As part of IASLC’s Lung Cancer Considered World Language Series, host Dr. Narjust Florez leads a Spanish-language discussion with three leaders in thoracic oncology across Latin America: Dr. Mónica Castro, Dr. Dolores de la Mata, and Dr. Maritza Ramos Ramírez. 

They discuss the current landscape of lung cancer in women across the region including unique risk factors and social challenges. The guests share their career paths, the barriers women face in thoracic oncology in Latin America, and their advice for the next generation entering the field. 

LCC in Spanish: Mujeres and oncologia toracica – Latinoamerica

BUFFALO, NY — December 1, 2025 — A new #research paper featured on the #cover of Volume 17, Issue 11 of Aging-US was #published on October 30, 2025, titled “SAMP-Score: a morphology-based machine learning classification method for screening pro-senescence compounds in p16 positive cancer cells.”

In this study led by first author Ryan Wallis along with corresponding author Cleo L. Bishop, from Queen Mary University of London, researchers developed a machine learning tool to identify compounds that induce cancer cells into senescence. The tool, called SAMP-Score, offers a new strategy for drug discovery in cancers with poor treatment options like basal-like breast cancer.

Senescence is a process where damaged or aged cells stop dividing. In cancer therapy, inducing senescence is an approach to control tumor growth. However, it is difficult to detect true senescence in cancer cells that already appear aged. These cancers, often called Sen-Mark+ cancers, include basal-like breast cancer and typically lack reliable markers to confirm senescence. SAMP-Score was designed to address this problem.

Instead of relying on traditional markers, the researchers built a machine learning model trained to recognize patterns based on senescent cells’ shape and structure under a microscope. These visual patterns, known as senescence-associated morphological profiles (SAMPs), allowed the model to distinguish real signs of aging from other effects such as toxicity or normal variation. By analyzing thousands of cell images, the model learned to classify whether a cell had truly entered senescence.

“To demonstrate the potential application of SAMP-Score in p16 positive cancer therapeutic discovery, we assessed a diversity screen of 10,000 novel chemical entities in MB-468 cells (p16 positive BLBC).”

The team used SAMP-Score to screen more than 10,000 experimental compounds. One compound, QM5928, consistently triggered senescence in several cancer cell types without killing them, making it a promising candidate for further study. Importantly, it worked in cancers resistant to known drugs like palbociclib, which are often ineffective in cancers with high p16 expression like basal-like breast cancer. 

Further analysis revealed that QM5928 caused the p16 protein to move into the nucleus of cancer cells, a possible sign that the protein is helping stop cell division. This subtle effect was only detectable using the detailed imaging and analysis made possible by SAMP-Score, highlighting the tool’s ability to distinguish true senescence from toxic responses and making it a powerful resource in cancer drug discovery.

By combining machine learning with high-resolution imaging, this study introduces a new way to find and evaluate cancer therapies. SAMP-Score could accelerate efforts to develop treatments that exploit the body’s natural aging processes to fight cancer, especially for patients with resistant tumors. The tool is openly available at GitHub, making it accessible for other researchers exploring senescence-based cancer therapies.

DOI - https://doi.org/10.18632/aging.206333

Corresponding author - Cleo L. Bishop - c.l.bishop@qmul.ac.uk

Abstract video - https://www.youtube.com/watch?v=qXI_KI3EgHE

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MEDIA@IMPACTJOURNALS.COM

Aging-US

Machine Learning Identifies Senescence-Inducing Compound for p16-Positive Cancer Cells

Audio bootleg proyección de la película The Mother Of Flies, The Adams Family. Mierc26/Nov/25 | Multiplex Belgrano, CABA Argentina | Festival Buenos Aires Rojo Sangre 2025

Mother Of Flies - The Adams Family - BARS 26-11-2025

LocalHero säsong 3 avsnitt 94:

Vi är I Fronto Icommunication I Stockholm och samtalar med eldsjälen Fredrik Hallstensson 

