In honor of Cervical Health Awareness Month, the National Cervical Cancer Coalition presents the Cervical Cancer Survivor Series. Across eight episodes, we share stories from cervical cancer survivors across the country, touching on topics including diagnosis, treatment, and survivorship, as well as advice for others whose lives are impacted by this preventable disease. We also talked to providers in the field to answer questions about screening prevention and treatment.

In this episode we speak to Shaundra Hall. Shaundra tells us that her very first Pap test came back abnormal, but she still didn't know anything about cervical cancer when she was diagnosed. She also talks about how this experience changed the course of her life, both personally and professionally.

To learn more about clinical trials, visit https://clinicaltrials.gov. 

Learn more about Shaundra and her NCCC chapter at http://www.nccc-online.org/nccc-arizona-southwest-regional/

Learn more about cervical cancer prevention at the National Cervical Cancer Coalition website at www.nccc-online.org/

Cervical Cancer Survivor Series: Shaundra Hall

In honor of Cervical Health Awareness Month, the National Cervical Cancer Coalition presents the Cervical Cancer Survivor Series. Across eight episodes, we share stories from cervical cancer survivors across the country, touching on topics including diagnosis, treatment, and survivorship, as well as advice for others whose lives are impacted by this preventable disease. We also talked to providers in the field to answer questions about screening prevention and treatment.

In this episode, we speak to Aisha McClellan. Aisha went to a clinic with symptoms, and was sent home with antibiotics for an STI she didn't have. It took three visits before she was diagnosed with cervical cancer. Aisha had to be her own advocate for health care, which inspired her to become an advocate on TikTok, where she has over 25,000 followers.

Follow Aisha on TikTok at https://www.tiktok.com/@aisha_the_advocate

Learn more about cervical cancer prevention at the National Cervical Cancer Coalition website at www.nccc-online.org/

Cervical Cancer Survivor Series: Aisha McClellan

In honor of Cervical Health Awareness Month, the National Cervical Cancer Coalition presents the Cervical Cancer Survivor Series. Across eight episodes, we share stories from cervical cancer survivors across the country, touching on topics including diagnosis, treatment, and survivorship, as well as advice for others whose lives are impacted by this preventable disease. We also talked to providers in the field to answer questions about screening prevention and treatment.

In this episode we speak to Barbara Moscicki, a pediatrician and HPV expert. Dr. Moscicki explains cervical cancer screening in detail and helps us understand the follow-ups we may need if we have an abnormal result. She also talks about the importance of the HPV vaccine and the possibility that we could eliminate cervical cancer.

Learn more about cervical cancer prevention at the National Cervical Cancer Coalition website at www.nccc-online.org/

Cervical Cancer Survivor Series: Barbara Moscicki

Dee and Kate chat with Adrienne the Yoni Nutritionist about fishy vaginas, which smells worse: foreskin smegma or vaginal discharge, and how to gently tell your sex partner that you have anal warts. Marshall Island Tony has a moral compass and UK listener calls in with a cautionary tale about Planet of the Apes. Sign up for the Sick and Wrong Patreon to hear the Second Show, SW archives, and the bonus minisode Serial Killer Star Signs.

S&W Episode 981: Something Fishy Going On

There's a new way to screen for cervical cancer with self-collection. People can take a sample of cells from their own vagina to test for HPV. The FDA recently approved this for use in providers offices. There's no pelvic exam stirrups or speculum involved. Research has shown that the results are just as accurate as when samples are collected by a clinician. Self-collection has the potential to expand testing to other healthcare settings and reach underscreened populations.

In this episode, we speak to Barbara Moscicki, MD, who has been involved in the research around HPV for decades to explain this new method to us, and how it might help us reach the goal of eliminating cervical cancer.


Learning about HPV Self Collection with Barbara Moscicki, MD

There's a new way to screen for cervical cancer with self-collection. People can take a sample of cells from their own vagina to test for HPV. The FDA recently approved this for use in providers offices. There's no pelvic exam stirrups or speculum involved. Research has shown that the results are just as accurate as when samples are collected by a clinician. Self-collection has the potential to expand testing to other healthcare settings and reach underscreened populations.

In this episode, we speak to Jennifer S. Smith, PhD, who has been involved in the research around HPV for decades to explain this new method to us, and how it might help us reach the goal of eliminating cervical cancer.


Jennifer Smith and the Promise of HPV Self Collection

Les papillomavirus humains (HPV) sont des virus très contagieux qui se transmettent par contact intime. On estime qu’environ 80 % des femmes et des hommes y seront exposés au cours de leur vie. Dans certains cas, les infections aux papillomavirus peuvent être responsables de cancers.

Dans ce nouvel épisode, Dr Blanchi, infectiologue au #CHLeMans nous précise ce que sont les papillomavirus et comment s’en protéger, notamment grâce à la vaccination.

Prévention - #09 Les papillomavirus

قراءة صوتية لمقال "هل يمكن أن ينتقل فيروس الورم الحليمي عن طريق التقبيل؟" بصوت أحمد يوسف

لقراءة النص المكتوب، يمكنكم مطالعة: https://bit.ly/4hSkQgF

هل يمكن أن ينتقل فيروس الورم الحليمي عن طريق التقبيل؟

BUFFALO, NY - April 28, 2025 – A new #research paper was #published in Oncotarget, Volume 16, on April 24, 2025, titled “PD-L1 and FOXP3 expression in high-grade squamous intraepithelial lesions of the anogenital region."

