be living inside a simulation, Matrix-style. The talk is based on the lecturer's critically-acclaimed book “The Universe in a Box”, published in 2023.

About the Speaker
Andrew Pontzen, Professor of Cosmology at UCL

Andrew Pontzen is a professor of cosmology and author of the recent highly-acclaimed book The Universe In A Box. His award-winning research uses computer simulations to shed light on the cosmos. He has written for the Guardian, New Scientist, BBC Sky at Night and BBC Science Focus; appeared on BBC, Amazon Prime and Discovery Channel documentaries; and contributed to BBC radio programmes including Inside Science, CrowdScience and The Curious Cases of Rutherford & Fry.

Universes Multiverses And Simulations

Date of lecture: Tuesday 19 March 2024

About the lecture:
Beauty and aesthetics have always played a multi-faceted role in human society. During the last decades, smile attractiveness has become a very important factor influencing both personal and professional aspects of everyday life. This has been compounded by the effect of social media and marketing. Dentistry has also evolved significantly over the last decades and has the capacity to predictably restore missing teeth with various modalities, including dental implants, or completely transform the shape and colour of teeth with smile make-overs. The demand for such services has steadily increased and patients are faced with a multitude of offers from dental colleagues. Such dental treatment is usually elective and expensive which also leads to the phenomenon of dental tourism. This presentation will showcase the state-of-the-art dental treatment modalities available today for tooth replacement with dental implants and smile design/make-overs but will also highlight the pitfalls of misinformation, overtreatment and marketing of some dental services.

About the speaker:
Professor Lambis Petridis qualified from the Dental School of Aristotle University of Thessaloniki.

Lunch Hour Lecture - Dental implants and Hollywood smiles: Advances and pitfalls

What are individuals doing to fight climate change and how important is the role of local activism? This episode will be focusing on individual climate action, with our guests chatting to our hosts about the role of activism in initiating change. Featuring Louise Harris (songwriter and Just Stop Oil activist), Versha Jones, (Climate Reality Project - Volunteer National Coordinator, UK) Annabel Rice (Political Advisor at the Green Alliance) and Kris de Meyer (Senior Research Fellow in Climate Communications University College London, Dept of Earth Sciences).  

‘We Tried’ song by Louise Harris https://www.youtube.com/watch?v=o2XV20G85Tg 

The Climate Reality Project https://www.climaterealityproject.org/ 

For more information and to access the transcript: https://www.ucl.ac.uk/climate-change/podcasts-videos/generation-one-climate-podcast  

Sign up to our climate newsletter here: https://r1.dotdigital-pages.com/p/6T06-7DL/subscribe-to-ucl-climate-hubs-newsletters  

Date of episode recording: 14th February and 8th March 
Duration: 39.20 minutes  
Language of episode: English  
Presenter: Mark Maslin and Simon Chin-Yee  
Guests:  
Louise Harris, Just Stop Oil  
Versha Jones, The Climate Reality Project  
Annabel Rice, Green Alliance 
Kris de Meyer, Department of Earth Sciences, UCL 
Producer: Adam Batstone

Season 4: Post COP28 - Where does individual climate action go from here?

In this podcast, we examine what 'decent' living standards mean for people in low-income countries – including energy access and transport infrastructure – and how these are critically linked with the urgent need to reduce global carbon emissions. Join UCL experts Professor Priti Parikh, Professor Jing Meng and Dr Simon Chin-Yee as they discuss what's needed to lift living standards for low-income countries in the global climate crisis, and the role that high-income nations can play.

Transcription link: https://bartlett-review.ucl.ac.uk/podcast-lifting-living-standards-with-low-emissions/index.html

Date of episode recording: 2024-03-06T00:00:00Z
Duration: 00:31:40
Language of episode: English
Presenter: Professor Priti Parikh
Guests: Professor Jing Meng; Dr Simon Chin-Yee
Producer: Liz Griffith and Adam Batstone

The Bartlett Review Podcast: Lifting living standards with low emissions

To mark World Haemophilia Day, we sit down with Professor Amit Nathwani of the UCL Cancer Institute to explore his journey to commercialising the groundbreaking haemophilia A treatment, Roctavian. Host Nigel Campbell is joined by Prof Nathwani and Dr. Rick Fagan, UCLB Director of Biopharm, to explore how Amit’s work looking after patients with haemophilia in the NHS instilled a mission to develop a 'one and done' vaccine type approach to the condition. Amit’s lab to market story, working with UCLB, led to the creation of Roctavian, a one-time gene therapy used for the treatment of adults with severe haemophilia A. The therapy, which was licensed to BioMarin Pharmaceutical Inc, received marketing approval in Europe in 2022 and US FDA approval in 2023, and is now available to patients commercially.

