There's excitement in the air, as our stories of love and dementia both take a new twist.

The Marathon Years — 12. Taking the plunge

BUFFALO, NY — June 12, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 5, on May 3, 2025, titled “APOE genotype and biological age impact inter-omic associations related to bioenergetics.”

In this study, led by first author Dylan Ellis and corresponding author Noa Rappaport from the Institute for Systems Biology, researchers discovered that different versions of the APOE gene—particularly ε2 and ε4—are linked to metabolic patterns associated with aging and Alzheimer’s disease risk. Both variants were linked to increased levels of diacylglycerols, a type of fat molecule connected to insulin resistance and inflammation, suggesting shared disruptions in how the body regulates energy.

The research team analyzed data from over 2,200 adults without an Alzheimer’s diagnosis, exploring how APOE genotypes influence biological age, a measure of health that reflects how quickly or slowly someone is aging at a cellular level. They found that the same metabolic disturbances seen in ε2 carriers were also present in people considered biologically older, revealing unexpected overlap between genetic risk and aging-related metabolic changes.

To examine these connections in more detail, the researchers used a multi-omics approach, combining blood-based metabolism and protein data, gut bacteria analysis from stool samples, and clinical chemistry data. This method allowed them to map how genetic differences and biological aging affect the body’s energy systems. They observed altered connections between glucose metabolism, inflammatory markers, and key molecules that play roles in energy production, indicating early disruptions that could contribute to age-related diseases.

One of the study’s surprising findings was that the ε2 variant, usually associated with longer life and reduced Alzheimer’s risk, showed metabolic traits similar to those found in insulin-resistant individuals. This suggests that ε2 may carry metabolic disadvantages earlier in life, with its protective effects becoming more pronounced later. Conversely, ε4—linked to greater Alzheimer’s risk—may exert its influence based on interactions with lifestyle factors like diet, sex, and overall health status.

“‘Omics association patterns of ε2-carriers and increased biological age were also counter-intuitively similar, displaying significantly increased associations between insulin resistance markers and energy-generating pathway metabolites.”

By identifying these shared biological signatures, this study offers a new framework for understanding how genes and metabolism work together to influence aging. These findings could support more personalized health strategies aimed at delaying biological aging and reducing the risk of chronic diseases. As aging populations grow worldwide, understanding these pathways is essential to improving healthspan.

DOI - https://doi.org/10.18632/aging.206243

Corresponding author - Noa Rappaport - noa.rappaport@isbscience.org

Video short - https://www.youtube.com/watch?v=75hZQoO5U0U

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Keywords - aging, apolipoprotein E (APOE), biological age, metabolism, Alzheimer’s disease (AD), insulin resistance

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Aging (Aging-US)

APOE Gene Variants Linked to Metabolic Signatures of Aging and Alzheimer's Risk

Original Lyrics and Music by: Nova J (I Still Remember Love)℗
Portuguese translation and arrangement by: Paulo Sergio Carvalho

Acordo num quarto que não conheço
As cortinas brilham, o sol é doce
Ela sorri e diz meu nome
Mas o dela... me foge, me consome

Ela me ajuda a me sentar
Traz meu prato, começa a cuidar
Tento comer, mas mal sinto o gosto
Ela segura minha mão, com tanto gosto

Ainda me lembro do amor
Mesmo quando o resto se apaga
Ainda me lembro do amor
E é disso que a vida se embala

Um homem entra e me chama “meu bem”
Seu rosto é calmo, sua voz vem
Não sei o lugar, nem o dia também
Mas com ele, me sinto bem

Me perco fácil lá no corredor
Esqueço o caminho, esqueço quem sou
Me encontram ali e me trazem de volta
Ninguém ri, ninguém me solta

Ainda me lembro do amor
Mesmo quando a mente falha
Ainda me lembro do amor
Como a luz do alpendre na madrugada

Tem uma canção dentro de mim
Cantarolo, mesmo sem o fim
Não sei de onde vem a melodia
Mas cantar me traz calmaria

Ainda me lembro do amor
Mesmo se eu perder meu lugar
Ainda me lembro do amor
Quando alguém vem me cuidar

Então se eu esquecer seu nome
Ou não souber onde estou
Por favor, não se esconda, nem some
Fica aqui comigo, por favor
Esqueço muita coisa, sim
Mas se tem algo que me guia, enfim…

Eu ainda me lembro do amor
Eu ainda me lembro do amor

Ainda me Lembro do Amor (Portuguese)

As a carer, you always have to be on the look-out for dementia dangers – even in the home.

The Marathon Years - 40. Through the Looking-Glass

Sometimes, I'm told, dementia can lead to inappropriate behaviour. But whose behaviour is inappropriate in this story — mine or Lena's?