Researchers Humberto Carvalho Carneiro, Rodrigo de Andrade Natal, José Vassallo and Fernando Augusto Soares from the Instituto D’Or de Pesquisa e Ensino and Rede D’Or studied early tissue changes caused by human papillomavirus (HPV) in the anal, vulvar, and penile regions. They found that high-grade pre-cancer lesions triggered stronger immune responses and showed higher levels of two immune-related markers, PD-L1 and FOXP3. These findings are important because they help explain how some HPV-related lesions progress to cancer while others heal on their own.

High-risk HPV is known to cause several types of anogenital cancers. Before these cancers appear, the virus often leads to abnormal tissue changes known as high-grade squamous intraepithelial lesions. Many of these lesions disappear without treatment, but some become cancer—especially in people with weakened immune systems. This study explored how immune activity may play a role in this progression.

The researchers examined tissue from 157 patients—95 males and 55 females—with either high-grade or low-grade HPV-related lesions. They found that T-regulatory cells, marked by the FOXP3 protein, were more common in high-grade lesions. These immune cells are known to suppress immune responses, which can allow infected or abnormal cells to grow. The team also found higher expression of PD-L1, a protein that helps cells evade immune detection, particularly in inflammatory immune cells.

"Dense inflammatory infiltrates and high counts of FOXP3+ cells were significantly more frequent in patients with HSILs than in those with LSILsHR (p = 0.04 and 0.02, respectively). HSILs also exhibited higher PD-L1 expression (padj < 0.01 and < 0.01 for the SP142 and 22C3 clones, respectively), based on the Poisson generalized linear model.”

These findings suggest that HPV may begin avoiding the immune system early in infection, even before cancer develops. The combination of high FOXP3 and PD-L1 levels may create a protective environment for infected cells, making them harder for the body to eliminate. This immune evasion may allow the lesions to remain and, over time, become cancerous.

The study also compared patients with and without HIV to assess whether immune health influenced the results. While those with compromised immune systems had more extensive lesions, PD-L1 and FOXP3 expression was also found in patients with healthy immune systems. This evidence shows that immune evasion by HPV can happen regardless of a person’s immune status.

Understanding how PD-L1 and FOXP3 function in early HPV-related lesions may help clinicians predict which lesions are more likely to become cancer. These insights could lead to new strategies for monitoring, treating, or preventing HPV-related precancerous lesions and cancer in the anogenital region. The study highlights how early immune system changes can play a key role in the development of HPV-related cancers.

DOI - https://doi.org/10.18632/oncotarget.28715

Correspondence to - Humberto Carvalho Carneiro - humberto.carneiro@rededor.com.br

Video short - https://www.youtube.com/watch?v=6d8G8TUbgYc

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Oncotarget

Early Immune Evasion Found in HPV-Related Pre-Cancer Lesions of the Anogenital Region

Disco Regge - Mix live @ Lido Caina 21/05/2085

The Sex+Health podcast from the American Sexual Health Association covers all aspects of sexual health. Featuring interviews with medical professionals and experts in the field of sexuality, Sex+Health aims to offer information and resources to with the goal of helping people take charge of their sexual health and understand its importance to overall well being.

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

THE WORLD’S SOURCE FOR ANTI-SOCIAL COMMENTARY

Sick and Wrong is your hearing aid into the dark, depraved, and dripping abscess that is contemporary existence. An enchanting mélange of social criticism, pointed observation, and well-deserved derision; Sick and Wrong is the pepto-bismol for society’s indigestion. In their critically acclaimed weekly podcast, award-winning broadcasters Dee Simon and Lance Wackerle discuss the most vile, disquieting, and oddly amusing news items for your listening pleasure.

“The most foul thing I have ever heard. I can’t believe people listen to this shit.” — Katy Perry

“Sick and Wrong is my new favorite podcast.” — Drew Barrymore

“My mom told me about this podcast.” — Neil Patrick Harris

“These guys have seen Brokeback Mountain one too many times.” — Bruce Campbell

Écoutez le podcast du Centre Hospitalier du Mans.

موقع الحب ثقافة هو منصة للنقاش البناء حول الصحة الجنسية والإنجابية و الحب والعلاقات لمن يبلغ عمرهم 18 عام أو أكثر. من خلال هذه القناة، نعرض برامج من إنتاج منصتنا تناقش تلك الموضوعات.
تعمل المنصة في مصر من خلال مركز خدمات التنمية.

Lucid Sauna is Sigfrid Desire (Eros Nyström) and Vega Erotika (Italo Serpente), a Swedish duo of producers and deejays blending retrowave, Italo disco, and Chaos magick into a lush, hypnotic soundscape. Rooted in Stockholm’s underground and fueled by analog synths, spellcraft, and ketamine dreams, their music is a sensual collision of neon nostalgia and ritual intensity. With pulsing basslines, glittering arpeggios, and esoteric flair, Lucid Sauna transforms the dancefloor into a liminal space—part nightclub, part occult temple. Fiercely erotic and sonically subversive, they invite listeners into a lucid trance where time melts, bodies move, and magick happens.



New tracks tagged #HPV