EURO121 isn’t just another nootropic. It’s an experimental, next-generation molecule designed for people who think long-term — about their cognitive clarity, neurological resilience, and brain health for decades to come. In this episode, we dive deep into the science behind NEURO121 and why it’s attracting the attention of high-performance individuals across the world.

Built on over a decade of research into neurodegeneration and cellular aging, NEURO121 is aimed at professionals, decision-makers, and cognitive athletes who demand more than a temporary boost. It was engineered for those who think fast, decide under pressure, and need to stay mentally sharp — not just now, but for the next 20 years.

https://neuro-121.com/

NEURO121 - Advanced Neurological and Cognitive Support

This research investigates the efficacy and safety of Nicotinamide Mononucleotide (NMN) supplementation in healthy middle-aged adults. The study, a randomized, multicenter, double-blind, placebo-controlled clinical trial, specifically examines how NMN impacts blood NAD concentration, physical performance, biological age, insulin sensitivity, and overall health over a 60-day period. Researchers administered daily oral doses of 300 mg, 600 mg, or 900 mg of NMN, comparing the results against a placebo group. The findings suggest that NMN significantly increases NAD levels and positively influences physical endurance and general health, with a 600 mg dose appearing to achieve maximum efficacy without additional benefits from a higher 900 mg dose, and importantly, no safety concerns were identified within the trial.

NMN Supplementation: Efficacy and Safety in Middle-Aged Adults

The source "Advancements in NMN biotherapy and research updates in the field of digestive system diseases" is a review focusing on Nicotinamide Mononucleotide (NMN), a precursor to NAD+, a vital coenzyme. It explores over a decade of preclinical research on NMN's potential in treating age-related diseases, including its impact on various organs and its emerging role in digestive system health. The article also presents a balanced assessment of NMN's benefits, acknowledges the limitations of current studies, and highlights challenges for future research, particularly the need for more human clinical trials to confirm safety and efficacy.

NMN Biotherapy: Advances in Digestive System Disease Researc

This scientific paper, titled "Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults," details a double-blind, placebo-controlled clinical study. The research aimed to evaluate the effects of Pyrroloquinoline quinone disodium salt (PQQ) on cognitive function across a broad age range (20-65 years). The study found that PQQ positively impacted specific cognitive areas, with younger participants showing improvements in cognitive flexibility and executive speed within 8 weeks, while older adults experienced enhancements in composite and verbal memory after 12 weeks. The authors conclude that PQQ serves as a beneficial functional food for improving brain function across all adult age groups.

PQQ: Enhancing Brain Function Across Adulthood

The provided text discusses the safety and tolerability profile of the compound CMS121, drawing information from preclinical animal studies and a completed Phase I clinical trial in healthy human subjects. Animal studies indicated no significant adverse effects, even demonstrating benefits like increased lifespan in some models and good toleration in disease models without organ toxicity. The Phase I trial further supported its safety, showing that oral administration of CMS121, even at high doses, was generally well-tolerated, with most side effects being mild and transient, primarily gastrointestinal issues or headaches. Importantly, no significant abnormalities were found in laboratory tests related to liver, kidney, or blood function, nor in cardiac parameters. The text also notes favorable pharmacokinetics, including increased concentration in older individuals and improved bioavailability with food, ultimately concluding that CMS121 exhibits an encouraging safety profile at this stage of development.

CMS121: Preclinical and Phase I Safety Data

This systematic review evaluates the safety and effectiveness of Nicotinamide adenine dinucleotide (NAD+) and its precursors as human supplements across various clinical conditions. Researchers analyzed ten randomized controlled trials, encompassing 489 participants with conditions such as chronic fatigue syndrome, Parkinson's, and Alzheimer's disease, or healthy individuals. The review concludes that NAD+ supplementation, particularly NADH and nicotinamide riboside (NR), is generally well-tolerated with a low incidence of mild side effects, such as muscle pain and headaches. While findings suggest potential benefits like improved quality of life, reduced anxiety, and enhanced cognitive function in specific conditions, the authors emphasize the need for further high-quality research with standardized dosages and outcomes to solidify these conclusions.


CMS121: Preclinical and Phase I Safety Data

Neuro CMS

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