TMY - 50. Inappropriate_Behaviour

This is a four-part choral composed in 2025 (Soprano, Alto. Tenor, Bass). The lyrics come from a poem, "Do Not ask Me to Remember", by Owen Darnell < https://www.alzheimers.net/do-not-ask-me-to-remember-poem>. The poem is about Alzheimers/dementia. The poem resonated with me because I watched my mother slowly lose herself to the void. Again, no singers, just woodwinds representing the four voices.

Do Not Ask Me to Remember

How is venture philanthropy revolutionizing Alzheimer's drug discovery? We sit down with Karen Harris, CFO at the Alzheimer's Drug Discovery Foundation, to explore their game-changing approach to funding early-stage research.

With $370M+ awarded to 765+ programs globally, the ADDF operates like a VC firm—using convertible debt and preferred equity to accelerate breakthrough treatments.
 
Topics:
Venture philanthropy vs traditional grants
Shift from amyloid to combination therapies
Blood-based biomarkers & precision medicine
NIH funding cuts impact on research ecosystem

Karen brings 20+ years investment banking experience to discuss how strategic capital is changing Alzheimer's research.

ADDF's Karen Harris: Investing in Alzheimer's Like a VC

A song depicting the ups & downs of a person with memory loss. Paper rainbows have memories of loved ones written on them to help remember forgotten experiences. Dedicated with love to my Mother Linda.

Memories on Paper Rainbows

On this episode of STILL HERE BITCH: Mature LGBTQ+ Dating & Relationships Podcast, Gerry chats with a gerontologist who specializes in SGM (Sexual and Gender Minority) - including LGBTQ+ - people. Dr. Meki Singleton and Gerry discuss why advanced care directives have become increasingly important, the many ways they can be set up, when you might start thinking about it, and who should be involved. Meki also offers advice to 20-year-olds on how to use the aging process to live a life with no regrets and mastering the art of caring for yourself. No matter what age you are, YOLO - so find out how to make it clap.

SHB EP 2.2: Advanced Care Directives - Ask a Woman Who Knows with Dr. Meki Singleton

In this solo podcast episode I discuss why I believe Pure Krill oil is SUPERIOR to Fish oil and have done for almost 10 years now. 
Pure Krill oil has a phospholipid backbone which makes the DHA and EPA it contains more bioavailable and efficacious.  I recommend avoiding nearly all commercial fish oil supplements, because the DHA and EPA are delivered in the form of ethyl esters.  Ethyl esters are the least bioavailable and cheapest form of omega-3.
But a new lysophospholipid form of DHA found in Krill oil shows promise for preventing macular decline that often occurs alongside chronic inflammation and diseases like Alzheimer’s and diabetes. Whereas the DHA in most fish oil supplements cannot reach the retina, where DHA
 concentrates, LPC-DHA crosses into the retina from the bloodstream easily. Krill oil also counteracts neuroinfammatory processes, due to its phospholipids and additional antioxidant "astaxanthin". Find out more in this newest episode. Also the link to my previous video on krill oil is here;
https://youtu.be/JGJ4M8sVU3M

As always, please like share and subscribe if you haven't already. :)


#388 Why I believe Pure Krill oil is Superior to Fish oil.

In this episode, we talk with Dr. Christina Shenvi about ARIA, a finding associated with an early stage Alzheimer's infusion that can impact stroke and VTE care. 

The MRI of choice per neuroradiology are the T2 weighted and flare images seen on most routine head MRIs. The gradient recall echo are best for bleed and microhemorrhage. These are all part of a routine MRI. I would note in the order that you are looking for ARIA. 

Supported by Eli Lilly and Company

ARIA - Alzheimer's Treatments and Risk in the ED with Dr. Christina Shenvi

“Not Just A Little” is a heartfelt ballad about memory, loss, and the fading traces of someone once deeply loved. The song carries a haunting melody wrapped in tender vulnerability, where each verse reflects on a love slipping further into the past. With its emotional chorus and poignant bridge, it speaks to anyone who’s ever tried to hold onto someone they can’t let go of. This isn’t just a song of fading—it’s a declaration that the love felt was never ‘just a little,’ but something profound and unforgettable.”

