BUFFALO, NY — April 14, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 3, on March 4, 2025, titled “Deciphering age-related transcriptomic changes in the mouse retinal pigment epithelium.”

The study, led by first authors Sushil K. Dubey and Rashmi Dubey with corresponding author Mark E. Kleinman from East Tennessee State University, reveals that aging causes inflammation, oxidative stress, and gene disruption in the retinal pigment epithelium (RPE), a vital layer of cells in the eye. These changes may explain why older adults are more vulnerable to age-related eye diseases. The researchers also developed a human cell model to study retinal aging and test future therapies.

The RPE plays a key role in maintaining retinal health. It recycles light-sensitive molecules, supports the visual cycle, and protects the retina from damage. When this layer becomes damaged, vision problems such as age-related macular degeneration can develop.

In this study, researchers compared gene activity in RPE cells from young and aged mice. They found that aging increased the activity of genes involved in immune system responses, inflammation, and oxidative stress, three known triggers of tissue damage. At the same time, genes related to vision and light detection became less active, weakening the RPE’s ability to support healthy vision.

To reinforce these findings, the research team also aged human RPE cells in the lab. Over time, these cells showed the same patterns: inflammation increased, while genes tied to visual function decreased. This human cell model offers a practical way to explore how RPE degeneration happens over time and how it might be slowed down or reversed.

The research also identified “hub genes,” which are central players of the gene networks involved in RPE aging. These are connected to immune signaling, oxidative damage, and changes in the eye’s structural support. Many of these genes are already known to be involved in age-related retinal degeneration, so they may become important targets for future treatments aimed at protecting vision in older adults.

“GO annotation of downregulated genes included processes related to visual perception, sensory perception of light stimulus, detection of light stimulus, detection of visible light, detection of external stimulus, detection of abiotic stimulus, phototransduction, cellular response to interferon-beta, response to interferon-beta, and response to light stimulus.”

By mapping how the RPE changes with age at the molecular level, this study provides a clearer understanding of why aging leads to eye disease. It also introduces a reliable laboratory model that researchers can use to test new therapies. Altogether, the work is a key step toward developing treatments to slow or prevent vision loss tied to retinal aging.

Read the full paper: DOI: https://doi.org/10.18632/aging.206219

Corresponding author: Mark E. Kleinman- kleinman@etsu.edu 

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Keywords: aging, transcriptome, retinal pigment epithelium, oxidative stress, inflammation, chronological aging

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

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Aging (Aging-US)

Aging Triggers Inflammation and Stress in Retinal Cells, Raising Risk of Vision Loss

In this conversation I welcomed Renee Fitton onto the podcast to discuss some different ideas around fasting and how appropriate it is for women (and men), especially during peri menopause and as we get older. You will see there are a lot of considerations when it comes to fasting and in many cases, jumping into a water only fast is not smart for many of us. We discuss how fasting can directly influence hormones in both a good and bad way - improving insulin, yet impairing others like thyroid and progesterone. Again, a lot to be considered. We hope you enjoy this conversation and let us know if you have any questions or feedback in the comments. :)

Renee Fitton MS, RD is a leader in the intersection of nutrition, healthcare, and education. As Director of Education & Healthcare Sales at Prolon, she shapes sales strategies and equips healthcare practitioners with cutting-edge insights into nutrition and longevity as it relates to fasting and dietary patterns. Her expertise in evidence-based practices and nutritional science has made her a trusted authority. Find out more about Renee and her work here;
 Instagram / fittonnutrition  
 LinkedIn / reneefitton  
https://prolonlife.com/

If you find these videos or the podcasts helpful or interesting and you want me to continue making them, you can support me in making these and the podcasts because they really do take a lot of time, especially where the research is involved. You can buy me a coffee, I will share the link in the description. I really appreciate those of you who have supported me already, I do love coffee. Thank you so much for your generosity.
https://buymeacoffee.com/cmhthanks

And as always, please like, share and subscribe if you haven't already. 
Thank you!!!!
Chemaine :)

#370 Fasting and hormones, insight with Renee Fitton.

