Dr. Tony Nader is a medical doctor, neuroscientist, and the global leader of the Transcendental Meditation movement. He holds an MD from the American University of Beirut and a PhD in neuroscience from MIT. 

In this conversation, we explore Dr. Nader’s provocative claim that consciousness is not a byproduct of the brain—but the ground of all being. Drawing on neuroscience, quantum physics, and thousands of years of contemplative practice, he shares a paradigm that reframes life’s biggest questions—from free will and death to the nature of truth, karma, and the self.

Expect to learn:

— What Maslow got wrong and the practical value of transcending before striving

— Why expanding consciousness is the purpose of life

— Dr Nader’s views on the relationship between the brain and consciousness.

— What this model says about death, reincarnation, and the expansion of self

And more.

You can learn more about Dr. Nader’s work at https://drtonynader.com or by exploring his book, Consciousness is All There Is.

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Dr. Tony Nader is a globally recognized leader in the field of consciousness and a renowned neuroscientist with a distinguished academic background. He is the president of Maharishi International University, a medical doctor trained at Harvard University and Massachusetts Institute of Technology (Ph.D. in neuroscience) and a globally recognized expert in the science of Consciousness and human development. Dr Nader’s training includes internal medicine, psychiatry, and neurology, and he is a New York Times bestselling author. His award winning book Consciousness Is All There Is has received the highest praise much like his latest book Super Habits for Success.

Dr Nader has had recent discussions with some of the great thinkers, scientists, medical doctors and leaders in the world today. He has been featured by WIRED magazine, BBC, CNN, Gaia Network, and served as keynote for the United Nations, YPO and Stanford university’s “Hacking Consciousness”.

He’s the recipient of numerous award's for his outstanding contribution in human development, environment, education, and health.

He currently leads the global Transcendental Meditation organization, succeeding Maharishi Mahesh Yogi, and is dedicated to advancing the understanding of consciousness through both scientific and spiritual lenses.

---

Interview Links:

— Maharishi International University - https://www.miu.edu

— Dr Nader's website - https://drtonynader.com

— Dr Nader's book - https://amzn.to/45kVWCO

MIT Neuroscientist: Expanding Consciousness is the Purpose of Life — Dr. Tony Nader

I'm posting my music because I'm bored – Day 2

this edit will destroy your brain :3


BRAIN DAMAGE - 2025 EDIT

BUFFALO, NY — June 3, 2025 — A new #research paper was #published in  Aging (Aging-US) on May 1, 2025, as the #cover of Volume 17, Issue 5, titled “Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age.”

In this study, researchers Arjun Sapkota, Sebok K. Halder, and Richard Milner from San Diego Biomedical Research Institute investigated how aging affects the brain’s vulnerability to low oxygen, or hypoxia. Using C57BL/6J mice ranging from 2 to 23 months of age, they identified specific oxygen levels that disrupt the blood-brain barrier (BBB)—a critical structure that protects brain tissue from harmful substances. The findings are important for understanding age-related cognitive decline and the potential risks faced by individuals with chronic oxygen-limiting conditions such as asthma, sleep apnea, emphysema, and heart disease.

The BBB is essential for maintaining brain health. In this study, mild and prolonged hypoxia—called chronic mild hypoxia—was found to compromise the BBB in mice. Older mice showed significantly more BBB disruption than younger ones. Notably, barrier weakening and blood vessel changes occurred at oxygen levels of just 15% in aged mice, compared to 13% in young mice. These data suggest that the aging brain is more sensitive to oxygen deprivation, even at levels that may be considered only mildly hypoxic.

The researchers also determined when this vulnerability emerged. The BBB showed increased sensitivity to low oxygen not only in aged mice but also in mice as young as 2 to 6 months, with a second spike occurring between 12 and 15 months—equivalent to middle age in mice. These findings may reflect age-dependent changes in brain vascular function and remodeling capacity.

“Hypoxia-induced endothelial proliferation was relatively constant across the age range, but advanced age strongly enhanced the degree of BBB disruption (4-6-fold greater in 23 months vs. 2 months old).”

