Professor Jason Carroll speaks about his research in molecular oncology, with a focus on the work underpinning the PIONEER breast cancer trial and the outcomes of this clinical trial.

Jason is Professor of Molecular Oncology and Senior Group Leader at the CRUK Cambridge Institute, University of Cambridge, UK. He is also co-lead for the Precision Breast Cancer Virtual Institute at the CRUK Cambridge Centre, UK.

Integrated Cancer Medicine: Research in Focus

Molecular oncology research and the PIONEER breast cancer clinical trial

In today's episode, Marika Reinius and Maria Delgado Ortet talk about the multidisciplinary 3D mould guided radiogenomics project in ovarian cancer. They highlight how the process works and why it is potentially game changing in the treatment of a cancer where the standard of care has not really changed in over 20 years.

Marika is a clinical research fellow at the CRUK Cambridge Centre, University of Cambridge, UK.

Maria is a PhD Student in the Department of Radiology and the Department of Engineering at the University of Cambridge, UK.

3D tumour mould guided radiogenomics in ovarian cancer

This week, Ellie Wolmark is joined by Dr Claire King, Cherry May Sanchez and Dr Rhys Grant to discuss some of the amazing engagement, involvement and inclusion initiatives that we run here at the CRUK Cambridge Centre at the University of Cambridge, UK. They share how and why we engage and involve patients and the public in our research, and focus on the importance of championing equality, diversity and inclusion (EDI) in all aspects of our work. You will also hear about some of our projects for working with hard-to-reach communities, including how our Nursing and Allied Health Professionals Programme are helping to tackle health inequalities for people experiencing homelessness.

Claire is a Programme Manager for the Advanced Cancer Imaging and Cancer Immunology Programmes and an EDI Champion at the CRUK Cambridge Centre.

Cherry May is the CRUK Senior Research Nurse and co-Lead for the Nursing and Allied Health Professionals Programme at the CRUK Cambridge Centre.

Rhys is the Engagement Lead and an EDI Champion at the CRUK Cambridge Centre.

Engagement, involvement and inclusion in research

Dr Ines Machado, Dr Gabriel Funingana, Thomas Buddenkotte and Amied Shadmaan talk about the research they are undertaking within the collaborative project between GE Healthcare, the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. They also provide an update on the development of the Oncocare platform.

Ines is a Research Associate in the Crispin Lab at the CRUK Cambridge Institute, University of Cambridge, UK.

Gabriel is a Clinical Fellow and PhD student in the Department of Oncology, University of Cambridge, UK.

Thomas is a consultant to the Crispin Lab. He obtained his PhD at the University of Cambridge, UK, working at the Department of Applied Mathematics and Theoretical Physics and the Department of Radiology. He is now affiliated with the Department of Diagnostic and Interventional Radiology and Nuclear Medicine at the University Medical Center Hamburg-Eppendorf, Germany, and the Hamburg-based company Jung Diagnostics.

Amied is Director of AI & Clinical Collaborations at GE Healthcare.

AI in cancer research and an update on the GE Healthcare collaboration

Professor Kevin Brindle joins Ellie Wolmark to discuss his life's work in imaging research as he reaches retirement. Kevin is particularly interested in metabolic imaging. His research group has developed novel magnetic resonance-based molecular imaging techniques to detect the early responses of tumours to therapy, with a view to translating these into clinical application. He talks about how he got into this topic in the first place, his amazing contributions to the field over the past four decades, and about how his techniques can be translated into the clinic to impact patient treatment.

Kevin is Emeritus Professor of Biomedical Magnetic Resonance in the Department of Biochemistry and a Senior Group Leader in the CRUK Cambridge Institute at the University of Cambridge, UK. He is also a Fellow of the Academy of Medical Sciences and of the Royal Society.

Kevin Brindle – Reflections on a lifetime in imaging research

How is artificial intelligence being used in cancer care, and what do patients think about it?

In this 'Ask Me Anything' episode, Ellie Wolmark, Programme Manager for Integrated Cancer Medicine (ICM) at the CRUK Cambridge Centre, speaks with patient representatives Lorraine, Frankie, and Ann from across our Patient and Public Involvement groups, alongside ICM researchers Professor James Brenton, Dr Ines Machado, and Dr Gabriel Funingana from the University of Cambridge.

