Breakthroughs in cancer research are playing a pivotal role in advancing treatments and therapies to fight the disease. Discover Advancements in Cancer Research, Treatments, and Therapies, inside this edition of CTSI Discovery Radio!

Episode #136 - Advancements in Cancer Research, Treatments & Therapies

Rub3Nve - Kill$hot

Rub3Nve - Not Tha Same

Rub3Nve - They Hate Us

Rub3Nve - Beamed

Rub3Nve - Krazy shi

She found strength in Psalm 23 and now shares her testimony of healing and hope to encourage others walking through their own valleys.  https://www.klove.com/news/god-stories/thou-art-with-me-first-lady-deangeloa-wells-testimony-of-faith-and-victory-over-cancer-andpodcast-55877

'Thou Art With Me': First Lady DeAngeloa Wells’ Testimony Of Faith And Victory Over Cancer

BUFFALO, NY – August 15, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on August 13, 2025, titled “Clinical and analytical validation of MI Cancer Seek®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay.”

In this study, first authors Valeriy Domenyuk and Kasey Benson, along with corresponding author David Spetzler from Caris Life Sciences in Irving, Texas, introduce MI Cancer Seek, an FDA-approved test designed to deliver comprehensive tumor profiling. MI Cancer Seek demonstrated strong concordance with other FDA-approved companion diagnostics and serves as a powerful tool to guide treatment decisions in both adult and pediatric cancer patients.

Cancer remains one of the most complex and diverse diseases to treat. With many targeted therapies currently FDA-approved, selecting the right one for a specific patient requires detailed genetic insights. MI Cancer Seek addresses this need by analyzing both DNA and RNA from a single tumor sample. The tool identifies key biomarkers linked to FDA-approved treatments for several major cancers, including breast, lung, colon, melanoma, and endometrial cancers.

One of the most significant strengths of MI Cancer Seek is its ability to deliver accurate and reliable results from minimal tissue input (50 ng). Even when analyzing formalin-fixed paraffin-embedded samples, which are widely used but often degraded, the test maintained high levels of accuracy. It successfully detected important genetic alterations such as PIK3CA, EGFR, BRAF, and KRAS/NRAS mutations and measured tumor mutational burden (TMB) and microsatellite instability (MSI), both of which are key indicators for immunotherapy response.

In clinical comparisons, the test achieved over 97% agreement with other FDA-approved diagnostic tools, confirming its reliability in detecting critical biomarkers. Notably, it showed near-perfect accuracy in identifying MSI status in colorectal and endometrial cancers. The researchers also demonstrated that the test maintains precision across different lab conditions and varying DNA input levels, confirming its robustness for routine clinical use.

Beyond its role as a companion diagnostic, MI Cancer Seek incorporates additional features developed under its predecessor, MI Tumor Seek Hybrid. These include detection of homologous recombination deficiency, structural variants, and cancer-related viruses. It also includes advanced tools such as the Genomic Probability Score for identifying the tissue of origin in cancers of unknown primary, as well as a gene signature to guide first-line chemotherapy in colorectal cancer.

“One limitation to be considered is the low PPA for ERBB2 CNA detection.”

By offering deeper genetic insights from a single, small sample, MI Cancer Seek has the potential to streamline diagnostics, reduce testing costs, and connect patients to effective therapies more quickly. As precision medicine continues to expand, this assay stands out as a comprehensive and efficient solution for meeting the evolving needs of modern oncology.

DOI - https://doi.org/10.18632/oncotarget.28761

Correspondence to - David Spetzler - dspetzler@carisls.com

Video short - https://www.youtube.com/watch?v=D4hd2FxCYY8

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Oncotarget

FDA-Approved MI Cancer Seek Test Enhances Tumor Profiling for Precision Oncology

Have you ever felt almost afraid to set a boundary—especially with someone you love? You’re not alone. In this episode, I share the story of a client who jokingly called it “boundary phobia” and how that phrase perfectly captures the fear and discomfort so many of us feel when we try to protect our time, energy, or emotional well-being.

We’ll talk about:

The fears that keep us saying “yes” when we want to say “no”

The myths we’ve been taught about boundaries and relationships

Why boundaries are about action as much as they are about words

How to set healthy boundaries with yourself first—and why that’s the key to holding them with others

A short guided reflection to help you identify one internal boundary you can start practicing today

If you’ve been feeling drained, resentful, or guilty about saying no, this episode will help you shift the way you think about boundaries so they feel less like walls and more like doors you control.



References from this episode:

Parents Magazine study on accepting unwanted invitations: https://www.parents.com/why-saying-no-is-good-for-your-mental-health-8415963

Stanford Student Affairs research on boundaries strengthening relationships: https://studentaffairs.stanford.edu/how-life-treeting-you-importance-of-boundaries

2020 study on relational boundaries and enforcement: https://self-compassion.org/wp-content/uploads/2021/11/Luchner-and-Snyder-2020-The-Importance-of-Flexible-Relational-Boundaries-.pdf

Mental Health Center on boundaries and burnout: https://www.mentalhealthctr.com/boundaries-and-mental-health

Dr. Kristin Neff’s self-compassion research: https://self-compassion.org/the-three-elements-of-self-compassion-2



Resources Mentioned:

Better Than Before Breast Cancer Life Coaching Membership: https://www.thebreastcancerrecoverycoach.com/lifecoaching

Creating a Life You Love in 168 Hours a Week: https://www.thebreastcancerrecoverycoach.com/168-hours-sp



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#424 Boundary Phobia After Breast Cancer

Los Titulares de Hoy - 15 de agosto de 2025

CTSI Discovery Radio is a unique facet of the Clinical & Translation Science Institute (CTSI) of Southeast Wisconsin. Each 30-minute monthly show informs and educates listeners about translational research relative to current health topics, clinical studies and advancements in biomedical research leading to better outcomes. CTSI Discovery Radio is hosted and produced by award-winning veteran radio personality Bryan Belmer.

Visit the CTSI website at https://ctsi.mcw.edu

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Democracy Now! es un programa independiente de noticias internacionales y de difusión diaria  que se transmite a través de más de 1300 emisoras de radio y televisión en todo el mundo. Esta es la cuenta de nuestra programación en español.

New tracks tagged #Cancer