D'oh! We had technical difficulties this week and so we are presenting this encore presentation of one of our most popular episodes.

It also happens to be Kirby's birthday, and we're eager to honor his awesomeness by sharing with you this fabulous episode we did with him on December 16, 2021. Enjoy the ride!

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DR. KIRBY RUNYON is a planetary geomorphologist and morphodynamicist seeking to understand the evolution of planetary landscapes and the associated near-surface processes through the analysis of remote sensing imagery and laboratory experiments.  He is a science team affiliate on the New Horizons mission to Pluto, Charon, and the Kuiper Belt and a science team collaborator on the HiRISE (High Resolution Imagaing Science Experiment) camera currently in orbit around Mars. Kirby is passionate about engaging the general public in the passion, beauty, and joy of space exploration and promoting scientific literacy among non-scientists. He lives in Columbia, MD, with his cat, Nixie, named after Nix, a small moon of Pluto.

Read Kirby's Op-Ed in The Baltimore Sun, "Why go to space? You might as well ask: Why make music?" https://www.baltimoresun.com/opinion/op-ed/bs-ed-op-1208-space-exploration-20211208-26uthbg4v5a6fpjqlzuetqryla-story.html

Visit his website: https://kirbydanielrunyon.space

Follow him on all the socials:

Twitter: @nasaman58
Instagram: @kirbydanielrunyon
Facebook: https://www.facebook.com/kirby.runyon

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Keep On IFFin',
Philip, Matt & Gaby

Riding GRAVITY FORCE ONE with KIRBY RUNYON

Our guest this week is science fiction author Nicholas Casbarro, who brings us a universe-changing concept from his novel Vitalerium - a radioactive space rock that enables faster-than-light travel. What the if humans discovered this exotic material so powerful that a fist-sized chunk can propel a football field-sized spaceship at 12 times the speed of light? Matt helps us explore the real science behind faster-than-light travel, from grandfather paradoxes and causality violations to the vast scale of our galaxy and the communication delays that would plague interstellar colonies. Join us as we chart a course through the galaxy's most mind-bending possibilities.

Born in Providence, Rhode Island, in 1990, Nicholas Casbarro attended Northeastern University’s Doctor of Physical Therapy Program in Boston, class of 2013. Though he never practiced, he maintained his curiosity and love for the sciences. After college, he worked in the medical device field with a specialty in wound-healing and burn treatment. In 2021, he joined a regenerative medicine company where he would spend five days a week on a plane, traveling the country to work with burn surgeons and victims. While flying, he experienced a spark of inspiration, and decided to follow the thread. Since childhood, he had a deep love for science fiction, growing to appreciate the greats in sci-fi like Aldous Huxley, George Orwell, Frank Herbert, Isaac Asimov, and many others. Nicholas used his time on countless flights to create the Vitalerium Series and its universe. The majority of the Vitalerium novel was written at 36,000 feet. He has seven books planned in the Vitalerium Series and continues to craft the narrative of Roman Matthews.

Learn more about Nick’s novel, “Vitalerium” at his website: https://vitaleriumseries.com

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Check out our membership rewards! Visit us at Patreon.com/Whattheif

Got an IF of your own? Want to have us consider your idea for a show topic? Send YOUR IF to us! Email us at feedback@whattheif.com and let us know what's in your imagination. No idea is too small, or too big!

Don’t miss an episode! Subscribe at WhatTheIF.com

Keep On IFFin',Philip, Matt & Gaby

VITALERIUM with Nicholas Casbarro!

What the if you found a rock on Mars that might - emphasis on might - show signs of ancient life? NASA's Perseverance rover discovered intriguing leopard spots in a 3.5-billion-year-old rock that contain vivianite, a mineral that could potentially indicate biological activity, though scientists remain cautiously skeptical. These dark-outlined splotches bear some resemblance to patterns that microbes can leave behind, but resemblance isn't proof. Join our trio as they explore the painstaking scientific process of investigating possible signs of life from tens of millions of miles away using lasers, spectroscopes, and instruments cleverly named Sherlock and Watson. From "poppy seed" nodules to the methodical work of ruling out every conceivable non-biological explanation, discover why scientists are being extraordinarily careful about what could potentially be intriguing evidence - if it survives rigorous scrutiny.

