This episode, 'Translating Promising Drug Candidates from Preclinical Screening to Clinical Trials,' will explore the challenges and successes of moving promising drug candidates from preclinical screening to clinical trials in oncology.

Join Dr. Steve Shnyder, Associate Professor at the Institute of Cancer Therapeutics, University of Bradford, as he explores:

- The unique challenges in oncology drug development.
- Preclinical model limitations and needed innovations.
- Translating preclinical insights into effective clinical trial design.
- The role of AI and machine learning in overcoming development hurdles.
- Real-world case studies of successful oncology drug approvals.



ranslating Promising Drug Candidates from Preclinical Screening to Clinical Trials

How is artificial intelligence being used in cancer care, and what do patients think about it?

In this 'Ask Me Anything' episode, Ellie Wolmark, Programme Manager for Integrated Cancer Medicine (ICM) at the CRUK Cambridge Centre, speaks with patient representatives Lorraine, Frankie, and Ann from across our Patient and Public Involvement groups, alongside ICM researchers Professor James Brenton, Dr Ines Machado, and Dr Gabriel Funingana from the University of Cambridge.

Together, they explore how artificial intelligence (AI) is being applied in cancer research, how it could support personalised treatment, and what the future might hold. The patients share thoughtful questions and concerns about the role of AI in healthcare, while the researchers explain how it's currently being used and what challenges remain.

This lively and insightful discussion highlights just how valuable patient involvement is in shaping research that truly meets the needs of those it aims to help.

Ask me anything about cancer

Ask me anything about... the use of artificial intelligence in healthcare

Why does eating more not fix the severe weight loss seen in some cancer patients, and what can be done about it?

In this 'Ask Me Anything' episode, Dr Hui-Ling Ou, Programme Manager for the Pancreatic Cancer and Cancer Immunology Programmes at the CRUK Cambridge Centre, speaks with researchers from the Cancer Cachexia Action Network (CANCAN): Dr Claire Connell (University of Cambridge and Cambridge University Hospitals NHS Foundation Trust), Dr David Lewis (CRUK Scotland Institute), and Dr Tobias Janowitz (Cold Spring Harbor Laboratory).

Together, they unpack what cancer-associated cachexia is, why it's so devastating for patients, and how scientists are working to understand and reverse this syndrome. The guests share how their research, spanning metabolism, imaging, immunology, and clinical studies, is bringing fresh insights and hope to a problem that affects quality of life for so many.

This thought-provoking discussion shines a light on the collaborative efforts driving progress against one of cancer's most challenging complications.

Ask me anything about... the science of cancer-associated cachexia

What do you most want to know about pancreatic cancer and cancer-associated cachexia?

In this special episode, we bring you a recording of a live 'Ask Me Anything (AMA)' event hosted by the CRUK Cambridge Centre Pancreatic Cancer Programme for World Pancreatic Cancer Day 2024.

A multidisciplinary and international panel of experts, including clinicians, researchers, nurses, dietitians and physiotherapists, answer thoughtful questions from the public about pancreatic cancer, cachexia and the latest research and care approaches. Topics range from understanding the biology of these diseases to managing symptoms and improving quality of life.

The discussion sheds light on the progress being made and the ongoing challenges in improving outcomes for people affected by these conditions.

Ask me anything about... cachexia research and management

Breakthroughs in cancer research are playing a pivotal role in advancing treatments and therapies to fight the disease. Discover Advancements in Cancer Research, Treatments, and Therapies, inside this edition of CTSI Discovery Radio!

Episode #136 - Advancements in Cancer Research, Treatments & Therapies

How can artificial intelligence (AI) support both cancer research and healthcare more generally? Anoushka Harit (University of Cambridge) and Dr Zhongtian Sun (University of Kent) join today's episode to discuss this topic.

Anoushka talks about her research in hereditary diffuse gastric cancer (HDGC) and the development of an AI system to enable early detection of signet ring cell carcinoma (SRCC) during endoscopy. This new AI system could help to treat SRCC better or to prevent or delay drastic life-changing treatment, preserving patients' quality of life.

