Make a wish / DNA

~ extra time added for copyrights ~

thx for listening :) 

Free Download: https://catchcasper.bandcamp.com/track/frederick-again

Original Songs Used:
Fred Again ft. Skepta - Victory Lap
Kendrick Lamar - DNA

FREDERICK AGAIN (DNA x VICTORY LAP MASHUP)

In this insightful episode of Parallax, Dr Ankur Kalra explores the emerging field of cardiac epigenetics with Dr Manuel Rosa-Garrido, assistant professor of medicine at the University of Alabama in Birmingham. Their conversation examines how the three-dimensional organization of DNA within the cell nucleus influences heart disease development beyond traditional genetic sequencing.

Dr Rosa-Garrido shares his pioneering work using Hi-C technology to map genome structure, revealing that DNA arrangement plays a crucial role in cardiac pathology. The discussion covers key concepts including chromatin loops, topologically associating domains, and compartmentalization—explaining how these structures regulate gene expression and how their disruption contributes to cardiovascular disease.

The episode explores practical implications for clinical practice, from early biomarker identification to potential CRISPR-based therapies that could target chromatin structure. Dr Rosa-Garrido outlines how this research could transform cardiovascular care within the next decade, offering new approaches to both inherited cardiomyopathies and environmentally-influenced conditions like atherosclerosis.

Valuable insights for cardiologists interested in precision medicine and the evolving understanding of how genetic architecture influences cardiovascular risk and treatment strategies.

Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio

Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

EP 138: Mapping the Heart's Hidden Code: How 3D Chromatin Structure Shapes Cardiac Disease

bobby G bringt Qualität

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Bobbyezz - DNA (prod. axz)

ADN musique, une exploration, une connexion, une guérison

Les Oiseaux Médecines

Free Download

Kendrick Lamar - DNA (Xenotype Flip)

// /  /   /    /     \    \   \  \ \\ \  \   \    \     /    /   /  / //

`` d N a ``

Je me tiens sur la mémoire du monde,
dans l’appel de la Terre, là où les pieds
boivent la force du sol,
et les anciennes racines me reconnaissent.
Sous mes genoux, je plie mais je me relève,
les courbures sont des prières
que je murmure en avançant.
Je ne crains plus le détour.
Dans les angles sacrés de mes bras,
de mes hanches, de mes coudes,
la souplesse retrouvée me rend à moi-même.
Je redeviens fluide, comme la vie.
Tendus comme des cordes prêtes à rompre,
mes fibres se souviennent de leur force tranquille.
La tension relâchée est un souffle.
Je ne porte plus ce qui n’est pas mien.
J’habite une cathédrale d’os,
un temple de calcaires vivants.
Ma structure sacrée me tient sans me figer.
Je fais de la place.
Dans le lâcher des poisons, le colon libère l’histoire.
Ce qui doit partir part.
Je n’ai plus besoin de le retenir.
Dans la spirale de l’intérieur,
le discernement intime trie l’essentiel.
Je ne suis pas ce que j’avale.
Je suis ce que je transforme.
Dans la fosse chaude du ventre,
j’accueille l’expérience, je digère la lumière.
Je cesse de contracter mes peurs.
Quand le feu monte sous la cage,
je sens la libération de la colère,
et je ne m’y attache plus.
Je suis brasier traversé.
Dans la clarté d’action, la bile ne déborde plus.
Je tranche sans trancher.
Je marche sans rager.
Une légèreté me revient
par la joie qui s’ouvre dans la rate,
je retrouve le goût de danser pour rien.
Et la douceur incarnée caresse mon sucre intérieur,
je cesse de me punir
en oubliant d’être tendre avec moi.
Au creux du dos, dans les reins tremblants,
je rencontre les bêtes anciennes.
Et je leur dis : je suis là.
Je ne partirai plus.
La lente rivière intérieure
emporte mes excès.
Dans la purification lymphatique,
je me nettoie sans violence.
J’ouvre, même brisé.
Je suis passage de l’amour,
et dans le battement du cœur,
je redeviens accueil.
Je respire la profondeur de l’espace,
les poumons s’ouvrent,
je cesse de m’étrangler
avec mes propres silences.
Sous ma peau,
la frontière aimante se détend.
Je m’autorise à être touché
par la vie.
Offrande et création s’inventent dans mes mains.
Je tends, je façonne,
je transforme ce que je saisis.
Entre tête et poitrine,
je relie les mondes.
Ma nuque se dénoue.
Je m’autorise à dire oui.
Et dans la vérité murmurée,
je parle avec ce que je suis.
Ma gorge n’est plus barrage,
elle est rivière.
Je goûte la morsure et le verbe,
mes dents ne gardent plus la peur.
Je dis. Je chante. Je vis.
Je regarde ce qui est.
Mes yeux ne fuient plus la lumière.
Ils apprennent à aimer même ce qui blesse.
Et dans le silence des sons,
je tends l’oreille au subtil.
Ce qui est faible devient source.
Ce qui est discret devient force.
Ma tête s’éclaircit.
Le mental se tait,
le flot cesse de me noyer.
Je retrouve le rivage.
Je touche la mémoire pacifiée,
là où l’émotion devient mémoire
sans être blessure.
Je rends ce qui ne m’appartient plus.
Dans le noir derrière le front,
je vois les yeux fermés.
La lumière sans lampe
guide mes pas intérieurs.
Le balancier de mon souffle
écoute l’oscillation sacrée.
Je ne lutte plus contre moi-même.
Je me régule avec amour.
Et puis, enfin,
je suis corps du monde, battement du cosmos.
Je ne suis plus séparé.
Je suis traversé.
Je suis prêt.