Another key focus was microglial activation, a sign of brain inflammation. Aged mice exhibited higher microglial activation across all oxygen levels, including normal conditions. Chronic microglial activation is closely linked to neuroinflammation and has been implicated in diseases such as Alzheimer’s. While the rate of blood vessel formation was constant across ages, the degree of BBB disruption increased sharply with age, suggesting that repair mechanisms may weaken over time.

These results may help explain why older adults with chronic hypoxia-related diseases are at higher risk for neurodegeneration and cognitive decline. The study also draws attention to the risks of high-altitude exposure for aging populations, where oxygen levels naturally drop.

Altogether, these findings underscore the importance of protecting brain health in older individuals by managing oxygen exposure and reducing hypoxia-related risks. The researchers emphasize the need to develop new therapies that support blood-brain barrier integrity, particularly in aging populations exposed to chronic or intermittent low-oxygen conditions.

DOI - https://doi.org/10.18632/aging.206241

Corresponding author - Richard Milner - rmilner@sdbri.org

Video short - https://www.youtube.com/watch?v=Nr6rTm7aJRo

Keywords - aging, blood-brain barrier integrity, endothelial, proliferation, microglia, chronic mild hypoxia, hypoxic threshold

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Bluesky - https://bsky.app/profile/aging-us.bsky.social
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

Aging Increases Brain’s Sensitivity to Hypoxia and Blood-Brain Barrier Damage in Mice

me and @shino_music
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patapim (ft. shino)

Texas DEI ban impact on higher education diversity, African American and LGBTQ+ students face reduced support as SB 37 restricts curriculum, threatening equity and academic freedom.

Texas DEI Ban Sparks Higher Ed Future Crisis

Stimulates brain activity and neural regeneration.
[C_預防失智與神經連結_40hz_soothing-meditation-191944]

40Hz | Dementia Prevention & Neural Pathways

Spotify

BAG OF PILLS 2025 - DNB REMIX

Mog Your Neighbors

BUFFALO, NY - June 11, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on May 29, 2025, titled “Durable complete response in leptomeningeal disease of EGFR mutated non-small cell lung cancer to amivantamab, an EGFR-MET receptor bispecific antibody, after progressing on osimertinib.”

A team led by first author Jinah Kim, from the University of Vermont Medical Center, and corresponding author Young Kwang Chae, from the Feinberg School of Medicine, reports a clinical case in which a patient with advanced non-small cell lung cancer (NSCLC) carrying rare EGFR mutations responded remarkably to amivantamab after other treatments had failed. The patient experienced a complete resolution of brain and spinal fluid metastases, suggesting that amivantamab may be a viable option for patients with uncommon genetic profiles and limited therapy options.

Lung cancer remains one of the leading causes of cancer-related deaths worldwide. Patients with NSCLC who have rare mutations in the EGFR gene often face limited treatment options and poor outcomes, especially when the disease spreads to the brain or spinal fluid. This case involved a 67-year-old man diagnosed with NSCLC who had two rare EGFR mutations—G719A and A289V. After disease progression on osimertinib and other therapies, the patient began amivantamab monotherapy.

Within six weeks, his lung tumor shrank by over 30 percent. By six months, imaging confirmed the disappearance of brain metastases and leptomeningeal disease, a serious condition affecting the membranes of the brain and spinal cord. Blood tests showed no detectable cancer-related mutations, and the patient, previously wheelchair-bound, regained the ability to walk and perform daily activities. This response has been sustained for more than 19 months.

 “Treatment produced a durable response over 19 months, including a 32.2% reduction in tumor size at six weeks, and complete resolution of brain metastases and LMD by six months.”

Amivantamab is a bispecific antibody that targets EGFR and MET, two key drivers of tumor growth. While it is approved in combination regimens for common EGFR mutations, its effectiveness as a single agent in rare mutations or in treating brain metastases remains largely unproven. This case challenges the assumption that large antibody drugs cannot cross the blood-brain barrier and suggests that amivantamab may have potential in managing central nervous system involvement. Further research is needed to clarify how the drug achieves these effects and to explore its broader use in patients with rare EGFR mutations and limited treatment options.

