In this ASCO-GI research special, Dr. Bekaii-Saab of Mayo Clinic provides an insightful and comprehensive roundup of the most groundbreaking studies unveiled at the ASCO GI 2024 meeting. Delving into the realm of hepatocellular carcinoma, he dissects the pivotal previously-reported data from IMbrave050 and ASCO GI findings from EMERALD-1. Then, he sheds light on developments in colorectal cancer, exploring the impact of KEYNOTE-177 and CheckMate 8HW. Moreover, Dr. Bekaii-Saab explores the latest advancements in minimal residual disease assessment with a focus on studies like BESPOKE and GALAXY, as well as the prognostic value of ctDNA assessment showcased in COBRA.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

ASCO-GI Research of Note With Tanios Bekaii-Saab

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Los antiácidos son sustancias alcalinas que se venden para mitigar las molestias estomacales. Se anuncian como remedio para cortar el exceso de acido estomacal y la mayoría de las personas creen que esa es la solución, no obstante nosotros necesitamos ese acido para poder digerir las proteínas y las grasas y para destruir bacterias y otros agentes infecciosos que entran por la boca.

Los antiácidos pueden crear muchos mas problemas de los que resuelven. Se puede combatir naturalmente el exceso de acidez en el sistema.

Puede obtener este Programa en LA Farmacia Natural en Los Angeles, Van Nuys, Huntington Park, El Monte, Arleta, Pico Rivera, y en Burbank o llamando a la Línea de la Salud, al 1-800-227-8428 si desean que se lo enviemos a su casa.

240910 Martes Salud Gastrointestinal

In the November 2024 episode of Critical Decisions in Emergency Medicine, Drs. Danya Khoujah and Wendy Chang discuss investigating lower GI bleeding in the emergency department and testicular torsion presentations. As always, you’ll also hear about the hot topics covered in CDEM’s regular features, including pediatric facial nerve palsy in Clinical Pediatrics, a distal triceps tendon tear in Orthopedics and Trauma, reverse Valsalva maneuver in The Critical Procedure, high-risk airway management in The LLSA Literature Review, and a patient with foot drop in The Critical Image.

November 2024: Investigating Lower GI Bleeding in the Emergency Department and Testicular Torsion Presentations

Bem-vindos ao OncoPonto, o podcast do Grupo SOnHe que traz temas essenciais da oncologia e hematologia.

Neste episódio especial, com o tema "Decifrando as Zebras: o Essencial sobre Tumores Neuroendócrinos", contamos com a participação de dois oncologistas:

Dr. Rafael Luís (CRM: 156.336 | RQE: 71.669)
Dra. Isabela Pinheiro (CRM: 176.931 | RQE: 111.231)

Junto à Renata Sasse, Diretora Executiva do Grupo SOnHe, eles esclarecem os desafios e avanços no diagnóstico e tratamento desses tumores raros, trazendo informação acessível e de qualidade para médicos, pacientes e o público geral.

📌 Ouça este episódio completo no Spotify do Grupo SOnHe ou assista no Canal do YouTube do Grupo.

🔔 Não se esqueça de curtir, comentar e se inscrever no canal para ficar por dentro dos próximos episódios do OncoPonto.

📢 Compartilhe com colegas e amigos interessados em oncologia e saúde!

Decifrando as zebras: o essencial sobre tumores neuroendócrinos.

Drs. Emil Lou and Shruti Patel join Chadi on the podcast to unpack the alarming rise of gastrointestinal cancers in younger patients. They explore a range of possible environmental contributors—from plastic exposure and processed meats to alcohol and tobacco use—and discuss how these factors might be investigated through laboratory science. The conversation also highlights the promise of genomic profiling in shedding light on these trends, and reviews key findings from ASCO GI that could help steer future research and prevention efforts.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

GI Cancers in Young Patients With Emil Lou and Shruti Patel

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Endoscopia Gastrointestinal superior

BUFFALO, NY — September 9, 2025 — A new #research paper was #published in Volume 17, Issue 8 of Aging-US on August 1, 2025, titled “Causal relationships between gut microbiome and hundreds of age-related traits: evidence of a replicable effect on ApoM protein levels.”

In this study, Federica Grosso, Daniela Zanetti, and Serena Sanna from the Institute for Genetic and Biomedical Research (IRGB) of the National Research Council (CNR), Italy, uncovered new associations between gut microbiome and the aging process. The researchers found that certain microbial characteristics may causally influence proteins in the blood linked to inflammation and heart health. These findings could help explain how age-related diseases like cardiovascular conditions and macular degeneration are influenced by changes in the gut ecosystem.

The gut microbiome, the collection of microorganisms living in the digestive system, plays a major role in immune function and metabolic health. As people age, this microbial community shifts, often leading to imbalances associated with inflammation and chronic disease. To explore how these changes might affect the body, the researchers used Mendelian Randomization—a method that leverages genetic data—to test over 55,000 possible causal connections between gut microbial characteristics and age-related health indicators.

The study identified 91 significant causal relationships. Among them, the researchers found that higher levels of certain gut bacteria were associated with increased risk of age-related macular degeneration. Another finding was the association between a metabolic pathway in the gut, called “purine nucleotides degradation II,” and lower levels of apolipoprotein M (ApoM), a protein that helps protect against heart disease. This result was validated using data from an independent study, strengthening the evidence.

“Unlike previous studies, we performed replication analyses for the significant results using independent GWAS datasets, a fundamental step that has often been overlooked.”

The study also revealed how some bacteria may affect protein levels differently depending on a person’s blood type. Specifically, in individuals with blood type A, certain gut microbes that can break down a sugar called GalNAc may influence proteins related to inflammation and cardiovascular health. This suggests that personalized approaches to managing age-related diseases could consider both gut microbiota and genetic factors like blood type.

The research team followed strict guidelines to reduce false findings and confirmed its key results in independent datasets. By carefully testing for reverse causality and other biases, the authors provided strong evidence that the gut microbiome can influence critical aspects of aging biology.

Although more research is needed to fully understand the biological pathways involved, these findings suggest that targeting the gut microbiota might help delay or reduce age-related inflammation and disease. The study lays a foundation for future therapeutic strategies that could include diet, probiotics, or other microbiome-based interventions.

DOI - https://doi.org/10.18632/aging.206293

Corresponding author - Serena Sanna - serena.sanna@cnr.it

Abstract video - https://www.youtube.com/watch?v=CWky6jlHKUs

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To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

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Aging-US

Gut Microbiome Influences Proteins That Drive Aging and Disease

El programa de la nutricionista Neyda Carballo-Ricardo, transmitido 24 horas por Internet, inclusive en vivo desde Los Angeles, CA de lunes a viernes, 10 AM - 12 PM (Pacific Time) via Radio KWKW 1330 AM. Sintonize por Internet a cualquier hora para escuchar noticias, meditaciones, llamadas, y un premio cada viernes. Para mayor detalle, visite http://lafarmacianatural.com o llame al (800) 227-8428.

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Healthcare Unfiltered is an honest, raw, timely podcast tackling any and all topics in healthcare that affect stakeholders. Dr. Chadi Nabhan uses his dynamic conversational skills to challenge his guests to address controversial and important topics. He also brings on world renowned experts to discuss clinical advances in medicine.

New tracks tagged #Gastrointestinal