ADN Corps-Monde

Confiram o que rolou na edição desta semana do programa Cult 22 (18/7) pela Rádio Cultura FM (100,9MHz) em transmissão simultânea com a Radioweb Cult 22

Produção e apresentação: Marcos Pinheiro
Participação: Welbert Rabelo + Duda Rabelo (“Metal Attack”)
Entrevistas: CEO Pedro Franco e apresentadores Johnny Luna e Leco Bezerra (Capital Motoweek) e banda Kobracaio e os Vida Cobra

Set list: www.cult22.com/blog/2025/07/programa-cult-22-1872025-set-list-e-podcast

CULT 22 - 18.7.2025 - Capital Motoweek, Kobracaio e os Vida Cobra, Metal Attack

DALLAS

BUFFALO, NY — July 23, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 6, on June 16, 2025, titled “rDNA copy number variation and methylation from birth to sexual maturity.”

In this study, led by first authors Alina Michler and Sarah Kießling along with corresponding author Thomas Haaf from Julius Maximilians University in Germany, researchers explored how ribosomal DNA (rDNA) copy number and methylation change from infancy to adolescence. They discovered that the epigenetic changes often associated with aging in adults do not occur before sexual maturity. This finding offers new insights into when the biological aging process truly begins.

Ribosomal DNA plays a critical role in producing proteins essential for cell survival. The researchers analyzed blood samples from 280 individuals, ranging from newborns to 18 years of age, including healthy individuals and those with developmental delays. They measured the number of rDNA copies and examined how genes are switched on or off through methylation, a chemical modification of DNA. The results showed that while adults experience a gradual loss of active rDNA copies and increased methylation—a hallmark of aging—these changes were absent in children and teenagers. In fact, during childhood and adolescence, the number of active, unmethylated rDNA copies slightly increased.

These findings support the long-debated idea that biological aging begins only after the body reaches reproductive maturity. Until that point, cells appear to actively maintain rDNA in a youthful state, ensuring that protein production remains efficient. This may help explain why children and teenagers are better at resisting many age-related diseases and why their cells recover more easily from stress.

The study also shows that changes in rDNA copy numbers are not associated with unexplained developmental delays. This suggests these epigenetic processes are probably not involved in early-life syndromes. The findings highlight how the body works to preserve genetic stability during childhood and raise important questions about what triggers the shift to aging-related changes after puberty.

“Collectively our data suggest that the rDNA hypomethylation state is actively maintained in somatic tissues of young individuals.”

The insights gained from this research expand the understanding of the molecular clock of aging. They suggest potential new ways to delay aging processes by exploring how youthful rDNA methylation patterns are maintained. As scientists continue to investigate these mechanisms, the study provides a clear foundation for future research aimed at extending cellular health beyond adolescence.

