BUFFALO, NY - December 30, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on December 24, 2024, titled “Pitfalls and perils from FDA-approved germ-line cancer predisposition tests."

Authored by Dr. Wafik S. El-Deiry, Editor-in-Chief of Oncotarget, and Dr. Eli Y. Adashi from Brown University, the article highlights concerns about the risks of a newly approved genetic test for cancer risk. This test, called the “Invitae Common Hereditary Cancers Panel," was approved in 2023 and examines 48 genes linked to inherited cancers, including breast, ovarian, and Lynch syndrome-related cancers. Although the test increases access to genetic information, the authors warn that using it without professional guidance may lead to confusion, stress, and potential harm.

One concern is that people can order this test online without consulting healthcare professionals or genetic counselors. Without expert help, users might struggle to understand their results especially if they indicate risks that are unclear or difficult to act on. This can cause unnecessary anxiety and confusion.

“The DTC option of germ-line testing for cancer susceptibility should be discouraged given the risks of anxiety, lack of adequate interpretation for variants not strongly associated with cancer, potential for minors to be tested outside the healthcare system and potential for loss of follow-up if test results are not shared with health care professionals or never make it into the medical record.”

The editorial also points out ethical and medical issues when minors use these tests. If a child’s test is done without medical oversight, results might not be added to their health records, making follow-up care harder to manage and potentially risking their long-term health.

Cost is another issue. These tests are often not covered by insurance, which can place a financial burden on families who might need additional testing or medical advice.

The researchers emphasize that genetic testing for cancer risk should always include healthcare providers and genetic counseling. This ensures users fully understand their results and receive proper guidance. The authors also call on the US Food and Drug Administration (FDA) to provide clear rules for using these tests, particularly for minors.

In conclusion, while genetic testing holds great potential for improving cancer prevention and care, its benefits must not come at the cost of safety and public health. Responsible use of these tests will require collaboration between regulators, healthcare professionals, and testing companies to address the risks and ensure these tools are used effectively.

DOI - https://doi.org/10.18632/oncotarget.28677

Correspondence to - Wafik S. El-Deiry - wafik@brown.edu

Video short - https://www.youtube.com/watch?v=DjKpiBNDWHo

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About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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MEDIA@IMPACTJOURNALS.COM

Oncotarget

Pitfalls of FDA-Approved Germline Cancer Predisposition Tests

Would you take a test to find out your cancer risk? At-home genetic testing makes it easy, but experts warn that these tests may create more harm than good.

A New Approach to Genetic Testing

Genetic testing has traditionally been performed under the supervision of healthcare providers, with genetic counseling to help patients navigate their results. This approach ensures that individuals receive proper guidance, reducing the emotional and practical challenges of interpreting complex genetic information.

In September 2023, the United States Food and Drug Administration (FDA) approved a new test called the Invitae Common Hereditary Cancers Panel. This test checks for changes in 48 genes linked to hereditary cancers, including breast, ovarian, and Lynch syndrome-related cancers. What makes it different is that it can be ordered online and taken at home with no doctor required.

While the convenience of these tests is appealing, health experts have raised serious concerns. An editorial titled “Pitfalls and Perils from FDA-Approved Germ-line Cancer Predisposition Tests,” authored by Dr. Wafik S. El-Deiry, Editor-in-Chief of Oncotarget, and Dr. Eli Y. Adashi, both from Brown University, highlights the potential risks of using these tests without professional guidance.