Gästas på Förebildspodden:

https://youtu.be/PpNETUwySCI?si=oxayQkYOuuRr6uKi

Vi samtalar om:

Om Förebildspodden.
Om by utanför Sundsvall och jobba på finska företaget Motonet varuhus.
Om köng 2018.
Om aktiv lokal ägare driva Electrolux Home-butik och importera kaffe i syditalien.
Att vara naiv.
Om vi bygger starka barn så slipper vi laga så många trasiga vuxna.
Om egoist tänkande i positiv mening.
Om ordet makt och maktposition.
Att ha haft struligt, trasigt och tufft hemma.
Att se sig själv I spegeln och säga att man är bra.
Att bryta Jantelagen och tacksamhet.
Att se olika perspektiv.
Om stiftelsen och om Göran Melin.
Att stiftelsen ska riktas till barn och ungdomar.
Om bilolyckan dä Göran omkom.
Om Anders Granström som hjälpte till.
Om hopp och glädje.
Att prata om barn som går bort.
Om Alexander Westman, 11 som hade en obotlig hjärntumör.
Om när Fredrik blev själv sjuk.
Om dödsbeskedet, att fråga någon hur man mår, ett ord kostar ingenting och bekräftelse.
Att se det lilla, leende, civilkurage och att göra saker för att hjälpa andra.

Om barnsjukhus och träffa många barn som har cancer.
Att barn är förebilder.
Om inre barnet och om nuet.
Om Ukraina resan, om mannen som hade ingen höger arm och perspektivet.
Om sjukvården och om ofiltrerad barn.
Om oskyldiga barn, människor i krig, om sidor, hat, att välja sidor och att rädda liv.
Om ambulans bilarna och om engagemangen.
Om föreläsningar, att se människan och att vara en riktig barnrättskämpe.
Om begreppet förebild och eldsjäl.







"Jag har bestämt mig att Fredrik ska få 25% av mina krafter nu" - Fredrik Hallstensson

Audio roundup of selected biopharma industry content from Scrip over the business week ended November 28, 2025. In this episode:  2027 Medicare price cuts likely not as large as CMS estimates; Zai Lab leads DLL3 lung cancer ADC race; Phase II failure for J&J’s Alzheimer’s asset posdinemab; Bayer's positive Phase III data for asundexian in stroke; and Pfizer/Astellas’s Padcev's first big win in bladder cancer study.

Story links: https://insights.citeline.com/scrip/podcasts/scrips-five-must-know-things/quick-listen-scrips-five-must-know-things-R4RCDF2RXVGVHPEX2WQ7A3JVKU/

This episode was produced with the help of AI text-to-voice and voice emulation tools.

Playlist: soundcloud.com/citelinesounds/sets/scrips-five-must-know-things

Scrip's Five Must-Know Things - Dec. 1, 2025

Порежь мне руки и скажи что я молодец

Ломай

BUFFALO, NY — December 3, 2025 — A new #essay was #published in Volume 17, Issue 11 of Aging-US on November 19, 2025, titled “On the intergenerational transfer of ideas in aging and cancer research: from the hypothalamus according to V.M. Dilman to the mTOR protein complex according to M.V. Blagosklonny.”

In this work, Aleksei G. Golubev from the N.N. Petrov National Medical Research Center of Oncology reflects on the legacy of two influential Russian scientists, Vladimir M. Dilman and his son Mikhail V. Blagosklonny, who each introduced groundbreaking ideas about aging and cancer. Drawing from his own experience working in Dilman’s lab, Golubev explores how their ideas remain deeply relevant to today’s scientific understanding.

The essay connects Dilman’s “elevation theory” with Blagosklonny’s “hyperfunction theory,” two frameworks that challenge the conventional view of aging as a process of decline. Instead, both propose that aging results from continued biological processes that once supported growth but eventually become harmful when left unchecked.

