Have we as a culture become expert at globalizing industries, but are we failing when it comes to truly world-changing technological breakthroughs? Is competition bad for business?  Should you bother with creating the “nth” social network (the answer is no)? Chris Dixon and Blake Masters dig into these themes, plus “power laws” and the importance of secrets from Peter Thiel's new book with Masters, “Zero to One.”  Dixon tries to pry a secret from Masters, but they aren’t called “secrets” for nothing.

a16z Podcast: Secrets, Power Laws, and Technology – The Ideas of  “Zero to One”

Part 1 of An Autobiography - The Story of my Experiments with Truth

My Experiments With Truth Autobiography By Gandhi Audio Book Part 1 Of 8

"The challenge of our future is to say, are we going to connect and amplify the positive tribes that want to make things better for all of us?" Entrepreneur and digital wise man Seth Godin on our capacity to use connection to elevate and advance the human spirit. Find more at onbeing.org/becoming-wise.

We Choose Our Own Tribes | Seth Godin [Becoming Wise]

"All of a sudden you can program the world" -- it's the continuation of the software eating the world thesis we put out over five years ago, and of the trajectory of past and current technology shifts. So what are those shifts? What tech trends and platforms do we find most interesting on the heels of raising our fifth fund? Are we just building on and extending existing platforms though, or will there be new platforms; and if so, what will they be? Well, distributed systems for one...

This episode of the a16z Podcast covers all things distributed systems -- encompassing cloud and SaaS; A.I., machine learning, deep learning; and quantum computing -- to the role of hardware; future interfaces; and data, big and small. Podcast guests Marc Andreessen and Ben Horowitz (in conversation with Scott Kupor and Sonal Chokshi) also share the one piece of advice from a management and go-to-market perspective that all founders should know. And finally, why simulations matter... and what do we make of our current reality if we are all really living in a simulation as Elon Musk believes?

a16z Podcast: Software Programs the World

A Trip With The Stars

To subscribe on Apple podcasts please visit apple.co/2r40QPA or on Andriod subscribeonandroid.com/www.lse.ac.uk…unesStore.xml or search for 'LSE IQ' in your favourite podcast app or visit lse.ac.uk/iq

Welcome to LSE's award-winning podcast, LSE IQ, where we ask leading social scientists - and other experts - to answer an intelligent question about economics, politics or society.

With more and more information about us available electronically and online, this episode of LSE IQ asks, ‘Is big data good for our health?’

Advances in bio-medical technologies, along with electronic health records and the information we generate through our mobile phones, Smart Watches or Fit bits, our social media posts and search engine queries, mean that there is a torrent of information about our bodies, our health and our diseases out there. 

Alongside this, the tremendous growth in computing power and data storage means that this ‘Big Data’ can be stored and aggregated and then analysed by sophisticated algorithms for connections, comparisons and insights. 

The promise of all of this is that big data will create opportunities for medical breakthroughs, help tailor medical interventions to us as individuals and create technologies that will speed up and improve healthcare. 

And, of course, during the COVID-19 pandemic we’ve also seen some countries use data, generated from people’s mobile phones, to track and trace the disease. 

All of this poses opportunities for the tech giants and others who want to be part of the goldrush for our data -  and to then sell solutions back to us.

What are the risks in handing over our most personal data? Will it allow big data to deliver on its hype? And is it a fair exchange?

In this episode, Oliver Johnson speaks to Dr Leeza Osipenko, Senior Lecturer in Practice in LSE’s Department of Health Policy; Professor Barbara Prainsack, Professor of Comparative Policy Analysis at the University of Vienna and Professor Sociology at King’s College London; Dr Stephen L. Roberts, LSE Fellow in Global Health Policy in LSE’s Department of Health Policy; and Dr James Somauroo, founder of the healthtech agency somX and presenter of The Health-Tech Podcast. 

Research 
Blockchain’s potential to improve clinical trials by Leeza Osipenko
Big Data, Algorithmic Governmentality and the Regulation of Pandemic Risk by Stephen Roberts
Personalized Medicine: Empowered Patients in the 21st Century? by Barbara Prainsack


Contributors
Dr Leeza Osipenko
Professor Barbara Prainsack
Dr Stephen L. Roberts
Dr James Somauroo

LSE IQ podcast

Is big data good for our health?

We all know the basics of losing weight: don't consume more calories than your body needs. And yet many of us still overeat anyway, sometimes continually, sometimes to the point where it leads to obesity, diabetes, and a significantly lower quality of life. Why does our behavior betray our intentions to be lean and healthy? 

My guest today argues that the answer lies in the ancient instincts of our brains that no longer fit the environment of the modern world. His name is Stephan Guyenet, and he's a neuroscientist, obesity researcher, and the author of The Hungry Brain: Outsmarting the Instincts That Make Us Overeat. We begin our conversation with what's changed in our country to turn obesity into an epidemic, and why Americans started gaining more weight in the 1970s. We then dive into exactly how the reward system in our brains leads us to eat more than we need to, how modern manufactured foods like Doritos hijack this reward system, and the factors that ramp up our cravings, including the buffet effect. We then explain how to push back on the desire to overeat, including reevaluating the assumption that all the food you consume needs to be delicious. From there we turn to the role that the hormone leptin plays in appetite regulation, how it can make it hard to keep the weight you lose from coming back, and the best techniques to manage this countervailing force. We end our conversation with the role stress and sleep play in weight gain.

Get the show notes at aom.is/hungrybrain.