Full blog - https://www.oncotarget.org/2025/01/03/the-hidden-risks-of-at-home-genetic-cancer-tests/

Paper DOI - https://doi.org/10.18632/oncotarget.28677

Correspondence to - Wafik S. El-Deiry - wafik@brown.edu

Video short - https://www.youtube.com/watch?v=DjKpiBNDWHo

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Keywords - cancer, cancer predisposition, germline, marketing authorization, hereditary cancer, direct to consumer

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

Facebook - https://www.facebook.com/Oncotarget/
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Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

The Hidden Risks of At-Home Genetic Cancer Tests

Effective Landing Page Tactics for 2025 ft. Adam Pivko | S3 EP1 | Two Ecomm Experts 
 
Adam Pivko is an award-winning e-commerce expert with a 15+ year track record of success in the performance marketing industry. Adam has spent the majority of his career servicing merchants, helping them save more money, make more money and grow. From high-volume subscription models, through to affiliate driven traffic on direct response e-commerce, he's extremely proficient with CRO and performance driven pages and assets. Today, he runs his own direct-to-consumer brand, Autumn DNA, while helping brands grow and thrive through strategic marketing and design with Tierra Agency.
 
In this episode, Adam and Viktor discuss must-know strategies for 2025: creating high-converting landing pages, unlocking opportunities with platforms like AppLovin and refining upselling techniques. They’ll also share insights on understanding customer behavior and eliminating the common mistakes that hold back conversion rates.
 
The host of the Two Ecomm Experts podcast is Viktor Stoilov - an advertising strategist, Founder & CEO of Markademics, an ecommerce advertising agency, as well as a co-founder of a 7-figure e-commerce store.
 
Get ready to level up your e-commerce game with the Two Ecomm Experts. Join our host Viktor Stoilov, founder of Markademics, in his conversations with top-notch e-commerce specialists from all over the world. Listen to them unpack the latest trends in the e-commerce world together with hot topics such as marketing, advertising, supply, and logistics. Take your business to the next level with this library of valuable conversations and reach your full e-commerce potential!
 
Follow Adam Pivko on social media:
<a href="https://www.linkedin.com/in/adampivko/">LinkedIn</a>
 
Follow Viktor:
<a href="https://www.instagram.com/viktor.stoilov.official/">Instagram</a>
<a href="https://www.facebook.com/ViktorStoilovOfficial">Facebook</a>
<a href="https://www.linkedin.com/in/viktor-stoilov/">LinkedIn</a>
 
Follow Markademics:
<a href="https://www.instagram.com/markademics/">Instagram</a>
<a href="https://www.linkedin.com/company/18144816/admin/feed/posts/">LinkedIn</a>
 
We’ve recorded episodes with Alex Fedotoff, Matt Patoli, Carl Weische, Jem Bourouh, and Sebastian Szalinski. 
<a href="https://www.youtube.com/playlist?list=PLmnrhAo_DTThJSzUIC4V9GFEzKLOdFQnj">You can check them out in this playlist</a>
 
Markademics - an E-commerce agency specializing in performance marketing for D2C brands. 
✅ Over $3 million in invested Ad spend on Facebook alone
✅ Managed the ads or consulted 100+ brands in 15+ markets.
✅ We don't work with everyone but when we do - we deliver results.
If you want to work with us, visit our website and book a call <a href="https://markademics.com/">here</a>
 
Thank you for listening to the podcast! More episodes to come!
 
Timestamps:
(0:00) Introduction
(2:33) Customer Feedback Driven Growth
(8:33) Ad Creatives and Targeting Strategies
(10:47) Cold Customer Acquisition
(14:40) The importance of looking at the right metrics 
(19:52) Analysing customer feedback
(25:47) Balancing Lifetime Value & Profitability 
(27:45) Product Market-Fit Testing
(36:50) AppLovin for E-commerce Growth
(43:32) High Performing Landing Pages & Common Mistakes
(1:00:20) Grindr, Favourite Non-traditional Platform
(1:06:27) The Why, How, What in 2025
 
Two Ecomm Experts formerly known as The Markademics Podcast!

Effective Landing Page Tactics for 2025 ft. Adam Pivko | S3 EP1

In dieser Folge des E-Commerce Dudes Podcasts gibt es ein echtes Highlight von Daniel Höhnke und Tim Schestag: Die Strix Gruppe geht mit Delta Equity eine strategische Partnerschaft ein! Was bedeutet das für die zukünftige Entwicklung und internationale Expansion? Wir sprechen über die Hintergründe, Ziele und welche neuen Möglichkeiten sich für Kunden, Partner und das Strix-Team ergeben.

