In this month's Talk Evidence, Helen Macdonald and Joe Ross are back with a wry look at the world of Evidence Based Medicine.

They give us a round up of real world data emerging to address various uncertainties about vaccinations against covid

Helen has an update on NHS Digital’s project to extract GP coding for planning of healthcare and research, and talks to Natalie Banner from Understanding Patient Data, to find out what the public really cares about.

Finally, as routine care must go on a clinical review on cardiovascular disease in older adults introduces us to geroscience.


Reading list

Vaccines;
Effectiveness of BNT162b2 and mRNA-1273 covid-19 vaccines against symptomatic SARS-CoV-2 infection and severe covid-19 outcomes in Ontario, Canada: test negative design study - https://doi.org/10.1136/bmj.n1943 

Effectiveness of the CoronaVac vaccine in older adults during a gamma variant associated epidemic of covid-19 in Brazil: test negative case-control study -  https://doi.org/10.1136/bmj.n2015

Associations of BNT162b2 vaccination with SARS-CoV-2 infection and hospital admission and death with covid-19 in nursing homes and healthcare workers in Catalonia: prospective cohort study
https://doi.org/10.1136/bmj.n1868

Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study - https://doi.org/10.1136/bmj.n1931 

CVD
Cardiovascular care of older adults - https://doi.org/10.1136/bmj.n1593

Talk Evidence - real world vaccine data, GP records and CVD

Free book reading of "Maisy Goes to Hospital" by Lucy Cousins in a British English accent - Podcast 10

Book Reading of "Maisy Goes to Hospital" by Lucy Cousins in a British English Accent - Podcast 10

British Accent Podcast 16 by Chris from http://www.learnbritishenglish.co.uk/

Please listen freely, download and share. Thank you.

Reading of "If" by Rudyard Kipling in a British English Accent - Podcast 16

Recording of an Academy of Ideas debate on Tuesday 28 June 2022.

INTRODUCTION
Around the world, prices of a wide range of goods and commodities have been rising sharply for the past few months. In particular, the wholesale cost of energy has been rising fast as the world economy recovered from the pandemic restrictions. Petrol prices have risen by almost a third in the past 12 months. The UK domestic energy ‘price cap’, which hit a low of £1,042 in 2020, is expected to rise to £2,800 in October. Consumer price inflation has hit 9% and is likely to reach 10% by the end of the year. For those on lower incomes, who spend more of their income on food and energy, the impact is even greater.

There are multiple explanations for the rises: the post-pandemic recovery and problems with shipping have been widely cited. The war in Ukraine and sanctions against Russia are hitting energy and food prices. Many economists also point to the rise in the money supply – thanks to ultra-low interest rates, quantitative easing and huge government spending programmes. Rises in production have not kept pace with rising demand, so prices have risen.

But the other side of the story is that wages are not keeping up with rising prices. As a result, most people are seeing real-terms cuts in their living standards. Governments and central bankers seem desperate to keep a lid on wage rises, desperate to avoid a ‘wage-price spiral’, but the effect is to make most people significantly poorer. Those on fixed incomes may be hardest hit of all.

What are the main reasons for the rise in living costs? What can be done to help reduce the impact? Should we be looking beyond short-term and temporary factors? Is this a crisis that has been coming for some time?

SPEAKERS
Robert Fig 
principal, Metals Risk Team, a commodity risk-management consultancy; previously worked at ArcelorMittal and London Metals Exchange

Phil Mullan
writer, lecturer and business manager; author, Beyond Confrontation: globalists, nationalists and their discontents

Hilary Salt
actuary; founder, First Actuarial

How can we end the cost-of-living crisis?

In this episode of the Heart podcast, Digital Media Editor, Professor James Rudd, is joined by Dr Helen Routledge from Worcester Royal Hospital, UK. They discuss all aspects of intervention for ischaemic stroke, including the workforce challenges in delivering this lifesaving therapy. If you enjoy the show, please leave us a podcast review at https://itunes.apple.com/gb/podcast/heart-podcast/id445358212?mt=2

Link to published paper:
https://heart.bmj.com/content/109/10/794

Percutaneous management of acute ischaemic stroke

In this episode of the IJGC podcast, Editor-in-Chief, Dr. Pedro Ramirez, is joined by Dr. David Cibula to discuss the 2023 ESGO-ESTRO-ESP Guidelines for Cervical Cancer. Dr. Cibula is the Chair of the Department of Obstetrics and Gynecology at the General Faculty Hospital in Prague, Professor at the First Medical Faculty of the Charles University, Chair of the Central and Eastern European Gynaecologic Oncology Group (CEEGOG), member of the Strategic group of the ENGOT (European Network for Gynaecological Oncological Trial Groups) as well as a Former ESGO president.

