While we cannot see small nanoscopic objects like proteins or other molecules that make up virtually all living matter including our cells, tissues, as well as pathogens such as viruses, our computational algorithm allows us to make its material manifestation audible.  This piece is a musical representation of the amino acid sequence and structure of the spike protein of the pathogen of COVID-19, 2019-nCoV (protein data bank identifier 6VSB [1]). 

MUSICAL DECEIT

A virus’ genome hijacks the host cell’s protein manufacturing machinery, and forces it to replicate the viral genome and produce viral proteins to make new viruses from it.  This musical art teaches us something about the fine line between beauty of life and death as an opposite pole.  As you listen to the protein you will find that the intricate design results in incredibly interesting and actually pleasing, relaxing sounds. This doesn’t really convey the deadly impacts this particularly protein is having on the world. This aspect of the music shows the deceiving nature of the virus, how it hijacks our body to replicate, and hurt us along the way. So, the music is a metaphor for this nature of the virus to deceive the host and exploit it for its own multiplication. 

HOW IT IS DONE: 

What you hear is a multi-layered algorithmic composition featuring both the vibrational spectrum of the entire protein (expressed in sound and rhythmic elements), the sequence and folding of amino acids that compose the virus spike structure, as well as interwoven melodies - forming counterpoint music - reflecting the complex hierarchical intersecting geometry of the protein [2].

Scientific references:

[1] Wrapp et al., "Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation," Science, 2020, DOI: 10.1126/science.abb2507

[2] Buehler et al., "A Self-Consistent Sonification Method to Translate Amino Acid Sequences into Musical Compositions and Application in Protein Design Using Artificial Intelligence," ACS Nano, 2019, DOI: pubs.acs.org/doi/10.1021/acsnano.9b02180

Viral counterpoint of the coronavirus spike protein (2019-nCoV)

Viral Counterpoint of the Coronavirus Spike Protein (2019-nCoV)

Poema de San Juan de la Cruz 

Entréme donde no supe:
y quedéme no sabiendo,
toda ciencia trascendiendo.

1. Yo no supe dónde estaba,
pero, cuando allí me vi,
sin saber dónde me estaba,
grandes cosas entendí;
no diré lo que sentí,
que me quedé no sabiendo,
toda ciencia trascendiendo.

2. De paz y de piedad
era la ciencia perfecta,
en profunda soledad
entendida, vía recta;
era cosa tan secreta,
que me quedé balbuciendo,
toda ciencia trascendiendo.

3. Estaba tan embebido,
tan absorto y ajenado,
que se quedó mi sentido
de todo sentir privado,
y el espíritu dotado
de un entender no entendiendo.
toda ciencia trascendiendo.

4. El que allí llega de vero
de sí mismo desfallece;
cuanto sabía primero
mucho bajo le parece,
y Su ciencia tanto crece,
que se queda no sabiendo,
toda ciencia trascendiendo.

5. Cuanto más alto se sube,
tanto menos se entendía,
que es la tenebrosa nube
que a la noche esclarecía:
por eso quien la sabía
queda siempre no sabiendo,
toda ciencia trascendiendo.

6. Este saber no sabiendo
es de tan alto poder,
que los sabios arguyendo
jamás le pueden vencer;
que no llega su saber
a no entender entendiendo,
toda ciencia trascendiendo.

7. Y es de tan alta excelencia
aqueste sumo saber,
que no hay facultad ni ciencia
que la puedan emprender;
quien se supiere vencer
con un no saber sabiendo,
irá siempre trascendiendo.

8. Y, si lo queréis oír,
consiste esta suma ciencia
en un subido sentir
de la divinal esencia;
es obra de su clemencia
hacer quedar no entendiendo,
toda ciencia trascendiendo.

Toda Ciencia Trascendiendo

wondereland

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