Not Just A Little

BarbaraQuesada_Alzheimers

Mary Holmes, the Executive Director of the Martha's Vineyard Center For Living, speaks with Ray Whitaker about their "Yoga For Living" event coming up on October 4th, 2025, between 9:00a & -1:00p at The Grange Hall

To Register: https://form-renderer-app.donorperfect.io/give/marthas-vineyard-center-for-living/yoga-for-living-2025-registration

MV Center for Living (Yoga For Living)

In this episode, I chat with the wonderful and very sweet Jules Vasquez (Brain Body by Jules) about how to keep yours and your children's brains healthy in today’s modern world. We dive into the science of stress and inflammation, and how they destroy the brain. The importance of sleep and dreaming, blue light, and even the role that technology (like ChatGPT) might play in shaping our memory and cognitive health (decline). I soooo enjoyed this conversation and was blown away by Jules and her knowledge, including how she delivers information. I think you will too! 
✨ What you’ll learn in this episode:
Stress and Inflammations impact on the brain
How the amygdala, the brain's emotional processing center, plays a critical role in the stress the "fight-or-flight" or "rest-and-digest" reaction
The prefrontal cortex's part in rational logical thinking
How blue light and poor sleep impair brain performance
Why you need to dream for memory 
Natural and nutritional approaches to supporting your brain
Is ChatGPT destroying our brain performance and ability to think for ourselves
And LOTS more!

If you’ve ever wondered how to support your brain against the challenges of modern life and aging, this conversation will give you both clarity and practical tools.

👉 Jules Vazquez holds a Master’s in Health Informatics and works as a Health Scientist and Data Scientist, bridging the gap between research, practice, and innovation. She also teaches a graduate-level course in the School of Health and Rehabilitation Sciences, and is a Certified Somatic Reprocessing Practitioner for Illness and Pain through Wellsprings Academy, which deepens her work in nervous system and mind-body healing. Jules has a very popular Instagram page where she provides fun brain game videos and brain health tips. Check her out here;
 Instagram - brainbodybyjules  
https://brainbodybyjules.podia.com
https://www.skool.com/brainbodybyjules

👉 If you found this helpful, please like, share, subscribe, and hit the notification bell so you never miss future conversations from me and other experts who want to help you feel your best. 
I also appreciate your support on these videos because they actually do take time, especially where studies are involved and I don't monetize them. So if you would like to support me in making my videos or podcasts, and would like me to keep doing it, it would really mean a lot to me if you bought me a coffee - I do love coffee. Thank you so much for your generosity.
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Chemaine xo

🛑 DISCLAIMER: This video is for educational purposes only and does not replace medical advice.

#396 Protecting Your Brain & Boosting Memory; from Blue Light to ChatGPT with Jules Vazquez.

Episode 138 -Value-Based Care in Action: CMS’s GUIDE Model for Caregiver Support  

As CMS continues to expand value-based care programs, one stands out for its focus on supporting some of our most vulnerable patients—and their caregivers. The GUIDE model (Guiding an Improved Dementia Experience) is designed to improve care for individuals with dementia and Alzheimer’s, while providing essential resources and support for the family members and caregivers who support them. 

On this episode Dan is joined by Seth Hyman, Co-Founder and Partner at JVS Health. Together, they explore the goals of the GUIDE model, why CMS is prioritizing dementia care, and how health systems can prepare to implement and benefit from this transformative initiative. 

To stream our Station live 24/7 visit www.HealthcareNOWRadio.com or ask your Smart Device to “….Play Healthcare NOW Radio”.

Find all of our network podcasts on your favorite podcast platforms and be sure to subscribe and like us. Learn more at www.healthcarenowradio.com/listen

VBC Insights: Value Based Care in Action: CMS’s GUIDE Model for Caregiver Support

Slow ageing with University of Sydney Experts

Madinah and Rocky discuss their favorite comedy bits, cruise ship chaos, and modern dating.
Rocky shares when he took a comedic impression too far.
TW: Suicide.

Get your tickets to see Madinah at an upcoming show!
https://linktree.com/madinahcomedy


10/19 Rockville, MD
10/24 Newark, DE
10/25 Frederick, MD
11/1 Wilmington, DE
11/8 Ocala, FL
11/13 Ardmore, PA
11/15 Philadelphia, PA & Claymont, DE
11/16 Lancaster, PA
11/29 Bethlehem, PA
12/6 Wilmington, DE


Episode #13 - White Guys Can Be Corny, Brothers Gotta Be Cool

Raised in Concrete Washington, I learned to play the guitar when I was 12 years old.  We had a music teacher by the name of Daryl Cooper who was like my older brother.  He started a guitar class and I couldn't wait to be in it.  By the 2nd or 3rd week I had probably outgrown the class but I enjoyed every minute of it.  I was in his band by the time I was 14 playing dances all over Western Washington.  I was awarded the National Choral Award Scholarship my senior year of high school.  This goes to one student in the United States.  I wasn't smart enough to use it.  I joined the United States Navy in 1979 and stayed for almost 22 years.  During that time I was a submariner and eventually the pilot of a small submersible (DSV3 Turtle) that would dive to 10,000 feet deep.  I was in bands playing guitar and singing throughout my military career.  We actually had a couple songs play on DC101 in the 80's.  Now in my 60's, I'm able to relax and write songs without any pressure or dreams of grandeur.  I like the songs I write and hope you like them too.

