utsubyou no tori

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BUFFALO, NY- June 10, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 10, entitled, “Relationships of depression and antidepressant use with epigenetic age acceleration and all-cause mortality among postmenopausal women.”

In this new study, researchers May A. Beydoun, Hind A. Beydoun, Jason Ashe, Michael F. Georgescu, Steve Horvath, Ake Lu, Anthony S. Zannas, Aladdin H. Shadyab, Su Yon Jung, Sylvia Wassertheil-Smoller, Ramon Casanova, Alan B. Zonderman, and Robert L. Brunner from the National Institute on Aging, U.S. Department of Veterans Affairs (Washington, DC), University of Texas Health Science Center at Houston, University of California Los Angeles, University of North Carolina at Chapel Hill, University of California San Diego, Albert Einstein College of Medicine, Wake Forest University School of Medicine, and University of Nevada Reno investigated relations of depressive symptoms, antidepressant use, and epigenetic age acceleration with all-cause mortality risk among postmenopausal women. 

“Frequently under-recognized depression is a major contributor to the Global Burden of Diseases [1, 2] while being the most prevalent mental illness among geriatric populations [2].”

Data were analyzed from ≤1,900 participants in the Women's Health Initiative study testing four-way decomposition models. After a median 20.4y follow-up, 1,161 deaths occurred. Approximately 11% had elevated depressive symptoms (EDS+), 7% were taking antidepressant medication at baseline (ANTIDEP+), while 16.5% fell into either category (EDS_ANTIDEP+). 

Baseline ANTIDEP+, longitudinal transition into ANTIDEP+ and accelerated epigenetic aging directly predicted increased mortality risk. GrimAge DNA methylation age acceleration (AgeAccelGrim) partially mediated total effects of baseline ANTIDEP+ and EDS_ANTIDEP+ on all-cause mortality risk in socio-demographic factors-adjusted models (Pure Indirect Effect >0, P < 0.05; Total Effect >0, P < 0.05). Thus, higher AgeAccelGrim partially explained the relationship between antidepressant use and increased all-cause mortality risk, though only prior to controlling for lifestyle and health-related factors. 

“Antidepressant use and epigenetic age acceleration independently predicted increased all-cause mortality risk. Further studies are needed in varying populations.”

DOI - https://doi.org/10.18632/aging.205868

Corresponding author - May A. Beydoun - baydounm@mail.nih.gov

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Keywords - aging, depressive symptoms, epigenetic age acceleration, mortality

About Aging-US

Aging publishes research papers in all fields of aging research, including but not limited to aging processes (from yeast to mammals), cellular senescence, age-related diseases (such as cancer and Alzheimer’s disease) and their prevention and treatment, anti-aging strategies and drug development, and, importantly, the role of signal transduction pathways in aging (such as mTOR) and potential approaches to modulate these signaling pathways to extend lifespan.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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Aging (Aging-US)

Depression, Antidepressants, Epigenetic Age Acceleration, and Mortality in Postmenopausal Women

Reseting "IamSober" streak... It was inevitable anyway..

Lyrics: NOSUNLIGHT

Music / Artwork: AI-Generated

Anxiety disorder, it’s got me in a chokehold,
Attacks hit hard, man, it’s outta control.
Suicidal thoughts creep in, I’m overdosing pills,
Can’t tell nobody, keepin’ secrets that kill.
All alone in this, yeah, I’m terrified,
What if they find out I tried to take my life?
The system’s run by fools, just fakin’ they care,
Preachin’ self-love, but they ain’t really there.

What’s wrong with you? "Nothin', just sad,"
Minimizing pain, man, it’s all I ever had.
Pop antidepressants, benzos, sedatives too,
Feelin’ numb inside, like I’m already through.
Tried to be kind, yeah, I gave it my best,
But the world’s so cold, kindness don’t invest.
Ain’t nobody checkin’ in, they just turn away,
Hopin’ for tomorrow, but it’s just another day.
Survivin’ while these thoughts cut deep,
Livin’ in a nightmare, no relief in sleep.
Wish someone would care, see the pain I hide,
But I’m stuck in this game, playin’ dead inside.

What’s wrong with you? "Nothin', just sad,"
Minimizing pain, man, it’s all I ever had.
Pop antidepressants, benzos, sedatives too,
Feelin’ numb inside, like I’m already through.

The world’s so fake, pretendin’ they care,
But where’s the action? It’s nowhere, it’s air.
I’m screamin’ for help, but no one hears the sound,
Drownin’ in silence, wishin’ I’d be found.

Minimizing Pain, Man, It’s All I Ever Had

tried matching a midi to my little lag pings im feeling from the antidepressant withdrawals, with some seasoning added of course.

