Glutamate is a neurotransmitter that has been extensively implicated in the neural basis of learning. D-Cycloserine (DCS) is a partial agonist for the glutamate receptor NMDA at the glycine site, and has been trialed as an adjunct to conventional exposure-based treatments based on the principle of cue extinction.

A role for glutamate has also been identified in the extinction of a cocaine-associated environmental stimuli through testing in rats. Specifically, the metabotropic glutamate 5 receptor (mGlu5) is important for the extinction of a cocaine-associated context and a cocaine-associated cue.

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