In this episode of the "Innovations in Cardiology" series, host Dr Dipti Itchhaporia (Hoag Heart and Vascular Institute, Newport Beach, CA, US) is joined by Dr Alexander Van Rosendael (Leiden University Medical Center, Leiden, NL) to discuss the findings from the CONFIRM2 trial. Conducted from up to 50 international clinical CCTA sites with 35,000 patients, CONFIRM2 aims to improve comprehensive quantification of coronary computed tomography angiography findings using an artificial intelligence algorithm that will enable an accurate quantification of coronary artery disease, including total coronary plaque volume and low attenuation plaque volume.

Findings showed that AI-guided quantative computational tomography quantification of coronary CTA lumen diameter stenosis and the noncalcified plaque volume were most predictive of MACE and added discriminative accuracy to the Diamond and Forrester predictive model. These atherosclerotic profiles as assessed by AI-QCT could guide the tailoring of anti atherosclerotic therapies or coronary interventional procedures to reduce the instance of cardiac events.

If you have any questions or suggestions for topics to cover on the Radcliffe Podcast, please email managingeditor@ecrjournal.com.

AI in Quantitative CT Assessments: CONFIRM2 with Dr Alexander Van Rosendael

In this thought-provoking episode of Parallax, Host, Dr Ankur Kalra engages in an illuminating conversation with Dr Karen Joynt Maddox, a distinguished cardiologist and health policy researcher at Washington University School of Medicine in St. Louis. Together, they navigate the complex intersection of cardiovascular medicine, health economics, and public health policy.

Dr Joynt Maddox shares her unique journey into health economics research, offering valuable insights for cardiologists considering this vital career path. The discussion delves deep into the need for enhanced collaboration between clinicians and policymakers, emphasizing how physicians' frontline experiences can inform more effective healthcare policies.

In examining the growing presence of private equity in cardiology practices, Dr Joynt Maddox provides nuanced insights into this transformative trend. Through thoughtful analysis, she explores how this financial model shapes healthcare delivery, innovation, and patient outcomes. The conversation extends to broader economic challenges in cardiovascular medicine, particularly the intricate balance between fostering medical innovation and ensuring accessible, affordable care for patients.

Drawing from her extensive research experience, Dr Joynt Maddox emphasizes the role of social determinants in cardiovascular health outcomes. The episode concludes with a compelling discussion on integrating public health principles into medical education, offering a vision for a more holistic approach to cardiovascular care.

EP 122: Beyond the Clinic: Addressing Social Determinants of Cardiovascular Health With Dr Karen Joynt Maddox

Join interventional cardiologists, Prof Nicolas Van Mieghem and Dr Joost Daemen from the Thoraxcenter as they unpack the most impactful late-breaking clinical trials and science data from this year's Transcatheter Cardiovascular Therapeutics Conference.

Dive into this practical and engaging discussion and learn more about the latest data for practice and for research.

Trials covered in detail include:
ECLIPSE (00:49 - 05:55)
FAVOR III (05:55 - 10:30)
FLASH (10:30 - 12:54)
DCB BIFURCATION (12:54 - 15:17)
EARLY TAVR (15:17 - 21:14)
EVOLVED (21:14 - 24:07)
TAVR-UNLOAD (24:07 - 28:57)
PEERLESS (28:57 - 31:14)
CLEAR IE (31:14 - 33:29)
TRISCEND II (33:29 - 36:36)
ACCESS TAVI (36:36 - 40:05)
ALIGN AR (40:05 - 41:49)
COSTAR RCT (41:49 - 43:36)
ACURATE IDE (43:36 - 46:42)
CLEAR SYNERGY(46:42 - 48:41)

This is an independent interview produced by Radcliffe Cardiology.

View from the Thoraxcenter: TCT 24 Late-breaking Science Wrap Up

In this exclusive episode of the "Innovations in Cardiology" podcast series, host Dr Dipti Itchhaporia, past president of the American College of Cardiology, delves into the latest advancements in cardiovascular health. She is joined by Dr Valentin Fuster, a pioneer in the field, who shares invaluable insights into the impact of biological ageing, the connection between the heart and brain, and the role of artificial intelligence in healthcare.

Dr Fuster challenges the traditional focus on chronological age, highlighting the significance of biological age as a more accurate predictor of cardiovascular risk. Together, he and Dr Itchhaporia explore innovative ways to measure biological age and discuss the factors that influence it.

The conversation then shifts to the importance of early intervention in cardiovascular disease, with Dr Fuster advocating for screening in younger individuals. They also discuss the transformative potential of polypills in preventing and treating heart disease, weighing the benefits against challenges such as adherence and cost-effectiveness.