Natürlich gibt es auch die News der Woche (NdW) mit spannenden Updates aus der E-Commerce-Welt:

🔹 Shopify hat seine Q4-Zahlen veröffentlicht – wir analysieren die wichtigsten Erkenntnisse und was sie für Händler und Partner bedeuten.

🔹 Google & Search – Wird die Suche immer mehr zum AI-Assistenten? Erste Websites bekommen mehr Traffic von ChatGPT als von Google!

🔹 Commerce in Deutschland – Von ChatGPT via Faxgerät bis zu den Herausforderungen des Einzelhandels: ein Blick auf die aktuelle Lage.

👉 Jetzt reinhören & up to date bleiben! 🎧

Daniel: www.linkedin.com/in/daniel-hoehnke/
Tim: www.linkedin.com/in/tim-schestag/

#148 Strix holt sich Delta Equity als strategischen Partner & internationale Expansion ins Boot

The longtime merchant discusses the myths and rewards of a channel that is getting renewed appreciation in the industry.

Talking wholesale with Liza Amlani

Listen DTC, my new sound !

Info / Booking : ludovic.ozka@gmail.com

Ludo Ozka - D T C

I WILL FALL IN THIS LINE FOR THE REST OF MY LIFE. ITS A LONG WAY UP WHAT GOD DO I LOOK TOO NOW ? _________THE LORD WHO LOOKS DOWN . 

HELLSCAPE OST

This podcast discusses the First-Tier Tribunal Tax Chamber addresses an appeal by Trevor John Masters against HMRC regarding UK income tax on pension withdrawals. The central issue revolves around the UK-Portugal Double Tax Convention (DTC), specifically whether Masters' pension withdrawals, received while he was a tax resident in Portugal, should be taxed in the UK or Portugal. The tribunal considers two main points: first, if the Self-Invested Personal Pension (SIPP) withdrawals were "paid in consideration of past employment" under Article 17 of the DTC, which would limit taxation solely to Portugal; and second, if they fall under Article 20 of the DTC, which concerns "income not expressly mentioned" and requires the income to be "subject to tax" in Portugal to prevent UK taxation. Ultimately, the Tribunal found in favor of Mr. Masters on the first issue, concluding that the withdrawals were indeed in consideration of past employment, thereby allocating the taxing rights to Portugal and resolving the appeal without needing to definitively rule on the second point.

Trevor John Masters v HMRC [2025] UKFTT 967 (TC)

Much love to John and Dagmar for the raids, and thanks to all who tuned in and supported! <3

=======================================

[RAIDERS]
https://www.twitch.tv/johnrawfunk
https://www.twitch.tv/dagmar_dj


=======================================

[TRACKLIST]

Juliet Fox - Silence Your Mind
Jay Lumen - Energy
Ilija Djokovic - Gravity
Zimmz - Sinematic
Spektre - Something Inside Us
Boris, Matt Sassari - Groove Vox
Pig&Dan - Take Me
Filterheadz - Rathouse
Adam Beyer, Alan Fitzpatrick - Human Reason
Maksim Dark - Balast
Several Definitions - Be
Lowkey & Kardinal - Vesperine
The Japanese Popstars - Disconnect/Reconnect (Maxime Dangles Remix)
Dualtec vs Balthazar & Jackrock feat. Alex Di Stefano - Puerto Rico Misfit (Sivro Mashup)
Lowkey & Kardinal - Scolopendra
Kaiserdisco - Get on the Dancefloor
Artento Divini & DTC vs. Delerium - Lift Off Silence (Markus Schulz Mashup)
Andres Gil - Distinctive (Sin Sin Remix)
Dataworx - Invasion
Francesco Terranova - Lira (Skober Remix)
Monika Kruse - Hidden Love
LAAT - Mask Yourself (Dub Mix)
Lia Organa - Black Deauville (Leon Vuksic Remix)
Marco Bailey - Horny Tiger (Filterheadz Remix)
Skober - Keep Calling

