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American Board of Clinical Genetics and Genomics (MD) Certification Exam

American Board of Laboratory Genetics and Genomics Certification Exam

BUFFALO, NY- August 12, 2024 – A new research perspective was published in Oncotarget's Volume 15 on July 16, 2024, entitled, “Targeting the multifaceted BRAF in cancer: New directions.”

In cancer patients, BRAF-targeting precision therapeutics are effective against Class I BRAF alterations (p.V600 hotspot mutations) in tumors such as melanoma, thyroid cancer, and colorectal cancer. However, numerous non-Class I BRAF inhibitors are also in development and have been explored in various cancers.

Researchers Eamon Toye, Alexander Chehrazi-Raffle, Justin Hwang, and Emmanuel S. Antonarakis from the Masonic Cancer Center, University of Minnesota-Twin Cities, Department of Medicine, University of Minnesota-Twin Cities, Perelman School of Medicine, University of Pennsylvania, and the City of Hope Comprehensive Cancer Center in Duarte, California, discuss the diverse forms of BRAF alterations found in human cancers and the strategies used to inhibit them in patients with cancers of various origins.

As part of their conclusion, the researchers highlighted that Class I BRAF inhibitors represent a landmark achievement in precision oncology, as demonstrated by the recent tissue-agnostic FDA approval of dabrafenib/trametinib for patients with metastatic BRAF p.V600E-mutant solid tumors. Additionally, the accelerated approval of tovorafenib for patients with relapsed/refractory BRAF-altered pediatric low-grade glioma underscores the therapeutic potential of this and other next-generation strategies targeting aberrant MAPK signaling.

DOI - https://doi.org/10.18632/oncotarget.28612

Correspondence to - Emmanuel S. Antonarakis - anton401@umn.edu, and Justin Hwang - jhwang@umn.edu

Video short - https://www.youtube.com/watch?v=3dRWRvOnssc

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Keywords - cancer, BRAF, MAPK, pan-cancer, precision oncology, genomics

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

Facebook - https://www.facebook.com/Oncotarget/
X - https://twitter.com/oncotarget
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Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

Oncotarget

New Directions in Targeting the Multifaceted BRAF in Cancer

Host Andrew Page is joined by Robert Petit from the Wyoming Public Health Laboratory. Robert, a key developer of the Bactopia pipeline, shares insights into how this end-to-end tool is transforming bacterial genomic surveillance. They dive into the origins of Bactopia, its applications in public health, and Robert's experience leading genomic projects in a rural setting. Discover how Bactopia streamlines pathogen detection, improves documentation, and integrates with other tools to deliver fast and accurate results.

Listen in as they discuss new innovations in bioinformatics, including visualizations and human-read filtering, and explore future projects like CamelHUMP, designed to simplify sequence-based typing. Recorded live at the Microbial Bioinformatics Hackathon in Bethesda, Maryland, this episode brings you the latest in pathogen genomics and the challenges and rewards of working on the frontier of public health.

129 Genomics on the Frontier: Bactopia, Bioinformatics, and Pathogen Surveillance with Robert Petit

In this episode of the Micro binfie Podcast, host Andrew Page sits down with Tim Dallman at the 10th Bioinformatics Hackathon in Bethesda, Maryland. Tim shares insights from his work at Utrecht University in the Netherlands, where he focuses on genomic surveillance and machine learning models to predict disease risk and severity. They discuss the challenges of integrating genomic variation into predictive models, the importance of high-quality metadata, and the complexities of working with pathogens like Shiga toxin-producing E. coli. Tim also talks about his role at the WHO Pandemic and Epidemic Intelligence Hub and how global collaboration can drive innovation in public health genomics. Tune in to hear about cutting-edge research, the importance of interdisciplinary teamwork, and how genomic data can be harnessed for future pandemic preparedness.

130 Exploring Genomic Innovation and Machine Learning in Public Health

In this episode of the Micro Binfie Podcast, host Andrew Page catches up with Torsten Seemann at the 10th Microbial Bioinformatics Hackathon in Bethesda, Maryland. They discuss the rapid evolution of bioinformatics, the challenges faced by labs worldwide, and the explosion of tools post-COVID. Torsten shares insights into his work at Melbourne’s Microbiological Diagnostic Unit (MDU), the development of platforms like OzTracker for bacterial genomics, and how his lab plays a national and international role in data sharing. 

The conversation dives into the future of the widely-used variant calling tool Snippy, as Torsten reveals exciting updates funded by the Chan Zuckerberg Initiative, including nanopore read support and the ability to process pre-assembled genomes. They also explore the importance of maintaining open-source bioinformatics tools to prevent them from becoming obsolete. Tune in for an in-depth discussion on the state of genomics, software development, and the challenges and rewards of open-source collaboration.

