healthy

true music

plenary

This week we answer a few questions: the first is from Patreon backer, Harry Hong, on Kaplan-Meier curves. The second is from a student at Mount Sinai Medical School who reached out with some ethical questions they had after the ASH annual meeting on the obligations and responsibilities of peer reviewers. Finally, we end the episode with an interview with Dr. Bishal Gyawali of Queens University in Kingston, Ontario, Canada on his new paper out today in the Journal of the National Comprehensive Cancer Network titled "Response Rates and Durations of Response for Biomarker-Based Cancer Drugs in Nonrandomized Versus Randomized Trials". 

Durations of Response: doi.org/10.6004/jnccn.2019.7345

Vinay's new book, Malignant: www.amazon.com/Malignant-Policy-…cer/dp/1421437635

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January 2020

2.31 Listener Questions, Responsibility of Reviewers, & Duration of Response with Dr. Bishal Gyawali

This week we discuss management of COVID-19 in the intensive care unit with Dr. Benjamin Singer, a pulmonary and critical care physician at Northwestern University. We discuss medications, PPE, ventilators, and more!

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March 2020

2.44 ICU Management of COVID-19 with Dr. Benjamin Singer

This week we discuss several recent articles on the novel coronavirus (SARS-CoV-2) and COVID-19, specifically Dr. Siddhartha Mukherjee's article on the history and science of humanity's history with viruses, Dr. Ezekiel Emanuel's essay on how to fairly allocate dwindling medical resources during this global pandemic, and Dr. John Ioannidis's article on the "evidence fiasco" that has been our response to COVID-19. We end the episode with a Classical Hematology Chat with Drs. Sven Olson and Joseph Shatzel.

Dr. Mukherjee's article: https://www.newyorker.com/magazine/2020/04/06/how-does-the-coronavirus-behave-inside-a-patient
Allocation of Medical Resources: doi.org/10.1056/NEJMsb2005114
Dr. Ioannidis's article: https://www.statnews.com/2020/03/17/a-fiasco-in-the-making-as-the-coronavirus-pandemic-takes-hold-we-are-making-decisions-without-reliable-data/

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April 2020

2.45 Viral Spread of SARS-CoV-2, Rationing Resources, "Evidence Fiasco", & Classical Hematology Chat

This week we have a far-reaching monologue on COVID-19 and how people are reacting to the public health recommendations concerning COVID-19 (such as cancelling conferences and school, maintaining 6+ feet of distance, wearing cloth masks). We end with an insightful interview with Dr. Venk Murthy on polygenic risk score and, at the end, a bit about how the world of science is failing to combat hype.

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2.46 Psychology Unearthed by COVID-19 Precautions & Polygenic Risk Score with Dr. Venk Murthy

This week we start with an in-depth monologue on various new developments surrounding COVID-19, specifically the new study in NEJM on the compassionate use of remdesivir as well as the CDC's advice for the general public to wear cloth masks. We end with an interview with Dr. Ameet Sarpatwari of Harvard Medical School on how to create a more effective pharmaceutical system, the CREATES Act of 2019, developing fair and equitable drugs to treat COVID-19, and how to create a just system that balances the need for innovation with the need for access. Dr. Ameet Sarpatwari is the Assistant Director of PORTAL.

Compassionate Use of Remdesivir: doi.org/10.1056/NEJMoa2007016
U.S. Gene Therapy Trials: doi.org/10.1001/jama.2019.22214
NIH Fair Pricing Condition: doi.org/10.7326/M19-2576

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2.47 Remdesivir, Cloth Masks, & Incentives for COVID-19 Drug Development with Dr. Ameet Sarpatwari

This week we have an announcement -- the audiobook of "Malignant: How Bad Policy and Bad Evidence Harm People with Cancer", written and narrated by our host Vinay Prasad, is available now on Amazon, iTunes, and Audible!
We also have an in-depth journal club for you on the findings of the PROfound trial as published in a new paper out in the New England Journal of Medicine titled "Olaparib for Metastatic Castration-Resistant Prostate Cancer". 
Finally, we end the episode with an interview with Dr. Adam Cifu of the University of Chicago on literature, medicine, maintaining a feeling of normalcy and self during COVID-19, and more! 

Listen to Malignant with a free 30-day trial of Audible: https://www.audible.com/pd/B08864KFHW/?source_code=AUDFPWS0223189MWT-BK-ACX0-195112&ref=acx_bty_BK_ACX0_195112_rh_us

PROfound: doi.org/10.1056/NEJMoa1911440
Crossover: doi.org/10.1093/annonc/mdy116

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May 2020

2.52 Malignant Audiobook, PROfound trial, & Literature and Medicine with Dr. Adam Cifu

Improvisation by Victor Sobolenko
Recorded in 1994 at Studio 2, Russian Television & Radio-Classica Studios, St. Petersburg, Russia. Recording Engineer: Boris Vacshenko

Improvisation Can Be On The Theme Of Folia Or Ground

The Sixth Sunday of Easter (Rogation Sunday) at The Church of the Advent, Boston / May 17, 2020 / Solemn High Mass

The Rev’d Dr Jeffrey A. Hanson, Celebrant
The Rev’d Canon Alistair Macdonald-Radcliff, Preacher

Hymns:
https://hymnary.org/hymn/EH1982/292 
https://hymnary.org/hymn/EH1982/291

Lections: https://www.lectionarypage.net/YearA/Easter/AEaster6.html 

Vidi aquam egredientem -– Tomás Luis de Victoria (c1548-1611)

Missa “Ego flos campi” -- Juan Gutiérrez de Padilla (c1590-1664)

Ego flos campi  -- Jacobus Clemens non Papa (c1510/5-1555/6) 

Ego flos campi et lilium convallium: sicut lilium inter spinas sic amica mea inter filias; fons hortorum et puteus aquarum viventium quae fluunt impetu de Libano.
(Song of Songs 2:1–2; 4:1)

Ave Maria -- Jacobus Clemens non Papa

Ave Maria, gratia plena, Dominus tecum; benedicta tu in mulieribus, Alleluia.

Hail Mary, full of grace, the Lord is with thee; blessed art thou among women, Alleluia.
(cf Luke 1:28)

Organ Voluntary: Solemn Procession -- William Southcombe Lloyd Webber (1914–1982) / Mark Dwyer, organist

2020.05.17 Sunday Mass Webcast

Mix Log is now up Still in WIP: https://somewhatincognito.com/2020/05/let-me-have-me/

Streaming Everywhere

Let Me Have Me

Music, lyrics, ac. guitar, vocal : Grave
Bas, drums, ac guitar, arrangement, & mix : PJ Project

So Lets Go Then W/ Grave

Dr Prasad currently serves as the Director of the Center for Biologics Evaluation and Resesarch (CBER) at the US FDA. The audio on this platform were posted before my FDA employment and do not necessarily represent the views of the FDA or the United States. This site will be inactive during my federal service.

A podcast on medicine, oncology, & health policy. 
Host: Vinay Prasad, MD MPH from University of California San Francisco.
Tweet your feedback to @Plenary_Session or e-mail plenarysessionpodcast@gmail.com

2.52 Malignant Audiobook, PROfound trial, & Literature and Medicine with Dr. Adam Cifu

Plenary Session - inactive due to federal service