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In addition to the famous treatment strategies such as antibiotics, probiotics, and immunostimulants, QSIs have also been used in aquaculture as a nutritional supplement to suppress pathogens. AHLs regulate quorum sensing systems depending on the similarity between AHLs molecules and the length of the acyl chain. Even a slight difference in the AHL molecule can mediate an inhibitory effect [142]. For instance, long chain AHLs lead to the reduction of virulence usually caused by short-chain AHLs in Aeromonas species.

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