Together, they explore how artificial intelligence (AI) is being applied in cancer research, how it could support personalised treatment, and what the future might hold. The patients share thoughtful questions and concerns about the role of AI in healthcare, while the researchers explain how it's currently being used and what challenges remain.

This lively and insightful discussion highlights just how valuable patient involvement is in shaping research that truly meets the needs of those it aims to help.

Ask me anything about cancer

Ask me anything about... the use of artificial intelligence in healthcare

Why does eating more not fix the severe weight loss seen in some cancer patients, and what can be done about it?

In this 'Ask Me Anything' episode, Dr Hui-Ling Ou, Programme Manager for the Pancreatic Cancer and Cancer Immunology Programmes at the CRUK Cambridge Centre, speaks with researchers from the Cancer Cachexia Action Network (CANCAN): Dr Claire Connell (University of Cambridge and Cambridge University Hospitals NHS Foundation Trust), Dr David Lewis (CRUK Scotland Institute), and Dr Tobias Janowitz (Cold Spring Harbor Laboratory).

Together, they unpack what cancer-associated cachexia is, why it's so devastating for patients, and how scientists are working to understand and reverse this syndrome. The guests share how their research, spanning metabolism, imaging, immunology, and clinical studies, is bringing fresh insights and hope to a problem that affects quality of life for so many.

This thought-provoking discussion shines a light on the collaborative efforts driving progress against one of cancer's most challenging complications.

Ask me anything about... the science of cancer-associated cachexia

What do you most want to know about pancreatic cancer and cancer-associated cachexia?

In this special episode, we bring you a recording of a live 'Ask Me Anything (AMA)' event hosted by the CRUK Cambridge Centre Pancreatic Cancer Programme for World Pancreatic Cancer Day 2024.

A multidisciplinary and international panel of experts, including clinicians, researchers, nurses, dietitians and physiotherapists, answer thoughtful questions from the public about pancreatic cancer, cachexia and the latest research and care approaches. Topics range from understanding the biology of these diseases to managing symptoms and improving quality of life.

The discussion sheds light on the progress being made and the ongoing challenges in improving outcomes for people affected by these conditions.

Ask me anything about... cachexia research and management

How can artificial intelligence (AI) support both cancer research and healthcare more generally? Anoushka Harit (University of Cambridge) and Dr Zhongtian Sun (University of Kent) join today's episode to discuss this topic.

Anoushka talks about her research in hereditary diffuse gastric cancer (HDGC) and the development of an AI system to enable early detection of signet ring cell carcinoma (SRCC) during endoscopy. This new AI system could help to treat SRCC better or to prevent or delay drastic life-changing treatment, preserving patients' quality of life.

Zhongtian shares insights on how AI can support health applications more generally and how he tries to make it as explainable as possible. He even talks about his wish to make the AI mimic as much as possible the way a human brain works!

Using AI to detect stomach cancer during endoscopy

Have you ever wondered how artificial intelligence (AI) is used in research in a healthcare setting? Rebecca Wray and Bill McGough, two PhD students at the University of Cambridge, both use AI in different ways in their research into the screening and treatment of kidney cancer.

Rebecca is an MRes PhD student investigating the response and resistance to therapy in patients with kidney cancer. She uses AI to find tumour features at multiple scales. For his PhD, Bill is developing AI models that will sift through the mounds of imaging data produced during the Yorkshire Kidney Screening Trial (funded by Yorkshire Cancer Research), flagging images that show masses in the kidneys.

This interesting conversation gives insight into how researchers are using patient data safely in order for AI models to integrate all the information about a patient to help review their treatment and personalise it. The discussion also highlights how using AI in the screening setting is speeding up processes to help save clinicians' time and allowing the potential earlier detection of kidney cancer in a cost-effective manner.

Using AI in the screening and treatment of kidney cancer

The Cancer Research UK Cambridge Centre unites over 1,000 world-leading biologists, chemists, physicists, engineers, mathematicians, computer scientists, clinicians, nurses and allied healthcare professionals from across Cambridge, UK to tackle cancer from every angle.

Our mission is to end death and disease caused by cancer through research, treatment and education. We are detecting cancer at its earliest stage and are developing personalised treatments for every patient through facilitating new collaborations and driving the translation of new scientific discoveries into clinical applications to improve patient care. By working together across a range of different disciplines, our members are breaking down the barriers between the laboratory and the clinic, enabling patients to benefit from the latest innovations in cancer science.

New tracks tagged #Cancer Research Uk