TLW - Aging

BUFFALO, NY — August 19, 2025 — A new #research paper was #published in Volume 17, Issue 7 of Aging (Aging-US) on July 7, 2025, titled “Epigenetic age and accelerated aging phenotypes: a tumor biomarker for predicting colorectal cancer.”

In this study led by Su Yon Jung from the University of California, Los Angeles, researchers found a strong association between accelerated epigenetic aging and an increased risk of colorectal cancer in postmenopausal women. The study also indicated that lifestyle factors influence this risk.

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide, particularly in people over the age of 50. However, individuals do not all age at the same biological rate. Two people of the same chronological age can differ in their biological aging, which reflects the condition of their cells and tissues. This study focused on a specific measure of biological aging known as epigenetic aging, which is based on chemical changes to DNA.

The researchers used data from the Women’s Health Initiative Database for Genotypes and Phenotypes (WHI-dbGaP), which includes genetic and health information from postmenopausal white women aged 50 to 79. They applied three established “epigenetic clocks” to estimate epigenetic age from blood samples collected up to 17 years before a colorectal cancer diagnosis. These clocks measure how quickly a person is aging at the molecular level by tracking DNA methylation. Women with a higher epigenetic age than expected were significantly more likely to develop colorectal cancer

“[…]we examined biological aging status in PBLs via three well-established epigenetic clocks—Horvath’s, Hannum’s and Levine’s […].”

The study also explored the role of lifestyle in modifying this risk. Women who consumed more fruits and vegetables showed no increased risk, even if they were epigenetically older. In contrast, women with both lower fruit and vegetable intake and signs of accelerated aging were up to 20 times more likely to develop colorectal cancer. This suggests that a healthy diet may help reduce cancer risk associated with biological aging.

Another key finding involved women who had both ovaries removed before natural menopause. These women had a higher epigenetic age and, when combined with accelerated aging, a greater likelihood of developing colorectal cancer. This highlights the potential influence of hormonal and reproductive factors on aging and disease risk.

The researchers validated their findings across several independent datasets, supporting the potential of blood-based epigenetic aging markers as early indicators of colorectal cancer risk. These markers could help guide early detection and prevention strategies in aging populations. However, the authors emphasize the need for independent large-scale replication studies.

Overall, this study contributes to a better understanding of the association between epigenetic aging and cancer. It also supports the idea that modifiable lifestyle factors may reduce disease risk, even among those aging more rapidly at the cellular level.

DOI - https://doi.org/10.18632/aging.206276

Corresponding author - Su Yon Jung - sjung@sonnet.ucla.edu

Video short - https://www.youtube.com/watch?v=cq1MphQKmSk

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Bluesky - https://bsky.app/profile/aging-us.bsky.social
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

Epigenetic Aging Markers Predict Colorectal Cancer Risk in Postmenopausal Women

A new #study published as the #cover of Aging (Aging-US) Volume 17, Issue 7, explores how factors in young human blood may affect the biological age of human skin. Researchers from Beiersdorf AG, Research and Development Hamburg in Germany, used a microphysiological co-culture system—a lab-based model simulating human circulation—to test the effects of young versus old blood serum on skin cells. The findings suggest that bone marrow-derived cells play a key role in converting blood-borne signals into effects that support skin rejuvenation.

Understanding Skin Aging and Systemic Influence

As we age, the skin’s ability to regenerate declines, while its biological age increases. This contributes to visible signs of aging and a weakened barrier function. While cosmetic treatments can improve appearance, they rarely target the cellular processes underlying skin aging.

Animal studies have shown that exposure to young blood can promote tissue repair and rejuvenation, likely due to molecules circulating in the bloodstream. However, reproducing these effects in human skin has proven difficult. Applying young serum directly to skin tissue has not produced significant results, indicating that additional cellular interactions may be required.

