monks (prod. maurice)

BUFFALO, NY – June 9, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on May 20, 2025, titled “Cigarette smoke and decreased DNA repair by Xeroderma Pigmentosum Group C use a double hit mechanism for epithelial cell lung carcinogenesis.”

In this study, led by first author Nawar Al Nasralla and corresponding author Catherine R. Sears, from the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indianapolis and the Richard L. Roudebush Veterans Affairs Medical Center, researchers investigated how cigarette smoke and reduced DNA repair capacity contribute together to the development of lung cancer. They found that when a critical DNA repair protein called XPC is decreased and lung cells are exposed to cigarette smoke, the combination causes extensive damage and significantly increases cancer risk.

Non-small cell lung cancer (NSCLC) develops through both genetic and environmental factors. This study focused on how cigarette smoke affects the body’s natural ability to repair DNA. The researchers studied the role of XPC, a protein essential for recognizing and repairing harmful DNA changes caused by tobacco smoke. They found that low levels of XPC — commonly seen in lung cancer patients — made lung cells less capable of repairing DNA. This made the cells unstable and more likely to become cancerous. These changes were most pronounced in normal lung cells, suggesting that the earliest stages of disease occur before cancer is even detected.

The findings support a “double hit” model, where both cigarette smoke and reduced DNA repair work together to drive cancer development. In laboratory experiments, normal lung cells with low XPC levels showed more damage and cell death after cigarette smoke exposure. By contrast, lung cancer cells were more resistant to smoke damage, even when XPC was low, indicating that critical changes had likely occurred earlier in the disease process.

“Our study suggests that cigarette smoke exposure leads to decreased XPC mRNA expression, exacerbates total and oxidative DNA damage, hinders NER, and may contribute to lung cancer development.”

The study also showed that DNA repair ability declined significantly in healthy cells after smoke exposure, but this effect was not seen in cancer cells. In addition, the researchers confirmed that XPC gene activity was lower in actual lung tumor tissue compared to nearby healthy lung tissue. This pattern was consistent across both adenocarcinoma and squamous cell carcinoma, the two main types of NSCLC.

These results add to our understanding of how lung cancer begins at the molecular level. By showing how cigarette smoke and reduced DNA repair combine to create genetic instability, the research points toward new strategies for prevention. A better understanding of XPC’s role could help identify high-risk individuals and inform future efforts to stop lung cancer before it begins.

DOI - https://doi.org/10.18632/oncotarget.28724

Correspondence to - Catherine R. Sears - crufatto@iu.edu

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Keywords - cancer, DNA repair, DNA damage, lung adenocarcinoma, squamous cell carcinoma, Xeroderma Pigmentosum Group C (XPC)

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Oncotarget

Cigarette Smoke and DNA Repair Deficiency Drive Lung Cancer Development

JUST TAKE THE TIME TO BREATH SOME FRESH AIR

GET SUMAIR

STBB 959 - SNOTTERS

BUFFALO, NY — August 14, 2025 — A new #research paper was #published in Volume 17, Issue 7, of Aging (Aging-US) on July 3, 2025, titled “Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort.”

In this study, led by first author Eleanor Kate Phillips from Brigham and Women’s Hospital and corresponding author Dawn L. DeMeo from Brigham and Women’s Hospital and Harvard Medical School, researchers investigated how frailty impacts lung health and survival in individuals with a history of cigarette smoking. They found that frailty raises the risk of lung attacks and death, even in smokers with preserved lung function. This result shows why all current and former smokers should be checked for frailty.

Frailty is a condition that makes the body more vulnerable to illness, especially in older adults. This study focused on more than 2,600 adults with a history of heavy smoking, many of whom showed no signs of lung damage on standard tests. At the second follow-up visit, participants were categorized as robust, prefrail, or frail and followed for about three years. Researchers tracked how often they experienced respiratory attacks, such as episodes of severe coughing or breathlessness, and whether they survived during that period.

“COPDGene is a cohort study of individuals aged 45–80 with a minimum 10 pack-year smoking history.”

The results showed that people who were frail had a three- to five-fold higher chance of developing serious or frequent respiratory attacks compared to those who were robust. These risks were not limited to people with chronic lung disease. In fact, many frail participants with normal lung function still faced a significantly higher chance of lung attacks and death. Even those in the “prefrail” stage, a milder form of frailty, were more likely to experience health complications.

The research team also found that frailty was associated with an accelerated pace of biological aging, measured using a DNA-based test called DunedinPACE. This supports the idea that frailty may reflect deeper biological changes in the body that go beyond what traditional lung function tests can detect. These findings challenge the idea that standard lung tests can rule out future respiratory complications in people with a history of smoking. 

Altogether, the study shows that simple frailty checks could help identify early health problems, allowing for timely interventions that may prevent hospitalizations and potentially save lives. The study suggests that frailty screening may be a valuable tool in public health efforts to reduce respiratory disease and improve outcomes for aging adults.

