Professor Michaela Higgins graduated from UCD Medicine in 2002 and completed medical and oncology training in Ireland prior to completing a three-year fellowship in medical oncology at Johns Hopkins Hospital, Baltimore, Maryland.

After fellowship, she was appointed as an Attending (Consultant) Physician at Massachusetts General Hospital, Boston and was an Assistant Professor of Medicine at Harvard Medical School, Boston from 2010 to 2014. 

Prof Higgins was a consultant oncologist in the Mater Misericordiae University Hospital, Dublin from 2015 to 2020. She was Clinical Director of the Cancer Directorate of the Mater Hospital from 2019 to 2020. 

Prof Higgins has been a Consultant Medical Oncologist at St. Vincent’s University Hospital, Dublin and a Clinical Professor at UCD since 2020.  

Prof Higgins specialises in the care of patients with breast cancer. She is actively involved in clinical cancer research and former Director of the UCD Cancer Clinical Trials Cluster supported by the Health Research Board. Prof Higgins is current President of the Irish Society of Medical Oncology (ISMO). 

MGA Clinical Influencers

UCD MGA launched its Podcast Series - MGA Clinical Influencers - in 2022.

During this podcast series, graduates give us a trip down memory lane when describing their time at UCD (and on some occasions in other Schools of Medicine) and as junior doctors.

They discuss their stellar careers in their chosen speciailty and highlights and challenges during those careers, how they share their expertise and coach others. On a personal level, they will discuss how they manage a decent work life balance, where that is possible and books for us to enjoy and holiday locations we should be thinking about. Our interviewees have compelling stories to tell that will spark your curiosity about life in the clinical speciality they have chosen and the career path they have travelled.

https://www.ucd.ie/medicine/alumni/mgapodcastseries/

Prof Michaela Higgins - Consultant Medical Oncologist SVUH & Clinical Professor (UCD Class of 2002)

En este episodio platicamos sobre: 

*México no va a tener relaci9ones con Ecuador mientras Noboa ejerza el cargo el presidente 
*Lunes de salud y tuvimos a la Dra. María de la Luz García Tinoco para platicar sobre el cáncer de colon
*Linkin Park estará en la final de la Champions League 2025 

21 abril 2025 - México vs Ecuador

Etter lang tid med diffuse plager bestiller Torill en time til en gynekolog, cystene de finner på eggstokkene viste seg å være kreft. Behandlingen er tøff, men hun tåler den forholdsvis bra. Den enorme støtten og kjærligheten fra familie og venner betyr veldig mye og gjør dagene lettere. Torill elsker å feire og hun arrangerer blant annet en stor 50-års fest, en «after ski» med busser og det hele. Dagen før fikk hun vite at hun må gjennomgå en stor operasjon, men det stopper ikke festen. I dag er hun opptatt av at kvinner bør undersøke seg jevnlig hos gynekolog og «kjenne etter» når noe er galt. Selv er hun i ferd med å ta tilbake livet med reiser, mentorskap og alt annet som gir henne glede i livet! Om du vil komme i kontakt med oss i Kreftkompasset:  E-post:  Instagram:  Facebook: &nbsp;

Kreftkompasset episode 169

à Anne et Manu 

reste avec moi


Si discrètement il est entré dans ta vie
je ne sais plus comment, peu m’importe aujourd’hui
quotidiennement il accapare ton esprit
Je le vois maintenant comme tes yeux s’en soucient 

Inexorablement dans ton corps il se blottit 
Et finalement tu ne penses qu’à lui
Je ne sais pas comment mais j’en pleure la nuit
Je voudrais tellement te libérer de lui!

