The global crisis surrounding opioid drugs underscores the critical need for advancements in the field of opioid antagonism. Among the potent opioids that have emerged as serious threats to public health, fentanyl and carfentanil stand out due to their high affinity for the opiate receptor. This inherent characteristic not only complicates the clinical reversal process but also raises concerns about achieving and maintaining an adequate duration of reversal. It is within this challenging context that I am honored to collaborate with distinguished co-authors — Martin Trøstheim, Marie Eikemo, Jan Haaker, and Siri Leknes — on our latest research endeavor.

Our newly published article, titled "Opioid Antagonism in Humans: A Primer on Optimal Dose and Timing for Central Mu-Opioid Receptor Blockade" represents a significant leap forward in addressing these challenges. Access the complete article [here].

In the pursuit of a comprehensive understanding, our study draws on a rich tapestry of human opioid receptor imaging data. We meticulously examined data from various sources, including my contributions spanning back to the earliest PET studies conducted in the 1980s. The synthesis of this extensive data culminated in the development of a sophisticated pharmacokinetic algorithm. This algorithm serves as a powerful tool for estimating mu, delta, and kappa receptor occupancy based on the dosage of naloxone or naltrexone.

The implications of this research extend far beyond the realm of academia. Our advanced approach to dose calculations offers a promising avenue for improving both clinical applications and research methodologies related to opioid antagonism. By providing enhanced knowledge and predictability regarding dose-antagonism relationships, we aim to revolutionize the strategies employed by clinicians and investigators in the opioid field.

Clinicians grappling with the complexities of opioid reversal now have access to a more refined and informed toolkit. Armed with our pharmacokinetic algorithm, they can tailor interventions with greater precision, optimizing both the dose and timing for central mu-opioid receptor blockade. This level of precision is paramount in a landscape where every moment counts, and the stakes are high.

As we present this pioneering research, we invite a diverse audience of clinicians, researchers, and policymakers to engage with its implications. The collective impact of our findings promises to shape a new era in the understanding and management of opioid antagonism, ultimately contributing to more effective and targeted interventions. In a world grappling with the repercussions of opioid misuse, our commitment to advancing knowledge in this field remains steadfast, driven by the shared goal of fostering a safer and more resilient society.

About BioMolecular Imaging

BioMolecular Imaging (BMI Consultants) is a molecular imaging and clinical trial consultancy owned and operated by Dr. J. James Frost M.D./Ph.D out of Baltimore Maryland. BMI has been involved with clinical, therapeutic & diagnostic imaging focused on Oncology, Brain, Biomarkers, Cardiology and Central Image Interpretations for over 20 years.

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Navigating the Complexities of Opioid Antagonism: A Paradigm Shift in Dose Precision and Imaging

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Fentanyl, Inc. How Rogue Chemists Are Creating the Deadliest Wave of the Opioid Epidemic

A riveting and deeply human examination of the synthetic-drug epidemic ? and in particular the rise of fentanyl, the newest and most deadly wave of the opioid crisis.A new crop of chemicals is radically changing the recreational-drug landscape. Known as Novel Psychoactive Substances (NPS), these chemicals include replacements for known drugs like cocaine, ecstasy, marijuana, and heroin. They are synthetic, made in a laboratory, and are much more potent than traditional drugs ? and, all too often, they are tragically lethal. Fentanyl, Inc. is the first deep-dive investigation of a hazardous illicit industry that has created a worldwide epidemic, ravaging communities and overwhelming and confounding the government agencies that are challenged to combat it.Drugs like fentanyl, with arcane acronyms like 4-ANPP, K2, and NBOMe, were all originally developed in legitimate laboratories for proper medicinal purposes. Their formulas were then hijacked by rogue chemists, largely in China but 
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A riveting and deeply human examination of the synthetic-drug epidemic ? and in particular the rise of fentanyl, the newest and most deadly wave of the opioid crisis.A new crop of chemicals is radically changing the recreational-drug landscape. Known as Novel Psychoactive Substances (NPS), these chemicals include replacements for known drugs like cocaine, ecstasy, marijuana, and heroin. They are synthetic, made in a laboratory, and are much more potent than traditional drugs ? and, all too often, they are tragically lethal. Fentanyl, Inc. is the first deep-dive investigation of a hazardous illicit industry that has created a worldwide epidemic, ravaging communities and overwhelming and confounding the government agencies that are challenged to combat it.Drugs like fentanyl, with arcane acronyms like 4-ANPP, K2, and NBOMe, were all originally developed in legitimate laboratories for proper medicinal purposes. Their formulas were then hijacked by rogue chemists, largely in China but 
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Peter Schweizer, author of Blood Money: Why the Powerful Turn a Blind Eye While China Kills Americans, joins us to discuss China's role in the fentanyl crisis that is killing hundreds of thousands of Americans, and how U.S. politicians are enriching themselves through their complicity in these crimes.       