As the episode wraps up, Dr Fuster offers his predictions for the future of cardiovascular care and shares valuable advice for those just beginning their careers in the field.

If you have any questions or suggestions for topics to cover on the Radcliffe Podcast, please email managingeditor@ecrjournal.com.

Biological Aging, AI & the Brain-Heart Connection: A Conversation with Dr Valentin Fuster

In this compelling episode of Parallax, host Ankur Kalra sits down with Dr Sharonne Hayes, a trailblazing Professor of Cardiovascular Medicine and the vice chair for academic advancement and faculty development at Mayo Clinic. Together, they explore the critical intersections of career flexibility, diversity, and inclusion in modern medicine.

Drawing from her extensive experience, Dr Hayes challenges traditional career paradigms in cardiology, offering a nuanced perspective on professional growth that prioritizes personal well-being and systemic change. The conversation delves deep into the complex landscape of medical careers, addressing unconscious biases, workforce equity, and the transformative power of inclusive leadership. Listeners will gain profound insights into strategic career navigation, practical strategies for achieving academic recognition, and the critical importance of health equity in cardiovascular care.

Throughout the episode, Dr Hayes provides a masterclass in professional development, sharing her unique approach to career management that balances personal priorities with professional aspirations. From founding the Women's Heart Clinic to her groundbreaking research on academic rankings, she offers a roadmap for cardiologists seeking meaningful and flexible career paths.

A must-listen for medical professionals, educators, and anyone passionate about creating more equitable and supportive healthcare environments.

Ep 123: Redefining Cardiology Careers: Flexibility, Equity and Advancement with Dr Sharonne Hayes

In this week's Parallax, Dr Ankur Kalra welcomes back Dr Sukhjinder Nijjer for their much-anticipated annual review of advancements in cardiovascular medicine that defined the year 2024.

Dr Nijjer, a Consultant Cardiologist in the UK, serves as the President of the Royal Society of Medicine and is an Honorary Senior Clinical Lecturer at Imperial College London.

This episode focuses on recent developments in interventional cardiology, covering coronary interventions, new device technologies and challenging patient populations. Drs Kalra and Nijjer share their perspectives and experiences, offering valuable insights, practical tips and considerations when interpreting this year’s most impactful trials:

REDUCE-AMI
PREVENT
FAVOR III
ORBITA-COSMIC
DANGer SHOCK
SENIOR-RITA
NOTION 3

What are the most impactful cardiovascular trials of 2024? How do Dr Kalra and Dr Nijjer integrate the latest information into their daily practices?

EP 124: Coronary Interventions and Evolving Technologies: The Year 2024 In Review with Dr Sukh Nijjer

In this week's Parallax, Dr Ankur Kalra welcomes back Dr Sukhjinder Nijjer for their much-anticipated annual review of advancements in cardiovascular medicine that defined the year 2024.

Dr Nijjer, a Consultant Cardiologist in the UK, serves as the President of the Royal Society of Medicine and is an Honorary Senior Clinical Lecturer at Imperial College London.

This episode explores emerging trends in the treatment of valvular heart disease, focussing on TAVI procedures and transcatheter interventions. It also covers recent advancements in pharmacological management for cardiovascular conditions. Drs Kalra and Nijjer share their perspectives and experiences, offering valuable insights, practical tips and considerations when interpreting this year’s most impactful trials:

EARLY TAVR
RESHAPE 2
MATTERHORN
TRILUMINATE
TOPSPIN
FINEARTS-HF

What are the most impactful cardiovascular trials of 2024? How do Dr Kalra and Dr Nijjer integrate the latest information into their daily practices?

EP 125: Structural Interventions and Emerging Pharmacotherapies: The Year 2024 In Review with Dr Sukh Nijjer

This episode examines the multidisciplinary team (MDT) in HCM, exploring its ideal structure, function, and real-world challenges. Prof Juan Pablo Kaski is joined by Dr Elena Biagini and Dr Jodie Ingles to share insights from their work on the 2023 ESC guidelines and MDT care.

HCM Practice Essentials: Multidisciplinary Team Working

The Radcliffe Cardiology Podcast brings you the latest advancements, research and best practices in the field of cardiology. Each episode features expert insights and engaging discussions with leading healthcare professionals, covering a breadth of topics in cardiovascular science. 

Our podcast aims to build on the best science, with key takeaways from the top cardiology conferences and recent publications from our journals.

AI in Quantitative CT Assessments: CONFIRM2 with Dr Alexander Van Rosendael

The Radcliffe Cardiology Podcast

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