Dilman believed that aging begins with reduced sensitivity in the hypothalamus, a brain region that regulates the body’s balance. This desensitization disrupts metabolism and hormone levels, setting the stage for many chronic illnesses. Decades later, Blagosklonny expanded on this idea at the molecular level. Central to his theory is the mTOR protein complex, which regulates growth and metabolism and is now a major focus in aging research.

Golubev also explores the historical and personal connections between the two scientists. Dilman, an endocrinologist trained in the Soviet Union, and Blagosklonny, a molecular biologist educated during the post-Soviet period, represent two generations shaped by a shared scientific tradition. 

“Dilman’s scientific legacy is not as well recognized as it should be, partly due to bias in citation practices.”

The essay also draws attention to a troubling trend in science: the tendency to overlook early contributions, especially from non-Western scholars. Many of Dilman’s insights, such as the connection between high blood sugar, insulin resistance, and cancer, have since been validated by modern tools, yet his work is rarely cited. Golubev points out how citation practices, language barriers, and historical isolation have contributed to this lack of recognition.

Finally, Golubev encourages the scientific community to look back and acknowledge the foundational work that shaped modern aging science. It also highlights the importance of cross-generational knowledge in moving science forward. By tracing the intellectual journey from hormonal regulation in the brain to molecular pathways in cells, this essay demonstrated the relevance of old ideas in a new biological era.

DOI - https://doi.org/10.18632/aging.206338

Corresponding author - Aleksei G. Golubev - lxglbv@rambler.ru

Abstract video - https://www.youtube.com/watch?v=LvrdghTKGws

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Keywords - aging, gerontology, history of science, hyperfunction, mTOR, hypothalamus, cancer, metabolism, immunity

To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media:

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MEDIA@IMPACTJOURNALS.COM

How Two Russian Scientists Changed the Way We Understand Aging and Cancer

SAHMRI's Precision Cancer Medicine Theme Leader Professor Deborah White and blood cancer survivor, Janet Anderson, join FIVEaa Breakfast to talk about the link between microbiome and cancer and the exciting progress being made in tailoring cancer therapy. Raising funds to further this crucial research is the focus of this year's SAHMRI Christmas Appeal. 

Exploring the link between gut health and cancer

Colorectal cancer (CRC) remains the second leading cause of cancer-related deaths globally. While early detection significantly improves outcomes, many patients are diagnosed at advanced stages when treatment options are limited and relapse is common. To address this challenge, researchers are exploring whether existing drugs can be repurposed for cancer therapy, a strategy that could accelerate drug development while reducing associated costs and risks.

One class of drugs under investigation is statins, commonly prescribed to reduce cholesterol and prevent cardiovascular disease. Several studies have observed a potential link between elevated cholesterol and increased CRC risk. Cholesterol may support tumor growth by promoting membrane synthesis and energy metabolism in rapidly dividing cells.

Building on this connection, researchers from leading Indian institutions, including the Indian Institute of Science Education and Research and the Center of Excellence in Epigenetics at Shiv Nadar Institution of Eminence, investigated how statins influence CRC cells at the molecular level. Their goal was to determine whether these widely used drugs could have a therapeutic role in oncology.

The Study: Investigating the Molecular Impact of Statins in CRC Cells

The study, titled “Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer,” was published in Oncotarget (Volume 16). Using a combination of lipidomics, transcriptomics, proteomics, and 3D tumor models, the researchers explored how two widely prescribed statins, atorvastatin and simvastatin, affect molecular pathways associated with CRC progression. This integrative, multi-omics strategy enabled tracing statin-induced effects across different layers of cellular function, linking lipid, transcript, and protein changes to pathway-level shifts.