=======================================

[SOCIALS]

Discord -- discord.gg/TWpReFxbzx
Twitch -- www.twitch.tv/sivrotv
YouTube -- www.youtube.com/@sivroofficial
Instagram -- www.instagram.com/sivroofficial
Facebook -- www.facebook.com/sivro
Raid Pal -- raidpal.com/en/profile/sivrotv

Live @ Twitch.tv/SivroTV - 10/10/2025 [Twitch DJs Techno Raid Train]

DTC - Radio Edit

Get ready to level up your e-commerce game with the 2 Ecomm Experts. Join our host Viktor Stoilov, founder of Markademics, on his conversations with top notch e-commerce specialists from all over the world. Listen to them unpack the latest trends in the e-commerce world together with hot topics such as marketing, advertising, supply, and logistics. Take your business to the next level with this library of valuable conversations and reach your full e-commerce potential!

🎶 French Art de Mix 🎶

Info / Booking : ludovic.ozka@gmail.com

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

TONY JAY - Résident FG Radio & Radio Maxximum
Afro-Tribal Underground-EDM
https://linktr.ee/french_Touch.Tony.Jay
▶️Promote : electroroomstudio@gmail.com
🛑https://www.facebook.com/tonyjaydj
🚨Résident    :   Radio FG DANCE 🇫🇷
https://www.radiofg.com/fg-mix-dance-tony-jay-8
🇫🇷  Radio Show Maxximum 
✴️ #FGRADIO MUSIC / PODCAST 
https://www.radiofg.com/maxximum-dj-s-tony-jay-4
🗽Supports Radio FG is the European reference for electronic music, a trandsetter media and talent digger. 🎶

Founded in 1991 and based in Paris, the French radio station has always discovered and supported upcoming artists & promoted the biggest DJ’s in the electronic music industry.

Playlisting House, International Dance music and tech-house, trendsetter & innovative, FG launched and supported from the early years the biggest artists such as Daft Punk, David Guetta, DJ Snake, Bob Sinclar, Martin Solveig & many more.

---

Radio FG est la référence européenne de la musique électronique, un média créateur de tendances et émulateur de talents. 🎶

Supporte Radio FG, qui est pionnière dans la diffusion de musique électronique en France. Elle contribue depuis 1991 à la découverte et la mise en avant des plus grands talents de la scène électronique française et mondiale.

Des Daft Punk à David Guetta, mais aussi Bob Sinclar, Carl Cox, Martin Solveig, les Cassius, les artistes de la scène électronique, particulièrement les ambassadeurs de la « French Touch » ont été révélés, soutenus et promus par Radio FG , Tony Jay en rêve .

when the devil and me spoke he said its a lonely path you've paved. evol direction driving eternal expansion
cut off the hand and i shall, walk till all else abandoned. walk alone you will fall in line and R O T.

Got Discord?
https://discord.gg/TWpReFxbzx

CATCH ME LIVE:
https://www.twitch.tv/sivrotv
Tuesdays @ 20:00 (EST) - Extended Sets
Thursdays @ 12:00 (EST) - Work & Lurk

Der E-Commerce Dudes Podcast ist dein wöchentlicher Begleiter in die Welt des Online-Handels. Moderiert von Daniel Höhnke und Tim Schestag, bietet der Podcast seit 2018 spannende Einblicke in aktuelle Trends und Entwicklungen im E-Commerce. Von praxisnahen Tipps für Unternehmer über tiefgehende Analysen bis hin zu innovativen Ideen - hier erfährst du alles, was du wissen musst, um im digitalen Handel erfolgreich zu sein. Egal, ob du gerade erst startest oder bereits ein etablierter Händler bist, die E-Commerce Dudes liefern wertvolle Inhalte und inspirierende Gespräche, die dich weiterbringen. Hör rein und entdecke, wie du deinen E-Commerce auf das nächste Level bringen kannst!

New tracks tagged #DTC