Citeline places biopharma and medical device professionals, and those who focus on these industries, at the forefront of knowledge and insight, by providing the perfect combination of news and information together with penetrating insight and analysis. Citeline is a leader in the field of healthcare industry information.

Purchase all maxwell 3 music from iTunes & amazon
Just an old guy with Parkinson's . . . Shaking it up, and having fun!
Helping with Happiness along the way.

Available on: Spotify, Apple Music, Deezer, YouTube Music, Amazon Music, iHeart, and many others. Search for "maxwell 3"

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ASCAP member

STILL HERE BITCH: Mature LGBTQ+ Dating & Relationships is the first podcast about the unique relationship issues of LGBTQ+ people ages 40 and older. Watch on YouTube and Instagram @stillherebitchpodcast.

Veteran comedian & Baby Boomer Rocky Wilson & his niece, Millennial budding stand-up comedian and politician Madinah Wilson-Anton, hang out and discuss pop culture, history, and comedy.

ACEP Frontline, hosted by Dr. Ryan Stanton, features in-depth conversations on the hottest topics in emergency medicine and critical care.

Sydney Ideas is the University of Sydney's premier public lecture series program, bringing the world's leading thinkers and the latest research to the wider Sydney community.

Proverbs 18:21 "Death and life are in the power of the tongue, and those who love it shall eat of its fruit."
It is my hope that my podcast and these conversations bring you insight and the tools to take responsibility for your health and hormones, so that you may live your best life AND fulfill your life's purpose with determination and happiness. Please like and subscribe if you are enjoying my content. :)

If you are considering reaching out, I work with high-achieving motivated people in a 1:1 position to optimize their health and life through a science backed holistic approach. This includes personalized nutrition and hormone therapy, 360° sleep improvement, strategic supplementation, movement and more.📝📊🧬

Don't be afraid to say Hi sometime!
support@chemainesmodelhealth.com or on Facebook and Instagram - I swear I do respond! ;)

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

RADIO FOR THE HEALTHCARE INDUSTRY
Healthcare NOW Radio and Podcast Network offers discussions on the latest developments and trends impacting the industry including: health tech, health IT, healthcare innovation, healthcare policy, healthcare data security, telehealth, interoperability, biotech, med tech, value-based care, pharma, healthcare compliance, and much more. Shows are hosted by industry thought leaders. Guests are a "who's who" across the healthcare spectrum.  The listening audience is predominantly physician and hospital-based, and the healthcare industry at large.

I see music in the stars, I hear music when I sleep, its a never ending story... Paulo Sergio Carvalho, known to the music world as iPauloSergio, was born in the stunning city of Ponta Delgada in the Azores, Portugal. His early years were enriched by the lush landscapes and vibrant culture of the islands. At the tender age of 13, Paulo discovered his passion for music, immersing himself in the sounds of the piano, keyboards, and guitar. This early exposure laid the foundation for his lifelong love of music and set him on a path to become a multifaceted musician.

Paulo’s music is a rich tapestry woven from a wide array of influences. He admires legends such as Johnny Cash, Willie Nelson, and Bob Dylan for their storytelling prowess, while also drawing inspiration from the melodic genius of Billy Joel and the powerful anthems of Journey and Van Halen. Furthermore, the innovative sounds of electronic pop icons like Pet Shop Boys and Depeche Mode can be felt in his work. This fusion of genres reflects Paulo's ability to connect with a diverse audience and create music that resonates on multiple levels.

In addition to his solo pursuits, Paulo has collaborated with fellow musician iGracie to write songs for various bands, including the country outfit Devils and Debutantes and the indie rock group Love Bomb Poets Society. These partnerships have allowed him to explore different musical styles and expand his songwriting repertoire, blending heartfelt lyrics with catchy melodies that appeal to listeners across genres.

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One of the last radio stations in the United States that not only features local/regional content, but never forgets that radio is a one on one mode of communication. And, of course, we bring you classic rock/folk/world music from the 20th Century, but Americana from the last and this century as well.

I bring words to life, and life to words. Like what you hear? Need professional narration or voiceover services for your next project? Contact me at barbara@thevoiceofbarbara.com

I'm using SoundCloud to release audio versions of the latest chapters from my book 'The Marathon Years' - the story of our decade-long battle defying dementia. (Oh, and It's a love story too) Catch new episodes at my website Miles Posts, where you can also sign up for my weekly newsletter keeping you updated with all the latest news and releases..

New tracks tagged #Alzheimers