I had the most EPIC conversation on the podcast with KINEON CEO Forest Smith. Sooo many rabbit holes were visited! If you are not convinced that you need to try targeted red light therapy after listening to this conversation, then I don't know what to say. But I am confident you won't be disappointed in this podcast episode. You will learn the many ways red light therapy supports health and healing. What we discussed;
- My powerful experience treating SIBO with KINEON targeted red light therapy
- Healing the gut with PBMT (photo biomodulation therapy - another term for red light therapy)
- Improving migraine, headaches and neck pain
- Improving blood flow and cardiovascular health
- Red light therapy showing amazing results for endometriosis and fertility
- Mental health improvements
- Cancer treatment support protocols
- Pain management and arthritis
- Energy production, metabolism, fatty liver and more!
This conversation is a game changer for understanding the many roles of red light therapy and I am thankful that Forest was so open to letting this conversation flow. Please let us know if you have any feedback in the comments. :)
You can avail of $100 (140 CAD) discount using code; CHEMAINE

Forrest Smith is the co-founder and CEO of Kineon (From the Greek for “kick ass”! 🙂). He is a dynamic entrepreneur and esteemed leader in the tech hardware industry, brings to the table an impressive 20-year track record of creating and scaling successful startups. His career trajectory at Kineon Labs stands as a testament to his unwavering optimism and innovative approach in the field of health and wellness technology. Forrest speaks, reads, and writes fluent Chinese and lives in Mexico. You can literally feel his excitement through the screen.
Find out more about KINEON here;
https://instagram.com/kineon_labs
‪@Kineon_Labs‬ 
https://kineon.io

If you find these videos or the podcasts helpful or interesting and you want me to continue making them, you can support me in making these and the podcasts because they really do take a lot of time, especially where the research is involved. You can buy me a coffee, I will share the link in the description. I really appreciate those of you who have supported me already, I do love coffee. Thank you so much for your generosity.
https://buymeacoffee.com/cmhthanks

As always, please like, share and subscribe if you haven't already! I appreciate your support. :)

Chemaine xo

#373 RED LIGHT THERAPY; Gut health, migraines, pain, metabolism & more, with KINEON CEO Forest Smith.

On the April 19, 2025, WAEB radio show, host Bobby Gunther Walsh is joined by Dr. Adam Teichman, DPM, to discuss how Res-Q omega-3 supplements can help improve heart health, reduce inflammation, and provide benefits for your overall well-being. Tune in for expert advice on enhancing your well-being!

Dr. Adam Teichman, DPM & host Bobby Gunther Walsh AM790 WAEB 04-19-25

Omega-3 Testimonials -- WAEB 04-19-25

In this #episode of the Longevity & Aging Series, Dr. Shubhankar Suman from the Department of Oncology at Georgetown University Medical Center joins host Dr. Evgeniy Galimov to discuss a #research paper he co-authored in Volume 17, Issue 1 of Aging (Aging-US), titled: “Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc1638N/+ mice.”

DOI - https://doi.org/10.18632/aging.206183

Corresponding author - Shubhankar Suman - ss2286@georgetown.edu

Author interview - https://www.youtube.com/watch?v=ClLO0ERwC0M

Video short - https://www.youtube.com/watch?v=M_WEht4vy4w

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Keywords - aging, senescence-associated secretory phenotype, senolytic agent, carcinogenesis, inflammation, β-catenin

To learn more about Aging (Aging-US), please visit our website at https://www.Aging-US.com​​ and connect with us:

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Longevity & Aging Series (S3, E4): Dr. Shubhankar Suman

It was a delight to speak to Wade T Lightheart of ‪@Bioptimizers‬ on the podcast today. In this powerful conversation with Wade, we dive deep into the world of enzymes and their critical role in gut health, reducing inflammation, improving recovery, and supporting muscle growth. Wade - co-founder of BiOptimizers and a 3-time natural bodybuilding champion - shares his expert insights on how enzymes can be the missing link in your wellness (and longevity) journey.
🔍 In this episode, you’ll learn:
What enzymes are and why they matter
How digestive enzymes support gut health and nutrient absorption
The connection between enzymes, inflammation, Fibromyalgia, and Rheumatoid Arthritis
Why athletes and active individuals should care about enzyme supplementation
How enzymes aid in faster recovery and better muscle gains
And lots more! 👇 Drop your questions or takeaways in the comments below.

📚 Learn more about Wade T. Lightheart & BiOptimizers:
https://bioptimizers.ca/
DISCOUNT CODE - modelhealth10
Instagram - https://www.instagram.com/bioptimizer...
YouTube - ‪@Bioptimizers‬ 
The Ultimate Nutrition Bible Book - https://a.co/d/dy0EZhI

💡 Whether you’re into biohacking, functional medicine, fitness, or just want better digestion and energy, this episode is packed with practical takeaways.

🎧 As always please like and share if you enjoyed this conversation. And don't forget to subscribe! Thank you xo

#380 Wade T Lightheart | Unlocking the Power of Enzymes for gut health, inflammation, recovery & gains.