T’y e e  eserres les dents pour masquer tes soucis
Mais ton comportement ton regard te trahit
Tu souffres en dedans pourtant tu me souris
Et tu t’ne défends je sens bien que tu me fuis

Il t’a promis sûrement les étoiles leur magie
Un piège évidemment reprend toi ma chérie 
tu sens au fond de toi que si tu baisses les bras
Que si tu pars la bas tu ne reviendras pas

Reste avec moi, reste avec moi pars pas là bas
Reste avec moi au creux de mes bras
Regarde derrière toi je serais toujours là 
Reste avec moi
Reste avec moi, reste avec moi pars pas là bas
Dans ton combat je suis ton soldat
Surtout Baisse pas les bras tu peux compter sur moi
Reste avec moi

en moi tant de colère et je n’ai plus de prise
Il est si pervers tu es sous son emprise 
Il joue avec tes nerfs maintenant il t’a soumise
Ta douleur est sévère pour lui elle est exquise 

Dans ta blouse tu es belle tu vas nous l’éjecter
Des flocons de Noël en plein cœur de l’été 
Ton combat éternel je vais t’attendre à côté 
Ne choisis pas le ciel reviens à mes côtés 

Reste avec moi, reste avec moi pars pas là bas
Reste avec moi au creux de mes bras
Surtout ne le crois pas alors sauve toi
Reste avec moi, reste avec moi pars pas là bas
Tu n’as plus le choix, je te tends mon bras
La vie est un combat je t’attends en bas 
Reste avec moi

DENATURATION

RESTE AVEC MOI

In this episode, we dive into groundbreaking cancer research from the Medical University of Wrocław, where scientists are challenging traditional treatment methods with a surprisingly simple combo: electricity and calcium. Forget high-tech pharmaceuticals—this deep dive explores how short electric pulses can crack open cancer cells and let calcium do the damage. You’ll hear about the three-pronged attack on drug-resistant colon cancer cells, the mysterious “calcium paradox,” and how this method might one day boost the immune system while sparing healthy tissue. Join us as we decode the future of cancer therapy through the lens of nanosecond electroporation, mitochondrial collapse, and immune activation. Podcast created with AI tools.

Shock to cancer cells. Electric pulse and calcium can jointly destroy cancer

In this deeply personal and powerful interview, Chef AJ opens up about her lung cancer diagnosis, how it changed her life, and what it means for her decades-long advocacy for whole food, plant-based living.

Diagnosed with stage 1A lung cancer in 2023, AJ chose to keep it private—until it progressed. Now, for the first time, she shares why she went public, how it’s reshaped her mission, and what she wants the plant-based community to understand about hope, healing, and health.

AJ talks candidly about:

 👉 The emotional impact of her diagnosis
 👉 Why diet isn’t a guarantee against disease
 👉 The power of support, community, and mindset
 👉 Her “Thriving in the Face of Cancer” series
 👉 Why she’s shifting her focus beyond weight loss

🎟️ Learn more about the Plant Powered Party: https://theplantpoweredparty.com/

Why Chef AJ Went Public With Her Cancer Diagnosis After 2 Years S03E08

A new study from the Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine, published in Oncotarget, reveals that the gene p53, long known as the “guardian of the genome,” may be even more powerful than previously thought. By studying it in non-cancerous human cells, researchers discovered how p53 stops risky cell growth and uncovered two new potential targets for cancer therapy.

Understanding p53: The Genome’s Guardian Against Cancer

The p53 gene is one of the most important natural defenses our body has against cancer. When functioning properly, p53 detects damage in a cell’s DNA and either stops the cell from dividing or pushes it to self-destruct. This process helps prevent potentially dangerous mutations from spreading. However, many cancers find ways to silence or mutate p53, allowing uncontrolled growth and resistance to treatments.

Studying p53 in a clear and accurate way has long been a challenge. Most cancer cell models used in research already carry numerous genetic mutations, which can mask or alter how p53 truly functions. To fully understand this vital tumor-suppressing gene, scientists needed a model that closely resembled healthy, genetically stable human cells—yet could still be maintained and studied over time in the laboratory.

The Study: Exploring p53 in Normal and Cancer Cell Models

Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz explored p53 activity using a uniquely suitable cell line: hTERT-RPE1. These non-cancerous human cells are immortalized using telomerase, meaning they continue dividing like cancer cells, but without the chaotic mutations seen in tumors. This makes them an excellent model for studying how p53 operates in near-normal conditions.

