BUFFALO, NY- November 22, 2023 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 21, entitled, “Antibiotics that target mitochondria extend lifespan in C. elegans.”

Aging is a continuous degenerative process caused by a progressive decline of cell and tissue functions in an organism. It is induced by the accumulation of damage that affects normal cellular processes, ultimately leading to cell death. It has been speculated for many years that mitochondria play a key role in the aging process. 

In this new study, researchers Gloria Bonuccelli, Darren R. Brooks, Sally Shepherd, Federica Sotgia, and Michael P. Lisanti from the University of Salford aimed to characterize the implications of mitochondria in aging using Caenorhabditis elegans (C. elegans) as an organismal model. The C. elegans were treated with a panel of mitochondrial inhibitors and assessed for survival. 

“In our study, we assessed survival by evaluating worm lifespan, and we assessed aging markers by evaluating the pharyngeal muscle contraction, the accumulation of lipofuscin pigment and ATP levels.” 

Their results show that treatment of worms with either doxycycline, azithromycin (inhibitors of the small and the large mitochondrial ribosomes, respectively), or a combination of both, significantly extended median lifespan of C. elegans, enhanced their pharyngeal pumping rate, reduced their lipofuscin content and their energy consumption (ATP levels), as compared to control untreated worms, suggesting an aging-abrogating effect for these drugs. Similarly, DPI, an inhibitor of mitochondrial complex I and II, was capable of prolonging the median lifespan of treated worms. On the other hand, subjecting worms to vitamin C, a pro-oxidant, failed to extend C. elegans lifespan and upregulated its energy consumption, revealing an increase in ATP level. 

“Therefore, our longevity study reveals that mitochondrial inhibitors (i.e., mitochondria-targeting antibiotics) could abrogate aging and extend lifespan in C. elegans.”

DOI - https://doi.org/10.18632/aging.205229

Corresponding authors - Michael P. Lisanti - m.p.lisanti@salford.ac.uk, and Federica Sotgia - f.sotgia@salford.ac.uk

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Keywords - aging, C. elegans, lifespan, lipofuscin, antibiotics, mitochondria, metabolism, DPI

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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Mitochondria-Targeting Antibiotics Extend Lifespan in C. Elegans

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distance (prod. oliver_01)

"So that's why if you have 1 billion to invest, we're not expecting the same return as if you invest 10 million. At that time, when all this money flowed to Southeast Asia, people there thought, "Oh, we made it. Now the world is looking at us. We're finally a good ecosystem.' Everyone was ready to invest in us, but that was just the tide, right? And when the tide recedes, the first place the money will leave is Southeast Asia because it's not offering the best returns. So, the money is going out, and I don't think it's coming back anytime soon. People shouldn't expect investors to be as aggressive as they were. Lastly, great companies will always raise capital. The top ones will always find their way, so there's no issue for them. The challenge is for the ones just below them. It will be very difficult for those companies. Some will have to become much more capital-efficient, for sure." 

Fresh out of the studio, Arnaud Bonzom, founder of Black Mangroves and angel investor, engages in a lively discussion with our host about the entrepreneurial and venture capital landscape in Southeast Asia for 2024. Arnaud shares his insights on the evolution of late-stage funding and the resetting of expectations in the region’s venture capital scene. He also offers valuable advice to founders on how to navigate the challenging fundraising climate and what success could look like for the region in the coming years. 

Audio Episode Highlights: 
[0:44] Quote of the Day by Arnaud Bonzom #QOTD [2:09] Arnaud’s Reflections on Southeast Asia Since 2018 [5:28] Southeast Asia’s Economic Challenges [6:15] New Outlook for the Region’s Startup Ecosystem [10:37] Lessons from India’s B2B Market [14:31] How Venture Capital Works in Southeast Asia [16:52] Over-Optimism in Southeast Asia’s VC Landscape [24:27] Challenges in Attracting Foreign Investments [27:38] The U.S. as the Biggest Accessible Market [30:29] Market Segmentation in Asia Pacific [35:44] IPO Slowdown and M&amp;A Challenges [37:59] Zombie Companies in Southeast Asia [39:14] The One Thing Arnaud knows about the SEA ecosystem that very few do [41:28] Explaining DPI (Distributions to Paid-In Capital) [47:48] Timing in Venture Capital Investments [51:48] Advice for Founders in 2023-2024 [53:33] Bottlenecks in Southeast Asia’s Startup Ecosystem [56:40] What does great look like for the Southeast Asia ecosystem? [58:45] Crypto Companies in Southeast Asia [60:44] Final Thoughts and Future of Southeast Asia’s Startup Ecosystem [61:10] Closing 

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Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

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Un podcast dedicato alla formazione ed all’approfondimento di varie tematiche giuridiche per chi lavora o per chi vorrebbe incominciare a lavorare per gli enti locali. Le lezioni sono tenute dal Dott. Chiarelli, dirigente di Ente Locale ed esperto di formazione. Per informazioni https://chiarelli.eu  . Podcast a cura di Diego Donzella - funzionario di ente locale.

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