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A decade ago, California voters passed Prop 47 which reduced the punishment of simple drug possession and petty theft to misdemeanors while raising the felony threshold from $400 to $950 for petty theft.

From the start, the measure passed by the voters has garnered criticism from law enforcement and other tough on crime groups and has been blamed for the rise in fentanyl use as well as a rash of high profile retail thefts and smash and grabs.

However, as Tinisch Hollins of executive director of Californians for Safety and Justice, the state’s leading public safety advocacy organization told the Vanguard – this is a false narrative.

“The troubling incidents we’ve all seen on television like smash and grabs were not changed by Proposition 47, nor are they implicated by this attempted repeal,” she said in a recent statement.

Moreover, as discussed this week on Everyday Injustice – crime is down.
“Since Proposition 47 passed property crime is down, recidivism is down, and racial disparities in the justice system are down,” Hollins said.

Listen as Tinisch Hollins discusses Prop 47, efforts to roll it back, and the future of criminal justice reform, and how efforts to reform the system actually lead to enhanced public safety.

Everyday Injustice Podcast Episode 240 - Tinisch Hollins on the Rollback Attempt of Prop 47

This week on Everyday Injustice, we sit down with LaToya Mitchell, Navigator Project Manager, CA Bridge Program and talked about the innovative program that helps get people from ER into drug treatment and reduce annual drug overdoses.

A few weeks ago, she was part of a rally at the California Capitol to push for a package of bills that would improve access to programs such as the Bridge Navigator Project.

The navigator program allows ER patients to connect with treatment medication and staff immediately.

Mitchell explained, “What most people don’t know is that it is the easiest substance use disorder to treat because medication like buprenorphine, which is commonly known by the brand name Suboxone, acts fast to stop the withdrawals without euphoria and allows the patient to feel like themselves before the addiction.”

Her job is to lower the barriers for patients to receive the treatment.
She said that “there’s a lot of stigma for people who use drugs and that creates barriers like obtaining a Suboxone prescription from big chain pharmacies, so it’s essential that I know which pharmacies are Suboxone friendly and provide that list to the patients.”

Mitchell noted, “We found that with the presence of the navigator, patients felt more comfortable coming in and saying, I’m here because I’m having opioid withdrawals, as opposed to them naming their symptoms and because they were afraid of admitting their substance use. Because of that, we’re able to get them treated and in and out in a couple of hours. Instead of spending six hours in the emergency room getting unnecessary and costly tests, we found that it actually saved resources and a lot of money.”

Listen as Latoya Mitchell discusses the importance of harm reduction and the use of treatment over incarceration.

Everyday Injustice Podcast Episode 245: The Bridge Program a Pathway Toward Better Drug Treatment

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Expert advice on imaging for clinical settings, trial design, data analysis as well as FDA, CROs & academic relations

End of Western Civilization got you down? All is tickety-boo on The Andrew Klavan Show as Andrew laughs his way though Armageddon with political satire, cultural commentary, interviews and relentless mockery of racial pieties, sexual perversities, and feminist absurdities. Monday thru Thursday.

Davis Vanguard Podcast will be covering criminal justice reform, mass incarceration, wrongful convictions, and more.

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