Dee and Kate investigate the conspiracy theory that Elon Musk’s botched penis enlargement surgery caused him to become a supervillain. Will the real Boner Villain please stand up? And Jizzy Jake is gutted that the show is ending. Sign up for the Sick and Wrong Patreon or Apple Podcasts to hear the Second Show, SW archives, and the bonus minisode Serial Killer Star Signs.

S&W Episode 987: Elon and the Angry Inch

Concomitant use with nitrates, such as nitroglycerin or isosorbide mononitrate, may cause a severe drop in blood pressure, leading to dizziness, fainting, or even life-threatening hypotension.
Alpha-blockers, such as tamsulosin or doxazosin, when used with tadalafil, may enhance the blood pressure-lowering effects, increasing the risk of dizziness or fainting.
Strong CYP3A4 inhibitors, such as ketoconazole or ritonavir, may increase tadalafil levels in the blood, leading to a higher risk of side effects like headaches, flushing, or low blood pressure.
CYP3A4 inducers, such as rifampin or carbamazepine, may decrease tadalafil levels, reducing its effectiveness.
Antihypertensive medications, including beta-blockers and calcium channel blockers, may enhance blood pressure-lowering effects when combined with tadalafil.
Excessive alcohol consumption while using tadalafil may increase the risk of dizziness, low blood pressure, and fainting.
Other phosphodiesterase-5 inhibitors, such as sildenafil or vardenafil, should not be used with tadalafil due to an increased risk of severe hypotension and cardiovascular effects.
Food Interactions
Following are the food interactions to be aware of with Tadalafil 20mg Tablet:

Grapefruit and grapefruit juice consumption should be avoided as they can significantly increase the blood levels of Tadalafil, potentially leading to an increased risk of side effects, especially related to the heart.
Alcohol intake should be limited or avoided as it can cause a sudden drop in blood pressure, which may be dangerous when combined with the vasodilating effects of Tadalafil.
High-fat meals can slightly delay the absorption of Tadalafil, but they do not significantly reduce its overall effectiveness.
Avoid excessive consumption of licorice as it can potentially interact with Tadalafil, affecting blood pressure and heart rate.
Caffeine intake should be monitored as it may slightly increase the heart rate, which could be of concern for individuals with cardiovascular conditions when combined with Tadalafil.
Keep a balanced diet, as Tadalafil may interact with certain nutrients, particularly those involved in nitric oxide production, which could influence its effectiveness.
Avoid excessive salt intake, as it can increase blood pressure, counteracting the effects of Tadalafil in individuals with hypertension.
Stay hydrated, as proper hydration can aid in maintaining cardiovascular health, which is crucial when using Tadalafil for certain conditions.
Storage/Disposal
Tadalafil 20mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. It is crucial to avoid exposing the medication to extreme temperatures, so steer clear of storage areas like bathrooms, kitchens, or near heat sources. Always check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Do not dispose of it via household waste or wastewater; instead, consult your pharmacist or local waste management guidelines for safe disposal methods. Keep the medication securely stored away from children to prevent accidental consumption.

Quick Tips, if any
Following are the quick tips for Tadalafil 20mg Tablet:

Consult a doctor for prescription and dosage instructions.
Take the tablet as directed, usually once daily.
Consume the tablet whole with a glass of water, preferably on an empty stomach.
Avoid heavy meals and high-fat foods before taking the tablet for better absorption.
Maintain a gap of at least 24 hours between doses to prevent overdose.
Do not crush, chew, or break the tablet; swallow it as a whole.
Store the medication at room temperature, away from light and moisture.

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