Full blog - https://www.oncotarget.org/2025/12/03/repurposing-statins-exploring-anti-tumor-effects-in-colorectal-cancer/

Paper DOI - https://doi.org/10.18632/oncotarget.28755

Correspondence to - Sanjeev Galande - sanjeev.galande@snu.edu.in

Abstract video - https://www.youtube.com/watch?v=A95ICULaH3Y

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Keywords - cancer, colorectal cancer, statins, SATB1, Wnt/β-catenin signaling, tumor-suppressive phenotype

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

Oncotarget

Repurposing Statins: Exploring Anti-Tumor Effects in Colorectal Cancer

So take me home…
Before I ruin something good on accident, again
Before I talk myself out loud into abandonment
Take me home, take me home, take me home….

I memorize escape routes
Every time I start to care
I wanna run, I wanna stay
But I hate myself for being scared
All the time

If I show you every broken part of me,
Would you put them back together?
Or would you leave and take a piece?

You look at me like it’s easy to stay
When I know I’m hard to keep
And it terrifies me, it terrifies me

I’m not ready for the honesty
Of what you might find inside of me
But God, I’m tired of being so strong

So take me home
Take me home

take me home (prod. everestdidthis)

What does abundance really mean when you are healing from cancer?

In this episode, Laura talks with cancer survivor and health coach Hayley Dubin about manifestation, mindset, intuition and the small actions that create meaningful change.

About Hayley Dubin:
Hayley is a Certified Health Coach, Metabolic Terrain Advocate and founder of reVIVE Wellness. She is also the host of The Cancer Liberation Project Podcast. As a 27-year ovarian cancer survivor, she supports people who have completed treatment or who have a strong family history of cancer. Her work focuses on helping clients release fear and step into confidence as they take ownership of their health.


Links:

Manifestation Quiz: https://www.thebreastcancerrecoverycoach.com/manifestation-block-quiz

Living With Intention 2026 Workshop: https://www.thebreastcancerrecoverycoach.com/2026

Andy Campbell | Finding Strength in the Storm: https://podcasts.apple.com/us/podcast/andy-campbell-finding-strength-in-the-storm/id1575422482?i=1000713564225


Hayley Dubin Links:

Website: www.revivewellness.com

Free Gift: 7 Top Tips to Keep Cancer Away and Feel Confident in Your Body Again! https://forms.aweber.com/form/81/821085181.htm

Podcast: The Cancer Liberation Project https://podcasts.apple.com/us/podcast/the-cancer-liberation-project/id1575422482

Social Media: 
Instagram: https://www.instagram.com/hayleydubin/ 
Facebook: https://www.facebook.com/revivewellness1
Linkedin: https://www.linkedin.com/in/hayley-dubin-91683627/



Let’s Connect!
If this episode helped you breathe a little easier, please share it with a friend or leave a review. Every share helps spread this message of hope, healing, and whole-person wellness.

💌 Join my email list for weekly wellness tips & podcast updates → The Breast Cancer Recovery Coach

👩‍💻 Follow me on Instagram for daily inspiration → @thebreastcancerrecoverycoach

👩‍💻 Follow me on Facebook → The Breast Cancer Recovery Coach

🎙 Subscribe & leave a review on Apple Podcasts → Better Than Before Breast Cancer with The Breast Cancer Recovery Coach

🎥 Watch on YouTube → @BetterThanBeforeBreastCancer

#440 Redefining Abundance - What Healing Looks Like Beyond the Body

Le chant du cygne

This episode of VHHA’s Patients Come First podcast features Tucker Smith, a future physician and student at the VCU School of Medicine who moonlights as a high-flying acrobat with Cirque du Soleil, an international company of modern circus performers who delight and dazzle. Our conversation covers Tucker’s unique path to medicine as well as aerial acrobatics and much more. Send questions, comments, feedback, or guest suggestions to pcfpodcast@vhha.com or contact on X (Twitter) (x.com/VirginiaHHA) or Instagram (www.instagram.com/virginiaHHA/) using the #PatientsComeFirst hashtag.

VHHA Patients Come First Podcast - Tucker Smith

"For three years, we knew Dad had a lump in his throat. He had trouble swallowing, and several times a day, he would be possessed by a mad coughing fit that would leave him clutching the furniture for support." 