Full blog - https://aging-us.org/2025/08/skin-rejuvenation-how-young-blood-and-bone-marrow-influence-it/

Paper DOI - https://doi.org/10.18632/aging.206288

Corresponding author - Elke Grönniger - elke.groenniger@beiersdorf.com

Video short - https://www.youtube.com/watch?v=_4spcgzPcEk

Sign up for free Altmetric alerts about this article - 
https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206288

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

Keywords - aging, skin rejuvenation, microphysiological systems, systemic factors, bone marrow model, human serum

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Bluesky - https://bsky.app/profile/aging-us.bsky.social
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Skin Rejuvenation: How Young Blood and Bone Marrow Influence It

Dr. Jill Kruse talks about the many health benefits of staying active in every season of life. She provides helpful guidance and encouragement to keep moving.

PDR 2025-08-18 Keep Moving - Dr. Jill Kruse

BUFFALO, NY — August 21, 2025 — A new #research paper was #published in Volume 17, Issue 7 of Aging (Aging-US) on July 17, 2025, titled “The influence of cancer on a forensic age estimation tool.”

In this study by Charlotte Sutter, Daniel Helbling, Cordula Haas and Jacqueline Neubauer from the Zurich Institute of Forensic Medicine, University of Zurich and Onkozentrum Zurich, the researchers investigated how cancer might affect the accuracy of forensic tools used to estimate a person’s age from blood samples.

DNA methylation is a natural chemical modification of DNA that changes with age. Forensic scientists can use these changes to predict someone’s age from biological traces, such as blood found at a crime scene. However, medical conditions like cancer can alter these patterns and potentially reduce the accuracy of such predictions. This study investigated whether various cancer types influence the DNA markers used in age estimation.

“Our study is among the first to show whether it might be necessary to account for the influence of cancer on forensic age estimation tools in order to enhance estimation accuracy as much as possible.”

The researchers applied the VISAGE enhanced age estimation tool, a widely used DNA methylation-based method, to blood samples from 100 cancer patients and 102 healthy individuals. Age predictions in the control group were generally accurate, with small average errors. Patients with solid tumors, including breast and lung cancers, showed only slightly less accurate results. In contrast, individuals with blood cancers, particularly chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML), sometimes had large errors, with ages overestimated by as much as 50 years. 

Despite these few extreme cases, the study found that cancer does not typically have a strong impact on the accuracy of this forensic tool. Most cancer patients, even those undergoing treatment, had DNA methylation patterns similar to those of healthy individuals. The researchers found no consistent differences based on cancer type, stage, or treatment, except in isolated cases involving aggressive forms of cancer.

The findings support the continued use of current forensic age estimation methods. While aggressive cancers may occasionally affect prediction accuracy, such cases are rare. The researchers suggest noting these conditions as a possible factor in unusually large errors, without requiring changes to standard practice.

This study provides valuable information about how health conditions, such as cancer, may influence DNA-based age estimation. It strengthens confidence in the reliability of forensic age prediction tools, even when applied to individuals with a medical history of cancer.

DOI - https://doi.org/10.18632/aging.206281

Corresponding author - Cordula Haas - cordula.haas@irm.uzh.ch

Video short - https://www.youtube.com/watch?v=lcpwE50O4ss

Sign up for free Altmetric alerts about this article - 
https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206281

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

Keywords - aging, forensic age, estimation age prediction, cancer, DNA methylation, age acceleration

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Bluesky - https://bsky.app/profile/aging-us.bsky.social
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Impact of Cancer on Forensic DNA Methylation Age Estimation

  This song has a totally made up lyrics about nobody real, all in my imagination. I wanted to write like an "Eleanor Rigby" type of song about loneliness, mental illness, and old age. Just following that type of format. Words came first and then I wrote the music. Which gives it that creepy vibe with a falling cliche bass line. Very eerie and haunting, trying to capture that getting old by yourself ambiance! I wrote it during the pandemic, so the scene was set! I added organ, guitars, bass, and a bunch of other instruments pre-pandemic and Charlie came over and added the vocals and a harmonica track post-pandemic. Great job by him on both accounts. So it just sat around for 3 years just gathering digital dust!😂 I never thought it was that good because the timing seemed off to me, probably because I had forgotten how it went after 3 years! Not our best effort I think. If you watch the video it will make more sense.