131 Bioinformatics Evolution: Torsten Seemann on Snippy, Open-Source Support, and Global Genomics

Unleash Your Inner Hero with Audio Genomics! 🧬🎶

Dive into the revolutionary Audio Genomics track—a sonic alchemy designed to activate your superhuman DNA and spark a transformation like no other. Imagine blending cutting-edge genetic harmonics with masterful soundscapes, creating a frequency cocktail that awakens latent powers within you. Whether you’re striving for lightning-fast focus, Herculean strength, or the boundless creativity of a genius, this track is your auditory key to unlocking extraordinary potential. Plug in, power up, and let the waves of Audio Genomics rewire your essence, turning everyday into epic. Why settle for ordinary when your soundtrack for greatness is just a play button away?

 #dnaactivation #lightworker #ascension #fifthdimension #innerknowing #higherfrequency #higherdimensions #lightbeings #innerguidance #starseed #universalknowledge #thehigherself #universalguidance #innerbeing #lightworkersunite #awakening #lightcodes #enlightenment #spiritualgrowth #manifesting #likeattractslike #raiseyourvibration #thirdeyevision #lightlanguage #selfaware #lawofattractionquotes #youcreateyourownreality #everythingisenergy #spiritualawakening #spirituality 

S CLASS SUPERHUMAN ACTIVATION (Screensaver Remix)

Unleash Your Inner Hero with Audio Genomics! 🧬🎶

Dive into the revolutionary Audio Genomics track—a sonic alchemy designed to activate your superhuman DNA and spark a transformation like no other. Imagine blending cutting-edge genetic harmonics with masterful soundscapes, creating a frequency cocktail that awakens latent powers within you. Whether you’re striving for lightning-fast focus, Herculean strength, or the boundless creativity of a genius, this track is your auditory key to unlocking extraordinary potential. Plug in, power up, and let the waves of Audio Genomics rewire your essence, turning everyday into epic. Why settle for ordinary when your soundtrack for greatness is just a play button away?

Alpha Dracon Virus (Post-Operative Dream Remix)

Shifter Star

In this episode of the Micro Binfie Podcast, host Andrew Page takes listeners to the heart of the microbial genomics hackathon in Bethesda, Maryland, for an engaging conversation with special guest Megan Phillips, a PhD student from Emory University. Megan delves into her research on Staphylococcus aureus (MRSA), highlighting its fascinating dual nature as both a harmless and potentially serious pathogen.

Megan discusses the complexities of tetracycline resistance, particularly focusing on plasmid-mediated mechanisms involving the pt181 plasmid. She explains how this plasmid’s efflux pump, encoded by the gene tetK, contributes to variable resistance levels and the factors influencing MIC (Minimum Inhibitory Concentration) variability. Listeners will learn about the intricacies of plasmid copy numbers, their global spread across clonal complexes, and the occurrence of horizontal and vertical gene transfer.

Throughout the episode, Megan shares insights on working with short-read sequencing data and the strategies she employs to detect plasmid presence using tools like BLAST. She also touches on the challenges and fascinating discoveries of tracking historical sample data and integrating findings from older research papers, showcasing her appreciation for the poetic style of scientific writing from the 1940s.

For those interested in antimicrobial resistance, evolutionary microbiology, and the subtleties of bacterial genome analysis, this episode offers a compelling blend of technical details and engaging storytelling. Tune in to hear more about Megan’s upcoming publications, her experiences navigating complex genomic data, and her thoughts on antimicrobial stewardship and historical perspectives on drug resistance.

138 Decoding Tetracycline Resistance in MRSA

In the second part of our conversation with Dr. Eric Topol, we explore how examining the past is necessary to ensure we’re more prepared for our future. From universal vaccines and advanced antiviral therapies to cutting-edge digital tools like wearable biosensors and genomic surveillance, Dr. Topol shares actionable insights on harnessing technology and data to revolutionize pandemic preparedness. Listen in as we discuss the path to a safer, healthier future. 

 //

Episode transcript: https://www.scripps.edu/_files/images/2024_images/topol-pandemic-prep-transcript.pdf
Twitter: https://twitter.com/EricTopol 
LinkedIn: https://www.linkedin.com/in/eric-topol-md-b83a7317/  
Ground Truths podcast: erictopol.substack.com  
Scripps Research Magazine: magazine.scripps.edu/ 

Futureproof: Eric Topol on revolutionizing pandemic preparedness

I am delighted to welcome Dr. Alexios Mentis to our podcast.

Dr. Alexios is a distinguished expert in genomics and precision medicine, with over a decade of experience in clinical and public health research. Currently serving as a Senior Scientific Officer at BGI Group, a global leader in the field, he has been at the forefront of advancing genomic science to improve human health and well-being.