DOI - https://doi.org/10.18632/aging.206271

Corresponding author - Thomas Haaf - thomas.haaf@uni-wuerzburg.de

Video short - https://www.youtube.com/watch?v=Ww21u33uUhk

Sign up for free Altmetric alerts about this article - 
https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206271

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

Keywords - aging, absolute rDNA copy number, active rDNA copy number, deep bisulfite sequencing, developmental delay, droplet digital PCR

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
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Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

Ribosomal DNA Methylation Patterns Reveal When Aging Begins

DNA flip [irsbnk.]

TMMT July 25 2025 Ruslana Remennikova 2 - Understanding Our 12 Stranded DNA

here is my DNA, Kendrick Lamar on speed garage mix, hope you like it

DNA KENDRICK LAMAR SPEED GARAGE - CEVEN

Blood carries information. Trauma can alter DNA. Patterns repeat unless something, or someone, interrupts the flow. 

THE BLOOD LINE BATTLE

HERO'S LOYALTY(with Kdot)

Lung cancer, particularly non-small cell lung cancer (NSCLC), is the deadliest cancer worldwide. Cigarette smoking is one of the main causes, but not every smoker develops the disease. This suggests that other biological factors help determine who develops cancer.

Researchers from the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indianapolis, and from the Richard L. Roudebush Veterans Affairs Medical Center have now found that cigarette smoke, combined with a weakened DNA repair system, can trigger the early stages of lung cancer, particularly NSCLC. This work, led by first author Nawar Al Nasralla and corresponding author Catherine R. Sears, was recently published in Volume 16 of Oncotarget.

Full blog - https://www.oncotarget.org/2025/08/11/cigarette-smoke-and-weak-dna-repair-a-double-hit-behind-lung-cancer-risk/

Paper DOI - https://doi.org/10.18632/oncotarget.28724

Correspondence to - Catherine R. Sears - crufatto@iu.edu

Video short - https://www.youtube.com/watch?v=UEiCz834a8c

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28724

Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/

Keywords - cancer, DNA repair, DNA damage, lung adenocarcinoma, squamous cell carcinoma, Xeroderma Pigmentosum Group C (XPC)

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

Facebook - https://www.facebook.com/Oncotarget/
X - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/@OncotargetJournal
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/
Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

Oncotarget

Cigarette Smoke and Weak DNA Repair: A Double Hit Behind Lung Cancer Risk

Free Download !!
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DNA JORDAN (AVIV & RYAN FAVIAN BLEND) *PREVIEW

DJ based in Jakarta 🇮🇩
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DJ & producer from Sheffield | 18
I make bassline, garage, UK bass 
New mixes, edits & originals dropping regularly stay locked.

irsbnk. [‘ears bank’]
everything is a leak.
i am not for sale.
yeshua is the greatest.

I have a message from the future : The World Wide Wise Revolution is coming. You are part of it, The world is moving, We are together, Humanity is joining together again !

Diving into the heart of things, exploring new ideas and new ways of seeing and being in this wondrous crazy world we share together, featuring in depth interviews with cutting edge creative out of the box thinkers, authors, healers and explorers of consciousness

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

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No ar desde 1991, o Cult 22 é um programa que toca rock de todos os tempos em vários estilos, com colaboradores, entrevistas e promoções, no ar todas as sextas-feiras, das 21h às 23h, ao vivo, pela Rádio 4 Tempos (www.radio4tempos.com.br) em transmissão simultânea com a Radioweb Cult 22 (www.cult22.com)

‘Parallax’ (/ˈparəlaks/)-noun: the effect whereby the position or direction of an object appears to differ when viewed from different positions. Join Ankur Kalra, MD as he shows you a different side to cardiovascular care, management and science. Listen to Ankur’s conversations with legendary cardiologists, critical reviews of key congresses and late-breaking trials, and concise summaries. Published every second Monday of the month, this is your fix of reliable updates on all things cardiology by someone from a non-traditional background, who is always trying to look at it from new angles! Dear cardiologists, we want to make this podcast about you, and for you! Please email us critical thoughts, comments and questions for Ankur at podcast@radcliffe-group.com.

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