In a new editorial, researchers discuss the impact of frailty on clinical decision-making in managing patients with atrial fibrillation and the prescription of oral anticoagulants.
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Atrial fibrillation (AF) is a type of heart arrhythmia that occurs when the ​​heart's electrical signals become irregular. This condition can increase the risk of stroke and heart failure, and becomes more common in older adults. Frailty is another condition that coincides with aging. Frailty encompasses an accumulation of deficits and can be defined as decreased physical function and resilience. For a significant proportion of the elderly population, both of these conditions coexist. This convergence can lead to additional health issues and further complicate the clinical landscape for aging individuals. 

“The impact of frailty on outcomes has not been previously well characterized in populations with AF.”

Studies on frailty and its overall impact on patients with AF are needed. In a new editorial paper, researchers Stephanie L. Harrison, Søren P. Johnsen and Gregory Y.H. Lip from Liverpool John Moores University and Liverpool Heart and Chest Hospital discuss some of the existing studies assessing frailty and AF in terms of patient outcomes and clinical decision-making. The researchers also discuss recommendations for clinical management of AF and frailty patients and include suggestions for future studies. On July 19, 2023, their editorial was published in Aging’s Volume 15, Issue 14, entitled, “The impact of frailty on the management of atrial fibrillation.”

Full blog - https://aging-us.org/2023/08/navigating-the-frailty-factor-in-atrial-fibrillation-management/

Paper DOI - https://doi.org/10.18632/aging.204918

Corresponding author - Gregory Y.H. Lip - gregory.lip@liverpool.ac.uk

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Keywords - aging, frailty, atrial fibrillation, multimorbidity and polypharmacy, ABC pathway

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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Navigating the Frailty Factor in Atrial Fibrillation Management

BLOG: Navigating the Frailty Factor in Atrial Fibrillation Management

On this Episode 429 of Health Solutions, Shawn Needham R. Ph. discusses atrial fibrillation with Dr. James Kneller. 

Dr. Kneller is available for second opinion consultations, both online and in person. Please use the following link to schedule your appointment with Dr. Kneller 👉 https://naturalheartdoctor.com/dr-kneller/

Dr. James Kneller is one of the nation’s leading heart rhythm specialists. Dr. Kneller is certified by the American Board of Internal Medicine (ABIM) in clinical cardiac electrophysiology, cardiovascular disease, and internal medicine. As a Fellow of the Heart Rhythm Society (FHRS) and Certified Cardiac Device Specialist (CCDS), Kneller provides comprehensive patient care, combining best medical practice with invasive procedures using state-of-the-art technologies to treat heart rhythm disorders.

00:00 - Start
00:34 - Dr. Kneller’s Intro
01:13 - Dr. Kneller’s Background
03:00 - Ablations
05:33 - Defining Atrial Fibrillation
07:54 - Symptoms 
09:47 - Cardioversion
12:16 - Causes 
14:00 - Contributing Factors
17:52 - Impact of Lifestyle
21:50 - Mineral Deficiency
24:07 - Potassium
25:33 - Various Herbal Treatments
32:53 - Sourcing Drugs from Plants
35:06 - Empowering Patients
36:27 - Dr. Kneller’s Passion
37:20 - Dr. Kneller’s Contact Information
39:32 - Closing Comments

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Website ~ www.JamesKnellerMD.com

EP 429: Dr. James Kneller Discussing Atrial Fibrillation with Shawn Needham R. Ph.

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EP 429: Dr. James Kneller Discussing Atrial Fibrillation with Shawn Needham R. Ph.

By listening to this podcast, you agree to the following terms: The content shared here is for informational purposes only and is not a substitute for professional medical advice. We do not offer medical guidance, and decisions regarding your health should be made in consultation with a qualified healthcare provider. If you suspect a medical issue, seek immediate attention. The podcast and its creators are not liable for any decisions or actions based on shared information.