This case highlights three key findings: amivantamab may be effective against rare EGFR mutations, can be used as monotherapy, and may overcome the challenges of the blood-brain barrier. Although based on a single patient, the results provide encouraging evidence to support further investigation of amivantamab in treating difficult-to-manage forms of NSCLC.

DOI - https://doi.org/10.18632/oncotarget.28730

Correspondence to - Young Kwang Chae - young.chae@northwestern.edu

Video short - https://www.youtube.com/watch?v=RJX3rmtH7h8

Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/

Keywords - cancer, amivantamab, monotherapy, rare EGFR mutation, NSCLC, leptomeningeal disease

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

Facebook - https://www.facebook.com/Oncotarget/
X - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/@OncotargetJournal
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/
Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

Oncotarget

Rare Non-Small Cell Lung Cancer with Brain Metastases Responds to Amivantamab Monotherapy

As we age, our brains become more sensitive to stress and disease. A recent study sheds light on a lesser-known risk: reduced oxygen levels. The study, titled “Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age” and recently published as the cover for Volume 17, Issue 5 of Aging (Aging-US), found that low oxygen—also called hypoxia—can harm the aging brain by disrupting the blood-brain barrier (BBB). This damage may contribute to cognitive decline, memory problems, and an increased risk of dementia.

Understanding Hypoxia in the Brain

The brain relies on a steady supply of oxygen to stay healthy. When oxygen levels fall—a condition known as hypoxia—the brain undergoes changes to adapt. These changes include the remodeling of blood vessels and, importantly, a weakening of the blood-brain barrier. The BBB acts as a filter, protecting brain tissue from harmful substances. When it breaks down, it can lead to inflammation, brain cell damage, and cognitive issues.

Hypoxia is common in older adults, especially those with conditions like sleep apnea, chronic obstructive pulmonary disease (COPD), heart failure, and asthma. That is why understanding the connection between low oxygen and the aging brain is crucial for preventing long-term neurological damage.

Full blog - https://aging-us.org/2025/06/oxygen-deprivation-and-the-aging-brain-a-hidden-trigger-for-cognitive-decline/

Paper DOI - https://doi.org/10.18632/aging.206241

Corresponding author - Richard Milner - rmilner@sdbri.org

Video short - https://www.youtube.com/watch?v=Nr6rTm7aJRo

Sign up for free Altmetric alerts about this article - 
https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206241

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

Keywords - aging, blood-brain barrier integrity, endothelial, proliferation, microglia, chronic mild hypoxia, hypoxic threshold

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Bluesky - https://bsky.app/profile/aging-us.bsky.social
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Oxygen Deprivation and the Aging Brain: A Hidden Trigger for Cognitive Decline

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Chinese Version
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English Version
Soul-healing audio with targeted frequencies to realign your mind, body, and spirit.
Tune in to transform.
Focused on: 528Hz Healing | 417Hz Cleansing | 963Hz Crown Activation
Now available on Spotify / Apple Music. Search for "Soul of Cosmos".

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Cancer and aging are two sides of age-related tumorigenesis.

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

NMD is an emerging force in the Australian Drum & Bass scene, blending the raw energy of AUS hip-hop with the heavy, filthy drops that'll make you slap yah Nan. After stepping away from producing Melbourne minimal for a few years, NMD has redefined his sound, carving out a unique space with his hard-hitting style and undeniable flair.

With collaborations alongside talents like LAVEZ, BURDBRAIN, JAB, RUDZKII, GREESY, CROFTY, and CORTEXT, as well as early support from heavyweights like COMPLETE, YNG MARTYR. NMD is quickly building momentum.

Still early in his journey, he’s already proving that he’s one to watch — delivering gritty, genre-bending tracks that hit just as hard in the headphones as they do on the dancefloor.

Insights for Evolving Consciousness

In-depth interviews with leading thinkers at the intersection of psychology, neuroscience, culture, and spirituality.

This show is for you if you’re interested in:

– Reducing suffering — in yourself and others
– Continuously upgrading your perspective
– Realising more of your potential
– Experiencing a greater sense of awe, meaning, and connection in everyday life.

New episodes every Thursday.

New tracks tagged #Brain