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Plant-based diets have grown significantly in popularity over the past decade. People adhere to them for multiple reasons because they offer many different benefits, including for health, economics, animal welfare and the environment. This program explores what plant-based diets are, their benefits, nutritional adequacy, and sustainability.

Host: Kaysie Vokurka, Nutritionist & Lifestyle Medicine Practitioner
Guest: Dr Winston Craig, Adjunct Professor

Plant-Based Diets - YLAM240032


L’injection intravitréenne – souvent appelée IVT – est un geste ophtalmologique très courant utilisé pour traiter des pathologies comme la dégénérescence maculaire liée à l’âge (DMLA), l’œdème maculaire ou encore certaines inflammations oculaires.
Dans cet épisode, nous vous expliquons en quoi consiste ce traitement, comment il est réalisé, ce que vous ressentirez pendant l’injection, et pourquoi il est si important pour stabiliser ou améliorer la vision.
Vous découvrirez également les réponses aux questions les plus fréquentes :
– Est-ce que l’injection est douloureuse ?
– Combien de temps cela dure-t-il ?
– Y a-t-il des risques ou effets secondaires ?
– Faut-il se préparer ou être accompagné ?
🎙️ Ce podcast vous accompagne pas à pas pour mieux comprendre ce geste essentiel… et vous rassurer avant votre rendez-vous.


🎧 Les gestes de la vision est un podcast proposé par OMMA Ophtalmologie Paris.
🔎 En savoir plus sur nos interventions :
🌐 ophta-omma.paris (https://ophta-omma.paris)
📍 Retrouvez-nous à Paris :
📌 OMMA Paris 5 (https://g.co/kgs/6ughauE) – 5e arrondissement
📌 OMMA Paris 11 (https://g.co/kgs/asrdW74) – 11e arrondissement
📱 Suivez OMMA sur les réseaux sociaux :
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💬 N’hésitez pas à partager cet épisode ou à nous laisser un avis sur votre plateforme d’écoute.
Hébergé par Ausha. Visitez ausha.co/fr/politique-de-confidentialite pour plus d'informations.

L'injection Intra-Vitréenne

🎙️ In this episode, I’m joined again by Dr. Justin Marchegiani Functional Medicine Practitioner, to dive deep into gut health issues like SIBO (Small Intestinal Bacterial Overgrowth), FIBO (Fungal Overgrowth), and acid reflux. We discuss the root causes behind chronic bloating, gas, indigestion, and why many people struggle with stubborn digestive symptoms—even when eating “healthy.” Also my experience with SIBO over the last few months and the supplements and tools that helped me heal. We also share some anecdotes from some of our clients that have also dealt with these gut issues. Unfortunately something went haywire with the video - we are trying to rectify it. But the sound is perfect. 😉
👉 What you’ll learn in this conversation;
What SIBO, FIBO, and acid reflux really are
How does one get SIBO, FIBO and acid reflux
Natural remedies, supplements and herbs we use to heal the gut
Testing for SIBO
Why acid-blocking medications might make things worse
Natural ways to support stomach acid and digestion
When to consider functional testing and targeted supplements
And lots more!

As always, Dr. Justin shares practical advice and insights you can start using today to support your gut health naturally. Connect with Dr J or find out more about his work here;
NEW THYROID BOOK - https://a.co/d/a547NAB
YouTube - ‪@JustInHealth‬ 
Web - https://justinhealth.com
Instagram -   / justinhealth  

👉 If you found this helpful, please like, share, subscribe, and hit the notification bell so you never miss future conversations from me and other experts who want to help you feel your best. Chemaine xo

#385 SIBO, FIBO, & Acid Reflux Explained; Root Causes & Solutions with Dr Justin Marchegiani

I’m joined by biological dentist Dr. Toni Engram to explore the critical connection between oral health, hormones, aging, and whole-body wellness.
We cover how inflammation and poor nutrition impact the mouth, how oral health changes as we age, and why hormonal shifts - especially in perimenopause and menopause - can directly affect your gums, teeth, and jaw. The importance of oral health is often overlooked when we think of "optimizing health", I hope this conversation encourages you to take your oral health more seriously and helps you understand what your oral health might be telling you about your body. 
🔍 We discuss:
The root causes of gum disease and cavities
How hormonal changes affect oral tissue and bone density
Why and how oral health is a mirror of systemic inflammation
Nutritional and lifestyle strategies to support healthy teeth and gums
Signs your mouth may be warning you about deeper health issues
Our opinions on coconut oil pulling (prepare to lol)
And lots more.
Whether you’re noticing bleeding gums, receding gum lines, teeth grinding, or changes in your bite, this conversation offers science-based insights to help you connect the dots between what’s happening in your mouth and what’s going on in your body.