VIDEO - https://youtu.be/H6TuC5eYUD4

     The video was challanging and I spent a ton of time on it, about a week last year. I made it about 2 people, both named Amanda, hence the title "Amanda, Amanda". The name was suggested by my wife who loves the name Amanda. The first Amanda was a middle aged woman wandering around at night in a forest with a torch and crying herself to sleep but the second Amanda was an elderly woman that quite frankly had gone a little bit crazy due to the lonliness. We can all relate especially during the pandemic! I tried to show that in the video. There's a ton of eye-candy in the video. It's a haunting tale and a haunting song. Thanks so much for visiting and take care everyone! Let's all try not to end up like either Amanda! 🙏😎✌🏼

“AMANDA, AMANDA”

AMANDA,
HAVE YOU SAID ALL YOUR PRAYERS TODAY?
FUNNY HOW TIME SLIPS AWAY,  
      
AMANDA,             
IS THAT LONELINESS IN YOUR EYES?      
IS LIFE SLOWLY PASSING YOU BY?
YOU CAN'T DENY,

AMANDA, AMANDA,
SITS AND WAITS YEAR AFTER YEAR,
AMANDA, AMANDA,  
NO ONE'S THERE TO WIPE HER TEARS,
WHEN SHE CRYS, NO ONE HEARS,
AMANDA, AMANDA,
AND LIKE A GHOST SHE'LL DISAPPEAR,
  
AMANDA,
IS YOUR MAILBOX EMPTY AGAIN?       
NO PHONE CALLS FROM LOVERS OR FRIENDS,
WHY PRETEND?       
      
AMANDA, AMANDA,
SITS AND WAITS YEAR AFTER YEAR,
AMANDA, AMANDA,  
NO ONE'S THERE TO WIPE HER TEARS,
WHEN SHE CRYS, NO ONE HEARS,
AMANDA, AMANDA,
LIKE A GHOST SHE'LL DISAPPEAR,
YEAH LIKE A GHOST SHE'LL DISAPPEAR,
OH LIKE A GHOST SHE'LL DISAPPEAR,
HMM LIKE A GHOST SHE'LL DISAPPEAR.

BY JIM VALDES
© 2021

"AMANDA, AMANDA" (Video - https://youtu.be/H6TuC5eYUD4)

This song covers the topic of time and how there is an absurdity to try to hold on to and control it because it's such a precious resource.

In the end, the best way we can deal with time is through a collection of various life lessons to change our perspective, but it's never enough.

I dedicate this song to anyone who faces the inevitable reality of seeing the people they love get older and feeling helpless along the way to stop it.

Lyrics:

I've spent so many day
Hoping love would turn the page
And bring to me the life that I yearn

As you grow and learn the faces
Of strange and lovely places
You'll find a path to life in between

But lost and never found
Are the pieces of the sounds
Of a voice that lived long, long ago

But my friend, all that you know
Will never find a way home
But in time, I feel you must go
And rise up and move on your own

You gotta run like a wolf to the morning sun
Walk in your blood like the prey they hunt
You can't stop now until the day is done
Woah, come the day

The rule for all you see
Is to change how you perceive
Find the peace that lives deep within

For all that's right and wrong
There's a place where you belong
It'll take you far beyond this disease

In the end time will tell
Of a men that found a hell
But lost a will they chose not to be

But my friend, all that you know
Will never find a way home
But in time, I feel you must go
And rise up and move on your own

You gotta run like a wolf to the morning sun
Walk in your blood like the prey they hunt
You can't stop now until the day is done
Woah, come the day

It never really matters from where you come
Just never turn back to what's said and done
You can't stop now you have to hold your guns
Woah, come the day

'Cause all we have in life is the endless search for time
To bring back into sight the youth we compromised

The hands that raise a life are the hands that fall to time
A concept in the mind or a place we leave behind
A place we leave behind
A place we leave, behind

Come The Day (Original Song)

What is happening during perimenopause and menopause? How can symptoms be treated? What concerns should we bring up to our physicians? Dr. Breanne Mueller answer these questions and more.

