Doom's Bride

The Heaviest Doom/Sludge/Drone Metal - 2

Я вконтакте: https://vk.com/id613353147
 Группа вк : https://vk.com/catboriscomposer
 Почта: bor88893@mail.ru  или bor88893@vk.com  и Traveler777777@gmail.com

Инферно | Inferno | infernus | hell

Hello new track,
On part sur une grosse mentalcore préhistorique,  j'espère que le son vous plaira.
Bonne écoute !

SPOTIFY ► https://open.spotify.com/artist/6Ztv937rk7iQxBObBW9ye0
SOUNDCLOUD ► https://soundcloud.com/vortek-s
DOWNLOAD  ► https://download.undergroundtekno.com...
Abonne toi : https://www.youtube.com/channel/UCmuH...

BOOKING : prod@pandemic-events.com

Artwork by Protokseed

Tyranno

Vortek's - Tyranno [OMN-085]

BUFFALO, NY- January 31, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, “Prognostic significance of senescence-related tumor microenvironment genes in head and neck squamous cell carcinoma.”

The impact of the senescence related microenvironment on cancer prognosis and therapeutic response remains poorly understood. In this new study, researchers Young Chan Lee, Yonghyun Nam, Minjeong Kim, Su Il Kim, Jung-Woo Lee, Young-Gyu Eun, and Dokyoon Kim from Kyung Hee University, Kyung Hee University Hospital at Gangdong, and the University of Pennsylvania investigated the prognostic significance of senescence related tumor microenvironment genes (PSTGs) and their potential implications for immunotherapy response. 

Using the Cancer Genome Atlas- head and neck squamous cell carcinoma (HNSC) data, the researchers identified two subtypes based on the expression of PSTGs, acquired from tumor-associated senescence genes, tumor microenvironment (TME)-related genes, and immune-related genes, using consensus clustering. Using the LASSO, they constructed a risk model consisting of senescence related TME core genes (STCGs). The two subtypes exhibited significant differences in prognosis, genetic alterations, methylation patterns, and enriched pathways, and immune infiltration. 

“Our risk model stratified patients into high-risk and low-risk groups and validated in independent cohorts.”

The high-risk group showed poorer prognosis and immune inactivation, suggesting reduced responsiveness to immunotherapy. Additionally, the team observed a significant enrichment of STCGs in stromal cells using single-cell RNA transcriptome data. Their findings highlight the importance of the senescence related TME in HNSC prognosis and response to immunotherapy. 

“This study contributes to a deeper understanding of the complex interplay between senescence and the TME, with potential implications for precision medicine and personalized treatment approaches in HNSC.”

DOI - https://doi.org/10.18632/aging.205346

Corresponding authors - Young-Gyu Eun - ygeun@khu.ac.kr, and Dokyoon Kim - dokyoon.kim@pennmedicine.upenn.edu

Sign up for free Altmetric alerts about this article - 
https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205346

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

Keywords - aging, cellular senescence, head and neck cancer, immunotherapy, microenvironment, single cell

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

Prognostic Significance of Senescence-related TME Genes in Head and Neck Squamous Cell Carcinoma

http://www.vice.com/read/abstracters-cruciform-is-a-theme-song-for-the-apocalypse-915

Abstracter's "Cruciform"

"Don’t mourn, organise" were the final words of American labour activist Joe Hill before his execution in 1915. But sometimes our feelings of grief don't lend themselves to good organising – sometimes we might just want revenge.

In her forthcoming book, critic and journalist Sarah Jaffe looks at the many kinds of grief that shape our social and political lives, from family bereavement and mass death during a pandemic, to factory closures and the spectre of climate breakdown. 

She joins Eleanor Penny to talks about the ghosts of the industrial worker, the fate of capital's "sacrifice zones", how Israel tries to weaponise Jewish grief, and what to do when we are denied the means of mourning our lost futures. 

<em>From the Ashes: Grief and Revolution in a World on Fire</em> is out in the UK on 10 October.

Help us build people-powered media: https://novara.media/support

Novara Media

Novara FM: Mourn the Dead, Fight Like Hell for the Living w/ Sarah Jaffe

03 - GOBLINSMOKER - THE KING'S ETERNAL THRONE

This was made by JackTheGen on YouTube Please go Subscribe to them.

https://youtube.com/@jackthegen?si=Bi3z80Hy0EIwo3-4

(BY ALL MEANS I DO NOT OWN THIS!)

JackTheGen- GOG OST-  HOTEL HELL REMIX

From the debut album "Burst", available May 12th digitally / June 30th physically via Sargent House.

CD / LP Pre-order: https://www.hellomerch.com/collections/brutus 
iTunes Pre-Order: http://smarturl.it/BrutusiTunes 

BRUTUS:
Website: http://smarturl.it/Brutus
Facebook http://smarturl.it/Brutus_fbook
Twitter http://smarturl.it/Brutus_twtr
Instagram http://smarturl.it/Brutus_insta

For more from Brutus subscribe here: http://smarturl.it/Brutus_Subscribe

03 - GOBLINSMOKER - THE KING'S ETERNAL THRONE

APF Records