DR. Toni Engram is a biological dentist, integrative health coach, and owner of Flourish Dental Boutique in Richardson, TX. She offers many resources and helpful tips on how to take care of your oral health on her social media and website which you can find here;
Instagram -   / drtoniengram  
YouTube - ‪@yourholisticdentist‬ 
Facebook -   / flourishdentalboutique  
Website - http://flourishdental.com/

👉 If you found this helpful, please like, share, subscribe, and hit the notification bell so you never miss future conversations from me and other experts who want to help you feel your best. Chemaine xo


#387 The Hidden Link Between Oral Health, Hormones & Disease with Dr Toni Engram

In this Wellness Waves episode, Dr. Rory Dopps explains the anatomy of the C7 nerve, discusses conservative treatments and shares tips for reducing inflammation through posture, nutrition and chiropractic care.

C7 – Gateway Between Neck and Thorax

In this solo podcast episode I discuss why I believe Pure Krill oil is SUPERIOR to Fish oil and have done for almost 10 years now. 
Pure Krill oil has a phospholipid backbone which makes the DHA and EPA it contains more bioavailable and efficacious.  I recommend avoiding nearly all commercial fish oil supplements, because the DHA and EPA are delivered in the form of ethyl esters.  Ethyl esters are the least bioavailable and cheapest form of omega-3.
But a new lysophospholipid form of DHA found in Krill oil shows promise for preventing macular decline that often occurs alongside chronic inflammation and diseases like Alzheimer’s and diabetes. Whereas the DHA in most fish oil supplements cannot reach the retina, where DHA
 concentrates, LPC-DHA crosses into the retina from the bloodstream easily. Krill oil also counteracts neuroinfammatory processes, due to its phospholipids and additional antioxidant "astaxanthin". Find out more in this newest episode. Also the link to my previous video on krill oil is here;
https://youtu.be/JGJ4M8sVU3M

As always, please like share and subscribe if you haven't already. :)


#388 Why I believe Pure Krill oil is Superior to Fish oil.

Can functional medicine unlock the secrets to healthy aging? In this special preview of the Functional Medicine is Longevity Medicine™ Masterclass happening on September 17- September 19, 2025, Dr. Kara Fitzgerald sits down with three leading voices in medicine and research:

- Dr. Bob Rountree: functional medicine pioneer in integrative approaches to health

- Dr. Dale Bredesen: internationally recognized expert on Alzheimer’s prevention and reversal

- Dr. Charles Serhan: Harvard researcher on inflammation resolution and aging biology

Together, they explore how functional medicine reframes longevity by addressing root causes, supporting cognitive health, and resolving chronic inflammation.

Whether you’re a clinician, health professional, or simply passionate about living longer and healthier, this conversation offers a glimpse into the science and practical applications that are transforming longevity medicine.

WATCH NOW TO LEARN:

- Why functional medicine is central to extending healthspan
- The latest insights on Alzheimer’s prevention and brain health
- How inflammation resolution impacts aging and chronic disease
- What to expect in the full Functional Medicine is Longevity Medicine™ Masterclass

Learn more & register for the Masterclass here: www.functionalmedicineislongevitymedicine.com

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Why Functional Medicine Is the Future of Longevity

What if one enzyme could link metabolism, epigenetics, and therapy across conditions as diverse as epilepsy, cancer, and inflammation?

In this episode, we dive into the fascinating world of adenosine kinase (ADK), an ancient enzyme that controls adenosine levels, energy balance, and even DNA methylation. Dr Detlev Boison join us to discuss their recent review in the Journal of Inherited Metabolic Disease, which reframes ADK not just as a metabolic regulator, but as a potential epigenetic drug target.

From seizure suppression to cancer immunology, ADK sits at a crossroads, and could be a future key to metabolic and epigenetic medicine.

