Five Michigan State students venture into the hills of Tennessee to spend their Spring Break vacation in an isolated cabin. There, they find the "Naturan Demanto", a Sumerian variation of the Book of the Dead. They also find a tape recorder that plays demonic incantations from the book, unleashing evil demons. The demons proceed to isolate and kill off the students, beginning with Cheryl, who is hypnotized by the voice of a demon and lured out into the woods at night. Alone and far from the safety of the cabin, Cheryl is attacked by trees possessed by the demons, which come to life in a tentacle-like fashion and brutally rape her. Escaping the trees, Cheryl flees back to the cabin and is nearly overtaken by a demon.
The others do not believe Cheryl's story and assume that she was attacked by a wild animal. Her brother, Ash, decides to drive her to town where she can find a place to stay for the night. However, they find that the only bridge connecting the cabin to civilization has been destroyed with the supports bent into the shape of a hand. Later, Cheryl, with the essence of a demon infesting her body following her encounter with the trees, becomes possessed and stabs Linda, Ash's girlfriend, in the ankle with a pencil. Scotty forces Cheryl into the cellar and locks it, but his girlfriend Shelly is also possessed by a demon, which spies on her from outside her bedroom as she is changing before hurling itself at her. Now possessed, Shelly attacks Scotty and sustains a number of brutal injuries before Scotty dismembers her with an axe. Clearly shaken by Shelly's death, Scotty leaves to go find an alternate trail through the woods.
Ash goes to check on Linda, but finds that she, too, has become possessed, but she makes no attempt to attack him. Scotty returns, having suffered grave injuries inflicted onto him by the possessed trees. He tells Ash that there is an alternate trail through the woods before passing out, and Linda and Cheryl start laughing maniacally at their predicament. The two women suddenly seem to snap out of their possession, but it is revealed to be a trick when Ash almost releases Cheryl from the cellar and she tries to strangle him through the door. Ash locks Linda outside of the cabin and tends to Scotty's injuries, but he quickly bleeds to death. Linda sneaks in through the backdoor and attacks Ash with a ceremonial dagger, but Ash is able to take the dagger from her and impale her through her torso, seemingly killing her.
Ash takes Linda's body to the work shed and tries to dismember her with a chainsaw, but finds that he cannot bring himself to do it and buries her instead. She rises from the grave and wrestles with Ash, who eventually lops her head off with a shovel. Returning to the cabin, Ash finds that Cheryl has escaped. Armed with a shotgun, Ash finds Cheryl hiding outside and shoots her in the shoulder, but it doesn't seem to have any effect. After barricading all of the doors, Ash descends into the cellar to find some extra shotgun shells, and while down there he experiences a series of strange events such as mysterious voices and blood seeping from numerous crevices and openings in the walls. Scotty's body reanimates, now possessed by a demon, and tries to kill Ash, but he cripples him by gouging out his eyes. Ash then notices that the Book of the Dead has fallen near the fireplace and is starting to burn, as are Cheryl and Scotty, giving the illusion that disposal of the book into the fire will destroy the demons.
Cheryl breaks into the cabin and knocks Ash down with little effort. While Scotty pins him down, Cheryl repeatedly beats Ash with a fireplace poker. Ash is able to grab the book after several attempts and tosses it into the fireplace just as Cheryl raises the poker to impale him. The demons leave the bodies of Cheryl and Scotty, which then become inanimate and rapidly decay and fall apart. Ash, believing he has survived the ordeal, heads outside. A demon emerges from the woods and descends upon Ash, who turns to see it and lets out a bloodcurdling scream.

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