Based on "In a Rock on Mars, NASA Sees Clearest Sign of Life (So Far)" by Kenneth Chang, published in The New York Times on September 10, 2025

Read the full article here: https://www.nytimes.com/2025/09/10/science/mars-rock-nasa-perserverance.html?unlocked_article_code=1.lE8.UiKA.kl-1r33U-Pd9&smid=url-share

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Find out more about Gaby's science fiction short story! 

Here are the links for the anthology. The physical copy can be ordered here : https://www.neonhemlock.com/books/luminescent-machinations-queer-tales-of-monumental-invention

The ebook can be ordered here: https://www.neonhemlock.com/ebooks/luminescent-machinations-queer-tales-of-monumental-invention

Science ROCKS On MARS!

What the if gravitational waves were big enough to see and feel? Instead of measuring distortions smaller than a proton, imagine watching your coffee table accordion in and out as ripples from distant black hole collisions pass through your local cafe. Every time Charlie the cat bats a toy mouse in Greenwich Village, sugar cubes scrunch in Williamsburg cafes. Brain surgeons would need to ask all of New York to sit perfectly still during operations to avoid gravitational interference. Even parking lots would seem impossibly far away one moment and right next to you the next as space itself stretches and compresses. From squirrels disrupting billion-dollar physics experiments to the strange world of noise-canceling gravity waves, discover why LIGO's incredible ability to detect universe-shaking events that distort space by one ten-thousandth the width of a proton might actually be humanity's most impressive scientific achievement.

Based on "Happy Birthday, LIGO. Now Drop Dead." by Dennis Overby, published in The New York Times on September 10, 2025: https://www.nytimes.com/2025/09/10/science/gravitational-waves-ligo-black-holes.html?unlocked_article_code=1.nE8.QM2f.ag_83DD_kR8e&smid=url-share

Learn More:

"Gravity's Kiss: The Detection of Gravitational Waves" - https://mitpress.mit.edu/9780262535120/gravitys-kiss/ Matt mentioned sociologist Harry Collins' nearly 900-page masterpiece about gravity wave detection as the first book he ever reviewed; find this comprehensive account of one of science's most remarkable discoveries written by someone embedded in the gravitational wave community for over 40 years.

Professor Tiffany Nichols - https://cssh.northeastern.edu/faculty/tiffany-nichols/ Matt recommended his friend Tiffany's dissertation (soon to be a book) about how LIGO chose their detection sites; explore her research on the epic story of selecting locations for these mile-long instruments and how surrounding environments become part of the scientific process.

What are Gravitational Waves - https://www.ligo.caltech.edu/page/what-are-gw Learn about the ripples in space-time that we imagined making visible in our thought experiment, including how these waves from colliding black holes create distortions 10,000 times smaller than an atomic nucleus.

What is LIGO - https://www.ligo.caltech.edu/page/what-is-ligo Discover how this unique observatory uses 4-kilometer-long laser interferometers to detect the universe's most violent events, from the instrument that Matt described as humanity's most sensitive measurement device.

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Find out more about Gaby's science fiction short story! 

Here are the links for the anthology. The physical copy can be ordered here : https://www.neonhemlock.com/books/luminescent-machinations-queer-tales-of-monumental-invention

The ebook can be ordered here: https://www.neonhemlock.com/ebooks/luminescent-machinations-queer-tales-of-monumental-invention

Gravity Waves Go WIGGLE

What the if your brain literally ran out of storage space like a laptop refusing to save one more file? Neuroscientist Nikolay Kukushkin explains how memory isn't a filing cabinet but more like water carving rivers down a mountain - and when you carve too many paths, everything becomes a muddy mess. Discover why Mr. S, who remembered everything perfectly, couldn't recognize faces or taste food because his brain was too full of details. Learn why sleep is your brain's nightly cleanup crew and why we're all currently running at 98% memory capacity thanks to information overload. Plus, find out why forgetting your ex might also wipe out your algebra skills, and how even your kidney cells form their own minute-by-minute memories.

