Synucleinopathies are a group of age-related neurological disorders, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. Most individuals are not diagnosed until these diseases have significantly progressed, as early symptoms, such as a reduced sense of smell, subtle cognitive or motor changes are too vague to serve as reliable indicators. 

To uncover specific biological signs that appear earlier and clearly point to the disease process, researchers from Saarland University developed a study titled “Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model,” featured as the cover Aging-US, Volume 17, Issue 10.

Full blog - https://aging-us.org/2025/11/alpha-synuclein-overexpression-in-rats-reveals-early-clues-to-synucleinopathies/

Paper DOI - https://doi.org/10.18632/aging.206331

Corresponding author - Thomas Hentrich - thomas.hentrich@uni-saarland.de

Abstract video - https://www.youtube.com/watch?v=Yl6AfVchkb0

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Keywords - aging, alpha-synuclein, transgenic rat model, different brain regions, transcriptome analysis

To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at:

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Aging-US

Alpha-Synuclein Overexpression in Rats Reveals Early Clues to Synucleinopathies

What if the key to healing the brain wasn’t in a pill or a surgery, but in a headset? By stepping into immersive digital worlds with virtual reality (VR), scientists are discovering new ways to enhance neuroplasticity. But with such power to reshape the mind, VR also raises big questions: how real should “virtual” therapy get, and who can access this kind of therapeutic strategy? Join us as we journey through the science, the promise, and the ethical puzzles of healing in a virtual world.

This episode is sponsored by the Connected Minds program. Connected Minds, funded by the Canadian First Research Excellence Fund, is a 7-year collaborative program between York University and Queen’s University that focuses on interdisciplinary, ethical, and socially responsible research and technology development. The program offers funding for trainees, researchers, and artists. To learn more and get involved, visit the Connected Minds website.


Website: https://www.yorku.ca/research/connected-minds/a

Authors: Eve Racette, Golnar Taheri

Email: thinktwicepodcast@outlook.com 
Instagram: @thinktwice_podcast
LinkedIN: Think Twice Podcast
Patreon: https://www.patreon.com/ThinkTwicePodcast 

Disclaimer: Think Twice is a podcast for general information and entertainment purposes only. The content discussed in the episodes does not reflect the views of the podcast committee members or any institution they are affiliated with. The use of the information presented in this podcast is at the user’s own risk and is not intended to replace professional healthcare services. 

50: Can VR games cure your brain?

Buy 'The First Step' - https://fanlink.tv/YAMREC052

Yamatai Records announce the arrival of Gui, DKN, Brain, and Fearful with their tracks 'Kaioken' and 'The First Step', two cuts that pay true homage to the underground sound that we all love.

These four artists have become household names over the past two years, consistently producing some of the finest music to emerge within the Drum & Bass scene

↪ https://soundcloud.com/braindnb
https://www.instagram.com/braindnb__/

↪ https://soundcloud.com/fearful
https://www.instagram.com/fearfuluk/

↪ https://soundcloud.com/yamatairecords
https://www.instagram.com/yamatairecords/

Brain & Fearful - The First Step

DeLuXe DeMo1 4.  GoT, MaLaCHi & NoiR MoNeY ~ MoNYuN! BRaiN. ~ PRoD DJ KiNTUK

Had to try making some brain-rot music, sorry :)

GG-EZ.

Scientists Think They’ve Found a Way to Slow Your Brain’s Aging Learning another language could be a total game-changer for your cognitive health. 

“Slow Your Brain” is a CyberneticFusion™ release from Sweet Songs, inspired by research showing how learning a new language can support long-term cognitive health. The track follows that idea through shifting patterns and evolving textures, mirroring the way fresh words can wake new pathways in the mind. It leans into curiosity, renewal and the steady practice of staying mentally alive by exploring the unfamiliar. 

Verse 1
Step into the unfamiliar, let the words reshape the night.
New sounds rising in the circuits, pulling shadows into light.
Every phrase becomes a pathway, every pattern builds a chain.
You can feel the current shifting as you learn to slow your brain.

Chorus
Slow your brain, let the rhythm rearrange you.
Slow your brain, let the new words re-engage you.
In the turning of the language, in the spark you can reclaim,
There's a way to stay awake inside the flow and slow your brain.

Verse 2
Older pathways lose their edges when you leave them undisturbed.
But a single whispered vowel can wake the senses with a word.
Let the mind begin its dance again, let the meanings rise and wane.
Every sentence is a doorway to a place that slows your brain.

Bridge
Hold the sound, let it wander.
Let the shape of it remain.
Every syllable you ponder
Is a hand upon the rein.

Chorus
Slow your brain, let the rhythm rearrange you.
Slow your brain, let the new words re-engage you.
In the turning of the language, in the spark you can reclaim,
There's a way to stay awake inside the flow and slow your brain.


BUY ON BANDCAMP!

