Have you ever wondered how artificial intelligence (AI) is used in research in a healthcare setting? Rebecca Wray and Bill McGough, two PhD students at the University of Cambridge, both use AI in different ways in their research into the screening and treatment of kidney cancer.

Rebecca is an MRes PhD student investigating the response and resistance to therapy in patients with kidney cancer. She uses AI to find tumour features at multiple scales. For his PhD, Bill is developing AI models that will sift through the mounds of imaging data produced during the Yorkshire Kidney Screening Trial (funded by Yorkshire Cancer Research), flagging images that show masses in the kidneys.

This interesting conversation gives insight into how researchers are using patient data safely in order for AI models to integrate all the information about a patient to help review their treatment and personalise it. The discussion also highlights how using AI in the screening setting is speeding up processes to help save clinicians' time and allowing the potential earlier detection of kidney cancer in a cost-effective manner.

Integrated Cancer Medicine: Research in Focus

Using AI in the screening and treatment of kidney cancer

Tany Espíndola de Muntaner

Jennifer Connelly, MD, Neuro-Oncologist with Froedtert's Cancer Center and Professor at MCW, will discuss the rarity of brain tumors and advancements being made in their diagnosis and treatment. She'll share the science, stories, and the strength of a community fighting back, showing how early research, small donations, and shared knowledge are fueling hope and prolonging life expectancy.

The Science Behind Brain Cancer

retardedautism

Special Request: An autistic father who lost his autistic son due to cancer

Shadows in the Silence

BUFFALO, NY – August 29, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on August 29, 2025, titled “In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma.”

In this study led by first author Kristen Kwong and corresponding author Amit J. Sabnis from the Department of Pediatrics, Division of Oncology, University of California San Francisco, researchers discovered that disrupting the protein quality control system in cancer cells slows tumor growth in rhabdomyosarcoma (RMS), the most common pediatric soft tissue cancer. This finding points to a new strategy for treating high-risk childhood cancers that often resist current therapies.

Rhabdomyosarcoma is a rare and aggressive cancer that primarily affects children and adolescents. Standard treatments like chemotherapy and radiation often have limited long-term success in high-risk cases. This study explored a different approach: targeting the cellular machinery that maintains protein quality, known as the proteostasis network. Cancer cells rely heavily on this system to survive stress caused by rapid growth and genetic instability.

“To examine whether MAL3-101 or more drug-like proteostasis inhibitors represent a new therapeutic strategy for RMS, we screened proteostasis components that might recapitulate the effects of MAL3-101 in vivo.”

The researchers first used a compound called MAL3-101 to disrupt protein control in RMS cells. They then identified which parts of the protein quality system were affected. Based on those findings, they searched for more drug-like compounds that could target the same pathways. 

They focused on a protein called p97, which plays a critical role in removing damaged or misfolded proteins. When they blocked p97 using a drug called CB-5083, the cancer cells could no longer manage internal stress and began to self-destruct. In both laboratory models and mice implanted with human RMS tumors, the treatment significantly slowed or stopped tumor growth. The drug triggered a stress response in the cells known as the unfolded protein response, which can lead to either recovery or programmed cell death.

However, not all tumors responded the same way. Some resisted the treatment by activating a backup system called autophagy, which allows cells to recycle parts of themselves under stress. By comparing tumors that responded well to those that did not, the researchers found that higher autophagy activity could serve as a warning sign for resistance. This insight may help identify which patients are more likely to benefit from therapies that target protein quality control.

While the results are promising, the drug’s effectiveness depended on the tumor’s genetic profile and how it handled stress. Combining p97 inhibition with other treatments or blocking alternative survival pathways like autophagy may improve outcomes. The researchers also noted the importance of developing safer and more targeted drugs to reduce side effects.

This study opens new possibilities for personalized cancer treatment, particularly for children with aggressive or relapsed RMS. By weakening the systems that cancer cells depend on to survive, rather than only using toxic treatments to kill them, scientists aim to develop more effective and less harmful therapies for young patients.

