It was a career-defining (and perhaps life changing) moment when Dr. Vittorio Sebastiano, a reproductive biologist by training, realized that because we are able to create life, that same body of information could be harnessed to create youth - that is, radically reverse our biological aging process to a younger time point without losing cellular identity. 

In 2014, he and his lab began unpacking this epiphany. They made the radical decision to conduct their investigations in human cells and tissue rather than in rodents, with the expectation that such a start would be a better bridge to human clinical trials.

Flash forward a decade and Dr. Sebastiano and his team stand poised to begin trials in humans. Dr. Sebastiano is, in my opinion, one of the most extraordinary scientists in the longevity space today who flies under the radar of most of us in functional medicine. 

In this podcast - which is actually two-in-one because I continued the conversation with him on a second date - you’ll hear about the remarkable work they’re undertaking at his lab. For example: They’ve created a biological clock that encompasses the whole genome consisting of millions and millions of CpG sites. They are able to clearly demonstrate the reversal of bioage using their methodology - a cocktail of Yamanaka factors plus, with clear time limits - which changes the epigenome first, and in so doing influences all of the hallmarks of aging. Teaser: they’ve identified one intervention routinely used in clinical practice that influences their bio age clock in the same way that their cocktail does. What is it? I was riveted with this conversation, as I am sure you’ll be. Leave a review if you like it, and - Yes - let me know what you think. I know this will prompt deep questions for you, as it did for me. ~DrKF


Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

Decoding Aging: The Science Of Cellular Rejuventation With Dr. Vittorio Sebastiano

Step into the microscopic world of our cells with "ADP-Powered Motors," a captivating song that takes you on an educational journey through the intricate dance of kinesin and dynein proteins. This song doesn't just entertain; it enlightens, offering a unique blend of music and molecular biology that opens your mind to the wonders of cellular mechanics.

At the heart of this innovative musical experience is a scannable QR code that unlocks deeper insights into the inner workings of our cells. By scanning the QR code, listeners can access detailed visuals and explanations about how ADP and ATP power the tiny motors that keep our cells functioning. This fusion of music and science transforms the song into an interactive educational tool, making complex biological processes accessible and fascinating.

"ADP-Powered Motors" is more than just a song; it's a bridge to understanding the marvels of life at the molecular level. Whether you're a science enthusiast or simply curious about the hidden symphony within your cells, this song offers a rhythmic gateway to knowledge. Embrace this innovative approach to learning and let the molecular melodies inspire your sense of wonder.

Lyrics:

In the secret chambers of our cells, where molecules roam free
A tiny world of machinery, working tirelessly for me
Microkinesis, the dance of the small, a symphony so fine
A world of wonder, hidden from our sight, yet vital to our prime

ADP-powered motors, spinning round
Energy released, molecular sound
A chemical waltz, a dance so neat
ADP-powered motors, at the heart of our beat

In the cytosol, a world of its own
Microtubules, the highways, where motors are grown
Kinesin and dynein, the dynamic duo
Moving cargo, with precision, to and fro

ADP-powered motors, spinning round
Energy released, molecular sound
A chemical waltz, a dance so neat
ADP-powered motors, at the heart of our beat

In harmony, they work as one
A symphony, that's never done
The rhythm of life, in every cell
A dance of wonder, that we can't quell

ADP-powered motors, spinning round
Energy released, molecular sound
A chemical waltz, a dance so neat
ADP-powered motors, at the heart of our beat

In the secret chambers of our cells, where molecules roam free
A tiny world of machinery, working tirelessly for me
Microkinesis, the dance of the small, a symphony so fine
A world of wonder, hidden from our sight, yet vital to our prime

ADP-powered motors, spinning round
Energy released, molecular sound
A chemical waltz, a dance so neat
ADP-powered motors, at the heart of our beat

ADP, The Power Source

Welcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF  

Copyright © 2023 by KF Education and Consulting, LLC
All Rights Reserved

https://xyloquint.com/

email: xyloquint@xyloquint.com

New tracks tagged #CellularBiology