Withdrawalwla

ono sendai

On this Episode 489 of Health Solutions, Shawn & Janet Needham R. Ph. discuss the reasons behind why Dr. Kourtney Chichilitti left retail pharmacy as well as her experiences during her time there. 

00:00 - Start
00:36 - Dr. Kourtney’s Introduction
01:34 - Leaving Retail Pharmacy
03:45 - SSRIs & Antidepressants
06:06 - Dr. Kourtney’s Experience with SSRIs
11:42 - Omega 3s
16:12 - Kickbacks
16:53 - Quality Products
21:01 - Hope for the Future
26:22 - GI
28:59 - Your Body Doesn’t Lack a Drug
32:03 - Ozempic
33:05 - Big Pharma Corruption
36:06 - Changes Over Time
39:46 - Look at the Source
42:00 - The Body and Toxins
44:54 - Dr. Kourtney’s Passion
46:31 - Dr. Kourtney’s Website
47:30 - Closing Comments

Episode Resources 
Facebook ~ https://www.facebook.com/kourtney.chichilitti
LinkedIn ~ https://www.linkedin.com/in/dr-kourtney-sanfelice-a20a393b
Website ~ https://wellness-solutions.co/about

EP 489: Discussing Reasons Behind Leaving Retail Pharmacy with Dr. Kourtney Chichilitti

~
#retailpharmacy #pharmacy #pharmacist #retail #healthcaresystem #doctor #medications #pharmaceutical #pharmaceuticals #ssri #antidepressant #depression #anxiety #mentalhealth #sideeffects #medicationsideeffects #omega3 #bigpharma #guthealth #healthygut #podcastshow #podcast #podcastguest #optimalhealth #healthfreedom #MedicalFreedom #medicaleducation 
#medicalcare #HealthCare #PriceTransparency #freemarket #Liberty #FitAfter50 #FitOver50 #fitover40 #fitafter40 #Boise #IdahoFalls #Tricities #SiouxFalls #Wenatchee 
#EducateAndEmpower #NeedhamHealthSolutions #TeamNeedham #ShawnNeedham #HealthSolutions #MosesLakeProfessionalPharmacy #MLRX #SickenedTheBook #ShawnNeedhamRPh #ThinkOutsideTheSystem #OptimalHealthMatters #ItsTime

~
*** #BenShapiro & #DaveRamsey Fans. Learn how to be in the driver's seat for your healthcare choices {not the system or doctors!} 💪 http://mybook.to/Sickened_The_Book
~
Follow our NEW FB Podcast Page! ~ https://www.facebook.com/HealthSolutionsPodcast
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Follow Shawn on Instagram ~ https://www.instagram.com/health_solutions_shawn_needham/
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Follow Shawn on LinkedIn ~ https://www.linkedin.com/in/shawn-needham-03a53816/
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Follow Shawn on X ~ https://x.com/ShawnNeedham2
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Follow Shawn on TikTok ~ https://www.tiktok.com/@shawnneedham447
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Sickened The Book Facebook Page ~ https://www.facebook.com/SickenedTheBook
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~
Subscribe to our YouTube channel ~ https://youtube.com/@MosesLakeProfessionalPharmacy

EP 489: Discussing Reasons Behind Leaving Retail Pharmacy with Dr. Kourtney Chichilitti

Tapering off medication refers to the gradual reduction of a drug dosage rather than an abrupt discontinuation. This process is typically used for medications that can cause withdrawal symptoms or a resurgence of the original condition if stopped suddenly, such as antipsychotics, antidepressants, and certain other psychiatric medications.
Key Aspects of Tapering Off Medication:  Listen for more...

The Art of Tapering: Navigating the Journey of Tapering -How to Taper Off Antipsychotics Safely?

Eastward Traversal

ANTIDEPRESSANT Sped UP (BONUS TRACK)

ANTIDEPRESSANT

DJ.Cyberlime@gmail.com

[ ref:!00DD00pxIW.!500Qx03iUn3:ref ]

Cancer and aging are two sides of age-related tumorigenesis.

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

http://instagram.com/morrow.er

Live performed dub techno house ambient deep house

┗ 27
┗ Songwriter
┗ Producer
► Open to Collab
┓ Having Passive SI, hope you be kind to me.

Boldly Empowering 30s ~ 60s+ to Take Charge of Their Health. Bio Identical Hormone Balancing. Medical Freedom. Optimal Health Tips. 25+ yrs as Cash Only Compounding Pharmacists. Twice weekly Live Podcast.

I might sound like Marge Simpson but just chill out, homie

New tracks tagged #Antidepressant