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Evolution that arises from the production of new and viable genetic information is an essential underpinning of Darwin's theory. Richard Dawkins in his book "The Greatest Show on Earth: Evidence for Evolution" provides evidence for this kind of evolution occurring. What does this evidence show? What type of evidence does it provide? What are the implications of this on Darwinian evolution? 

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What Evidence is There for Evolution? part 2 - SC2511

Scientists have engineered small, targeted proteins that can penetrate brain cancer cells and prevent them from invading healthy tissue, offering a promising new approach to treating glioblastoma multiforme (GBM), one of the deadliest forms of brain cancer. This strategy was developed by researchers at the University of Nevada, Reno, and published recently in Oncotarget.

The Challenge of Treating Glioblastoma Multiforme

Glioblastoma is an aggressive and fast-growing brain tumor that infiltrates healthy brain tissue, making complete surgical removal nearly impossible. Standard treatments like chemotherapy and radiation can slow its growth but rarely prevent it from returning. One major reason for this invasiveness is a group of enzymes known as matrix metalloproteinases (MMPs), which break down surrounding tissue to allow cancer cells to spread. Among these, MMP-9 plays a particularly important role in driving tumor progression and resisting existing therapies.

Attempts to block MMPs using small-molecule drugs have failed in clinical trials due to problems like poor selectivity and harmful side effects. Researchers have been searching for safer, more targeted methods to interfere with these enzymes and limit glioblastoma’s spread.

The Study: Engineered Proteins to Inhibit Tumor Invasion

In the study called “Effect of TIMPs and their minimally engineered variants in blocking invasion and migration of brain cancer cells,” researchers Elham Taheri and Maryam Raeeszadeh-Sarmazdeh investigated tissue inhibitors of metalloproteinases (TIMPs), which are natural blockers of MMPs, and their engineered modified versions made to work better. Specifically, the team studied TIMP-1, TIMP-3, along with two engineered molecules, mTC1 and mTC3, in laboratory cell models of GBM.

Full blog - https://www.oncotarget.org/2025/05/21/engineered-proteins-show-promise-in-stopping-glioblastoma-invasion/

Paper DOI - https://doi.org/10.18632/oncotarget.28691

Correspondence to - Maryam Raeeszadeh-Sarmazdeh - maryamr@unr.edu

Video short - https://www.youtube.com/watch?v=tdBlkOX50D8

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Keywords - cancer, TIMP minimal variants, glioblastoma multiforme (GBM), brain cancer, MMP inhibitors

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Engineered Proteins Show Promise in Stopping Glioblastoma Invasion

06 26 2025 Pastor Paul Interview- Michael - Fire in the Sky

Descubre el corazón de los vehículos eléctricos: las baterías de tracción. En este episodio, desglosamos cómo estos complejos sistemas definen la autonomía, el rendimiento y la seguridad del vehículo. Exploraremos sus componentes clave, desde las celdas y módulos hasta el paquete completo, y nos adentraremos en el Sistema de Gestión de Baterías (BMS), considerado el "cerebro" del sistema, crucial para su funcionamiento seguro, eficiente y duradero.

Baterías de Tracción: Potencia, Seguridad y el Cerebro de la Electromovilidad

Mitosis by Louise Gluck

BUFFALO, NY — August 1, 2025 — A new #research paper featured on the #cover of Volume 17, Issue 7 of Aging (Aging-US) was #published on July 25, 2025, titled “Systemic factors in young human serum influence in vitro responses of human skin and bone marrow-derived blood cells in a microphysiological co-culture system.”

The study, led by first author Johanna Ritter and corresponding author Elke Grönniger from Beiersdorf AG, Research and Development Hamburg, shows that components in young human blood serum can help restore youthful properties to skin, but only when bone marrow cells are also present. This discovery highlights the role of bone marrow in supporting skin health and may allow for novel approaches aimed at slowing or reversing visible signs of aging.

The research explored how factors present in blood serum, already known to influence aging in animal studies, act on human cells. Using an advanced system that mimics human circulation, the researchers connected a 3D skin model with a 3D bone marrow model. They found that young human serum alone was not enough to rejuvenate skin. However, when bone marrow cells were present, these serum factors changed the activity of those cells, which then secreted proteins that rejuvenated skin tissue.

“Interestingly, we detected a significant increase in Ki67 positive cells in the dynamic skin model co-cultured with BM model and young serum compared to the model co-cultured with BM and old serum, indicating an improved regenerative capacity of the tissue.”

Detailed analysis indicated that young serum stimulated the bone marrow to produce a group of 55 proteins, with 7 of them demonstrating the ability to boost cell renewal, collagen production, and other features associated with youthful skin. These proteins included factors that improved energy production in cells and reduced signs of cellular aging. Without the interaction between skin and bone marrow cells, these rejuvenating effects did not occur.

