Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) published a new research paper in Volume 15, Issue 4, entitled, “Isoform-specific effects of neuronal repression of the AMPK catalytic subunit on cognitive function in aged mice.”

AMP-activated protein kinase (AMPK) functions as a molecular sensor that plays a critical role in maintaining cellular energy homeostasis. Dysregulation of the AMPK signaling has been linked to synaptic failure and cognitive impairments. In a recent study, researchers Xueyan Zhou, Wenzhong Yang, Xin Wang, and Tao Ma from Wake Forest University School of Medicine demonstrated abnormally increased AMPK activity in the hippocampus of aged mice. The kinase catalytic subunit of AMPK exists in two isoforms α1 and α2, and their specific roles in aging-related cognitive deficits are unknown. 

“Taking advantage of the unique transgenic mice (AMPKα1/α2 cKO) recently developed by our group, we investigated how isoform-specific suppression of the neuronal AMPKα may contribute to the regulation of cognitive and synaptic function associated with aging.” 

The team found that aging-related impairment of long-term object recognition memory was improved with suppression of AMPKα1 but not AMPKα2 isoform. Moreover, aging-related spatial memory deficits were unaltered with suppression of either AMPKα isoform. Biochemical experiments showed that the phosphorylation levels of the eukaryotic initiation factor 2 α subunit (eIF2α) were specifically decreased in the hippocampus of the AMPKα1 cKO mice. They further performed large-scale unbiased proteomics analysis and revealed identities of proteins whose expression is differentially regulated with AMPKα isoform suppression. These novel findings may provide insights into the roles of AMPK signaling pathway in cognitive aging.

“In summary, the current study reported that suppression of neuronal AMPKα1 isoform can improve aging-related impairments of long-term recognition memory.”

Full Paper: DOI: https://doi.org/10.18632/aging.204554 

Corresponding Author: Tao Ma - tma@wakehealth.edu 

Keywords: AMPK, aging, protein synthesis, learning and memory, proteomics

Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204554

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
Twitter - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/

Media Contact
18009220957
MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

Isoform-Specific AMPK Repression Affects Cognitive Function in Aged Mice

Berberine is one of my favorite supplements out there and has been for several years. The reason is simple: berberine helps treat the biggest and most important conditions that people face including weight gain, insulin resistance, and gut dysfunction. It’s not only healthy for people who are already healthy, but it’s also amazing for people who want to stay healthy!

You can use it to assist with weight loss, balance your blood sugar, build more muscle mass, or just optimize your physique.

Let’s talk about the benefits of berberine and why you can make a strong case to use it. 

Many of the benefits we are going to be discussing today stem from Berberine’s ability to increase something called AMPK or AMP kinase. This is the same enzyme that is increased when you exercise. So when you think about the benefits, think about berberine as a tiny bottle of exercise. It doesn’t replace exercise but it’s helpful to wrap your head around how it’s working. 

Activating AMPK increases fat burning potential, mitochondrial proliferation in muscle tissue, insulin sensitivity, and much more. 

With this in mind, let’s talk about the benefits:

1. Berberine can help improve insulin resistance and low blood sugar. It has been shown to be as powerful as some medications at lowering blood sugar (metformin). 

2. Berberine can help you lose weight. Berberine enhances the effectiveness of diet and exercise. 

3. Berberine can help improve your gut health. Berberine increases butyrate production and reduces local inflammation in the gut. 

4. Berberine can help lower cholesterol. Some studies show that berberine can reduce cholesterol more effectively than statins. 

5. Berberine helps treat metabolic disorders like non-alcoholic fatty liver disease, type II diabetes, PCOS, high blood pressure, obesity, and elevated triglycerides. 

6. Berberine can help your brain stay healthy. 

For everyday general health, use around 500 to 1,000 mg each day. 

For metabolic conditions use 1,000 to 2,000 mg each day 

#berberine #nutrition #weightloss #highcholesterol #diabetes #insulinresistance #supplements #naturaltreatment 

Download my free thyroid resources here (including hypothyroid symptoms checklist, the complete list of thyroid lab tests + optimal ranges, foods you should avoid if you have thyroid disease, and more): https://www.restartmed.com/start-here/

Recommended thyroid supplements to enhance thyroid function:
- Supplements that everyone with hypothyroidism needs: https://bit.ly/3tekPej
- Supplement bundle to help reverse Hashimoto’s: https://bit.ly/3gSY9eJ
- Supplements for those without a thyroid and for those after RAI: https://bit.ly/3tb36nZ
- Supplements for active hyperthyroidism: https://bit.ly/3t70yHo

See ALL of my specialized supplements including protein powders, thyroid supplements, and weight loss products here: 
https://www.restartmed.com/shop/

Want more from my blog? I have more than 400+ well-researched blog posts on thyroid management, hormone balancing, weight loss, and more. See all blog posts here: 
https://www.restartmed.com/blog/

