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By analysing data used to produce the ASUs, we aimed to describe the advances made by Italy towards elimination of measles and rubella. Moreover, we propose a set of major interventions that could facilitate the elimination process.



Citation: 
Adamo G, Baccolini V, Massimi A, Barbato D, Cocchiara R, Di Paolo C, et al. (2019) Towards elimination of measles and rubella in Italy: Progress and challenges. PLoS ONE 14(12): e0226513.


The first three indicators are the standard indicators used by the WHO to assess the incidence of measles and rubella and the number of CRS cases. The 4th indicator relates to the number of outbreaks notified in a given year and has been newly created based on information contained in the outbreak section of the ASU. Moreover, since the WHO requires that for each outbreak being notified a report form, containing a description of the epidemic and the control and prophylaxis measures taken to contain its spread, should be completed by the regional surveillance systems [7], further two indicators have been created to assess the quality of outbreak investigation. Specifically, the 5th indicator relates to the percentage of outbreaks with submission of the outbreak reporting form, while the 6th indicator relates to the percentage of outbreak reporting forms that contain description of outbreak (e.g. index case, case contacts, setting, pattern of transmission) and measures taken. The 7th to 22nd indicators are WHO standard indicators used in the national ASU to assess the performance of measles and rubella surveillance systems [2]. The 23rd to 26th indicators are the standard vaccination coverage indicators for measles and rubella; the last two indicators, which have been drawn up from scratch, relate to the SIAs performed across the country (i.e. strategies for delivering vaccination to children missed by routine services or to older susceptible individuals) and the percentage of Regions reporting SIAs. WHO targets are available for standard indicators since these indicators are used by the RVC to make reliable conclusions regarding achievement of the elimination objectives in each MS.


In countries with decentralized health policies, progress towards elimination should also be assessed at the subnational level [2, 6]. In Italy, which consists of 21 administrative Regions, regional differences can hinder the achievement of elimination goals [6]. This is particularly evident for vaccination coverage, which is a key measure for evaluating the performance of the immunization system at both national and subnational level [2].


However, despite these improvements, the elimination of measles and rubella in Italy is not yet on the horizon. The analysis of the ASUs revealed in fact some critical aspects of the Italian elimination programme that still need to be addressed. One of these aspects is the poor quality of outbreak monitoring highlighted by the low number of report forms submitted and the incomplete nature of the relevant information. There are two reasons for this. Firstly, the great number of outbreaks with only two cases might have discouraged the conduction of thorough outbreak investigations. Secondly, to date, Regions produce such report forms only in retrospect in response to a specific ministerial request, with the consequence that some information can be lost.


Several issues are still hindering the achievement of the elimination goals in our country. In view of these problems, a set of major interventions aimed at improving the elimination process have been recommended by the Italian NVC.


In the European Region of the World Health Organization, in 1998, the elimination of measles and reduction in the incidence of CRS to < 0.01 per 1000 live births by 2010 was endorsed. The current goal, endorsed in 2010 with Resolution EUR/RC60/R12, comprises th

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Economists, historians, political economists, and sociologists have adopted different perspectives in their analyses of capitalism and have recognized various forms of it in practice. These include 
laissez-faire
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Capitalism in its modern form emerged from agrarianism in 16th century England and mercantilist practices by European countries in the 16th to 18th centuries. The Industrial Revolution of the 18th century established capitalism as a dominant mode of production, characterized by factory work and a complex division of labor. Through the process of globalization, capitalism spread across the world in the 19th and 20th centuries, especially before World War I and after the end of the Cold War. During the 19th century, capitalism was largely unregulated by the state, but became more regulated in the post-World War II period through Keynesianism, followed by a return of more unregulated capitalism starting in the 1980s through neoliberalism.


In the English language, the term "capitalism" first appears, according to the 
Oxford English Dictionary
 (OED), in 1854, in the novel 
The Newcomes
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Capitalism, in its modern form, can be traced to the emergence of agrarian capitalism and mercantilism in the early Renaissance, in city-states like Florence.[33] Capital has existed incipiently on a small scale for centuries[34] in the form of merchant, renting and lending activities and occasionally as small-scale industry with some wage labor. Simple commodity exchange and consequently simple commodity production, which is the initial basis for the growth of capital from trade, have a very long history. During the Islamic Golden Age, Arabs promulgated capitalist economic policies such as free trade and banking. Their use of Indo-Arabic numerals facilitated bookkeeping. These innovations migrated to Europe through trade partners in cities such as Venice and Pisa. Italian mathematicians traveled the Mediterranean talking to Arab traders and returned to popularize the use of Indo-Arabic numerals in Europe.[35]