Slow Your Brain

Dr. Donna Thomas is a social scientist and researcher specializing in children's consciousness studies. With over 28 years of experience researching with children, she has pioneered investigations into children's transcendental experiences and altered states of consciousness, challenging conventional materialist paradigms.

In this conversation, we explore:

— How a near-death experience at age 15 transformed Dr. Thomas's understanding of identity and consciousness

— Why children may naturally access altered states of consciousness that adults often need "gateway tools" like meditation or psychedelics to reach

— The fascinating research on children's near-death experiences, including common patterns like spirals, tunnels, and feelings of "coming home"

— How our materialist paradigm often pathologizes children's transcendental experiences rather than recognizing their potential validity

— The compelling evidence for past life memories in children, including the surprising correlation between birthmarks and wounds from previous lives

And more.

You can learn more about Dr. Thomas's work through her book: "Children's Unexplained Experiences in a Post-Materialist World".

Get access to the 7 Insights Monthly Newsletter: http://bit.ly/seven-insights

---

Dr. Donna Thomas is a researcher, author, and lecturer whose pioneering work explores children’s unexplained experiences and what they reveal about consciousness and the nature of being human. She is the author of Children’s Unexplained Experiences in a Post-Materialist World, a groundbreaking book that challenges materialist views of reality and gives voice to children’s lived experiences of the extraordinary.

A Research Fellow and Co-Director at the University of Central Lancashire’s ICreateS International Research Unit, Dr. Thomas has spent over two decades studying how children describe experiences such as telepathy, near-death events, and intuitive knowing — and what these stories can teach us about the deeper dimensions of self and awareness.

Inspired by her own transformative experience at age fifteen, Dr. Thomas believes that listening to children with openness and respect can expand our understanding of consciousness and point toward a more compassionate, post-materialist worldview.

---

Interview Links:

— Dr Thomas’ book: https://amzn.to/3XofnW6

— Dr Thomas’ X: https://x.com/donnamthomas / @donnamthomas

Children, Consciousness & Near-Death Experiences — Dr. Donna Thomas

disdain

I had brain surgery, and the noise was powerful, even with ear plugs in.  As a composer, I concentrated on the timing and that same day came up with this tune.  Crazy but serious...nuffsaid

MY MRI

Tell Me

Get your critical thinking caps on! ‘Think Twice’ discusses controversial topics in the field of neuroscience with the goal of bringing more nuance and rigor to mainstream media. We’ll take you past the headlines by breaking down relevant neuroscience topics, interviewing experts in the field and overcoming misinformation/disinformation with evidence-based content. This podcast is run by a small group of graduate students at the Centre for Neuroscience Studies at Queen’s University. We hope to bring down barriers to the dissemination of scientific information, give early-career neuroscientists a voice, and foster a culture of entertaining and accessible science communication.

I’ve been producing EDM in southern Sweden since 2009, spending my early years deep in Malmö’s club scene. That energy shaped my sound, and after studying experimental production at Malmö University, I kept pushing boundaries, exploring different styles of electronic music. 

My main focus is house and progressive house, lately iv'e been blending my style with my old style: gritty electronic synths, they always get me going! I'm trying to always blend new ideas with the classic sounds that I love. 

One of the most unforgettable moments of my career was performing in front of 30,000 people—an experience of a lifetime. 

You can find my latest music under here on SoundCloud and beyond.

Please pay for the songs you like by clicking the "buy" button (shopping cart) next to the 3 dots> ...

Composer/ Producer working hard to submit some music for Artists, Sports, Movies and TV Placements.

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

SNB126 - https://skankandbass.fanlink.tv/SNB126

underground. curated.

Insights for Evolving Consciousness

In-depth interviews with leading thinkers at the intersection of psychology, neuroscience, culture, and spirituality.

This show is for you if you’re interested in:

– Reducing suffering — in yourself and others
– Continuously upgrading your perspective
– Realising more of your potential
– Experiencing a greater sense of awe, meaning, and connection in everyday life.

New episodes every Thursday.

ON MY 3RD SMURF ALLREADY <(:3)EX|X3({:)>
|/\/\/|\/\/\|~216~201~72~72~9005~|/\/\/|\/\/\|
~~~~~~~~~The Eternal =DoW=²~~~~~~~~~
i WiLL FoReVeR ReMaiN.,~'`~,~`~,~`~,~`~,
Be aBoVe DeaTH~,~`~,~`~,~`~,~`~,~`~,~`~,
`~,~`~,~`;GiVe ouT TreaSure:~`~,~`~,~`~,~`
,~`~,~`~,~`~,~`~,~:BeLieF aLTeRS DuRaTioN`~,


FiND MoRe oF MY MuSiC oN DJKiNTUK YouTuBe PaGe!!!


FYCJ YUH BIUTCH

New tracks tagged #Brain