Full blog - https://www.oncotarget.org/2025/04/22/new-insights-into-p53-a-powerful-genes-role-in-cancer-therapy/

Paper DOI - https://doi.org/10.18632/oncotarget.28690

Correspondence to - Fred Bunz - fredbunz@jhmi.edu

Video short - https://www.youtube.com/watch?v=Psxj3ctbTuk

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28690

Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/

Keywords - cancer, p53, ionizing radiation, immortalized cells, ALDH3A1, NECTIN4

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

Facebook - https://www.facebook.com/Oncotarget/
X - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/@OncotargetJournal
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/
Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

Oncotarget

New Insights into p53: A Powerful Gene’s Role in Cancer Therapy

23. april 2025

I dagens podkast snakker vi om siste nytt fra Nykode og Zelluna. I tillegg bruker vi litt tid på en studietur Jónas var på før påsken til Mexico, der han møtte andre innovasjonsledere fra hele verden.

Episode 326: Nyheter og studietur til Mexico

Cancer Alley lawsuit fights environmental racism & seeks LA plant moratorium.

Urgent Cancer Alley Lawsuit Fights Back

⛧🖤⛧ PODCAST DROP! ⛧🖤⛧

You've Got Mail Edition - The Whizbanger Show #259 April 25, 2025

The Bands: Baest, Behölder, Bell of Mimir, Black Sasquatch, Cancer, Candlemass, Canyon Lights, Dead Meadow, Electric Citizen, Fly!, Hellcrash, Lobo Is Mute, The Lowcocks, Nytt Land, Point Mort, Sodom, Thammuz

The Labels, Distros & PR: Almost Famous, Argonauta Records, Black Lion Records, Blues Funeral Recordings, Burning House Management, Century Media Records, Dying Victims Productions, Grand Sounds PR, Heavy Psych Sounds Records, Napalm Records, Octopus Rising, Palmer Turner Overdrive, Pavement Public Relations, Peaceville Records, Prophecy Productions, Purple Sage PR, Qabar PR, Rogue PR, Secret Service PR, Shake Promotion, Steamhammer Records

The Countries: Argentina, Australia, Denmark, England, Finland, France, Germany, Italy, The Netherlands, Russia, Sweden, USA



Whizbanger Socials: 

NEW! Merch: https://the-whizbanger-show.printify.me  
E: whizbangershow@gmail.com 
W: www.thewhizbangershow.com 
IG: https://www.instagram.com/sara.whizbanger 
FB: https://www.facebook.com/WhizbangerShow 
LT: https://linktr.ee/sarawhizbanger 
BS: https://bsky.app/profile/sarawhizbanger.bsky.social 
BC: https://bandcamp.com/sarawhizbanger  




You've Got Mail Edition - The Whizbanger Show #259 April 25, 2025

No Mercy (iniskein diss)

BUFFALO, NY - April 28, 2025 – A new #research paper was #published in Oncotarget, Volume 16, on April 24, 2025, titled “PD-L1 and FOXP3 expression in high-grade squamous intraepithelial lesions of the anogenital region."

Researchers Humberto Carvalho Carneiro, Rodrigo de Andrade Natal, José Vassallo and Fernando Augusto Soares from the Instituto D’Or de Pesquisa e Ensino and Rede D’Or studied early tissue changes caused by human papillomavirus (HPV) in the anal, vulvar, and penile regions. They found that high-grade pre-cancer lesions triggered stronger immune responses and showed higher levels of two immune-related markers, PD-L1 and FOXP3. These findings are important because they help explain how some HPV-related lesions progress to cancer while others heal on their own.

High-risk HPV is known to cause several types of anogenital cancers. Before these cancers appear, the virus often leads to abnormal tissue changes known as high-grade squamous intraepithelial lesions. Many of these lesions disappear without treatment, but some become cancer—especially in people with weakened immune systems. This study explored how immune activity may play a role in this progression.