The economic doctrine prevailing from the 16th to the 18th centuries is commonly called mercantilism.[38][39] This period, the Age of Discovery, was associated with the geographic exploration of foreign lands by merchant traders, especially from England and the Low Countries. Mercantilism was a system of trade for profit, although commodities were still largely produced by non-capitalist methods.[40] Most scholars consider the era of merchant capitalism and mercantilism as the origin of modern capitalism,[39][41] although Karl Polanyi argued that the hallmark of capitalism is the establishment of generalized markets for what he called the "fictitious commodities", i.e. land, labor and money. Accordingly, he argued that "not until 1834 was a competitive labor market established in England, hence industrial capitalism as a social system cannot be said to have existed before t

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25. Climate change is a global problem with grave implications: environmental, social, economic, political and for the distribution of goods. It represents one of the principal challenges facing humanity in our day. Its worst impact will probably be felt by developing countries in coming decades. Many of the poor live in areas particularly affected by phenomena related to warming, and their means of subsistence are largely dependent on natural reserves and ecosystemic services such as agriculture, fishing and forestry. They have no other financial activities or resources which can enable them to adapt to climate change or to face natural disasters, and their access to social services and protection is very limited. For example, changes in climate, to which animals and plants cannot adapt, lead them to migrate; this in turn affects the livelihood of the poor, who are then forced to leave their homes, with great uncertainty for their future and that of their children. There has been a tragic rise in the number of migrants seeking to flee from the growing poverty caused by environmental degradation. They are not recognized by international conventions as refugees; they bear the loss of the lives they have left behind, without enjoying any legal protection whatsoever. Sadly, there is widespread indifference to such suffering, which is even now taking place throughout our world. Our lack of response to these tragedies involving our brothers and sisters points to the loss of that sense of responsibility for our fellow men and women upon which all civil society is founded.


29. One particularly serious problem is the quality of water available to the poor. Every day, unsafe water results in many deaths and the spread of water-related diseases, including those caused by microorganisms and chemical substances. Dysentery and cholera, linked to inadequate hygiene and water supplies, are a significant cause of suffering and of infant mortality. Underground water sources in many places are threatened by the pollution produced in certain mining, farming and industrial activities, especially in countries lacking adequate regulation or controls. It is not only a question of industrial waste. Detergents and chemical products, commonly used in many places of the world, continue to pour into our rivers, lakes and seas.


34. It may well disturb us to learn of the extinction of mammals or birds, since they are more visible. But the good functioning of ecosystems also requires fungi, algae, worms, insects, reptiles and an innumerable variety of microorganisms. Some less numerous species, although generally unseen, nonetheless play a critical role in maintaining the equilibrium of a particular place. Human beings must intervene when a geosystem reaches a critical state. But nowadays, such intervention in nature has become more and more frequent. As a consequence, serious problems arise, leading to further interventions; human activity becomes ubiquitous, with all the risks which this entails. Often a vicious circle results, as human intervention to resolve a problem further aggravates the situation. For example, many birds and insects which disappear due to synthetic agrotoxins are helpful for agriculture: their disappearance will have to be compensated for by yet other techniques which may well prove harmful. We must be grateful for the praiseworthy efforts being made by scientists and engineers dedicated to finding solutions to man-made problems. But a sober look at our world shows that the degree of human intervention, often in the service of business interests and consumerism, is actually making our earth less rich and beautiful, ever more limited and grey, even as technological advances and consumer goods continue to abound limitlessly. We seem to think that we can substitute an irreplaceable and irretrievable beauty with something which

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The Embassy Billiards Club hosted this prestigious Championship on eight occasions between 1995 and 2012, and is now owned by last year's United States National Snooker Champion, Steven Wong, so it will prove to be an extra special occasion for him when he defends his title in his own club.


Wong told SnookerUSA.com: "I don't believe I am a naturally talented snooker player, but what I do believe is that a lot of dedicated hard practice, year after year, helped me become the champion in 2022.


The Embassy Billiards club has eight regulation standard snooker tables in the main area of the club, plus another regulation standard snooker table in a private room. This year's Championship will utilize the eight tables in the main area of the club over the four days of play.


With the hosting of this year's Championship back at the Embassy Billiards Club, Alan Morris, the Executive Director of the United States Snooker Association (USSA), said: "I really am so very pleased to have the Championship back at the Embassy Billiards Club after such a long time away, as the club boasts the most number of snooker tables of any billiard club in the United States, which which will afford the opportunity to have the largest number of players to ever participate in the Championship.


"I know Steven has put in a lot of investment in upgrading the snooker facilities in the past year, and so will have every right to feel very proud of his achievements when he starts the defense of his title on September 1st in his own club.


"On behalf of the Board of the United States Snooker Association I would like to offer my thanks to Steven and everyone at the Embassy Billiards Club, and we cannot wait to welcome all snooker players from around the nation for what we know will be a truly magnificent and high quality Championship."