PDR 2025-08-25 Perimenopause - Dr. Breanne Mueller

BUFFALO, NY — August 26, 2025 — A new #research paper was #published in Volume 17, Issue 7 of Aging (Aging-US) on July 21, 2025, titled “Association of DNA methylation age acceleration with digital clock drawing test performance: the Framingham Heart Study.”

In this study, led by first author Zexu Li from the Department of Anatomy and Neurobiology at Boston University Chobanian and Avedisian School of Medicine, and corresponding author Chunyu Liu from Boston University Chobanian and Avedisian School of Medicine and Boston University School of Public Health, researchers found that individuals with signs of faster biological aging had lower scores on a digital cognitive test taken seven years later. The findings suggest that the rate at which a person ages at the molecular level may be associated with how well their brain functions as they grow older.

Using data from the Framingham Heart Study, the researchers examined the relationship between biological aging and cognitive health. They used DNA methylation (DNAm) patterns—chemical changes that occur in the DNA with aging, known as epigenetic aging—to estimate biological age acceleration, and used the digital Clock Drawing Test (dCDT) to assess cognitive performance. The dCDT is a computerized version of a traditional pen-and-paper test that evaluates memory, thinking speed, and motor control. It provides an overall score and measures performance in specific areas such as spatial reasoning and movement.

Among 1,789 participants, higher levels of epigenetic age acceleration were associated with significantly lower cognitive scores, particularly those over age 65. Of all the epigenetic aging markers examined, the DunedinPACE measure showed the strongest association with reduced brain function in both younger and older adults. Other measures, such as Horvath and PhenoAge, were associated with lower scores only in older adults. Key areas affected included motor skills and spatial reasoning.

The researchers also studied blood-based protein markers used in an aging measure called GrimAge. Two proteins, PAI1 and ADM, were closely associated with lower cognitive scores, especially in older individuals. These results suggest that declines in brain and motor functions may reflect broader aging-related changes throughout the body.

“Digital cognitive measures displayed stronger associations with most DNAm aging metrics among older compared to younger participants, likely to reflect the cumulative and nonlinear age influences on both brain health and DNAm.”

This study supports the idea that epigenetic age may be a more accurate predictor of cognitive decline than chronological age. The dCDT, which is easy to use, automated, and more precise than traditional tools, may help detect early signs of brain aging. When combined with DNAm measures, it could become a valuable part of regular health screenings.

Overall, the findings provide strong evidence that faster biological aging is associated with cognitive decline. This research may lead to better ways of identifying and monitoring brain health in aging populations.

DOI - https://doi.org/10.18632/aging.206285

Corresponding author - Chunyu Liu - liuc@bu.edu

Video short - https://www.youtube.com/watch?v=4hyjDqnPs8w

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Bluesky - https://bsky.app/profile/aging-us.bsky.social
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Faster Biological Aging Linked to Cognitive Decline in Older Adults

BUFFALO, NY — August 27, 2025 — A new #research paper was #published in Volume 17, Issue 7 of Aging (Aging-US) on July 24, 2025, titled “RNA-binding protein AUF1 suppresses cellular senescence and glycolysis by targeting PDP2 and PGAM1 mRNAs.”

In this study, Hyejin Mun, Chang Hoon Shin, Mercy Kim, Jeong Ho Chang, and Je-Hyun Yoon from the University of Oklahoma and Kyungpook National University investigated how changes in cellular metabolism contribute to aging. Their findings offer potential targets for therapies aimed at slowing or reducing the effects of aging.

As cells age, they often lose their ability to divide and begin releasing harmful signals that damage nearby tissues. This process, called cellular senescence, is linked to many age-related diseases. A key feature of senescent cells is their altered metabolism, where they use more glucose and oxygen, even when oxygen levels are low. This leads to the production of inflammatory substances and fatty acids, which can accelerate tissue damage. The study examined how these metabolic changes are controlled at the molecular level.