The researchers examined tissue from 157 patients—95 males and 55 females—with either high-grade or low-grade HPV-related lesions. They found that T-regulatory cells, marked by the FOXP3 protein, were more common in high-grade lesions. These immune cells are known to suppress immune responses, which can allow infected or abnormal cells to grow. The team also found higher expression of PD-L1, a protein that helps cells evade immune detection, particularly in inflammatory immune cells.

"Dense inflammatory infiltrates and high counts of FOXP3+ cells were significantly more frequent in patients with HSILs than in those with LSILsHR (p = 0.04 and 0.02, respectively). HSILs also exhibited higher PD-L1 expression (padj < 0.01 and < 0.01 for the SP142 and 22C3 clones, respectively), based on the Poisson generalized linear model.”

These findings suggest that HPV may begin avoiding the immune system early in infection, even before cancer develops. The combination of high FOXP3 and PD-L1 levels may create a protective environment for infected cells, making them harder for the body to eliminate. This immune evasion may allow the lesions to remain and, over time, become cancerous.

The study also compared patients with and without HIV to assess whether immune health influenced the results. While those with compromised immune systems had more extensive lesions, PD-L1 and FOXP3 expression was also found in patients with healthy immune systems. This evidence shows that immune evasion by HPV can happen regardless of a person’s immune status.

Understanding how PD-L1 and FOXP3 function in early HPV-related lesions may help clinicians predict which lesions are more likely to become cancer. These insights could lead to new strategies for monitoring, treating, or preventing HPV-related precancerous lesions and cancer in the anogenital region. The study highlights how early immune system changes can play a key role in the development of HPV-related cancers.

DOI - https://doi.org/10.18632/oncotarget.28715

Correspondence to - Humberto Carvalho Carneiro - humberto.carneiro@rededor.com.br

Video short - https://www.youtube.com/watch?v=6d8G8TUbgYc

Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

Facebook - https://www.facebook.com/Oncotarget/
X - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
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LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/
Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

Early Immune Evasion Found in HPV-Related Pre-Cancer Lesions of the Anogenital Region

I studion sitter Martin, Theo, Emil Erlandsson och Saga Jonasson. 
I veckans avsnitt täcker vi ämnen som behandlar världens alla hörn. Från New York till Los Angeles, till centraleuropa och hela vägen in i det svenska folkhemmet. Theo har varit och sett En Fanfare på bio, Emil har varit på stadsteatern och sett deras uppsättning av Amadeus och Saga och Martin har sett bra och dålig film i tryggheten av sitt vardagsrum. Hör dem recensera den rykande färska Team Starkid-musikalen Cinderella’s Castle samt de två extremt folkkära Lukas Moodysson-filmerna Tillsammans och Tillsammans 99. Det blir ordentligt med skratt denna vecka, det lovar vi!

12:52 - Intro
15:30 - Age of Mythology DLC
21:18 - En Fanfare (Min oväntade bror)
33:50 - Cinderella’s Castle
1:01:04 - Amadeus
1:13:40 - Tillsammans & Tillsammans 99

Har DU något att säga till oss? Tips på något att prata om, åsikter om något vi sagt eller vill kanske bara säga hej? Skriv till oss på Facebook, följ oss på Instagram @medisradio och mejla till oss på medisradio@gmail.com. Vill ni se oss spela spel på Twitch så följ oss på @MedisRadioTV.

Musik: Pontus Ljung


188 - En Fanfare, Cinderella’s Castle, Amadeus, Tillsammans och Tillsammans 99

🎙️ Confira o novo episódio do Podcast OncoPonto!

 Vamos falar sobre o EBUS no câncer de pulmão, um exame inovador que tem transformado a precisão do diagnóstico.

👥 Participação especial do oncologista Dr. Vinícius Conceição e dos cirurgiões torácicos Dr. Humberto Campoy, Dra. Luciahelena Trevisan e Dra. Mariana Canevari.

Nossos especialistas vão explicar como o EBUS funciona, quando ele é indicado, e por que é essencial no tratamento do câncer de pulmão. 

Informação clara, prática e indispensável para pacientes, familiares e interessados no tema!