#636: Why You Overeat and What to Do About It

When people start on a self-development journey, they'll sometimes create a bucket list -- all the things, all the typically exciting and pleasurable things, they hope to do before they die. My guest started his own self-improvement journey very differently, by creating an anti-bucket list consisting of things he didn't want to do, and embarking on a "year of adversity."

His name is Ben Aldridge and he's the author of How to Be Comfortable With Being Uncomfortable: 43 Weird & Wonderful Ways to Build a Strong, Resilient Mindset. Ben and I begin our conversation with how his struggle with debilitating panic attacks inspired him to study philosophical and psychological ideas on how to fight back against his anxiety, what he learned that can benefit anyone looking to be more resilient, and how he was particularly inspired by the Stoic idea of intentionally practicing adversity to prepare for adversity. We then talk about the project Ben set for himself of embarking on a year of mental, physical, and skill-based challenges designed to push himself outside his comfort zone, how he decided what kinds of challenges to do, and how doing hard things changed him. From there we get into the specific challenges Ben completed, from taking cold showers to learning Japanese, and what they taught him about self-discipline, facing your fears, and the human potential for growth. We end our conversation with the ways he's continued to push himself after the year of challenges was through, even in the midst of the pandemic lockdown, including climbing Mt. Everest from inside his house.

Get the show notes at aom.is/getuncomfortable.

#640: Weird and Wonderful Ways to Get Comfortable Being Uncomfortable

For centuries, people have been looking to the stars to tell us all kinds of things — what our future holds, who we should date. So what does the science say about astrology? It turns out, there’s some surprising stuff here. We speak to astronomer Prof. Caty Pilachowski, Prof. Dave Henningsen and astrology lover Natalie Norman. 

Here’s a link to the transcript: https://bit.ly/31VTDoM 

This episode was produced by Meryl Horn and Rose Rimler, with help from Wendy Zukerman, Michelle Dang, Hannah Harris Green and Nick DelRose. We’re edited by Blythe Terrell with help from Caitlin Kenney. Fact checking by Diane Kelly. Mix and sound design by Peter Leonard. Music written by Peter Leonard, Marcus Bagala, Emma Munger, and Bobby Lord. Thanks to everyone we got in touch with for this episode including Professor Todd Tinsley, Dr. Peter Hartmann, Dr. Katie Mack, Dr. Kathy Cooksey, Professor John Mcgrew, Professor Jim Kaler, Dr. Alex Storrs, Julius Bjerrekær, Laura Gilmore and others. And special thanks to Chris Suter, Max Gibson, the Zukerman family and Joseph Lavelle Wilson.

Science Vs

Astrology: Are Geminis the Worst?

A riveting, deeply personal account of history in the making - from the president who inspired us to believe in the power of democracy.

In the stirring, highly anticipated first volume of his presidential memoirs, Barack Obama tells the story of his improbable odyssey from young man searching for his identity to leader of the free world, describing in strikingly personal detail both his political education and the landmark moments of the first term of his historic presidency - a time of dramatic transformation and turmoil.

Obama takes listeners on a compelling journey from his earliest political aspirations to the pivotal Iowa caucus victory that demonstrated the power of grassroots activism to the watershed night of November 4th 2008, when he was elected 44th president of the United States, becoming the first African American to hold the nation's highest office.

Reflecting on the presidency, he offers a unique and thoughtful exploration of both the awesome reach and the limits of presidential power, as well as singular insights into the dynamics of US partisan politics and international diplomacy. Obama brings listeners inside the Oval Office and the White House Situation Room and to Moscow, Cairo, Beijing and points beyond. We are privy to his thoughts as he assembles his cabinet, wrestles with a global financial crisis, takes the measure of Vladimir Putin, overcomes seemingly insurmountable odds to secure passage of the Affordable Care Act, clashes with generals about US strategy in Afghanistan, tackles Wall Street reform, responds to the devastating Deepwater Horizon blowout and authorises Operation Neptune's Spear, which leads to the death of Osama bin Laden.

A Promised Land is extraordinarily intimate and introspective - the story of one man's bet with history, the faith of a community organiser tested on the world stage. Obama is candid about the balancing act of running for office as a Black American, bearing the expectations of a generation buoyed by messages of 'hope and change', and meeting the moral challenges of high-stakes decision-making. He is frank about the forces that opposed him at home and abroad, open about how living in the White House affected his wife and daughters and unafraid to reveal self-doubt and disappointment. Yet he never wavers from his belief that inside the great, ongoing American experiment, progress is always possible.

This beautifully written and powerful book captures Barack Obama's conviction that democracy is not a gift from on high but something founded on empathy and common understanding and built together, day by day.

A Promised Land - written and read by Barack Obama

Co-winner of Stormzy’s #Merky Books New Writer’s Prize, Hafsa Zayyan chats to Nihal about her debut novel ‘We Are All Birds Of Uganda’.

She chats to Nihal about completing the book in 6 months and why a sense of belonging and home is so important no matter where you live. Hafsa also bought along some objects which inspire her, including letters from her late Nigerian grandfather #PenguinPodcast

‘We Are All Birds Of Uganda' is available to buy as an audiobook now - https://apple.co/39MMI3S

WIN a year’s supply of audiobooks! To be in with a chance to win, tap the link and tell us what you think about the Penguin Podcast. https://bit.ly/PodcastSurvey2020

The Penguin Podcast: Hafsa Zayyan with Nihal Arthanayake

The a16z Podcast discusses tech and culture trends, news, and the future -- especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!