Researchers found that AUF1, a protein that binds to RNA, normally helps prevent aging by breaking down two enzymes involved in glucose metabolism: PGAM1 and PDP2. When AUF1 is missing or inactive, these enzymes build up. This causes the cell to produce more energy and inflammatory molecules, which are common features of senescent cells.

“Our high throughput profiling of mRNAs and proteins from Human Diploid Fibroblasts (HDFs) revealed that the expression of pyruvate metabolic enzymes is inhibited by the anti-senescent RNA-binding protein (RBP) AUF1 (AU-binding Factor 1).”

The team also identified another protein, MST1, which becomes active during cellular stress and aging. MST1 modifies AUF1 in a way that stops it from doing its protective job. As a result, PGAM1 and PDP2 accumulate, leading to faster aging of the cell. Experiments using human fibroblast cells and mouse models confirmed that higher levels of these enzymes are linked to stronger signs of cellular aging.

These findings improve our understanding of how metabolism affects the aging process. They highlight the MST1-AUF1-PDP2/PGAM1 pathway as a key factor in the metabolic shift seen in aging cells. Since these enzymes and proteins are already known to be involved in other diseases, existing or future therapies might be used to block this pathway and reduce the effects of aging.

This study offers a new direction for senotherapy—a field focused on treating or removing aging cells. By adjusting glucose metabolism through AUF1 and its targets, scientists believe it may be possible to slow aging or limit its effects on tissue function. More research is needed, but these insights could lead to new strategies for managing age-related diseases and promoting healthier aging.

DOI - https://doi.org/10.18632/aging.206286

Corresponding authors - Jeong Ho Chang - jhcbio@knu.ac.kr, and Je-Hyun Yoon - jehyun-yoon@ouhsc.edu

Video short - https://www.youtube.com/watch?v=Gbu6USUSkgg

Sign up for free Altmetric alerts about this article - 
https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206286

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

Keywords - aging, AUF1, MST1, senescence, glycolysis

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Bluesky - https://bsky.app/profile/aging-us.bsky.social
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

AUF1 Protein Plays Anti-Aging Role by Regulating Cellular Metabolism

**I NEVER USE A.I. IN ANY OF MY SONGS!** Hi everybody, my name is Jim and I’m a songwriter, I've written over 300 songs, I play guitar, bass, piano, and am an okay lyricist.  I play all types of music and have my own recording studio.  I use no A.I. or DAW or any computers to make my songs, all the instruments are played by me live on a multitrack studio recorder and Charlie, my vocalist, sings most of my songs and also plays the Harmonica on several tracks. I'm not a pro or a great musician but I do what I can with the tools that I have! I belong to the "Keep Humans In Music Movement" (KHMM)! We're NOT perfect but we're REAL! Thanks everyone for listening and the world needs more music now, real music made by HUMANS not MACHINES! So let's all sing a song with our own voices, please! I do not consent to any of my songs or videos being used or sampled or lifted in any way or fashion. Take care!👍😎✌🏼.

Hi, i'm TLW and i love music, so i started making my own!

I started making my own music back in 2017. I started uploading my content on YouTube in July 2024.
And if you want to know, i am a autodidactic musician (But i'm far from being a professional, but i don't want to be professional! I just want people to enjoy my music i make for fun, while having my own unique style^^
Oh yeah, and my favorite instrument is the Piano^^

"What do you use as DAW (Digital-Audio-Workstation) to make your music?"
I use FL Studio (Started with the Trial-Version of FL Studio 11...)

"What genres do you make?" you're probably wondering. My answer: yep ._.
(Just Kidding. I think mostly Trap/Hip-Hop, DnB, LoFi and so on... but often it's something experimental or something in short: I make everything i like and can make at this point)

Another Info: I'm mostly active on YouTube since i upload always upload my content there at first and you can find my posts there too^^

[FOR BUSINESS / LAWFUL PURPOSES ONLY] - tlwsounds[AT]gmail.com

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

I write songs and sometimes I like to share them.

New tracks tagged #Aging