This finding explains why earlier experiments in mice, where young and old animals shared a blood supply, showed rejuvenation across organs. It suggests that bone marrow-derived cells are critical messengers that transform signals from blood into effects on other tissues, including the skin.

While these results are preclinical and not from human trials, they offer a starting point for new strategies in regenerative medicine and skin care. By identifying specific proteins that may carry rejuvenating signals, the study points to a new way to address age-related changes. Researchers emphasize that further studies will be needed to confirm these effects in humans and to test how these proteins can be safely and effectively applied in future therapies.

Overall, this research is an important step in understanding how young blood serum factors influence human tissue and could guide the development of novel methods to maintain healthier skin as people age.

DOI - https://doi.org/10.18632/aging.206288

Corresponding author - Elke Grönniger - elke.groenniger@beiersdorf.com

Video short - https://www.youtube.com/watch?v=_4spcgzPcEk

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Aging (Aging-US)

Young Human Blood Serum Factors Show Potential to Rejuvenate Skin Through Bone Marrow

A new #study published as the #cover of Aging (Aging-US) Volume 17, Issue 7, explores how factors in young human blood may affect the biological age of human skin. Researchers from Beiersdorf AG, Research and Development Hamburg in Germany, used a microphysiological co-culture system—a lab-based model simulating human circulation—to test the effects of young versus old blood serum on skin cells. The findings suggest that bone marrow-derived cells play a key role in converting blood-borne signals into effects that support skin rejuvenation.

Understanding Skin Aging and Systemic Influence

As we age, the skin’s ability to regenerate declines, while its biological age increases. This contributes to visible signs of aging and a weakened barrier function. While cosmetic treatments can improve appearance, they rarely target the cellular processes underlying skin aging.

Animal studies have shown that exposure to young blood can promote tissue repair and rejuvenation, likely due to molecules circulating in the bloodstream. However, reproducing these effects in human skin has proven difficult. Applying young serum directly to skin tissue has not produced significant results, indicating that additional cellular interactions may be required.

Full blog - https://aging-us.org/2025/08/skin-rejuvenation-how-young-blood-and-bone-marrow-influence-it/

Paper DOI - https://doi.org/10.18632/aging.206288

Corresponding author - Elke Grönniger - elke.groenniger@beiersdorf.com

Video short - https://www.youtube.com/watch?v=_4spcgzPcEk

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Keywords - aging, skin rejuvenation, microphysiological systems, systemic factors, bone marrow model, human serum

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Skin Rejuvenation: How Young Blood and Bone Marrow Influence It

🎧 “Cells” by mhatanGRAUZAHN — A haunting reflection on the battle within.

“Cells” dives deep into the daily struggle against one’s own body and mind, where every small sin and regret resurfaces to haunt the soul. With poetic lyrics, immersive soundscapes, and melancholic undertones, the track captures the feeling of fighting yourself from the inside out — one cell at a time.

Blending Indie Pop, Downtempo, and touches of Tropical and Deep House, mhatanGRAUZAHN creates a sound that’s both intimate and cinematic. “Cells” is for those quiet late-night moments when your thoughts won’t rest, and your body feels like an adversary.

💬 Lyrics highlight:

“All my cells fight among themselves —
Who has the honor of dragging me into Hell.”

🩸 Themes: inner conflict, aging, guilt, redemption, survival
🎶 Genre: Indie Pop / Downtempo / Deep House
🎤 Artist: mhatanGRAUZAHN
📍 Listen on SoundCloud: https://soundcloud.com/kim-long-boom/cells

If you’ve ever felt your own body turn against you — this song will resonate.

#IndiePop #Downtempo #DeepHouse #TropicalHouse #DarkPop #EmotionalPop #AlternativeMusic #IndieArtist #ElectronicPop #IntrospectiveMusic #mhatanGRAUZAHN #Cells #NewMusic #SoundCloudArtist #DarkIndie

CELLS

cell memory -ft. kemmanuel-

Medical Missionary Sharing the Healing Message of the Gospel of Jesus Christ

Mostly:  Synthpop, Electro, melancholy, sad, House, Trance, Trip-Hop, Electronica, Synthwave

Also a YouTuber (aber nur für Deutsche)

For a wealth of life changing information visit:  3abnaustralia.org.au/radio/listen 

3ABN (Three Angels Broadcasting Network) Australia Radio is the "Mending Broken People Network," broadcasting Christian content 24/7.

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Ex-BBC Broadcaster readings of poetry & stories + archive radio/audio features. PLEASE SHARE LINKS with others. 
I’m a self-confessed sound, speech and language nerd.

New tracks tagged #Cells