DOI - https://doi.org/10.18632/aging.206275

Corresponding author - Dawn L. DeMeo - redld@channing.harvard.edu

Video short - https://www.youtube.com/watch?v=G1XQhQN6PQ8

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Keywords - aging, frailty, cigarette smoking, respiratory exacerbations, COPD, epigenetic aging

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Aging (Aging-US)

Frailty Linked to Higher Risk of Respiratory Complications and Death in Smokers

ion like the old me

DISCLAIMER! This is a Remix of the original song. This remix was made for educational and personal use only — I do not intend to make any money from it, nor do I plan to distribute it commercially. All rights to the original song and vocals belong to the respective copyright holders.

-Lungs - Ruti (Playaparty.exe) Remix

BUFFALO, NY — September 11, 2025 — A new #research paper was #published  in Volume 17, Issue 8 of Aging-US on August 8, 2025, titled “AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging.”

In this study, researchers Fedor Galkin, Shan Chen, Alex Aliper, Alex Zhavoronkov, and Feng Ren from Insilico Medicine used artificial intelligence (AI) to investigate the similarities between idiopathic pulmonary fibrosis (IPF), a severe lung disease, and the aging process. Their findings show that IPF is not simply accelerated aging, but a distinct biological condition shaped by age-related dysfunction. This insight may lead to a new approach in how scientists and clinicians treat this complex disease.

IPF mainly affects individuals over the age of 60. It causes scarring of lung tissue, making it harder to breathe and often leading to respiratory failure. Current treatments can slow the disease but rarely stop or reverse its progression. The researchers used AI to identify shared biological features between aging and fibrosis, finding new potential targets for therapy.

The team developed a “proteomic aging clock” based on protein data from more than 55,000 participants in the UK Biobank. This AI-driven tool accurately measured biological age and found that patients with severe COVID-19, who are at increased risk for lung fibrosis, also showed signs of accelerated aging. This suggests that fibrosis leaves a detectable biological trace, supporting the use of aging clocks in studying age-related diseases.

“For aging clock training, we used the UK Biobank collection of 55319 proteomic Olink NPX profiles annotated with age and gender.”

They also developed a custom AI model, ipf-P3GPT, to compare gene activity in aging lungs versus those with IPF. Although some genes were active in both, many showed opposite behavior. In fact, more than half of the shared genes had inverse effects. This means IPF does not just speed up aging but also disrupts the body’s normal aging pathways.

The study identified unique molecular signatures that distinguish IPF from normal aging. While both involve inflammation and tissue remodeling, IPF drives more damaging changes to lung structure and repair systems. This difference could guide the development of drugs that specifically target fibrosis without affecting normal aging.

By combining AI with large-scale biological data, the study also introduces a powerful toolset for examining other age-related conditions such as liver and kidney fibrosis. These models may support personalized treatments and expand understanding of the relationships between aging and disease, opening new directions for therapy development.

DOI - https://doi.org/10.18632/aging.206295

Corresponding author - Alex Zhavoronkov - alex@insilico.com

Abstract video - https://www.youtube.com/watch?v=24lX2lHbt7o

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Keywords - aging, IPF, generative AI, transformer, proteomics

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Aging-US

AI Tools Uncover New Link Between Idiopathic Pulmonary Fibrosis and Aging

Idiopathic Pulmonary Fibrosis (IPF) is a progressive lung disease that primarily affects people over the age of 60. It causes scarring in the lung tissue, which gradually reduces lung capacity and makes breathing difficult. Despite years of research, the exact causes of IPF remain largely unknown, and current treatments mainly aim to slow its progression rather than reverse or cure the disease.

Because IPF tends to develop later in life, researchers have long suspected a connection with biological aging. This is the focus of a recent study by scientists from Insilico Medicine. Their research, titled “AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging,” was published recently in Aging-US, Volume 17, Issue 8.

Full blog - https://aging-us.org/2025/09/ai-tools-reveal-how-ipf-and-aging-are-connected/

Paper DOI - https://doi.org/10.18632/aging.206295

Corresponding author - Alex Zhavoronkov - alex@insilico.com

Abstract video - https://www.youtube.com/watch?v=24lX2lHbt7o

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Keywords - aging, IPF, generative AI, transformer, proteomics

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AI Tools Reveal How IPF and Aging Are Connected

"THAT OTHER RAP SHOW" the September 2025 issue.

www.instagram.com/grownassfm

Grown Ass Folks Melodies presents "That Other Rap Show".
Monthly news mix covering the independent US Rap scene leaning towards the more soulful and deep side of things, call it neo-boom-bap, drumless, or whatever you're comfortable with… it's the G.A.F.M. way, attached to the vibe of its original and more musically open vinyl show.
Thank you for taping in… keep it locked — The Boo Inc. <3