In this episode, Dr. Alexios Mentis will provide valuable insights from his research, "The Role of Genomic Data in Shaping Public Health Policies."

Genomic data has become a transformative tool in shaping public health policies by providing insights into the genetic underpinnings of diseases, the effectiveness of treatments, and the distribution of health risks across populations. This data allows policymakers to make evidence-based decisions, from targeted disease prevention strategies to personalized healthcare approaches. By integrating genomic information, public health systems can better address genetic predispositions, predict disease outbreaks, and optimize resource allocation. Dr. Alexios Mentis' research explores how genomic data can guide these decisions, highlighting its potential to improve health outcomes and inform more equitable, data-driven policies.

Dr. Alexios holds an M.D. from the National & Kapodistrian University of Athens, a Ph.D. in Neurogenetics from the Pasteur Hellenic Institute, and an MPH in Infectious Diseases Epidemiology from the National School of Public Health. Additionally, he is an alumnus of Johns Hopkins University and has earned professional certifications in Clinical Pharmacology, Drug Development, and Regulation from Tufts University, as well as Digital Health Business from Columbia University.

With a prolific publication record of over 90 peer-reviewed articles in leading journals and numerous presentations at international conferences, Dr. Alexios has earned widespread recognition for his contributions. His work continues to bridge the gap between genomic research and practical applications, shaping the future of public health and precision medicine. 

This podcast is brought to you by Global Management Consultancy. For more information, please visit www.globalmanagementconsultancy.com.

Disclaimer:

A. The background music used in this video is the property of its respective developer and is protected by Copyright. Although it is a free version, Business Talk, Global Management Consultancy and Deepak Bhatt do not hold the rights to this music.

B. Dr. Alexios Mentis has granted permission to share insights from his research, "The Role of Genomic Data in Shaping Public Health Policies" on Business Talk Podcast Channel. The uploaded video contains copyrighted material; therefore, any modifications to graphics, music, or the presence of the author or host are strictly prohibited.

Shaping Public Health Policies Through Genomic Data A Conversation with Dr. Alexios Mentis

Get ready to level up your playlists with “Next CEO Wacked,” the audacious, genre-defying single that merges cutting-edge audiogenomics with a playful nod to the beloved green-hatted underdog, Luigi. From its sinister synth lines to the uproarious bass drops, the track embodies a mischievous, high-stakes vibe—like watching corporate boardrooms go into meltdown mode. With DNA-engineered harmonics that shimmer and shift, it’s a sonic journey through neon-lit back alleys, palace corridors, and everything in between. It’s both a sly wink at power structures and a rallying cry for anyone who’s ever been underestimated—just ask Luigi. Bold, catchy, and delightfully subversive, “Next CEO Wacked” is a must-listen for fans of thrilling next-gen music and cheeky rebellion.

Next CEO Wacked

Unraveling the Mysteries of Life
The New World of Genomic Medicine
With Eric Green, MD, PhD
Director, National Human Genome Research Institute, NIH
Recorded at The Torah Center ATL on Wednesday, January 15, 2025

Just over two decades ago, researchers completed a historic effort to read out the approximately 3 billion “letters” of DNA that make up the human genome. Progress since then has been breathtaking and spectacular, including the emergence of real-world examples involving the use of a patient’s genomic information to improve their clinical care—something known as genomic medicine.

Dr. Eric Green is Director of the National Human Genome Research Institute at the U.S. National Institutes of Health and one of the scientists who led the effort to map and sequence the human genome during the Human Genome Project. In this talk Dr. Green describes the story of human genomics and how genomics is becoming mainstream in medicine—including some important applications for the Jewish community.

Unraveling the Mysteries of Life: The New World of Genomic Medicine | Dr. Eric Green

For years, breast cancer has been classified as either HER2-positive or HER2-negative, determining whether a patient could receive HER2-targeted therapies like trastuzumab (Herceptin). However, a growing body of research suggests a middle category—HER2-low breast cancer—which has led to important changes in how clinicians approach treatment.

A recent review published in Oncotarget, titled “Evolving Concepts in HER2-Low Breast Cancer: Genomic Insights, Definitions, and Treatment Paradigms,” explores what this means for both patients and clinicians​.

Full blog - https://www.oncotarget.org/2025/02/12/her2-low-breast-cancer-a-new-understanding/

Paper DOI - https://doi.org/10.18632/oncotarget.28680

Correspondence to - Andrew A. Davis - aadavis@wustl.edu

Video short - https://www.youtube.com/watch?v=dn54UrHCUNQ

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Keywords - cancer, breast cancer, HER2-low, genomics

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

Facebook - https://www.facebook.com/Oncotarget/
X - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/@OncotargetJournal
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/
Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

HER2-Low Breast Cancer: A New Understanding

This song fully activates your latent superhuman potential from deep within you. Beyond just buzzing, our audiogenomics technology will bring out the best in you!!!

