What do we know about using specific probiotics for different health conditions? And is it time to move away from broad-spectrum probiotics and into condition-specific strains? With an explosion of new research on probiotics and a recent change in nomenclature, it’s easy to get confused. In this episode of New Frontiers, I lean on Dr. Noelle Patno’s extensive research knowledge to tease apart the science on probiotics. Dr. Patno holds a PhD in Molecular Metabolism and Nutrition and has designed and monitored clinical trials on microbiome and immune health. Together, we dive into the latest evidence on therapeutic uses of specific probiotic strains, including Lactobacillus rhamnosus GR-1, for women’s health and other conditions. Dr. Patno also shares excellent pearls on dosing, duration, delivery methods and antibiotic resistance. Many thanks to Noelle and the team at Metagenics for always leading the way and researching interventions. Appreciate you listening, sharing, and commenting, and always, thanks for subscribing.  - DrKF

Sergey Young's Tech Innovations for Longevity and Biological Age Reversal

The therapeutic value of curcumin makes it a fabulous recommendation as both a foundational and medicinal supplement. And since finding a preparation that is bioavailable is key to efficacy, affordability, and patient compliance, I’m excited to have Dr. Sonia Malani (from Integrative Therapeutics) here to talk about the latest advances in curcumin deliverability. 
Dr. Malani breaks down the progress of curcumin deliverability and the keys to bioavailability in a way that is simple to understand and easy to pass on to our patients in order to help them move away from the less effective brands that are currently lining the shelves of local markets so they get the therapeutic influence we are hoping for. Lots to learn, let me know what think in this great interview sponsored by Integrative Therapeutics! ~DrKF

Advances in Curcumin Bioavailability for Improved Absorption in Patients

Imagine accurately determining the status of your skin’s age to tell whether it is younger or older than your chronological age, and then use this technology to determine whether expensive anti-aging serums and creams are effective, or actually causing more harm than good. Amazing, right?

This is precisely the technology Dr. Carolina Reis Oliveira and her fellow stem cell biologists at OneSkin created and you will find this interview fascinating on so many levels – I know I sure did! After creating their skin clock, the OneSkin team discovered peptide OS1, which targets senescent cells, one of the root mechanisms of aging, and is being shown in current studies to have a positive effect on hydration, firmness, elasticity, and the skin barrier.  

Listen as Dr. Reis explains the science and ongoing studies exploring the possible benefits of OS1 for the skin microbiome, hair loss, inflammation, and overall health.

Disrupting Anti-Aging Skincare by Targeting Senescent Cells

As we gain insight into microbiome impact on our health, we need accurate tests that tell us not only what and how much is there, but also which metabolites, or post-biotics created that can have downstream effects. So today I’m thrilled to welcome the brilliant Dr. Erika Ebbel Angle, PhD, biochemist, CEO, and co-founder of Ixcela, to discuss their fingerstick gut microbiome test. We’ll discuss the 11 key markers, the value of a blood sample over urine, and the impact of endurance sports and chronic stress on health markers as revealed by the test.

We also chat about my own results, how impressed I was by the insight provided – and how they clearly identified changes I could make to improve my markers. Listen and take notes -- I know I did! ~DrKF

Measuring Metabolites of Dysbiosis and Gut Function to Create Targeted Interventions

After my conversation with Dr. Greg Fahy in August, I realized that I had additional questions that we didn't have time to address the first time around. Importantly, since here I am studying the effects of dietary and lifestyle interventions on aging, I wanted to know his thoughts on the dietary components of the TRIMM study and beyond. Dr. Fahy shares his thoughts on my question and some others on side effects on different medication and supplement interventions, the mechanism by which he thinks the restoration of hair color occurred in some of his study participants, and how to think about (and feel motivated about!) incorporating safe exercise. This brief bonus podcast episode is just right for squeezing into your holiday schedule. Enjoy! ~DrKF

Missed the first conversation with Dr. Greg Fahy? Catch up on the original episode for key insights and context before diving into the follow-up! https://tinyurl.com/bdcwktbj

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast for the full list of links and resources.

GUEST DETAILS

Greg Fahy, PhD

Intervene Immune: https://interveneimmune.com/who-we-are/

Email: fahy@interveneimmune.com

Dr. Greg Fahy received his Ph.D. in Pharmacology and Cryobiology from the Medical College of Georgia in 1977. A world-renowned cryobiologist, Dr. Fahy is the chief science officer and co-founder of Intervene Immune, where he leads groundbreaking research on thymus regeneration and combating age-related immune decline. He designed and led the TRIIM trial, the first to demonstrate both thymus rejuvenation and the reversal of human epigenetic age. His work has been pivotal in advancing aging research, resulting in successful follow-up trials like TRIIM-XA, and further planned studies aimed at refining and expanding these innovative treatments.

WORK WITH OUR TEAM

At Dr. Fitzgerald’s New Frontiers Functional Medicine and Nutrition Clinic, we specialize in personalized root cause medicine, offering both in person and virtual consultations. Our team of functional medicine physicians and nutritionists is trained in the research based, Younger You Longevity Protocol and experienced in working with many conditions, including gastrointestinal, immune, cardiovascular, metabolic, brain, and many more, and in supporting those seeking optimal wellness. Ready to explore how we can help you feel your best? Visit https://tinyurl.com/yx4fjhkb to book a free15-minute Discovery Call today.

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The Podcast After the Podcast: More on Age Reversal with Dr. Greg Fahy

As a former Olympian and current Iron Man triathlete, (he qualified for the world championship in Hawaii this year!) Dr. Keith McCormick was diagnosed with severe osteoporosis at 45 years old. His own healing journey lead him to become a world expert on treating osteoporosis from a functional and integrative perspective. His 2008 book, The Whole Body Approach to Treating Osteoporosis, is useful for patient and clinician alike. This podcast is a goldmine of pearls for clinicians treating individuals with bone loss. Topics covered include underlying pathogenic mechanisms, laboratory evaluations and treatments-pharmaceutical and natural. Health savvy patients will find Dr. McCormick’s content useful.

Episode 5: Osteoporosis- Metabolic Disease of the Bone with Dr. Keith McCormick

According to Dr. Bob Hedaya, it’s malpractice NOT to use functional medicine when practicing psychiatry. ALL of the nodes on the Functional Medicine Matrix [gastrointestinal, endocrine, immune, toxicity, nutritional status and especially psychological, social and spiritual] influence mental health, mental function and brain function. The bottom line is, a good functional approach yields better health, less medicine.  In this case-focused inspiring podcast, hear about Dr. Hedaya’s years of clinical experience in using functional medicine to address tough psychiatric conditions.

Episode 8: Functional Psychiatry with Bob Hedaya, MD

The Art of Medicine: A Soul-Stirring Chat with Sidney Baker, MD

Episode 15: The Art of Medicine: A Soul-Stirring Chat with Sidney Baker, MD

Enjoy a solid overview of our Methylation Diet and LIfestyle. Hear about the program and how it's working out in our clinic. Check out www.drkarafitzgerald.com for more info on our eBook!

Methylation Diet and Lifestyle DrKF and Romilly Hodges, CNS

Welcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF  

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The Podcast After the Podcast: More on Age Reversal with Dr. Greg Fahy

Dr. Kara Fitzgerald - Functional Med & Longevity

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