Our guest is Nikolay Kukushkin, neuroscientist at NYU and author of "One Hand Clapping: Unraveling the Mystery of the Human Mind." You can learn more about Nikolay's fascinating book at https://www.simonandschuster.com/books/One-Hand-Clapping/Nikolay-Kukushkin/9781493090648

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Check out our membership rewards! Visit us at Patreon.com/Whattheif

Got an IF of your own? Want to have us consider your idea for a show topic? Send YOUR IF to us! Email us at feedback@whattheif.com and let us know what's in your imagination. No idea is too small, or too big!Keep On IFFin',Philip, Matt & Gaby

MEMORY Maxed Out - with Nikolay Kukushkin!

Scientists just used artificial intelligence to design the world's first AI-generated viruses capable of hunting down and killing drug-resistant strains of E. coli. These bacteriophages look like tiny alien pineapples with syringes that stab bacterial cells, and they're just the beginning of AI-created life. From Matt's dream of dish-cleaning bacteria that won't eat you (hopefully) to the accidental discovery that trying to make super purple petunias actually created white flowers instead, this episode explores what the if happens when computers start writing genetic code. Discover why we're running out of antibiotics, how a virus with only 11 genes works, and why your future dish soap bottle might say "now with AI inside." Plus, learn about the scientist who tried to engineer the most purple petunias ever and accidentally won a Nobel Prize instead.

Based on "World's First AI Designed Viruses: A Step Towards AI Generated Life" by Katie Kavanagh, published in Nature on September 19, 2025. https://www.nature.com/articles/d41586-025-03055-y

Matt also mentions a book worth checking out during the episode: "The Genealogy of a Gene: Patents, HIV/AIDS, and Race" by Myles W. Jackson, published by MIT Press. The book explores how intellectual property law has transformed scientific research through the fascinating story of the CCR5 gene, examining everything from Big Pharma to personalized medicine. Learn more at https://mitpress.mit.edu/9780262533782/the-genealogy-of-a-gene/

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Find out more about Gaby's science fiction short story! 

Here are the links for the anthology. The physical copy can be ordered here : https://www.neonhemlock.com/books/luminescent-machinations-queer-tales-of-monumental-invention

The ebook can be ordered here: https://www.neonhemlock.com/ebooks/luminescent-machinations-queer-tales-of-monumental-invention

AI Viruses

Honey guide birds in Africa respond to culturally distinct human calls and lead hunters to beehives, where humans crack them open and birds feast on the exposed beeswax. But what the if humans could whistle for any wild animal to help with tasks? Call a deer to haul your Costco groceries home (extra cabbage as payment), summon crows to find your lost earring for peanuts, or live in a Viking village where bears help with the salmon harvest then hibernate in someone's hut all winter. From turkey truffle-hunting to dolphins demanding space station aquariums, explore a world where wild animals and humans exist in bizarre symbiotic relationships that might have prevented industrialization altogether.

Based on "Honeyguide Birds Learn Culturally Distinct Calls Made By Honey Hunters" by Walter Beckwith, published in AAAS Science on December 11, 2023. Read the full article at https://www.aaas.org/news/honeyguide-birds-learn-culturally-distinct-calls-made-honey-hunters

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Find out more about Gaby's science fiction short story! 

Here are the links for the anthology. The physical copy can be ordered here : https://www.neonhemlock.com/books/luminescent-machinations-queer-tales-of-monumental-invention

The ebook can be ordered here: https://www.neonhemlock.com/ebooks/luminescent-machinations-queer-tales-of-monumental-invention

Animals Train YOU!

What the if all bodies of water on Earth were fizzy like soda? In the real world, Seneca Lake in New York produces mysterious underwater booms called "Seneca guns" that scientists think come from occasional gas pockets, but nobody knows for sure. But in our imaginary world where every lake constantly fizzes like champagne, Chicago would relocate to the mountains as Lake Michigan burps methane clouds all day long. New York and London would move to higher ground, while only brave "soda dwellers" would live at water level like Mad Max characters in vans by the river. Niagara Falls would transform into a methane-harvesting factory with enormous vacuum cleaners shipping gas to Texas for barbecue. Cities would rebuild on mountainsides and clifftops, everyone would construct homes on stilts near shores, and Mentos would become weapons of mass destruction capable of triggering lake explosions.