DOI - https://doi.org/10.18632/oncotarget.28764

Correspondence to - Amit J. Sabnis - amit.sabnis@ucsf.edu

Video short - https://www.youtube.com/watch?v=YsdffTkXNRQ

To learn more about Oncotarget, visit https://www.oncotarget.com.

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Oncotarget

Blocking Protein Control Pathway Slows Rhabdomyosarcoma Growth in Mice

¿Es posible ir detectando las señales de alerta de un cáncer infantil?, ¿cuáles son estas?, ¿cuáles son los casos de cáncer infantil más comúnes en el Perú? , conversamos con la Dra. Essy Maradiegue Chirinos, directora de la Dirección de Prevenciòn y Control del Cáncer del ministerio de Salud (Minsa) quien nos orienta además sobre la prevención y tratamientos existentes.

Cáncer infantil: ¿Cuáles son los más frecuentes en el Perú?

N403 - Câncer e diabetes - Fernando Valente e Virgínia Fernandes

Danny Heinsohn the founder of My Hometown Heroes, a national scholarship fund for college bound cancer survivors enrolled in universities, community colleges, and trade schools. Their mission is to help bridge the gap between cancer and college, one scholarship at a time.  Every year there are over 77,000 young adults between the ages of 15 and 39 years old who are diagnosed with cancer. And more alarming is the fact that according to statistics released in January 2025 by the American Cancer Society, which found that cancer incidence rates in women under 50 are now 82% higher than their male counterparts. Danny Heinsohn tells his story of survival and how others benefit from his work and his non-profit organization.
MyHomeTownHeroes.org
Sageintl.com

Danny Heinsohn with My Hometown Heros

La Agencia Peruana de Noticias Andina los invita a escuchar los programas de Andina Radio y las entrevistas realizadas por nuestros periodistas en formato podcast de libre descarga. Pueden seguirnos en www.andina.pe

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Join Cheri Hill, “Wealth Protection Diva” for an array of fascinating topics centered on what it takes to start, grow, and maintain a successful business.
Not your ordinary business talk show, each week features a successful business owner, community leader or Industry expert who shares their challenges, insights, and advice. Learn about the hidden gems, resources and special events featuring local businesses and nonprofit organizations doing great work within our community. 
Sprinkle on relevant facts, new ideas, inspiring thoughts, invaluable guidance, and of course encouragement-All of the key things it takes to spark and fuel your entrepreneurial dream!
Airs Mondays at 11:30 am and Sundays at 1:00 pm (PDT) on 1060 AM KFOY  Radio.

Acompanhe as últimas novidades sobre o diabetes, tratamentos e muito mais, com os Podcasts da Sociedade Brasileira de Diabetes, exclusivos para profissionais da saúde.

Os programas contarão com a participação de grandes diabetologistas brasileiros, comentando artigos nacionais e internacionais, para que você esteja sempre bem informado sobre as últimas tendências.

Each month we’ll dig into the science behind a health topic making news today. Think of it as a virtual coffee break, with a science twist. You bring the coffee. We’ll bring a scientist. And together we’ll explore what science tells us about the health topics that matter to you!

Driven by a vision for a healthier Wisconsin, the Advancing a Healthier Wisconsin Endowment (AHW) reaches statewide, propelling the most promising work and ideas to build a healthier Wisconsin for generations to come.

The Cancer Research UK Cambridge Centre unites over 1,000 world-leading biologists, chemists, physicists, engineers, mathematicians, computer scientists, clinicians, nurses and allied healthcare professionals from across Cambridge, UK to tackle cancer from every angle.

Our mission is to end death and disease caused by cancer through research, treatment and education. We are detecting cancer at its earliest stage and are developing personalised treatments for every patient through facilitating new collaborations and driving the translation of new scientific discoveries into clinical applications to improve patient care. By working together across a range of different disciplines, our members are breaking down the barriers between the laboratory and the clinic, enabling patients to benefit from the latest innovations in cancer science.

New tracks tagged #Cancer