Adenosine Kinase: An Epigenetic Modulator and Drug Target
Uchenna Peter-Okaka, Detlev Boison
https://doi.org/10.1002/jimd.70033

Adenosine Kinase

                    
- Milestone- We'll look back to these days and be thankful. We will have a shock across the bow Michael was shown. Bold statements by Baltics, Europe and many other countries. Politics is guiding our lives. We are all part of humanity. Nations of bloodshed on the backs of innocents will fall. Wicked prosperity. 
- Russia/Ukraine- Russia not on last leg. Really Russia wars with NATO. Was said Ukraine is the front line of NATO. Russia using foreign troops and forced it's own to fight.
- Talk of the Spetsnaz when Obama came in as a stumbling block and went. Trump 1st term was a different man than Trump 2nd term. He tries to bring righteousness back because he was touched. Satan is the president of this system. Trump is giving Christians some time to stand up. Heaviest penalties have been when the church slipped up. Grace and mercy is with us. Council running nation now. God is involved with good and bad people. Don't be part of the kingdom of men. Pray for leaders. Qualified people aren't in leadership. Games ae being played. No warnings for weather or water. 
- inflammation- evoC60. Works. Ensure works too with water.
- Churches had 501C3 tax status. Degraded church. 
- Determine the tree by it's fruit, not the leaves. We are created to become specific individuals. What God made you to be, not whatever you want to be. Hybrids bear a foreign fruit. Never forget you are what God intended you to be. Purge darkness of rebellion. Don't wear strange garments. 
- We'll hear of a majestic woman that will assume power over all nations. Timing depends on us. Born in a process and close to the end? 
- Important people have "died". COT consensus that something's amiss. Death of multitudes goes unreported. AI architect gave a warning. Sentient in 1 yr. not 20 yrs. Data centers NY sized underground. Cars, medical, parking in moments.
- Babylon is the model til the end of Earth. Daniel's statue with 4 eras. 4th most diverse. Last kingdom described as full of eyes. (Like today)  1700's abduction stories before planes. 
- Those from the seas will surface again. US abandoned deep sea exploration. In league? Peace treaties in Arctic. No arms. Why? Abandoned moon as well. NASA admits photos are doctored. Things can be seen there that men put there. UFO story is a lie. It's about fallen angels. 
- Lasers seen mounted on vehicles/Abram's tanks from Michael's dream. US troops deploying against crime.  4 places "on menu" of 7. Must be consequences. 
- This process isn't for our destruction.


09 03 2025  The Final Age of Earth - Have we Arrived?

Even though polychlorinated biphenyls (PCBs) were banned nearly 50 years ago, these persistent chemicals are still part of our daily environment. In this episode of Plugged into Public Health, we talk with Dr. Amanda Bullert, neuroscientist and research consultant at the University of Minnesota, about what PCBs are, how exposure still happens today, and what her team’s research reveals about their effects on the brain.

Amanda breaks down how PCBs influence metabolism, inflammation, and long-term brain health, why certain communities are more at risk, and what steps individuals and public health leaders can take to reduce harm. It’s a conversation that sheds light on the hidden legacy of environmental pollutants and the lessons they offer for today’s public health challenges.

A transcript of this episode is available at https://www.public-health.uiowa.edu/news-items/plugged-in-to-public-health-persistent-pollution-reducing-the-risk-of-pcbs-on-brain-health/

Have a question for our podcast crew or an idea for an episode? You can email them at CPH-GradAmbassador@uiowa.edu

You can also support Plugged in to Public Health by sharing this episode and others with your friends, colleagues, and social networks.

#publichealth #environmentalhealth #PCBs #foreverchemicals #brainhealth #pollution #inflammation

Persistent Pollution: Reducing the Risk of PCBs on Brain Health with Dr. Amanda Bullert

For a wealth of life changing information visit:  3abnaustralia.org.au/radio/listen 

3ABN (Three Angels Broadcasting Network) Australia Radio is the "Mending Broken People Network," broadcasting Christian content 24/7.

Welcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF  

Copyright © 2023 by KF Education and Consulting, LLC
All Rights Reserved

Proverbs 18:21 "Death and life are in the power of the tongue, and those who love it shall eat of its fruit."
It is my hope that my podcast and these conversations bring you insight and the tools to take responsibility for your health and hormones, so that you may live your best life AND fulfill your life's purpose with determination and happiness. Please like and subscribe if you are enjoying my content. :)

If you are considering reaching out, I work with high-achieving motivated people in a 1:1 position to optimize their health and life through a science backed holistic approach. This includes personalized nutrition and hormone therapy, 360° sleep improvement, strategic supplementation, movement and more.📝📊🧬

Don't be afraid to say Hi sometime!
support@chemainesmodelhealth.com or on Facebook and Instagram - I swear I do respond! ;)

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

The University of Iowa College of Public Health is a top-ranked school of public health, meeting the public health challenges of the 21st century through education, research, outreach, and community engagement.

JIMD Podcasts is home to the Journal of Inherited Metabolic Disease podcast and the JIMD Shortcast. We're also proud to showcase Metabolic Mysteries and the new Footprints in IMD podcast.

New tracks tagged #Inflammation