Evolution's Prayer

HEAL Security Dispatch Daily Digest is your essential briefing on the latest cybersecurity trends and developments, with a special focus on healthcare security. Hosted by Richard Simmons from London, this podcast delivers expert insights into the evolving digital threat landscape. In this edition, we cover pressing security concerns, including 23andMe's bankruptcy raising alarms over genetic data privacy, a critical vulnerability in the NGINX Ingress Controller allowing remote code execution, and a massive data breach at Numotion exposing nearly 500,000 individuals' information. We also discuss McAfee’s findings on Android malware campaigns leveraging Microsoft’s .NET MAUI framework, rising cyber threats targeting Counter-Strike 2 players through Browser-in-the-Browser attacks, and a zero-day vulnerability exploited by EncryptHub attackers via Windows MMC. Additionally, we highlight the UK-based Milner Therapeutics Institute’s efforts in genomic screening for drug discovery. Stay informed and secure with the latest in cybersecurity intelligence. 
https://healsecurity.com/

23andMe Bankruptcy, NGINX Vulnerability, and Android Malware Tactics Uncovered

The Torah Center ATL takes pride in offering innovative, inclusive, and impactful educational programs to all. People from a diverse spectrum of life find the Center to be a warm and non-judgmental community in which to experience the richness and authenticity of Jewish learning and heritage. 
~
Support our work!
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The Daily HEAL Security Dispatch Podcast is a leading source for up-to-the-minute news and deep insights in the realm of healthcare cybersecurity and threat intelligence. 

At the heart of HEAL Security's vision is the commitment to equipping organizations and individuals with rapid, contextually rich cybersecurity updates, establishing itself as a pivotal force in unifying practice and data against the ingenious tactics of criminal and malicious entities. HEAL Security is fervently devoted to constructing a robust resource and community that champions the defense of the healthcare sector against the growing cyber threats from organized crime groups and antagonistic nation-states. Our core focus encompasses the protection of vital IT infrastructures, the security of sensitive patient and clinical information, the safeguarding of critical healthcare systems, and the assurance of continuous, undisturbed patient care services.

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Welcome to Business Talk, your go-to podcast for the latest trends, insights, and thought-provoking discussions in the business world. Whether you're a business professional, entrepreneur, researcher, or academic, our episodes will challenge you to rethink conventional wisdom and inspire actionable ideas.

Brought to you by Global Management Consultancy, we are committed to driving innovation and excellence in the business community. All content Copyrighted 2024 by Global Management Consultancy.

For more information about our past and upcoming podcasts, please click here:https://www.deepakbbhatt.com/businesstalk

The award-winning Science Changing Life podcast offers an inside look into how Scripps Research scientists are solving the most pressing mysteries in human health and disease. Join hosts Lauren Fish and Melissa Suran, PhD, as they speak with world-class scientists at the forefronts of immunology, infectious disease, artificial intelligence, personalized medicine, neuroscience and much more. 

Science Changing Life gives listeners a glimpse into the people behind the science, their motivations, paths to discovery, and how they’re changing the world. 

Follow us on social media for more updates:
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music that alters DNA is my game
superhuman powers, not tame
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lets be bright throughout the night 
My music upgrades your DNA and gives you superpowers...

#CACACOM #UOVIM #UPAAH #ESIASCH #ESEMELI #AUDIOGENOMICS is #raisingreality 

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Microbial Bioinformatics is a rapidly changing field marrying computer science and microbiology. Join us as we share some tips and tricks we’ve learnt over the years. If you’re student just getting to grips to the field, or someone who just wants to keep tabs on the latest and greatest - this podcast is for you. 

The hosts are Dr. Lee Katz from the Centres for Disease Control and Prevention (US), Dr. Nabil-Fareed Alikhan from the University of Oxford (UK), and Prof. Andrew Page from Theiagen Genomics (UK) and bring together years of experience in microbial bioinformatics.

The opinions expressed here are our own and do not necessarily reflect the views of Centres for Disease Control and Prevention, University of Oxford or Theiagen Genomics.

Intro music : Werq - Kevin MacLeod (incompetech.com)
Licensed under Creative Commons: By Attribution 3.0 License
http://creativecommons.org/licenses/by/3.0/

Outro music : Scheming Weasel (faster version) - Kevin MacLeod (incompetech.com)
Licensed under Creative Commons: By Attribution 3.0 License
http://creativecommons.org/licenses/by/3.0/

Question and comments? microbinfie@gmail.com

New tracks tagged #Genomics