the word "overdose" implies that there is a common safe dosage and usage for the drug; therefore, the term is commonly applied only to drugs, not poisons, even though many poisons as well are harmless at a low enough dosage. Drug overdose is sometimes used as a means to commit suicide, as the result of intentional or unintentional misuse of medication. Intentional misuse leading to overdose can include using prescribed or non-prescribed drugs in excessive quantities in an attempt to produce euphoria.

Usage of illicit drugs, in large quantities, or after a period of drug abstinence can also induce overdose. Cocaine and opioid users who inject intravenously can easily overdose accidentally, as the margin between a pleasurable drug sensation and an overdose is small.[4] Unintentional misuse can include errors in dosage caused by failure to read or understand product labels. Accidental overdoses may also be the result of over-prescription, failure to recognize a drug's active ingredient or unwitting ingestion by children.[5] A common unintentional overdose in young children involves multivitamins containing iron.

The term 'overdose' is often misused as a descriptor for adverse drug reactions or negative drug interactions due to mixing multiple drugs simultaneously.

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Avoidant personality disorder (AVPD) is a mental health condition characterized by profound feelings of inadequacy, hypersensitivity to criticism or rejection, and avoidance of social situations due to a deep fear of being criticized, humiliated, or rejected. People with AVPD desire social connection but their maladaptive avoidance patterns, stemming from their feelings of being socially inept or inferior, lead to significant distress and difficulty functioning in daily life.

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