Você sabe o que é EBUS? Qual a relação com o câncer de pulmão?

og: agonyost - 8ball ////

re-released as single

carcinogen

femdboy

29. april 2025

I dag har vi med oss CEO Michael Engsig og Agnete Brunsvik Fredriksen, forskningsdirektør og ansvarlig for forretningsutvikling i Nykode. 

De forteller om siste måneds dramatikk i selskapet og hvordan veien blir videre.

Episode 327: Nykode Therapeutics

30. april 2025

I dag har vi med oss Sigrid Bratlie, strategisk rådgiver i Kreftforeningen og Langsikt - og ikke minst høyaktuell med bok om covid-pandemiens opphav: "Mysteriet i Wuhan". 

I dag er temaet celle-og genterapier, noe Sigrid kan mye om. Vi snakker om: Hva er det, hvilke behandlinger er godkjent, hva er flaskehalser og muligheter. Og vi snakker selvfølgelig mye om det norske forskningsmiljøet her, vårt porteføljeselskap Zelluna og; Karl-Johan Malmberg sin forskning som han i år er gitt  Kong Olav Vs kreftforskningspris av Kreftforeningen. Han for den for sitt arbeid med NK-celler, det vil si naturlig drepeceller.

Sigrid kommer tilbake i podkasten 11. juni. Da skal vi snakke om potensialet i kombinasjonen kunstig intelligens og bioteknologi, og hvilke implikasjoner det kan ha for kreftfeltet. 

Send oss gjerne spørsmål!

Episode 328: Celle- og genterapi med Sigrid Bratlie

Melodia este emoționantă și sinceră, in care vorbim despre viața lui Ștefan, un prieten care trece prin multe greutăți și neînțelegeri. Versurile ating subiecte precum lipsa de încredere a celor din jur, mai ales când vine vorba de lucruri aparent incredibile – cum ar fi faptul că deține o vilă în Monaco. Este o poveste despre lupta cu prejudecățile, dar și despre loialitate, susținere și adevărul care nu are nevoie de dovezi când vine din inimă.

Vrei să adaug și un ton ironic sau serios în descriere?

Monaco

Freshly squeezed podcasts every Friday on Soundcloud, The Whizbanger Show is a mix of raucous sounds from psychedelic to doom, sludge to punk, grind to black, and the occasional Judas Priest worship for good measure. You’ll hear everything from 3 Inches of Blood to 7 Year Bitch, The Abadox to Zeke, curated collections from secreted-away stash boxes, and bands from around the world. With the occasional surprise co-host and special shows dedicated to women, trans and nonbinary folks, DIY bands, and even cover shows, The Whizbanger Show will surprise you, delight you, and feed those inner demons.

¡TE INFORMAMOS LO BUENO, DONDE QUIERA QUE ESTES!

Leading in medical research and education, Wrocław Medical University drives innovation in health sciences and clinical advancements. Based in Wrocław, Poland.

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Radium er en podkast som utgis av RADFORSK. I studio snakker Elisabeth Andersen og Jónas Einarsson om siste nytt innen kreftforskning og utvikling av ny kreftbehandling og porteføljebedriftene til RADFORSK - alene eller sammen med gjester.

The Plant Based News (PBN Podcast) delivers pioneering vegan news and ethical views weekly. Your go to podcast for plant-based nutrition and everything to do with living a vegan lifestyle.

Hosts in order of episodes:

Robbie Lockie
Joe Best
Klaus Mitchell
Sarah Tweed
Shabnam Islam

En podcast om all möjlig fin- och fulkultur! Film, spel, serietidningar, skidskytte och mycket mer. Hålls i Stockholm av ett gäng unga vuxna med ett lite för stort intresse för media. Lyssna och skratta om konversationer och recensioner om allt från AAA-filmer till de mest obskyra gamla PSP-spelen. Varje avsnitt bjuder på nya upplevelser. Häng med!

Real Smart Media is a Dublin based audiovisual production and web management company. Recording and podcasting events is a specialty.

un vétérinaire la journée, un auteur-compositeur-interprète de chanson française le soir sous le nom de Clouman!

New tracks tagged #cancer