In this opening from a highly-praised novel, an adult daughter begins to face her father's chronic pain, his impending death. How will she respond to his request for a merciful release?

Naked Singularity

“Moonshield Heart” is a glowing anthem of emotional depth, protection, and unconditional love. Inspired by the spirit of Cancer, this song tells the story of a heart that feels everything — deeply, quietly, fiercely — and still chooses to love.
It’s about being soft in a hard world, carrying storms inside your chest, and standing between darkness and the people you care about.

Moonshield Heart

Férias do meu tratamento de câncer de mama: é possível? 
No Onco Ponto de hoje você entenderá.

Tirar uma pausa do tratamento… pode?

Essa é uma das dúvidas mais frequentes entre pacientes com câncer de mama — especialmente quando chegam as férias, feriados prolongados ou momentos especiais em família.
Neste episódio do OncoPonto, as oncologistas Dra. Vivian Antunes, Dra. Susana Ramalho e Dr. Higor Mantovani, do Grupo SOnHe, explicam de forma leve e objetiva quando é seguro flexibilizar o tratamento, quais terapias permitem ajustes, o que jamais deve ser interrompido e como planejar viagens ou períodos fora da rotina com segurança.

Você vai entender:
• Se existe “pausa segura” no tratamento
• Diferenças entre quimioterapia, hormonioterapia e terapias-alvo
• Como alinhar expectativas com o seu oncologista
• Quais sinais de alerta exigem atenção mesmo durante as férias
• Como manter qualidade de vida sem comprometer os resultados

Um episódio essencial para pacientes, familiares e cuidadores que desejam viver a vida com mais liberdade, mas sem abrir mão da segurança.

Ouça agora no Youtube ou Spotify – Grupo SOnHe

Férias do meu tratamento de câncer de mama: é possível?

The paper featured on the cover of this issue of Aging-US, published on October 30, 2025, entitled “SAMP-Score: a morphology-based machine learning classification method for screening pro-senescence compounds in p16-positive cancer cells,” represents an important methodological and conceptual advance at the interface of senescence biology, imaging and drug discovery.

In this study, led by first author Ryan Wallis and corresponding author Cleo L. Bishop (Queen Mary University of London), the authors introduce SAMP-Score, a machine-learning–based framework designed to identify bona fide senescence induction in cancer cells where canonical markers fail. This is a timely and much-needed contribution to the field.

Therapy-induced senescence has emerged as a powerful strategy to restrain tumor growth, yet its reliable detection in cancer cells remains a major bottleneckIn these contexts, cells often already display features associated with cellular aging, rendering conventional senescence markers ambiguous or misleading. Distinguishing true senescence from toxicity, stress responses or baseline “aged” phenotypes is therefore a critical unmet need.

Rather than relying on predefined molecular readouts, the authors take a different approach and train a machine-learning model to recognize senescence-associated morphological profiles (SAMPs) which are subtle but reproducible changes in cellular architecture captured through high-content microscopy. By learning directly from image-based phenotypes, SAMP-Score is able to identify senescence with a level of precision that is difficult to achieve using marker-based strategies alone.

The strength of the platform demonstrated through a large-scale screen of over 10,000 novel chemical entities in p16-positive basal-like breast cancer cells. From this screen, the compound QM5928 emerged as a robust inducer of senescence across multiple cancer models, notably without inducing cytotoxicity. Importantly, QM5928 retains activity in cellular contexts that are resistant to CDK4/6 inhibition, including palbociclib-refractory, p16-high tumors.

Mechanistically, the authors show that QM5928 promotes nuclear relocalization of p16, consistent with a functional engagement of cell-cycle arrest pathways. These nuanced phenotypic changes would likely have gone undetected without the resolution and discrimination provided by SAMP-Score, underscoring the platform’s ability to separate true senescence from confounding cellular states.