Based on "Why is this lake burping?" published in The New York Times on Oct. 8, 2025: https://www.nytimes.com/2025/10/08/nyregion/seneca-lake-guns-drums.html?unlocked_article_code=1.vU8.hjhV.kfNyB5WcMwSr&smid=url-share

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Find out more about Gaby's science fiction short story! 

Here are the links for the anthology. The physical copy can be ordered here : https://www.neonhemlock.com/books/luminescent-machinations-queer-tales-of-monumental-invention

The ebook can be ordered here: https://www.neonhemlock.com/ebooks/luminescent-machinations-queer-tales-of-monumental-invention

The BURPING Lake!

What the if Frankenstein was real and doctors actually tried stitching corpses together to create new people? Forget dramatic lightning strikes and brooding in Gothic towers - the real adventure is managing the world's most complicated pharmacy order when seventeen different immune systems meet for the first time and immediately start fighting. Join us as we explore why creating a functional monster requires less "It's alive!" moments and more "Does this insurance plan cover interdimensional tissue rejection?", discover the eternal question of whose blood type gets to be in charge, and meet today's synthetic biology scientists who figured out you can just build new life from genes like tiny biological LEGO blocks. Turns out whether you're using body parts or DNA, humanity's been enthusiastically playing god for centuries - we've just gotten way better at the paperwork.


FRANKENSTEIN

What the if mosquitoes were helpless against the sweet smell of their own doom? Scientists genetically engineered Metarhizium fungus to smell so irresistibly delicious that mosquitoes can't help but fly straight into deadly traps with a 90-100% success rate. Discover why these bloodsuckers are actually tiny recycling agents in nature (who knew?), learn why we can't just eliminate them without the whole ecosystem throwing a tantrum, and find out why one will inevitably end up on a future space station driving the crew absolutely bonkers. From glowing green fungus-covered mosquitoes that look like tiny Marvel villains to biological pest control that beats slathering industrial chemicals on everything, explore humanity's eternal quest to outsmart bugs that have been annoying us since the dawn of time.

Based on "This Genetically Engineered Fungus Could Help Fix Your Mosquito Problem" by Jason Dinh, published in The New York Times on November 1st, 2025. Read the full article here: https://www.nytimes.com/2025/11/01/science/fungus-mosquitoes-genetic-engineering.html?unlocked_article_code=1.y08.x0jx.9OuE2HKzYyez&smid=url-share

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Find out more about Gaby's science fiction short story! 

Here are the links for the anthology. The physical copy can be ordered here : https://www.neonhemlock.com/books/luminescent-machinations-queer-tales-of-monumental-invention

The ebook can be ordered here: https://www.neonhemlock.com/ebooks/luminescent-machinations-queer-tales-of-monumental-invention

Mosquitoes Fall for FUNGI!

Alex is excited about collaborative filtering and he could see using it in his startup to help people unlearn toxic behaviors and beliefs in a productive way. Apurva started working remotely; she found it hard to stay motivated to study. She has issues with collaborative filtering in Netflix; she feels like Netflix's recommendation algorithm is not good for discovering new things because she thinks the recommendations tend to be similar to the past. Edderic's been busy with work at Lingo Live. Edderic enjoys the part of the video lesson where Jeremy destroys the movie data set recommender benchmark seamlessly with a Neural Network.

Episode 009 - Lesson 4 - Part 2 (Practical Deep Learning for Coders)

Startup Data Science is the podcast where you learn startup-ready data science with programming basics. We discuss how to bootstrap data science techniques and understand their underlying mechanics by discussing open-source learning materials. Startup Data Science helps forward-thinking entrepreneurs, novice programmers, and seasoned software engineers to use Data Science to make a bigger impact.