Zhongtian shares insights on how AI can support health applications more generally and how he tries to make it as explainable as possible. He even talks about his wish to make the AI mimic as much as possible the way a human brain works!

Integrated Cancer Medicine: Research in Focus

Using AI to detect stomach cancer during endoscopy

Have you ever wondered how artificial intelligence (AI) is used in research in a healthcare setting? Rebecca Wray and Bill McGough, two PhD students at the University of Cambridge, both use AI in different ways in their research into the screening and treatment of kidney cancer.

Rebecca is an MRes PhD student investigating the response and resistance to therapy in patients with kidney cancer. She uses AI to find tumour features at multiple scales. For his PhD, Bill is developing AI models that will sift through the mounds of imaging data produced during the Yorkshire Kidney Screening Trial (funded by Yorkshire Cancer Research), flagging images that show masses in the kidneys.

This interesting conversation gives insight into how researchers are using patient data safely in order for AI models to integrate all the information about a patient to help review their treatment and personalise it. The discussion also highlights how using AI in the screening setting is speeding up processes to help save clinicians' time and allowing the potential earlier detection of kidney cancer in a cost-effective manner.

Using AI in the screening and treatment of kidney cancer

The Rise of Precision Medicine in Modern Cancer Research by Pier Paolo Pandolfi

What if a time machine could be built, not from metal but from human tissue, to help us understand cancer and how it responds to treatment?

Dr Alecia-Jane Twigger, Dr Akanksha Anand, Dr Kui Hua, Dr Pedro Victori and Dr Jo Worley from the University of Cambridge have done just that. In this episode, they talk about their project funded by Wellcome LEAP under the Delta Tissue programme to build a 'tissue time machine'. By studying tumour samples from patients with triple negative breast cancer before and after treatment, they aim to build a model that can predict how patients would respond to therapy.

The conversation offers a fascinating look at how a truly multidisciplinary team, bringing together scientists from very different fields, can achieve something remarkable.

Building a tissue time machine

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🔥🐓 Chicken Farm Fires | 🧬 Glucose & Cancer? | 💪 Protein Power for Health 🌿

Dr. Pier Paolo Pandolfi, an internationally recognized cancer researcher, resides in Baltimore, Maryland. Born and educated in Rome, Italy, he earned his M.D. and Ph.D. from the University of Perugia and later received an honorary master’s degree from Harvard Medical School. Pier Paolo has dual citizenship in Italy and the United States and has traveled extensively for his work. His career highlights include serving as an Attending Physician at Memorial Sloan-Kettering Cancer Center and holding academic roles at the University of Turin, Harvard, and Cornell. At the PTEN Research Institute (ptenresearchinstitute.org), he continues to pioneer new therapies aimed at treating and ultimately curing a broader range of cancers.

CTSI Discovery Radio is a unique facet of the Clinical & Translation Science Institute (CTSI) of Southeast Wisconsin. Each 30-minute monthly show informs and educates listeners about translational research relative to current health topics, clinical studies and advancements in biomedical research leading to better outcomes. CTSI Discovery Radio is hosted and produced by award-winning veteran radio personality Bryan Belmer.

Visit the CTSI website at https://ctsi.mcw.edu

Empowering & Connecting People To Real Solutions For Health

The Cancer Research UK Cambridge Centre unites over 1,000 world-leading biologists, chemists, physicists, engineers, mathematicians, computer scientists, clinicians, nurses and allied healthcare professionals from across Cambridge, UK to tackle cancer from every angle.

Our mission is to end death and disease caused by cancer through research, treatment and education. We are detecting cancer at its earliest stage and are developing personalised treatments for every patient through facilitating new collaborations and driving the translation of new scientific discoveries into clinical applications to improve patient care. By working together across a range of different disciplines, our members are breaking down the barriers between the laboratory and the clinic, enabling patients to benefit from the latest innovations in cancer science.

New tracks tagged #Cancer Research