Now Available On Amazon: THE AFIB HACK: 10 Natural Remedies for Managing Atrial Fibrillation: A Comprehensive Guide



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AFib Awareness: Heart Health Simplified

10 Diet and Nutrition Tips for Managing AFib in 30 Days 2025

By listening to this podcast, you agree to the following terms: The content shared here is for informational purposes only and is not a substitute for professional medical advice. We do not offer medical guidance, and decisions regarding your health should be made in consultation with a qualified healthcare provider. If you suspect a medical issue, seek immediate attention. The podcast and its creators are not liable for any decisions or actions based on shared information.

Now Available On Amazon: THE AFIB HACK: 10 Natural Remedies for Managing Atrial Fibrillation: A Comprehensive Guide


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Key Words:
AFib
Atrial Fibrillation
Heart Health
Best diet for afib
afib awareness
afib and fatigue
afib natural remedies
afib and anxiety
afib complications
afib chest pain

10 Important Roles of Sleep in Heart Health and AFib Management in 2025

BUFFALO, NY — May 14, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 4, on April 10, 2025, titled “Impact of Factor Xa inhibitors on cardiovascular events in older patients with nonvalvular atrial fibrillation.”

In this study, first author Masahiko Takahashi and corresponding author Keisuke Okawa led a research team from Kagawa Prefectural Central Hospital and Hyogo Medical University that investigated whether Factor Xa inhibitors (Xa-Is)—a type of blood thinner—can reduce the risk of heart-related complications in patients over 80 with nonvalvular atrial fibrillation (NVAF). The study found that patients using Xa-Is experienced significantly fewer cardiovascular problems than those on other anticoagulants. This finding is especially relevant, as older adults face a high risk of both stroke and heart disease.

Atrial fibrillation is a common heart rhythm disorder, particularly in the elderly, that increases the risk of blood clots, heart failure, and stroke. Anticoagulants are often prescribed to prevent clots, but not all types have the same effects on heart health. This study focused on comparing Xa-Is—specifically rivaroxaban, apixaban, and edoxaban—with commonly used drugs such as warfarin and dabigatran.

Researchers followed more than 1,000 patients aged 80 and above for up to five years to assess the long-term impact of these medications on cardiovascular outcomes. Patients who used Xa-Is had significantly lower rates of heart failure, artery disease, and cardiovascular death. The risk of cardiovascular problems in the Xa-I group was less than half that of those on non-Xa-I medications. These benefits remained even after adjusting for factors like age, existing heart conditions, and kidney function. Additionally, stroke and all-cause death rates were notably lower in the Xa-I group. 

“Xa-Is may be useful for not only anticoagulation but also the prevention of cardiovascular events in very old patients with NVAF.”

What makes Xa-Is different, according to the researchers, is their ability to inhibit a specific biological pathway—known as Factor Xa–PAR2—that contributes to inflammation, fibrosis, and damage in blood vessels and heart tissue. This effect extends beyond their traditional role in preventing blood clots. Although the study was conducted at a single medical center in Japan, its rigorous design and long follow-up period enhance the reliability of the findings for real-world clinical decision-making.

While further studies, especially across multiple centers, are needed to confirm the full range of benefits, this study strongly suggests that Xa-Is may offer broader cardiovascular protection for very old patients. The findings could influence how clinicians choose blood thinners for elderly individuals with atrial fibrillation, potentially improving both survival and quality of life in this growing population.

DOI - https://doi.org/10.18632/aging.206238

Corresponding author - Keisuke Okawa - k-ookawa@chp-kagawa.jp

Video short - https://www.youtube.com/watch?v=YtbYpfVDVDI

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Keywords - aging, Factor Xa inhibitor, atrial fibrillation, older patient, cardiovascular events

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Blood Thinners Called Factor Xa Inhibitors Lower Heart Risk in Elderly with Atrial Fibrillation

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

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Boldly Empowering 30s ~ 60s+ to Take Charge of Their Health. Bio Identical Hormone Balancing. Medical Freedom. Optimal Health Tips. 25+ yrs as Cash Only Compounding Pharmacists. Twice weekly Live Podcast.

New tracks tagged #AtrialFibrillation