This week we’re joined by Brain Under Construction – a legend bringing pure energy and good vibes to the Doof Disorder mix. Expect an absolutely beatufiul and totally entrancing set that’ll keep you moving start to finish.

FIND BRAIN UNDER CONSTRUCTION BELOW: 

INSTAGRAM: https://www.instagram.com/brain__under__construction?utm_source=ig_web_button_share_sheet&igsh=ZDNlZDc0MzIxNw==

SOUNDCLOUD: https://on.soundcloud.com/UuFOLUhUw1GvAhVqCb

Doof Disorder l Episode 9 l Brain Under Construction

We often contemplate superintelligent entities, and advances in AI and human mind augmentation may soon bring them about. But how big could they get? What would they think about? And might you, or I, one day become one ourselves?

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SFIA Discord Server: https://discord.gg/53GAShE
Credits:
Jupiter Brains & Mega Minds [2025 Extended Edition]
Written, Produced & Narrated by: Isaac Arthur
Graphics:
Jeremy Jozwik
Sergio Botero
Ken York
Select imagery/video supplied by Getty Images
Music Courtesy of Epidemic Sound http://epidemicsound.com/creator

Jupiter Brains & Mega Minds

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. While the development of targeted therapies has improved outcomes for many patients with EGFR-mutated NSCLC, those with rare EGFR variants often face limited treatment options, especially when the disease involves the central nervous system (CNS).

A recent research paper, titled “Durable complete response in leptomeningeal disease of EGFR mutated non-small cell lung cancer to amivantamab, an EGFR-MET receptor bispecific antibody, after progressing on osimertinib” published in Volume 16 of Oncotarget, describes a patient with NSCLC harboring two uncommon EGFR mutations—G719A and A289V—who experienced a prolonged and clinically significant response to amivantamab monotherapy, after prior treatments had failed.

Full blog - https://www.oncotarget.org/2025/08/26/amivantamab-monotherapy-in-rare-egfr-mutated-advanced-nsclc/

Paper DOI - https://doi.org/10.18632/oncotarget.28730

Correspondence to - Young Kwang Chae - young.chae@northwestern.edu

Video short - https://www.youtube.com/watch?v=UEiCz834a8c

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28730

Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/

Keywords - cancer, amivantamab, monotherapy, rare EGFR mutation, NSCLC, leptomeningeal disease

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

Oncotarget

Amivantamab Monotherapy in Rare EGFR-Mutated Advanced NSCLC

All about an active mind that just can't shut down. Always thinking.
www.roadrunnerreverie.com

A Ceiling Fan Mind

Jennifer Connelly, MD, Neuro-Oncologist with Froedtert's Cancer Center and Professor at MCW, will discuss the rarity of brain tumors and advancements being made in their diagnosis and treatment. She'll share the science, stories, and the strength of a community fighting back, showing how early research, small donations, and shared knowledge are fueling hope and prolonging life expectancy.

The Science Behind Brain Cancer

vivacious brain tumor

Demon eye (Prod. LxcalGus)

Brain knife

Brainrot - Grandson Cover by Nick Parry

Hey there, pickers and dreamers! We're thrilled to share "Your Brain's Alive," a bluegrass barnburner inspired by a groundbreaking neuroscience study that mapped a mouse's brain at single-cell resolution. This song's got the high-lonesome twang of mandolin, violin, and guitar, weaving a tale of neurons firing and decisions sparking across the mind's vast frontier. With foot-stomping rhythms and soaring harmonies, it celebrates the wonder of choice and the global quest to unlock the brain's secrets. Crank it up, let the strings sing, and feel your own brain light up! Recorded with love for fans of bluegrass, Americana, and the mysteries of the mind.

Your Brain's Alive

FREE DOWNLOAD: https://hypeddit.com/amuze/love-on-the-brain

Free Download

Love On The Brain x American Boy (AMUZE Edit - PITCHED, FILTERED)

ВНЕДРИЛИ ЧИПЫ

prod #me

#yrics_

i've lost my train of thought
i've lost my brain in an instant

if i talked it out
would even try to listen?

hold on again
just wait til may

you'll feel again
just one more day

hold on again
just wait til may

you'll feel again
just one more day

brain

sialorrhea

A bold statement against shallow rap culture. This track challenges rappers to move beyond “bitches, cars, and cash” and show that clever, conscious rap can be just as powerful and streetwise.

Brains Over Bitches (RAP)

kludwick

Love being in THE OUTCAST
still young 
freestyle artists 
Email for business inquiries:  tokyobobbybs@gmail.com

Musician | Musicologist | Composer/Producer | Music Teacher

Australia’s rave-born psychedelic and techno label/podcast.

Treatment: Immediate Bassline Therapy!

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Works of Levi Wilbert. Wyoming-based Colorado transplant, focusing on ambient/downtempo/soundtrack compositions, and audio recording studio experimentations.

Covers
I'm on facebook... it links you back here...
https://www.facebook.com/Nick-does-covers-952652974945395

Each month we’ll dig into the science behind a health topic making news today. Think of it as a virtual coffee break, with a science twist. You bring the coffee. We’ll bring a scientist. And together we’ll explore what science tells us about the health topics that matter to you!

Driven by a vision for a healthier Wisconsin, the Advancing a Healthier Wisconsin Endowment (AHW) reaches statewide, propelling the most promising work and ideas to build a healthier Wisconsin for generations to come.

New tracks tagged #Brain