Prefer to listen via podcast? Download all of my podcast episodes here: https://apple.co/3kNYTCS

Disclaimer:
Dr. Westin Childs received his Doctor of Osteopathic Medicine from Rocky Vista University College of Osteopathic medicine in 2013. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Childs is no longer practicing medicine and does not hold an active medical license so he can focus on helping people through videos, blog posts, research, and supplement formulation. To read more about why he is no longer licensed please see this page: https://www.restartmed.com/what-happened-to-my-medical-license/

This video is for general informational, educational, and entertainment purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patie

The Benefits of Berberine (Weight Loss, Blood Sugar & More)

This episode takes a long look at the mechanisms behind aerobic adaptations from high intensity exercise, starting with an early study showing how AMPK activation leads directly to mitochondrial biogenesis, followed by a recent meta-analysis showing when high intensity exercise does and doesn't lead to adaptation. We provide guidelines in terms of exercise intensity, duration, and how well trained you are. Then we give some practical takeaways, plus debunk all the ways "hacking" this adaptive signal chain don't work. Marinus Petersen of KiloWatt Coaching steps in as a guest co-host for Kyle and provides an additional perspective from his coaching experience, and his formal exercise physiology education.

Watts Doc #45: How High Intensity Aerobic Adaptations With AMPK Do (And Don't) Work

Una nueva arista se ha descubierto entre el hábito de beber café y la salud humana. Se trata de un gran estudio, que logra demostrar que el consumo de café, bajo ciertas condiciones, podría incrementar la expectativa de vida. Y todo a través de la interacción con una enzima llamada AMPK.  Se han realizado poderosas investigaciones sobre la relación entre la acción de la cafeína y la AMPK. El estudio publicado en la prestigiosa revista científica “Microbial Cell” (revisada por pares), corrobora que el compuesto neuroactivo más consumido es la cafeína, al actuar activando la AMPK. Esta entra en acción cuando las células tienen poca energía ayudándolas a adaptarse y sobrevivir, lo que puede tener efectos positivos en la salud y la longevidad. Al activar la enzima AMPK se favorece la función celular, preservando los tejidos y mejorando la salud en general. Ello podría contribuir para tener una vida algo más larga, al lado de un estilo de vida saludable. En este "podcast" lo explico mejor; son apartes del contenido del libro próximo a publicar: "EL PODER DEL CAFÉ, VALOR SALUDABLE", del autor.

El café y la longevidad

Médico Cirujano, bioquímico, escritor, consultor urbano, educador ciudadano, divulgador científico, innovador social, diseñador de ciudades saludables, Creador, director y conductor del programa CIUDAD FELIZ Una forma distinta de vivir. Columnista y bloguero en múltiples medios de comunicación. Candidato a Premio Nacional de Paz (Colombia 2012) Campeón del Mundo en atletismo en los World MEDIGAMES.

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Do you feel like your thyroid is taking over your life? Are you suffering from symptoms like weight gain, hair loss, fatigue, brain fog, or mood swings? If so, you aren’t alone. 

In fact, millions of other thyroid patients in the United States and around the world suffer from the same issues. And these issues persist even in the face of normal treatment with thyroid medication!

The question is: what can you do about it?

That’s exactly what this podcast is about.

I’m Dr. Westin Childs (D.O.) a former practicing osteopathic physician and my goal is to help thyroid patients get back to feeling 100%. 

Well, I actually have 2 goals:

#1. The first is to help 1 million thyroid patients directly or indirectly. 

And #2. To create the most comprehensive and helpful thyroid resource for thyroid patients on the internet. 

I know just how debilitating thyroid disease can be and I also know that it is possible to take control of your life. 

One of the biggest problems with thyroid management is that we just don’t talk about it enough. 

This podcast changes that. 

We are going to discuss all sorts of topics ranging from thyroid management, the use of less talked about thyroid medications, opinions on emerging treatments and therapies from leading experts, the use of natural therapies and how they fit into the conventional model, and so much more. 

If you want more information aside from the standard thyroid treatment of TSH and levothyroxine then this is the place for you. 

We won’t just stop at your thyroid, either. 

Other topics that are relevant and important to thyroid function will be discussed including things like hormone balance, menopause, testosterone replacement therapy, and weight loss therapies. 

If something helps you to better manage your thyroid, improve your symptoms, lose weight, or balance your hormones then it’s something I want to include. 

For more information on me and why I do what I do check out my website here: www.restartmed.com 

If you have any questions or have a topic you want me to discuss please shoot me an email on my website to submit a request in the "contact" section!

Do you want to know how training makes you faster? Listen in. Kolie is a leading expert in endurance, sprint, and strength training for cyclists. Kyle is a NASA scientist and national champion sprinter on the track.

Empirical Cycling is a coaching company specializing in individualized training plans for all cycling disciplines. If you like the podcast, please consider a donation at http://www.empiricalcycling.com/donate.html

New tracks tagged #AMPK