Art: Taylor Simmons "Vision After The Sermon" (2022)
www.instagram.com/taytheism

// TRACKLIST

NOWAAH THE FLOOD & DANI "THE HEART CHECK"
JAY ELECTRONICA FEAT. WESTSIDE GUNN & HIT-BOY "BEST WISHES"
THA GOD FAHIM FEAT. SKYZOO [PROD. CARTUNE BEATZ] "AUDIBLE AMMUNITION"
K. SOLAR FEAT. KONCEPT JACK$ON "DATA"
YL, PHIIK, LUNGS & ILL SUGI "OFF THE WAKE UP"
FATBOI SHARIF & ROPER WILLIAMS "JESUS CHAIN"
RAPSODY & MADLIB "DADDY'S GIRL"
CHESTER WATSON FEAT. GABE 'NANDEZ "HEXAGRAM"
SOL CHYLD [PROD. FRANKIE P & BUDDY MINNELLI] "FAKE THE FUNK"
KEMP DUPRI & NAK "PATENT LEATHER BAPES"
BIGG DOGG FEAT. LORD SKO "MOMENT IN TIME"
MADLIB & YOUR OLD DROOG FEAT. KILLER MIKE "THE EDGE"
SHRAPKNEL & OHBLIV "THRIFT ULTRA"
ANDY SAVOIE FEAT. ICECOLDBISHOP & BLU "SEEING GREEN"
THERAVADA "SUCKA MCS PT. 2"
DEEVODAGENIUS FEAT. MONDAY NIGHT "2LIVES (JUSTICE RIDDIM)"
JAY WORTHY [PROD. SEAN HOUSE] "96 BIG BODY"
MAGNA CARDA FEAT. E'NAJ "ANGELS/DEVILS"
SHUNGU FEAT. PINK SIIFU "STAY ALIVE"
LET THE DIRT SAY AMEN & SKINNY HIGHTOWER "BOBBI HUMPHREY"
ZELOOPERZ [PROD. DILIP] "FIRST INSTRUMENT"
EL COUSTEAU [PROD. TWELVEAM] "A GOOD LAUGH"
CARRTOONS "CASCADE" FEAT. THE KOUNT, WIKI & RAE KHALIL
BA PACE FEAT. 3WAYSLIM (PROD. THE BUILDER) "HEAVY IS THE HEAD THAT THINKS"
SWAMP THUG X DAY SOLO X JOSH THE AUTHOR X BROMETHAZINE "900 VINESHIRE"

THAT OTHER RAP SHOW - The September Issue

Mash-up of "You've Got The Love" by Florence + the Machine and "Can't Pin Me Down" by MARINA.

DISCLAIMER:
This is an unofficial mash-up of "You've Got The Love" by Florence + the Machine and "Can't Pin Me Down" by MARINA. I do not own the rights to the original songs — all rights belong to Florence + the Machine, MARINA and their respective copyright holders. This remix was made for entertainment and non-commercial purposes only.

If you are the copyright owner and would like this removed, please contact me and I will take it down immediately.

MARINA X Florence + the Machine - Can't Pin The Love (Mash-up)

lungs (hollowstakk)

demo from earlier this yr !!! 
love 2 family .tetsuo for sending thru this lungs beat fr + biiiig shout out 2 lungs , biiiiiiiiiiigesst love always <333
all love

my writing helps me speak prod. Lungs//Lonesword

Today we are bringing you a conversation on the evolving landscape for idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF) treatment. 

Ryan Haumschild, PharmD, MS, MBA, vice president of ambulatory pharmacy at
Emory Healthcare and Winship Cancer Institute, spoke with Marilyn Glassberg, MD, the John W. Clarke Professor and Chair of medicine at Loyola University Chicago Stritch School of Medicine; Ayodeji Adegunsoye, MD, MSc, PhD, FACP, FCCP, assistant professor at the University of Chicago; and Janet Pope, MD, MPH, professor of medicine and division member of rheumatology at the University of Western Ontario in Canada.

IPF and PPF are increasingly prevalent conditions that pose a growing burden on both patients and health care systems. Despite the availability of FDA-approved antifibrotic therapies, the median survival for patients with IPF and PPF remains less than 5 years after diagnosis—underscoring the critical unmet needs that persist in this field. The panelists discussed the impact these conditions have on patients' lives, evaluated emerging agents, and addressed economic considerations that affect treatment decisions and health care resource allocation.


Managed Care Cast Presents: New Evidence and Economic Considerations in IPF Care

Spiracle - Flower Face (WILLKO Edit)

Composer/ Producer working hard to submit some music for Artists, Sports, Movies and TV Placements.

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Grown Ass Folks Melodies
> www.instagram.com/grownassfm

Rinse France resident
> www.rinse.fr/artists/the-boo

Co-Founder of ClekClekBoom Recordings
> www.clekclekboom.com

https://www.instagram.com/peachuhere?igsh=dDRhMm5qODNwN3Ez&utm_source=qr

New tracks tagged #LUNGS