Date of episode recording: 2024-04-10T00:00:00Z
Duration: 00:23:58
Language of episode: English
Presenter: Nigel Campbell
Guests: Prof Amit Nathwani; Dr Rick Fagan
Producer: Nora Amin

Professor Amit Nathwani’s journey to create a one-shot cure for haemophilia A

Happy Earth Day! This episode’s focus is on entrepreneurial climate action: what are businesses – particularly the AI sector – doing to combat the climate crisis and help reach net zero?  

Helping our hosts Mark and Simon answer these questions are Sims Witherspoon (current UCL student studying for MSC in climate change and Climate and Sustainability Lead at Google DeepMind), Buffy Price (COO and Co-Founder of Carbon Re, an AI startup which aims to accelerate decarbonisation), and Zoe Cokeliss Barsley (Director of Sustainability at Oxford University Press) and UCL alumna (MSc Conservation 2003)  

Carbon Re https://carbonre.com/ 
Oxford University Press Responsible Publishing report https://oup.foleon.com/responsible-publishing-report-2022-23/2022-23/ 

For more information and to access the transcript: https://www.ucl.ac.uk/climate-change/podcasts-videos/generation-one-climate-podcast  

Sign up to our climate newsletter here: https://r1.dotdigital-pages.com/p/6T06-7DL/subscribe-to-ucl-climate-hubs-newsletters  

Date of episode recording: 14th February, 23rd February and 1st March 2024 
Duration: 32.15 minutes 
Language of episode: English  
Presenter: Mark Maslin and Simon Chin-Yee  
Guests:  
Sims Witherspoon, Google DeepMind 
Buffy Price, Carbon Re 
Zoe Cokeliss Barsley, Oxford University Press 
Producer: Adam Batstone

Season 4: Post COP28 – AI and the business of climate action

An estimand is a description of the research question a trial seeks to answer, which can help researchers better understand how their study should be designed and analysed. Estimands also provide a clear way to communicate treatment effects to different stakeholders.

This episode of the Trial Talk podcast features Principal Research Fellow Brennan Kahan, exploring how triallists could benefit from using estimands. Brennan also discusses his recent paper which aims to demystify new guidance on the use of estimands.

Resources:
•The estimands framework: a primer on the ICH E9(R1): https://www.bmj.com/content/384/bmj-2023-076316 
•'We must let the research question drive study methods' opinion piece: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908044/ 
•Estimands in cluster-randomized trials: choosing analyses that answer the right question: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908044/ 

For more information and to access the transcript: bit.ly/4dazsWF

For questions or feedback on the podcast series, message us at mrcctu.engage@ucl.ac.uk

As a listener, your opinion is very valuable to us. Please help us to improve the podcast in the future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g

Estimands: Answering the right research questions

In this second episode on Gaza, we talk about how the events in Gaza is echoed in Turkey, Iran, and Bosnia-Herzegovina.

Date of episode recording: 2023-12-19T00:00:00Z
Duration: 01:00:00
Language of episode: English
Presenter: Chair: Dr. Mezna Qato; Host: Dr. Sertaç Sehlikoglu 
Guests: Dr. Alireza Doostdar; Sumeja Tulic; Dr. Halil Ibrahim Yenigun
Producer: Dr. Sertaç Sehlikoglu; Meryem Zișan Köker; Hazal Aydın.

Echoes Of Gaza - Part 2

The Trial Talk podcast explores how our work at the MRC Clinical Trials Unit at UCL is improving health in the UK and worldwide. In this series, we hear from world-leading experts about the studies we carry out. We delve into trials on cancer, infections and neurodegenerative diseases, explore how public and patient involvement shapes our work, and discover new ways to run smarter studies.

Lessons from UKCTOCS, a large-scale trial in ovarian cancer screening

MRC CTU at UCL - Trial Talk podcast

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