After one of the clubs committee queried the cloth used as they looked on the Strachan web site and could not find Tournament 29oz , I have visited the Strachan web site and it states they do a 29 oz club cloth but no 29 oz tournament , I can assure the club and the two people who where their the two blue lines running through the side of the cloth and the embroidered Tournament stitched into the cloth , proved they do make tournament in 29 oz .
I do not supply club cloth and never will as there is very little cost to be saved on a full size recover if you use Club cloth maybe around £20 per table .
I value my reputation and my clients trust me to use the best so I order only tournament cloth and never use Club cloth on Snooker tables .
UNLESS a client asks for it , then I have to order it in as I never keep it in stock .
I will be contacting Strachan to see if they have made a mistake in their listing of the 29 oz and they should have stated tournament and not club .
Peradon list it as lightweight tournament and not 29oz .

2nd Table ready for play .



Isabel Enriquez:
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Isabel:
 People can usually find us at the Lair playing pool almost any time of the day or when we had our weekly club meetings pre-pandemic. At the moment, they can reach out either through email or Instagram. The whole point of the club is just to make the sport fun and enjoyable, and it is also a chance to hang out together and meet new people.


Snooker halls / clubs are found in a variety of premises, often converted from alternative uses, many being situated above secondary shops or in converted cinema premises. They tend to be located in poorer, lower value locations where there may be

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Note
: In 2017, security researchers identified a ransomware variant that appended an identical file extension (.akira) to encrypted files; however, this variant is not related to the Akira ransomware group.


Yes, but first it delete Windows Shadow Volume Copies from devices by running a PowerShell command. Then, as you rightly guessed, it proceeds to encrypt a wide range of data filetypes, and appends ".akira" to the end of their filename. According to a report by Bleeping Computer, files with the following extensions are encrypted in the attack:
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1: Actually, most Microsoft DLLs are compiled with the hotpatch option, which means that the prologue is prefixed with mov edi, edi (here's why), so searching for that instruction should be very easy.


The behaviour of the obfuscated code is quite simple. On the prologue, a 
state variable
 is affected witha numeric constant which indicates to the 
main dispatcher
 (and to 
sub-dispatchers
) the path to take to reach the target 
relevant
basic block. The 
relevant
 blocks are the ones of the original un-obfuscated function. At the end of each relevant basic block, the 
state variable
is affected with another numeric constant to indicate the next relevant block, and so on.


The code above is an example of just one basic block symbolic execution. In order to cover all the function's basic blocks, wecan use it by starting at the prologue of the target function and followthe execution flow. If we encounter a condition we must 
explore all branches
, one by one, until we cover the function entirely.


In order to do that, we can use the constant 
"shape"
 of OLLVM control flow flattening. Indeed, most of the relevants blocks (exceptedthe prologue and 
return
 basic block),are located at a very precise place we can detect. We have to start from the original protected function and make some coding to build a genericalgorithm which will find the relevants blocks:


Function names must be mangled in order for the profile loader tomatch them in the current translation unit. The two numbers in thefunction header specify how many total samples were accumulated in thefunction (first number), and the total number of samples accumulatedin the prologue of the function (second number). This head samplecount provides an indicator of how frequently the function is invoked.


The difference between the two sections is clear. When an experienced reverse engineer take a quick look at such binary code, he will immediately recognize that something is wrong with the section. Initially, he recognizes that the section contains code because the flags in the section header say that. If he looks at the code, for this case (other keys can produce different output), he cannot locate a valid procedure (every procedure calling convention has its own prologue and epilogue which does not change). This is strange but not unusual: it is not rare to write custom assembly code to perform some performance critical operation, so he can evince that some kind of custom assembly has been written.


The idea is just to obfuscate what is needed to obfuscate, and do not take in consideration what is useless to protect. Every procedure has a prologue and an epilogue, depending on the convention call used for your procedure. We will use such tokens as activator/deactivator of the encrypting routine. The target is to have legal routines recognized by any tool with obfuscated code inside. When someone tries to look them with reverse engineer tools (like IDA) then he will not be able to assign a logic to such routines, but it would be hard to think of them as obfuscated because they seem valid.





As you can see, there is no more the 0x99 pattern issue, so the section seems legal. In addition, avoiding such pattern avoid to expose our key. The prologue and epilogue identity this as a true procedure valid for the standard convention call. This is a valid procedure in a valid code section of your code. Identifying it as encrypted takes some time, and decrypt it is a little harder (due to the fact you do not know what resides inside the procedure). Now imagine extending this heuristic as we did with naive projects. Applying a multibyte key will make it more challenging enough to discourage any junior reverse engineer. You can have a 512 byt

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Do you have the integrated gpu still enabled or is it already disabled? You could try making sure its disabled both in bios/Windows and uninstall any amd & nvidia gfx driver left-overs via DDU in save mode, then re-try running 3dmark with the arc and Latest drivers.

Also as a side note, you're running a bios Version that's officially not recommended for that type of old apu .
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