This work exemplifies how machine learning and quantitative imaging can be harnessed to solve long-standing problems in senescence research, moving the field beyond binary marker expression toward phenotype-driven classification. Beyond its immediate relevance for cancer therapy, SAMP-Score offers a broadly applicable framework for senescence-based screening efforts across biological contexts.

DOI - https://doi.org/10.18632/aging.206333

Corresponding author - Cleo L. Bishop - c.l.bishop@qmul.ac.uk

Abstract video - https://www.youtube.com/watch?v=qXI_KI3EgHE

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To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at:

Bluesky - https://bsky.app/profile/aging-us.bsky.social
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MEDIA@IMPACTJOURNALS.COM

Aging-US Editors' Choice

https://hpgd.bandcamp.com/album/flies-dont-lie

Stranguliatorius return to Horror Pain Gore Death Productions to unleash their fourth album "Flies Don't Lie"! The Lithuanian savages Stranguliatorius are back with a vengeance, and deliver a brutal dose of raw Death Metal, infected by unhygienic guitars and a relentless grinding hangover. "Flies Don't Lie" delivers twelves tracks of sarcastic sadism, grotesque gory and relentless riffs that hit like a sledgehammer! Mastered by Jack Control (Aura Noir, Darkthrone, Cianide, Frozen Soul, etc.) at Enormous Door Mastering. For fans of Anatomia, Asphyx, Autopsy, Bolt Thrower, Cancer, Carcass, Coffins, Exhumed, Haemorrhage, Hooded Menace, Impetigo, Machetazo, Undergang and Unleashed

Stinks

my shit n beyond. #formulas
bootlegz, all kinda of em. concerts, movies, longtalks, presentations, jamz, covers,
Experimental rudimental mental live 
Here there n everywhere
xxxxxx

Citeline places biopharma and medical device professionals, and those who focus on these industries, at the forefront of knowledge and insight, by providing the perfect combination of news and information together with penetrating insight and analysis. Citeline is a leader in the field of healthcare industry information.

Local Hero är en podd om förebilder och eldsjälar där vi intervjuar personer som brinner för det de gör, inspirerar och gör något gott i världen. Dessa personer har olika yrken, sysselsättningar och professioner. Det kan vara stort som smått men något gott.  Antonio och Nils är två kollegor från en förskola, tycker inte att detta ska tas för givet och vill därmed lyfta dessa människor, sprida ljus och hopp samt inspirera andra.

The official HPGD SoundCloud page. Extreme Metal Record Label & Distro!

Follow us today and receive automatic updates with the latest new music from our entire roster!

Coming directly to you from Rangel City, and I'm going to deliver sick beats and banger tunes! FIRE EMOJI!!1!

Jag kommer direkt till dig från Rangelstan', och jag kommer leverera sjuka beats och banger tunes! FIRE EMOJI!!1!

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

The Strange Recital is an audio anthology of short fiction. We delight in perceptions of reality that warp and fold in unexpected ways. Each episode runs about 25 minutes and features a story by one writer, plus an author interview with a twist. For older episodes, visit our website.

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

I like to shoot guns and drive trucks and watch football and drink beer and eat chicken wings

reach out to me via social

Dr. Stephen Liu and Dr. Narjust Florez host Lung Cancer Considered, the podcast of The International Association for the Study of Lung Cancer (IASLC). IASLC is the only global organization dedicated solely to the study of lung cancer and other thoracic malignancies. Founded in 1974, the association's membership includes more than 11,000 lung cancer specialists across all disciplines in over 100 countries, forming a global network working together to conquer lung and thoracic cancers worldwide. The association also publishes the Journal of Thoracic Oncology, the primary educational and informational publication for topics relevant to the prevention, detection, diagnosis and treatment of all thoracic malignancies. Visit www.iaslc.org for more information.

Lung Cancer considered is funded in part by Current sponsors: 
•	AbbVie 
•	AstraZeneca
•	Gilead
•	J&J
•	Summit

New tracks tagged #Cancer