 Highlights:

- Multidisciplinary clinical practice guidelines developed jointly by ESGO/ESTRO/ESP in the field of gynaecological oncology, radiation oncology and pathology.

- Guidelines cover the management of all stages of cervical cancer, including separate sections dedicated to pathology reporting and management in pregnancy.

- The guidelines include recommendations, algorithms, and summaries of recent evidence published as supplements.

ESGO-ESTRO-ESP Guidelines for Cervical Cancer 2023 with David Cibula

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez is joined by Dr. Rene Pareja to discuss recent the cervical cancer management updates. Dr. Pareja is a gynecologist-oncologist at Astorga Oncology Clinic in Medellín and the National Cancer Institute in Bogotá, Colombia. He is a reviewer for more than 20 specialty journals and is an Associate Editor for IJGC. He is the author of ten book chapters and more than 80 publications in peer-reviewed journals, and at IGCS 2021 he received an award for Community Advancement in Resource-Limited Settings.

Highlights:
 - There is controversy in offering minimally invasive approaches to women with early-stage cervical cancer and tumors less than 2 cm.
 - The role of surgical staging remains controversial because guidelines still recommend it, despite evidence of a negative prospective randomized controlled trial.
 - Intermediate risk factors after a radical hysterectomy need to be re-evaluated in a very well designed prospective randomized trial, with modern radiotherapy techniques and updated inclusion criteria.

Cervical Cancer Management Updates with Rene Pareja

Klickt hier, um zum Manuskript zu gelangen: 

https://bit.ly/Deutschlernen_Langsam-Gesprochene-Nachrichten_26052023

Die Langsam gesprochenen Nachrichten der Deutschen Welle bieten von Montag bis Samstag aktuelle Tagesnachrichten aus aller Welt. Das langsam und verständlich gesprochene Audio trainiert das Hörverstehen. Zusätzlich gibt es den vollständigen Text zum Mitlesen. Die Audio-Datei kann auch heruntergeladen werden.

Hier geht's zur Übersichtsseite: dw.com/langsamenachrichten

Deutsch lernen (B2/C1) | Langsam Gesprochene Nachrichten vom 26.05.2023

British Accent Podcast 38 is the pronunciation of farm animals, by Chris from: http://www.learnbritishenglish.co.uk/

Farm Animals - Podcast 38

Lucy Hurst-Brown asks why so many learning disabled people are so lonely.

Having worked with learning disabled people for 25 years, Lucy describes a system which has moved a very long distance from the impersonal, institutional care of the twentieth century, but which still has a long way to go before learning disabled people are properly integrated into their communities.

And in describing how she and her colleagues realised they may be causing the problem, and how they set about finding a solution, she also challenges all of us to play our part.

Producer: Giles Edwards. Published on June 29, 2016.

A Lonely Society

On episode 29, Dr. Dan Brown, Ph.D. joins Dr. Hoye to discuss dissociation, trauma and attachment theory.&nbsp; Dr. Brown is Associate Clinical Professor of Psychology at&nbsp;Harvard Medical School&nbsp;and has served on the faculty for over 38 years.&nbsp;He is a senior meditation master, Dr. Brown has trained and taught with top Indo-Tibetan Bon &amp; Buddhist lamas for more than 48 years, including lineage holders from some of the great schools of Buddhism.&nbsp;An author of 24 books&nbsp;and&nbsp;has testified in over 200 child abuse cases and served as an expert witness for prosecutors at the&nbsp;International War Crimes Tribunal. Dan discusses dissociation, trauma and attachment disorders based on his work with the team that that organized the Three Pillars model of attachment treatment.&nbsp; This treatment is an integrative model of psychotherapy, based on many modalities and theories, including hypnosis, mentalization treatments, and collaborative approaches for working with patients.&nbsp; &nbsp;

Talk Evidence - real world vaccine data, GP records and CVD

BMJ talk medicine

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